• Korean Journal of Heritage: History & Science
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• v.48 no.3
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• pp.138-153
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• 2015

For preventing the biological damage domestically, insect damage control method using chemical medicine has been applied. However, it is trend to avoid existing chemical medicine such as Methyl bromide because of the problem of being harmful to human body and environment. Therefore, the research for new medicine to replace this has been done and the interest to the physical treatment such as temperature(high & low) treatment, hypoxic treatment, carbon dioxide treatment, and radiation treatment has increased. However the systematic application standard and way has not been established. Therefore, in this research, we are going to organize present condition of domestic cultural asset preventing biological damage after the 1980's. It will also consider the direction through the characteristic of technology, limit, and replacement medicine by examining the past research.

• Computers and Concrete
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• v.24 no.2
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• pp.151-158
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• 2019

The sustainable development principle of replacing natural resources with renewable material is an important research topic. In this study, waste LCD (liquid crystal display) glass powder was used to replace cement (0%, 10%, 20% and 30%) through a volumetric method using three water-binder ratios (0.47, 0.59, and 0.71) to make cement mortar. The compressive strength was tested at the ages of 7, 28, 56 and 91 days. The test results show that the compressive strength increases with age but decreases as the water-binder ratio increases. The compressive strength slightly decreases with an increase in the replacement of LCD glass powder at a curing age of 7 days. However, at a curing age of 91 days, the compressive strength is slightly greater than that for the control group (glass powder is 0%). When the water-binder ratios are 0.47, 0.59 and 0.71, the compressive strength of the various replacements increases by 1.38-1.61 times, 1.56-1.80 times and 1.45-2.20 times, respectively, during the aging process from day 7 to day 91. Furthermore, a prediction model of the compressive strength of a cement mortar with waste LCD glass powder was deduced in this study. According to the comparison between the prediction analysis values and test results, the MAPE (mean absolute percentage error) values of the compressive strength are between 2.79% and 5.29%, and less than 10%. Thus, the analytical model established in this study has a good forecasting accuracy. Therefore, the proposed model can be used as a reliable tool for assessing the design strength of cement mortar from early age test results.

• Journal of Applied Biological Chemistry
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• v.62 no.1
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• pp.31-38
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• 2019

Scutellaria baicalensis Georgi (Scutellariae Radix) has been widely used as a dietary ingredient and traditional herbal medicine such as diuretic, hyperlipidemia, antibacterial, anti-allergy, anti-inflammatory and anticancer properties. In this study, the isolation of biomarkers or bioactive compounds from complex S. baicalensis extracts represents an essential step for de novo identification and bioactivity assessment. The bioactive fraction consisted of eight compounds which was chromatographed on an analytical high performance liquid chromatography column using two different gradient runs. A simulative replacement of the analytical column with a medium pressure liquid chromatography and open column allowed the determination of gradient profile to allow sufficient separation in the preparative scale. From the optimized method, eight standard compounds have been identified in the fractions. In addition, MS, UV, HRMS detection was provided by ultraperformance liquid chromatographyequadrupole time-of-flight mass spectrometry (UPLC-QTof-MS) of all fractions. Therefore, this scale up procedure was successfully applied to a S. baicalensis extract.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.608-618
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• 2021

Objective : The endoscopic endonasal transsphenoidal approach is a widely-used method for the surgical treatment of pituitary adenomas. We aimed to evaluate the results of endoscopic surgery by comparing preoperative classification methods and investigating their relationship with postoperative resection and remission rates and complications. Methods : We retrospectively reviewed the medical records of 236 patients (118 males) who underwent surgery for pituitary adenomas. Preoperative Knosp classification, tumor size (TS), suprasellar extension (SSE), postoperative resection and remission rates, and complications were evaluated. Results : The follow-up period was 3 months to 6 years. The patients' ages ranged between 16 and 84 years. Endocrinologically, 114 patients (48.3%) had functional adenoma (FA), and 122 patients (51.7%) had non-functional adenoma (NFA). Among the FA group, 92 (80.7%) showed remission. A statistically significant difference was found between patients with and without remission in terms of the Knosp, TS, and SSE classifications (p<0.01). Knosp, TS, and SSE classification grades were found to be correlated with the resection rates (p<0.01). Meningitis was seen in seven patients (3.0%), diabetes insipidus in 16 (6.9%; permanently in two [0.9%]), and rhinorrhea in 19 (8.1%). Thirty-six patients (15.3%) developed pituitary insufficiency and received hormone replacement therapy. Conclusion : The resection categories and remission rates of FAs were directly proportional to the adenoma sizes and Knosp grades, while the degree of suprasellar growth further complicated resection and remission rates. Adenoma sizes less than 2 cm and SSEs less than 1 cm are associated with favorable remission and resection rates.

• Biomaterials Research
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• v.22 no.4
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• pp.271-278
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• 2018

Background: The chondrogenic differentiation of mesenchymal stem cells (MSCs) is regulated by many factors, including oxygen tensions, growth factors, and cytokines. Evidences have suggested that low oxygen tension seems to be an important regulatory factor in the proliferation and chondrogenic differentiation in various MSCs. Recent studies report that synovium-derived mesenchymal stem cells (SDSCs) are a potential source of stem cells for the repair of articular cartilage defects. But, the effect of low oxygen tension on the proliferation and chondrogenic differentiation in SDSCs has not characterized. In this study, we investigated the effects of hypoxia on proliferation and chondrogenesis in SDSCs. Method: SDSCs were isolated from patients with osteoarthritis at total knee replacement. To determine the effect of oxygen tension on proliferation and colony-forming characteristics of SDSCs, A colony-forming unit (CFU) assay and cell counting-based proliferation assay were performed under normoxic (21% oxygen) or hypoxic (5% oxygen). For in vitro chondrogenic differentiation, SDSCs were concentrated to form pellets and subjected to conditions appropriate for chondrogenic differentiation under normoxia and hypoxia, followed by the analysis for the expression of genes and proteins of chondrogenesis. qRT-PCR, histological assay, and glycosoaminoglycan assays were determined to assess chondrogenesis. Results: Low oxygen condition significantly increased proliferation and colony-forming characteristics of SDSCs compared to that of SDSCs under normoxic culture. Similar pellet size and weight were found for chondrogensis period under hypoxia and normoxia condition. The mRNA expression of types II collagen, aggrecan, and the transcription factor SOX9 was increased under hypoxia condition. Histological sections stained with Safranin-O demonstrated that hypoxic conditions had increased proteoglycan synthesis. Immunohistochemistry for types II collagen demonstrated that hypoxic culture of SDSCs increased type II collagen expression. In addition, GAG deposition was significantly higher in hypoxia compared with normoxia at 21 days of differentiation. Conclusion: These findings show that hypoxia condition has an important role in regulating the synthesis ECM matrix by SDSCs as they undergo chondrogenesis. This has important implications for cartilage tissue engineering applications of SDSCs.

• Computers and Concrete
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• v.27 no.5
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• pp.417-435
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• 2021

The optimal distribution of steel fibers over different layers of concrete can be considered as an appropriate method in improving the structural performance and reducing the cost of fiber-reinforced concrete members. In addition, the use of waste tire rubber in concrete mixes, as one of the practical ways to address environmental problems, is highly significant. Thus, this study aimed to evaluate the flexural behavior of functionally graded steel fiber-reinforced concrete containing recycled tire crumb rubber, as a volume replacement of sand, after exposure to elevated temperatures. Little information is available in the literature regarding this subject. To achieve this goal, a set of 54 one-, two-, and three-layer concrete beam specimens with different fiber volume fractions (0, 0.25, 0.5, 1, and 1.25%), but the same overall fiber content, and different volume percentages of the waste tire rubber (0, 5, and 10%) were exposed to different temperatures (23, 300, and 600℃). Afterward, the parameters affecting the post-heating flexural performance of concrete, including flexural strength and stiffness, toughness, fracture energy, and load-deflection diagrams, along with the compressive strength and weight loss of concrete specimens, were evaluated. The results indicated that the flexural strength and stiffness of the three-layer concrete beams respectively increased by 10 and 7%, compared to the one-layer beam specimens with the same fiber content. However, the flexural performance of the two-layer beams was reduced relative to those with one layer and equal fiber content. Besides, the flexural strength, toughness, fracture energy, and stiffness were reduced by approximately 10% when a 10% of natural sand was replaced with tire rubber in the three-layer specimens compared to the corresponding beams without crumb rubber. Although the flexural properties of concrete specimens increased with increasing the temperature up to 300℃, these properties degraded significantly with elevating the temperature up to 600℃, leading to a sharp increase in the deflection at peak load.

• Journal of the Korean Society of Safety
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• v.35 no.6
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• pp.85-92
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• 2020

Wet Scrubber reacts the incoming pollutant gas with cleaning water (water + absorbent) to absorb pollutants and release the clean air to the atmosphere. Wet scrubbers and packed tower scrubbers using this principle are widely used in businesses that emit acid gases. In particular, in the etching process using hydrochloric acid (HCl), alkaline washing water (NaOH) having a pH of about 8 to 11 is used to absorb a large amount of acid gas. However, These salts are attached to the injection nozzle (nozzle), filling material (packing), and the demister (Demister), causing air pollution, human damage, and inoperability due to clogging and acid gas discharge. Therefore, In this study, an improvement plan was proposed to manage the washing water with pH 3~4 acidic washing water. The test method takes samples from the Wet Scrubber flue measurement laboratory twice a month for 1 year. Hydrogen chloride (HCl) concentration (ppm) was measured, and nozzle clogging and scale conditions were measured, compared, and analyzed through a differential pressure gauge and a pressure gauge. As a result of the check, it was visually confirmed that the scale was reduced to 50% or less in the spray nozzle, filler, and demister. In addition, the emission limit of hydrogen chloride in accordance with the Enforcement Regulation of the Air Quality Conservation Act [Annex 8] met 3 ppm or less. Therefore, even if the washing water is operated in an acidic pH range of 3 to 4, it is expected to reduce air pollution and human damage due to clogging of internal parts, and it is expected to reduce maintenance costs such as regular cleaning or replacement of parts.

• Advances in concrete construction
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• v.10 no.6
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• pp.479-488
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• 2020

The experimental and numerical works were carried out on high performance fiber reinforced concrete (HPFRC) with w/cm ratios ranging from 0.25 to 0.40, fiber volume fraction (Vf)=0-1.5% and 10% silica fume replacement. Improvements in compressive and flexural strengths obtained for HPFRC are moderate and significant, respectively, Empirical equations developed for the compressive strength and flexural strength of HPFRC as a function of fiber volume fraction. A relation between flexural strength and compressive strength of HPFRC with R=0.78 was developed. Due to the complex mix proportions and non-linear relationship between the mix proportions and properties, models with reliable predictive capabilities are not developed and also research on HPFRC was empirical. In this paper due to the inadequacy of present method, a back propagation-neural network (BP-NN) was employed to estimate the 28-day compressive strength of HPFRC mixes. BP-NN model was built to implement the highly non-linear relationship between the mix proportions and their properties. This paper describes the data sets collected, training of ANNs and comparison of the experimental results obtained for various mixtures. On statistical analyses of collected data, a multiple linear regression (MLR) model with R2=0.78 was developed for the prediction of compressive strength of HPFRC mixes, and average absolute error (AAE) obtained is 6.5%. On validation of the data sets by NNs, the error range was within 2% of the actual values. ANN model has given the significant degree of accuracy and reliability compared to the MLR model. ANN approach can be effectively used to estimate the 28-day compressive strength of fibrous concrete mixes and is practical.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.6
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• pp.85-91
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• 2020

The necessity for ground reinforcement of structures has been increasing in South Korea because buildings have encountered constructional problems such as inclined structures and collapses caused by earthquakes or differential settlement of the foundations. With regard to a ground reinforcement method, an increasing number of high-strength concrete piles have been used based on their advantages, including a wide range of penetration depth and a high load-bearing capacity. However, problems such as the destruction of a pile head during on-site placement work can occur when the pile has insufficient strength. For this reason, the strength of such piles should be managed more thoroughly. Thus, this study analyzed the strength properties of high-strength concrete piles using blast furnace slag (BFS) powder as a cement replacement, which was generated as an industrial byproduct. The analysis results indicated that the compression strength of the concrete piles increased when 10% to 20% of the cement was replaced with ground granulated blast-furnace slag (GGBS). In addition, the compression strength of the concrete piles was calculated to be 80.6 MPa when 20% of the cement was replaced with GGBS, which was greater by 5% than that of an ordinary Portland cement (OPC) specimen.

• Journal of Korean Physical Therapy Science
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• v.28 no.3
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• pp.88-97
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• 2021

Purpose: Patients with total knee arthroplasty (TKA) have impaired balance and movement control. Exercise interventions have not targeted these impairments in this population. This study aimed to investigate the effect of complex balance exercises on unstable ground, on the gait, balance, and daily living ability of patients with total knee arthroplasty. Design: Randomized controlled trial. Methods: The participants consisted of 30 patients placed into two groups of 15 each: a experimental group (complex balance exercise) and a control group (physical therapy exercise). Both group exercise was applied for 3 times a week for 30 minutes for four weeks. Force plate for balance ability and Timed up and go (TUG) test were the primary outcome measures. The secondary outcome measures included 10-m walk test (10MWT) and the daily living ability using the Knee Outcome Survey Activities of Daily Living scale (KOS-ADL). Results: The result of this study showed that the experimental group had a significant difference in TUG and 10MWT than the control group, and balance was significantly different in CEA, CPL, and CAV. There was a significant difference in daily living ability between the experimental and control groups. This study confirms that the physical therapy with complex balance exercise on unstable surfaces has positive effects on balance, gait and daily living ability in patients with total knee arthroplasty. Conclusion: As a result of this study, complex balance exercise on unstable surface was more effective in improvement gait, balance and daily living ability in total knee arthroplasty. From this study, physical therapy with complex balance exercises on unstable ground may be proposed as and effective intervention method for improving gait, balance, and daily living ability in patients with early total knee arthroplasty.