• Molecules and Cells
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• 제39권5호
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• pp.389-394
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• 2016

Dovitinib (TKI258) is a small molecule multi-kinase inhibitor currently in clinical phase I/II/III development for the treatment of various types of cancers. This drug has a safe and effective pharmacokinetic/pharmacodynamic profile. Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. In addition, the mRNA expression of BMP-4, BMP-7, ALP, and OCN increased with dovitinib treatment. Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders.

• The Journal of Asian Finance, Economics and Business
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• 제7권12호
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• pp.555-564
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• 2020

The purpose of this study is to analyze the efficiency of research institutes of futures companies, and to promote the development of futures market and real economy. This study employs DEA-solver software to conduct super-efficiency data envelopment analysis (SE-DEA), and also selects 40 representative futures research institutes in China as decision-making units (DMUs). For data of input and output indicators, we collect from the China Futures Association, Futures Daily, Hexun.com and Webstock.com respectively, and the time duration is the 103 trading days between from October 2019 to February 2020. Then the indicator for the strategy accuracy rate is calculated separately by analyzing the strategies published by each DMUs in public media. In conclusions, most institutes have excessive investment in human resources, and also have insufficient strategy accuracy rate and insufficient published research reports. The findings of this study suggest that Chinese futures companies need to improve the efficiency of research institutes, and better meet the demand of the financial market. In fact, the analysis of the efficiency of the futures company research institute has not been found in the literature worldwide, Application of DEA model in efficiency analysis of securities and futures research institutions and establishment of indicators are the innovations of this paper.

• 복식문화연구
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• 제21권4호
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• pp.585-595
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• 2013

The most researches developing pattern of compression style sportswear were targeted at the live model that has muscular body build. The purpose of this study was developing a method for classifying men's lower body types in terms of muscular body build. The 3D human body scan data and body measurements of 30s of Size Korea were analyzed. The subjects (n=203) were men between the ages of 30 and 39 years. Men's muscular body build was classified with two key dimensions, thigh girth and calf girth. The subjects were divided into four groups. From each group, average subjects (n=42) whose height and weight were close to the mean value ($mean{\pm}1/2$ S.D.) were selected. 42 subjects were divided up as four groups. Group I (n=7) was thigh and calf developed body type. Group II (n=9) was thigh developed body type. Group III (n=11) was calf developed body type. Group IV (n=15) was thigh and calf undeveloped body type. Four groups had distinct different at widths (n=4), depths (n=4), and girths (n=9) dimensions. The results showed that the muscular men in their 30s could be defined by thigh and calf girths. The thigh developed muscular men had thigh girth over 60cm and the calf developed muscular men had calf girth over 38cm. From each group one representative was selected by 3D body scan figure.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.1-12
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• 2002

Objectives : Assuming That the Characteristic of Meridian System Has Been Similar to This of Electric Potentials in Human Body and That Measurements of Electric Potential at Well and Sea Points in Branches of the Twelve Meridians Will Be Representative of Measurements of the Twelve Meridians, to Measure the Electric Potentials in Healthy Volunteers(HG), Patients Diagnosed As a Cerebral Infarction(CG), a Arrhythmia(AG), a Other Intervertebral Disc Disorder(IG), and a Joint Disorder(JG), and Then to Find Out the Characteristic of Biophysical Meridian System, Finally to Compare with the Results of the Electric Potential in Those Groups. Methods : We Selected Who HG Were Diagnosed by a Blood Test, Urine Examination and Differentiation of Syndromes by Five Viscera among Volunteers, CG by CT and Wind-Syndrome Caused by Hyperactivity of the Liver-Yang, AG by EKG, CT, and Deficiency or the Heart Blood, IG by X-ray or CT and Pain in Waist, and JG by X-ray and Knee Pain. Their Electric Potential of Well and Sea Points in the Meridians Were Measured by hysiograph. Results and Conclusions : Measurements Were Analyzed by Factor Analysis, Analysis of Variance, and Logistic Regression Model, We Obtained That Most of the Results, In Conclusion, Hold Good for the Classical Meridian Doctrine.

• 정보관리연구
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• 제34권4호
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• pp.19-42
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• 2003

참고서비스는 도서관 업무의 중심이다. 정보통신 기술의 발달과 정보의 양적 팽창으로 인해 이용자 중심의 중요성은 과거에 비해 더욱 커지고 있다. 본 논문은 디지털 시대에 양질의 참고서비스를 제공할 수 있는 새로운 모델을 제안하려고 한다. 이를 위해 디지털 참고서비스의 개념과 유형을 조사하였으며, 현재 디지털 참고서비스를 운영하고 있는 주요 대학교와 'Aska' 서비스를 운영하고 있는 해외 주요 사이트의 특성 등을 조사하였다. 끝으로 이러한 조사 자료에 근거하여 도서관의 인적 및 물적 자원 공유형 디지털 참고서비스 모델을 제안하였다.

• 대한인간공학회지
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• 제35권3호
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• pp.143-153
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• 2016

Objective: The purposes of this study are to survey needs for changing accident investigation from blaming to systems approach and to briefly summarize systems-based accident analysis techniques. Background: In modern complex socio-technical systems, accidents are caused by a variety of contributing factors including human, technical, organizational, social factors, not by just a single violation or error of a specific actor, but accidents investigation used to be focused on the incorrect action of individuals. A new approach investigating causes of accidents as a symptom of a deficient system is required. Method: This study was mainly based on survey of literatures related to accidents, accidents investigation, which included academic journals, newspapers, etc. Results: This study showed that accidents investigation of Korea focusing on blaming is problematic. This was confirmed by two concepts of migration and hindsight bias frequently found in accident causation studies, and an attribute of accidents having varying causes. This was illustrated with an example of Sewol ferry capsizing accident. Representative systems-based accident analysis models including Swiss cheese model, AcciMap, HFACS, FRAM and STAMP were briefly introduced, which can be used in systematic accidents investigations. Finally, this study proposed a procedure for establishing preventive measures of accidents, which was composed of two steps: public inquiry and devising preventive measures. Conclusion: A new approach considering how safety-critical components such as technical and social elements, and their interactions lead to accidents is needed for preventing reoccurrence of similar accidents in complex socio-technical systems. Application: The results would be used as a reference or guideline when the safety relevant governmental organizations investigate accidents.

• Industrial Engineering and Management Systems
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• 제9권2호
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• pp.157-164
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• 2010

The objective of this study is to determine the dominance effects of environmental factors such as Illuminance, humidity and Wet Bulb Globe Temperature (WBGT) on the operators' productivity at Malaysian electronic industry. A case study was carried out at an electronic components assembly factory. The environmental factors examined were the Illuminance (lux), humidity and WBGT of the surrounding workstation area. Two sets of representative data including the illuminance, humidity and WBGT level and production rate were collected during the study. The production rate data were collected through observations and survey questionnaires while the illuminance level was measured using photometer model RS 180-7133, the humidity and WBGT level were measured by using Quest Temp apparatus and humidity. Taguchi Method was utilized to find the sequence of dominant factors that contributed to the productivity of operator at that specified production workstation. The study reveals that the dominant factor contributed to the productivity was WBGT, followed by illuminance and humidity.

• 한국입자에어로졸학회지
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• 제17권3호
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• pp.71-79
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• 2021

Ultrafine dust, which is emitted from industrial factories or all kinds of vehicles, threatens the human's respiratory system and our environment. In this regard, separating airborne particles is essential to mitigate the severe problem. In this work, an axial cyclone for the effective technology of eliminating harmful dust is investigated by numerical simulation using Ansys 2020, Fluent R2. In addition, the optimized structure of the cyclone is constructed by means of multi objective optimization based on the response surface method which is a representative method to analyze the effect of design parameter on response variables. Among several design parameters, the modified length of the vortex finder and dust collector is a main point in promoting the performance of the axial cyclone. As a result, the optimized cyclone exhibits remarkable performance when compared to the original model, resulting in pressure drop of 307 Pa and separator efficiency of 98.5%.

• 한국지리정보학회지
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• 제19권4호
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• pp.118-129
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• 2016

미세먼지($PM_{10}$)의 건강영향에 대한 많은 연구들은 정부의 대기오염 측정자료를 이용해서 악영향을 보고했다. 정부 대기오염 측정자료가 제한된 수의 측정소에서 생산되는 반면, 사망률이나 유병률과 같은 정부생산 건강결과 자료는 지역별로 집계되어 공개된다. 따라서 정부에서 생산하는 건강통계자료를 이용해서 건강영향을 분석하기 위해서는, $PM_{10}$ 농도의 지역적인 대푯값을 산출할 필요가 있다. 본 연구에서는 서울특별시를 대상으로 이전 연구에서 개발된 점 사상에 대한 $PM_{10}$ 농도 예측 모형을 이용하여 구별 대푯값을 산정하였다. 이를 위해, 세 가지 종류의 위치들을 대상으로 지점들을 생성한 후, 그 지점들에 예측한 $PM_{10}$ 농도의 구별 평균으로 구별 대푯값을 구했다. 세 가지 위치는 16,230개 집계구 내 가장 넓은 주거지역의 중심점, 424개 동 주민센터, 610개 1km 격자의 중심점이었다. 위치별 구별 대푯값들을 비교하기 위하여 측정치와의 관련성 및 추정치 간 관련성을 탐색하였다. 측정치와의 비교 결과, 측정치와 세 가지 구별 대푯값 추정치들 간의 관련성은 위치의 인구 대표성이 높아짐에 따라 향상되었고($R^2=0.06-0.59$), 상호비교에서는 격자 중심점을 이용한 추정치가 다른 추정치들과의 관련성이 상대적으로 낮았다(0.35-0.47). 본 연구는 $PM_{10}$의 지역별 평균 농도를 추정함으로써 향후 정부 통계에 기반한 전국 규모의 지역 단위 건강영향분석 연구에 기여할 수 있을 것으로 기대된다.

• 한국융합학회논문지
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• 제8권10호
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• pp.1-8
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• 2017

정확한 예측은 미래에 일어날 현상에 대해 효과적으로 준비 혹은 대처 할 수 있게 해준다. 특히, 기상 현상은 인간의 생활과 밀접한 연관이 있으며, 발생할 수 있는 기상 및 재난 예측을 통해 인명, 재산 등의 피해로부터 예방 할 수 있게 해준다. 해상에서 발생할 수 있는 재난 중 하나인 유류유출 사고에 대해 빠르고 효과적으로 대응하기 위해서는 유출유의 이동과 주변 해역의 기상을 정확하게 예측하는 것이 중요하다. 본 논문에서는 분류 및 회귀 예측과 관련된 연구에서 준수한 성능 및 예측 가능성을 보여준 기계학습 기법으로 서포트 벡터 머신, 가우시안 프로세스, 다층 퍼셉트론, 방사기저함수 네트워크의 총 4 개의 기계학습 기법을 선별하였다. 선별한 기계학습 기법을 이용하여 유류유출의 탐지와 바람, 강우량, 오존 등의 기상 데이터를 예측하는 연구들의 연구 방법과 결과 등을 설명하며 이를 활용한 기계학습 기반 유류유출 예측 모델의 적용 가능성을 제시한다.