• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.156-161
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• 2003

It is an interest problem to predict substance distributions in three-dimensional space. Recently, a research field as Geostatistics is advanced. It is a kind of inter- or extrapolation mathematically. Some useful means for the inter- and extrapolation are known, in which slide window method with neural networks is hopeful one. We propose multi-dimensional extrapolation using multi-layer neural networks and the slide-window method. The multi-dimensional extrapolation is not similar to one-dimension. It has plural algorithms. We researched line predictors and local-plain predictors I two-dimensional space. The both predictors are equivalent; however, in multi-dimensional extrapolation, it is very important to find the direction of predictions. Especially, since the slide window method requires information to predict the future in sampling data, if they are not ordered appropriately in the direction, the predictor cannot operate. We tested the extrapolation for typical two-dimensional functions, and found an excellent character of slide-window method based on local-plain. By using the method, we can extrapolate the function until twice-outer regions of the definitions.

• Genomics & Informatics
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• v.18 no.1
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• pp.3.1-3.8
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• 2020

Patient-derived xenograft (PDX) mouse models are frequently used to test the drug efficacy in diverse types of cancer. They are known to recapitulate the patient characteristics faithfully, but a systematic survey with a large number of cases is yet missing in lung cancer. Here we report the comparison of genomic characters between mouse and patient tumor tissues in lung cancer based on exome sequencing data. We established PDX mouse models for 132 lung cancer patients and performed whole exome sequencing for trio samples of tumor-normal-xenograft tissues. Then we computed the somatic mutations and copy number variations, which were used to compare the PDX and patient tumor tissues. Genomic and histological conclusions for validity of PDX models agreed in most cases, but we observed eight (~7%) discordant cases. We further examined the changes in mutations and copy number alterations in PDX model production and passage processes, which highlighted the clonal evolution in PDX mouse models. Our study shows that the genomic characterization plays complementary roles to the histological examination in cancer studies utilizing PDX mouse models.

• The Korean Journal of Ecology
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• v.19 no.5
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• pp.465-476
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• 1996

There are several environmental variables that may be influential to the spatial distribution of forest vegetation. To create a map of forest vegetation zone over southern part of Korean Peninsula, digital map layers were produced for each of environmental variables that include topography, geographic locations, and climate. In addition, an extensive set of field survey data was collected at relatively undisturbed forests and they were introduced into the GIS database with exact coordinates of survey sites. Preliminary statistical analysis on the survey data showed that the environmental variables were significantly different among the previously defined five forest vegetation zones. Classification of the six layers of digital map representing environmental variables was carried out by a supervised classifier using the training statistics from field survey data and by a clustering algorithm. Although the maps from two classifiers were somewhat different due to the classification procedure applied, they showed overall patterns of vertical and horizontal distribution of forest zones. considering the spatial contents of many ecological studies, GIS can be used as an important tool to manage and analyze spatial data. This study discusses more about the generation of digital map and the analysis procedure rather than the outcome map of forest vegetation zone.

• Bulletin of the Korean Chemical Society
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• v.25 no.7
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• pp.1061-1064
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• 2004

Molecular visualization software has the common objective of manipulation and interpretation of data from numerical simulations. They visualize many complicated molecular structures with personal computer and workstation, to help analyze a large quantity of data produced by various computational methods. However, users are often discouraged from using these tools for visualization and analysis due to the difficult and complicated user interface. In this regard, we have developed an easy-to-use three-dimensional molecular visualization and analysis program named POSMOL. This has been developed on the Microsoft Windows platform for the easy and convenient user environment, as a compact program which reads outputs from various computational chemistry software without editing or changing data. The program animates vibration modes which are needed for locating minima and transition states in computational chemistry, draws two and three dimensional (2D and 3D) views of molecular orbitals (including their atomic orbital components and these partial sums) together with molecular systems, measures various geometrical parameters, and edits molecules and molecular structures.

• Culinary science and hospitality research
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• v.16 no.2
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• pp.322-329
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• 2010

The objective of this study is to investigate the attributes of purchasing soybean paste and calculate the priorities among the attributes focusing on traditional soybean paste in the Jeju region. To achieve this goal, the priorities was analyzed through a survey for restaurants and housewives with AHP methodology. The result showed that soybean paste made in B company was most preferred among domestic products, followed by one made in A company and traditional Jeju soybean paste. As a result of the sensitivity analysis, traditional Jeju soybean paste is considered to have a high market share if its price can be lower.

• The Journal of Information Technology and Database
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• v.7 no.2
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• pp.47-59
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• 2000

In this paper, we analyze the applicability of a general optimization algorithm to a database optimization problem. The index selection problem Is the problem to choose a set of indexes for a database in a way that the cost to process queries in the given workload is minimized subject to a given storage space restriction for storing indexes. The problem is well known in database research fields, and many optimization and/or heuristic algorithms have been proposed. Our work differs from previous research in that we formalize the problem in the form of non-linear Integer Programming model, and investigate the feasibility and applicability of a general purpose optimization algorithm, called OPBDP, through experiments. We implemented algorithms to generate workload data sets and problem instances for the experiment. The OPBDP algorithm, which is a non-linear 0-1 Integer Programming problem solver based on Davis-Putnam method, worked generally well for our problem formulation. The experiment result showed various performance characteristics depending on the types of decision variables, variable navigation methods and ocher algorithm parameters, and indicates the need of further study on the exploitation of the general purpose optimization techniques for the optimization problems in database area.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.45 no.6
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• pp.10-15
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• 2008

This paper describes virtual environment and sensor modeling to analyze and verify the performance of autonomous navigation system. Virtual synthetic environment is constructed with 6 subgroups which cover from virtual environment construction to virtual sensor modeling of real systems. This research is applied to validate and assess performance of concerned algorithms and complex functions for autonomous navigation system based on virtual environment.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.7 no.1
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• pp.57-66
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• 2012

This paper analyzes the relationships between knowledge-centered culture, learning process, and knowledge/learning outcomes. Knowledge management researches have emphasized the important role of a knowledge-centered culture in venture business. After a literature review, research model is developed and the research hypothesis is made. And then, the hypothesis is tested using regression analysis with data collected from venture firms. The results of the empirical study show that cooperative learning does not strengthen the knowledge outcomes on the autonomy and organizational climate of knowledge-centered culture.

• 한국경영정보학회:학술대회논문집
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• 2008.06a
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• pp.454-471
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• 2008

This study suggests the dynamic pricing model which reveals the organic relationship between ASP (Application Service Provider) price and the related factors, using system dynamics methodology. Basically, we applied the law of supply and demand for analyzing price changes. Then, we deducted ASP price, focusing on fixed cost and variable cost. We also researched the customer's buying behavior according to version differentiation policy. In the version policy, we set up the proposition about customer's satisfaction and willingness-to-pay, using option system. As a result, this research designed the simulation model which analyzes the changes of the sales according to version differentiations and customer's willingness-to-pay. Through this research, we can find effective version differentiation strategies. This paper also found that the larger the number of package, the greater the demand and customer's willingness-to-pay. The increase of the number of package causes the increase of the sales. The increase of the sale is not exactly relative to the number of package. Drawing S-curve, the sales was increased. This dynamic pricing model suggests the ground that the ASP price changes based on the existing version differentiation theory and the demand of customers can affect the changes of the sales. We expect that this model suggests a clear standard of ASP pricing by combining real cases.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.80-86
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• 2007

In this paper, we identified factors that affect the usage of UCC, which is becoming increasingly popular in our society and throughout the globe. Four hypotheses were tested using a new integrative model of UCC usage, which is built up by incorporating the TAM and the PAD(pleasure-arousal-dominace)model. We analyzed the data collected in our survey of 258 individual UCC users during the period from Oct 2006 to Dec 2006. We found that pleasure and arousal showed a strong significant effect on individual's UCC usage, supporting the findings of the exiting research on TAM. To be specific, arousal had an effect on the UCC usage through its effect on pleasure and self efficacy. Pleasure affected the UCC usage in two ways: First, pleasure affected UCC usage through increasing the ease of UCC service. At the same time, pleasure had a direct effect on the UCC usage. Contrary to what the prior research on technology acceptance suggested, we found ease of use and social influence had no significant effect on individual's UCC usage. We further found that such effects of the ease of use and pleasure factors are more positive in the entertainment-based UCC than in the relationship-based UCC.