• Nutrition Research and Practice
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• 제4권4호
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• pp.270-275
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• 2010

Catecholamines are among the first molecules that displayed a kind of response to prolonged or repeated stress. It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine ${\beta}$-hydroxylase (DBH) in adrenal medulla. The aim of the present study was to evaluate the effects of ginseng on TH and DBH mRNA expression. Repeated (2 h daily, 14 days) immobilization stress resulted in a significant increase of TH and DBH mRNA levels in rat adrenal medulla. However, ginseng treatment reversed the stress-induced increase of TH and DBH mRNA expression in the immobilization-stressed rats. Nicotine as a ligand of the nicotinic acetylcholine receptor (nAChR) in adrenal medulla stimulates catecholamine secretion and activates TH and DBH gene expression. Nicotine treatment increased mRNA levels of TH and DBH by 3.3- and 3.1-fold in PC12 cells. The ginseng total saponin exhibited a significant reversal in the nicotine-induced increase of TH and DBH mRNA expression, decreasing the mRNA levels of TH and DBH by 57.2% and 48.9%, respectively in PC12 cells. In conclusion, immobilization stress induced catecholamine biosynthetic enzymes gene expression, while ginseng appeared to restore homeostasis via suppression of TH and DBH gene expression. In part, the regulatory activity in the TH and DBH gene expression of ginseng may account for the anti-stress action produced by ginseng.

• The Korean Journal of Physiology and Pharmacology
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• 제13권4호
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• pp.315-319
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• 2009

Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2h/day) and AM (400mg/kg) given by oral administration, in the AM group, for the same period. Starting on the eighth day, the rats were tested for spatial memory on the Morris water maze test (MW) and for anxiety on the elevated plus maze (EPM). Changes of expression on immunohistochemistry were studied for cholineacetyl transferase (ChAT) and tyrosine hydroxylase (TH) in the brain. The results showed that the rats treated with AM had significantly reduced stress-induced deficits on learning and memory on the spatial memory tasks. In addition, the ChAT immunoreactivities were increased. In the EPM, treatment with AM increased the time spent in the open arms (p<0.001) compared to the control group. In addition, AM treatment also normalized increases of TH expression in the LC (p<0.001). In conclusion, administration of AM improved spatial learning and memory and reduced stress-induced anxiety. Thus, the present results suggest that AM is able to recover behavioral and neurochemical impairments induced by stress.

• 한국농공학회논문집
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• 제52권2호
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• pp.51-57
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• 2010

Many models have been used to represent the effects of confining stress, bulk stress, and shear stress on the value of the resilient modulus (Mr). This study was conducted to estimate Mr of the recycled materials such as recycled concrete aggregate (RCA) and recycled asphalt pavement (RAP) through the repeated load cyclic test. Also, two models were applied to estimation of Mr for comparing between measured Mr values and predicted Mr values. The first model (A-model) can provide a quick and easy estimation of the Mr based on the bulk stress, while the second model (N-model) includes not only the bulk stress but also the shear stress. Statistical analysis indicated that all results using the both of models are significant at a 95 % confidence level. Therefore, the both of models could be used as an effective prediction model of Mr for RCA and RAP. Especially, the Model 2 including the parameters of the bulk stress and the shear stress could give more reliable estimation at the high range of Mr values.

• 한국지반공학회논문집
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• 제21권3호
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• pp.55-63
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• 2005

본 연구는 모형실험을 통하여 지중응력 분포상태를 기존의 Boussinesque, Westergaard, K$\"{o}$ogler, Newmark의 이론식값과 Model Test에 의한 실험값을 비교 검토하였다. 본 모형실험 결과 깊이별 재하하중에 의한 지중응력의 변화는 Westergaard이론과 가장 유사하게 나타났으며, 패하하중의 증가에 따라 지중응력은 거의 직선적으로 증가하는 경향을 보였고, 이론식과 비교하면 깊이 15cm 까지는 크게 나타났으나 그 이하의 깊이에서는 이론식 보다 작아지는 경향이 나타났다. 재하하중(${\sigma}r$)과 지중응력$\Delta\sigma$)의 상관관계식은 $\Delta\sigma\;=\; 0.009\cdot{\sigma}r-0.1$(깊이 60cm)로 나타났다.

• The Korean Journal of Physiology and Pharmacology
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• 제14권6호
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• pp.371-376
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• 2010

Glycyrrhizae radix (GR) is an herbal medicine that is commonly used in the East Asia for treating a variety of diseases, including stomach disorders. The objective of the present study was to examine the anti-stress effects of GR on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2 h/day) to the rats in the Control and GR groups (400 mg/kg/day, PO). Starting on the eighth day, the rats were tested for spatial memory on the Morris water maze test (MW) and for anxiety on the elevated plus maze (EPM). We studied the changes of the expressions of cholineacetyl transferase (ChAT) and tyrosine hydroxylase (TH) in the locus coerleus (LC) using immunohistochemistry. The results showed that the rats treated with GR had significantly reduced stress-induced deficits on their learning and memory on the spatial memory tasks. In addition, the ChAT immunoreactivities were increased. Gor the EPM, treatment with GR increased the time spent in the open arms (p<0.001) as compared to that of the control group. Moreover, GR treatment also normalized the increases of the TH expression in the LC (p<0.001). In conclusion, administration of GR improved spatial learning and memory and reduced stress-induced anxiety. Thus, the present results suggest that GR has the potential to attenuate the behavioral and neurochemical impairments caused by stress.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.103-108
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• 2000

Since the ceramic/metal joint material is made at a high temperature, the residual stress development when it is cooled from bonding temperature to room temperature due to remarkable difference of thermal expansion coefficient between ceramic and metal. As residual stress at ceramic/metal joints influences the strength of joints, it is important to estimate residual stress quantitatively. In this study, it is attempted to estimate joint residual stress of $Si_3N_4/STS304$ joints quantitatively and to compare the strength of Joints. The difference of residual stress is measured when repeated thermal cycle is loaded under the conditions of the practical use of the ceramic/metal joint. And 4-point bending test is performed to examine the influence of residual stress on fracture strength. As a residual it is known that the stress of joint decreases as the number of thermal cycle increases.

• 한국공작기계학회논문집
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• 제14권1호
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• pp.37-43
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• 2005

Plant pipe has a fatigue life which is induced by repeated stress come from the variation of temperature and pressure. To avoid the fatigue crack of plant pipe which is produced by long term repeated stress, plant operator has to limit the mont of operating transient. This paper introduced the study result about discrimination methodology of plant transient by using the fuzzy pattern recognition. As result of applying the fuzzy pattern recognition to actual plant operation data, it is confirmed that fuzzy pattern recognition methodology can be useful for the comparison of similarity for the transients of similar output but has different time pattern.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.585-590
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• 2001

Turbine blade is subject to torsional load by torsion-mount, centrifugal load by rotation of rotor and repeated bending load by steam pressure. Turbine with partially cracked blade has normal working condition at initial repair time but vibratory working condition at middle repair time due to crack growth. Finite element analysis on turbine blade indicates that repeated bending load out of all loads is the most important factor on fatigue strength of turbine blade. Therefore, this study shows root mean square roughness has linear relation with stress intensity factor range in 12% Cr steel and can predict loading condition of fractured turbine blade.

• 한국자동차공학회논문집
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• 제9권6호
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• pp.170-177
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• 2001

Turbine blade is subject to torsional load by torsion-mount, centrifugal load by rotation of rotor and repeated bending load by steam pressure. Turbine with partially cracked blade has normal working condition at initial repair time but vibratory working condition at middle repair time due to crack growth. Finite element analysis on turbine blade indicates that repeated bending load out of all loads is the most important factor on fatigue strength of turbine blade. Therefore, this study shows root mean square roughness has linear relation with stress intensity factor range in 12% Cr steel and can predict loading condition of fractured turbine blade.

• KSTLE International Journal
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• 제1권1호
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• pp.48-51
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• 2000

Surface damage accumulation of alumina ceramics under the cyclic stress state was analyzed. The alternating stress state in repeat pass sliding contact was simulated by a synchronized biaxial (normal and tangential) repeated indentation technique. Wear debris formation mechanism through damage accumulation and fatigue grain failure in both alumina ceramic balls and flat disks was confirmed, and the contact induced surface degradation due to fatigue cracking accumulation was quantified by measuring vertical contact displacement. Variation of structural compliance (slope of load-displacement curve) of two contacting bodies was expressed as a variation of the apparent elastic property, called pseudo-elastic constant, of the contact system.