• The Korean Journal of Rehabilitation Nursing
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• v.7 no.1
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• pp.58-67
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• 2004

Behavioral symptoms are frequent and problematic components of dementia. The aim of this study was to detect behavioral problem of the 25 item of dementia problem behaviour(DPB)assesment scale for demented older adults. Seventy-three patients with dementia staying in the day care center, group home, dementia hospital, nursing home were recruited data on problematic behavior obtained through interviews with their caregiver during 2 months from March to May 2004. Results shows that problematic behaviors common occurring in 95% of subjects. The most frequently exhibited problematic behaviors were repetitive movement(1.05), repetitive questions(1.03), restlessness(1.0). indifference(0.97). shouting/screaming(0.92). Problematic Behaviors of the demented older adults were closely associated to the distress for caregiver. Most distressful ones for caregivers were repetitive questions(1.46), repetitive movement(1.42), shouting/screaming (1.42), indifference(1.41). restlessness(1.41). Problematic Behaviors of the demented older adults were divided into six subdivisions, among those restless behavior was positively correlated with aggressive behavior, nervous symptom and psychotic symptom. and then nervous symptom was interrelated to psychotic symptom(P<0.01). This study has limitation that field study data were derived from various primary caregivers.

• Journal of Ocean Engineering and Technology
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• v.33 no.1
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• pp.85-91
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• 2019

In a cryogenic storage structure, the insulation system is in an environment in which fluid impact loads occur throughout the lifetime of the structure. In this study, we investigated the effect of repetitive impact loading on the mechanical performance of glass fiber-reinforced polyurethane foam. The repeated impact loading test was conducted in accordance with the required impact energy and the required number of repetitive impacts. The impact behavior of glass fiber-reinforced polyurethane foam was analyzed in terms of stress and displacement. After the impact test, the specimen was subjected to a compression test to evaluate its mechanical performance. We analyzed the critical impact energy that affected mechanical performance. For the impact conditions that were tested, the compressive strength and elastic modulus of the polyurethane foam can be degraded significantly.

• Toxicological Research
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• v.30 no.4
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• pp.267-276
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• 2014

Exposures to lead (Pb) are associated with neurological problems including psychiatric disorders and impaired learning and memory. Pb can be absorbed by iron transporters, which are up-regulated in hereditary hemochromatosis, an iron overload disorder in which increased iron deposition in various parenchymal organs promote metal-induced oxidative damage. While dysfunction in HFE (High Fe) gene is the major cause of hemochromatosis, the transport and toxicity of Pb in Hfe-related hemochromatosis are largely unknown. To elucidate the relationship between HFE gene dysfunction and Pb absorption, H67D knock-in Hfe-mutant and wild-type mice were given drinking water containing Pb 1.6 mg/ml ad libitum for 6 weeks and examined for behavioral phenotypes using the nestlet-shredding and marble-burying tests. Latency to nestlet-shredding in Pb-treated wild-type mice was prolonged compared with non-exposed wild-types (p < 0.001), whereas Pb exposure did not alter shredding latency in Hfe-mutant mice. In the marble-burying test, Hfe-mutant mice showed an increased number of marbles buried compared with wild-type mice (p = 0.002), indicating more repetitive behavior upon Hfe mutation. Importantly, Pb-exposed wild-type mice buried more marbles than non-exposed wild-types, whereas the number of marbles buried by Hfe-mutant mice did not change whether or not exposed to Pb. These results suggest that Hfe mutation could normalize Pb-induced behavioral alteration. To explore the mechanism of repetitive behavior caused by Pb, western blot analysis was conducted for proteins involved in brain dopamine metabolism. The levels of tyrosine hydroxylase and dopamine transporter increased upon Pb exposure in both genotypes, whereas Hfe-mutant mice displayed down-regulation of the dopamine transporter and dopamine D1 receptor with D2 receptor elevated. Taken together, our data support the idea that both Pb exposure and Hfe mutation increase repetitive behavior in mice and further suggest that these behavioral changes could be associated with altered dopaminergic neurotransmission, providing a therapeutic basis for psychiatric disorders caused by Pb toxicity.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.394-395
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• 2022

Exergames are playing an important role in healthcare/rehabilitation. It has also been used to improve motivation among patients with reduced cognition. The purpose of this pilot study was to evaluate the feasibility of using augmented reality (AR) with game-based cognitive-motor training programs for executive function, restricted and repetitive behaviors (RRBs) in children with autism spectrum disorder. Sixteen children aged 6 -16 years were randomly allocated to the experimental group and control group. Outcome measures were performed before and after the intervention and included executive function, restricted and repetitive behavior. A satisfactory survey was conducted post-intervention. A statistically significant improvement was observed in working memory and cognitive flexibility in the experimental group (P<0.05). However, despite no statistical improvements in cognitive inhibition and four subscales of RRBs, promising changes were observed in all the subscales of the executive function and the behavioral outcomes. Parents appreciated the program and children enjoyed the interaction with the AR game-based training. The findings of this preliminary feasibility study showed that AR using Kinect v2 motion with a cognitive-motor game content can be used for children with autism. However, there is a need for conducting a large-scale study to evaluate his effectiveness on executive function and restricted and repetitive behaviors.

• Geotechnical Engineering
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• v.7 no.3
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• pp.33-42
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• 1991

Increasing demand of rational analysis of dynamic soil behavior subjected to repetitive loading has evolved soil dynamics which is essential for proper design and/or analysis of dynamically loaded soil structure. In this paper, the stress-strain behavior of weathered granite soil under cyclic loading is stud- ied by measuring the strength and the strain before and after application of at least 11, 000 cycles of repetitive load. Relationships are suggested for predicting results of soil dynamics from those of soil statics.

• Composites Research
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• v.14 no.5
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• pp.38-45
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• 2001

Kaiser effects of thermo-acoustic emission (AE) from composite laminates under the repetitive thermal cyclic loads have been quantitatively analyzed in consideration of AE source mechanisms. The repetitive thermal load brought about a large reduction. i.e. an exponential decrease in AE total ringdown counts and AE amplitudes. It was thought that generation of thermo-AE during the first thermal cycle was not caused by crack propagation but by secondary microfracturing due to abrasive contact between crack surfaces. For the repetitive thermal cycles, a few number of weak thermo-AE events were generated due to some frictional sliding contact. Such behavior of thermo-AE showed different characteristics according to specimen kinds and the maximum temperature in the thermal load cycles.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.3
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• pp.375-380
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• 2020

In this study, we tried to evaluate the mechanical properties of Polycarbonate(PC) and acrylonitrile-butadiene-styrene(ABS) plastic materials, which are frequently used as parts of home appliances and machinery, when repeated impacts were applied. A repeating impact tester for this research was designed and manufactured to apply repetitive impacts. Two types of plastic were repeatedly impacted under a constant load, and a tensile test was performed on the plastic material that was impacted. The tensile strength of PC plastic materials that received impact more than 2000 times was reduced by about 45 % and elongation was reduced by about 10 % when compared to impact free specimens. On the other hand, in ABS plastic, a reduction of tensile strength of about 20 % was observed at about 2,000 impacted specimen, but at about 20,000 repetitive impacted specimen, a tensile strength decrease of about 65 % was observed. And the elongation was reduced by 10 % due to the cyclic harding behavior of the material.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.111-115
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• 2001

Thermo-acoustic emission (AE) from composite laminates under the repetitive thermal cyclic loads have been quantitatively analyzed in consideration of AE source mechanisms. The repetitive thermal load brought about a large reduction, i.e. an exponential decrease in AE total ringdown counts and AE amplitudes. It was thought that generation of thermo-AE during the first thermal cycle was not caused by crack propagation but by secondary microfracturing due to abrasive contact between crack surfaces.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.232-237
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• 2022

Autism spectrum disorder (ASD) having core characteristics of social interaction problems and repetitive behaviors and interests affects individuals at varying degrees and comorbidities, making it difficult to determine the precise etiology underlying the symptoms. Given its heterogeneity, ASD is difficult to treat and the development of therapeutics is slow due to the scarcity of animal models that are easy to produce and screen with. Based on the theory of excitation/inhibition imbalance in the brain with ASD which involves glutamatergic and/or GABAergic neurotransmission, a pharmacologic agent to modulate these receptors might be a good starting point for modeling. N-methyl-D-aspartic acid (NMDA) is an amino acid derivative acting as a specific agonist at the NMDA receptor and therefore imitates the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA selectively binds to and regulates the NMDA receptor, but not other glutamate receptors such as AMPA and kainite receptors. Given this role, we aimed to determine whether NMDA administration could result in autistic-like behavior in adolescent mice. Both male and female mice were treated with saline or NMDA (50 and 75 mg/kg) and were tested on various behavior experiments. Interestingly, acute NMDA-treated mice showed social deficits and repetitive behavior similar to ASD phenotypes. These results support the excitation/inhibition imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model of ASD-like behaviors.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.168-177
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• 2019

Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There is ample evidence that overstimulation of NMDA-dependent neurotransmission may induce neurobehavioral abnormalities, such as repetitive behaviors and hypersensitization to nociception and cognitive disruption, pharmacological modeling using NMDA has been limited due to the induction of neurotoxicity and blood brain barrier breakdown, especially in young animals. In this study, we examined the effects of intraperitoneal NMDA-administration on nociceptive and repetitive behaviors in ICR mice. Intraperitoneal injection of NMDA induced repetitive grooming and tail biting/licking behaviors in a dose- and age-dependent manner. Nociceptive and repetitive behaviors were more prominent in juvenile mice than adult mice. We did not observe extensive blood brain barrier breakdown or neuronal cell death after peritoneal injection of NMDA, indicating limited neurotoxic effects despite a significant increase in NMDA concentration in the cerebrospinal fluid. These findings suggest that the observed behavioral changes were not mediated by general NMDA toxicity. In the hot plate test, we found that the latency of paw licking and jumping decreased in the NMDA-exposed mice especially in the 75 mg/kg group, suggesting increased nociceptive sensitivity in NMDA-treated animals. Repetitive behaviors and increased pain sensitivity are often comorbid in psychiatric disorders (e.g., autism spectrum disorder). Therefore, the behavioral characteristics of intraperitoneal NMDA-administered mice described herein may be valuable for studying the mechanisms underlying relevant disorders and screening candidate therapeutic molecules.