• IMMUNE NETWORK
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• v.12 no.1
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• pp.1-7
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• 2012

Interleukin-24 (IL-24) belongs to the IL-10 family of cytokines and is well known for its tumor suppressor activity. This cytokine is released by both immune and nonimmune cells and acts on non-hematopoietic tissues such as skin, lung and reproductive tissues. Apart from its ubiquitous tumor suppressor function, IL-24 is also known to be involved in the immunopathology of autoimmune diseases like psoriasis and rheumatoid arthritis. Although the cellular sources and functions of IL-24 are being increasingly investigated, the molecular mechanisms of IL-24 gene expression at the levels of signal transduction, epigenetics and transcription factor binding are still unclear. Understanding the specific molecular events that regulate the production of IL-24 will help to answer the remaining questions that are important for the design of new strategies of immune intervention involving IL-24. Herein, we briefly review the signaling pathways and transcription factors that facilitate, induce, or repress production of this cytokine along with the cellular sources and functions of IL-24.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.138-147
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• 2007

Recently, framed structure is increasingly being used as apartment structure due to the advantages during remodeling. Therefore, the use of lightweight panel as separating wall is increasing. To construct lightweight panel structures with sound insulation performance appropriate to the conditions of each field, measurement of sound reduction index(SRI) through panel structures should be performed. In this study, measurement of SRI through 46 kinds of panel structures was performed in the condition of various factors such as surface density, air space and absorber. The result showed that SRI of panel structures was generally higher by increasing of surface density. In the case of double panel with no absorber, SRI at below critical frequency was gradually increased according to rise of air space. Double panel with absorber make remarkable improvement in SRI at low frequency, but there is a little difference compared with SRI of double panel with no absorber over critical frequency.

• BMB Reports
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• v.43 no.10
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• pp.649-655
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• 2010

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder and shows progressive memory loss and cognitive decline. Intraneuronal filaments composed of aggregated hyperphosphorylated tau protein, called neurofibrillary tangles, along with extracellular accumulations of amyloid $\beta$ protein (A$\beta$), called senile plaques, are known to be the neuropathological hallmarks of AD. In light of recent studies, epigenetic modification has emerged as one of the pathogenic mechanisms of AD. Epigenetic changes encompass an array of molecular modifications to both DNA and chromatin, including transcription factors and cofactors. In this review, we summarize how DNA methylation and changes to DNA chromatin packaging by post-translational histone modification are involved in AD. In addition, we describe the role of SIRTs, histone deacetylases, and the effect of SIRT-modulating drugs on AD. Lastly, we discuss how amyloid precursor protein (APP) intracellular domain (AICD) regulates neuronal transcription. Our understanding of the epigenomes and transcriptomes of AD may warrant future identification of novel biological markers and beneficial therapeutic targets for AD.

• BMB Reports
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• v.48 no.8
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• pp.429-430
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• 2015

Angiogenesis is a complex process involving dynamic interaction of various cell to cell interactions. Endothelial cell interactions regulated by growth factors, inflammatory cytokines, or hemodynamic stress are critical for balancing vascular quiescence and activation. Yes-associated protein (YAP), an effector of Hippo signaling, is known to play significant roles in maintaining cellular homeostasis. However, its role in endothelial cells for angiogenic regulation remains relatively unexplored. We demonstrated the critical role of YAP in vascular endothelial cells and elucidated the underlying molecular mechanisms involved in angiogenic regulation of YAP. YAP was expressed in active angiogenic regions where endothelial cell junctions were relatively loosened. Consistently, YAP subcellular localization and activity were regulated by VE-cadherin-mediated PI3K/Akt pathway. YAP thereby regulated endothelial sprouting via angiopoietin-2 expression. These results provide an insight into a model of coordinating endothelial junctional stability and angiogenic activation through YAP. [BMB Reports 2015; 48(8): 429-430]

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.104-109
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• 2010

Management innovation as a strategic alternative to create competitive advantages in the global market, is being actively progressed by conglomerates such as Samsung, LG and Toyoda as they cut a brilliant figure in the 21 century by using various innovation methods. However, the domestic railway sectors, in particular urban railway depots have neglected management innovation as they undertake Operation and Management in non-competitive settings of a corporate enterprise. This paper analyzes the critical success factors that have switched the most obsolete depots to a benchmark model for domestic railway depots based on the remodeling businesses undertaken in Gunja rolling stock maintenance office, Korea's first urban railway depot, along with 5S 6sigma program.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.27-31
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• 1996

암환자의 생명을 가장 위협하는 암세포의 전이는 숙주와 암세포의 상호작용을 포함하는 여러단계의 연쇄적인 과정이다. 전이의 발생은 하나의 세포나 집단의 암세포가 첫번째 암발생 부위에서 분리되어 국소적으로 침투하고 순환기계에 들어가 다른곳에 흡착 후 다른 장기의 interstitium과 parcnchyma에 입출(extravasate)하게 되며 2차적 colony로서 자라나 stroma나 basement membrine과 같은 생물학적 울타리를 파괴한다. 전이의 각단계에서 암세포는 면역세포의 공격을 피하여야만 한다. 세포의 이동은 태아의 생성(embryonic events), 성장세포의 재조함(remodeling), 상처 치유(wound healing), 맥관형성 (angiogenesis), 면역 방어 (immune defence)의 경우에 아주 중요한 역활을 한다. 정상적인 경우에 세포의 이동은 잘 통제가 되지만 암세포의 이동은 비정상적으로 통제가 되거나 자체내에서 통제가 된다. 암세포는 숙주에서 생산되는 scatter factors, growth factor, extracellular matrix components, 그리고 암세포에서 발생되는 autocrine utility factors를 포함한 여러가지 인자에 의해 영향을 받는다.

• The Journal of Advanced Prosthodontics
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• v.6 no.6
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• pp.547-554
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• 2014

Implant success is achieved by the synergistic combination of numerous biomechanical factors. This report examines the mechanical aspect of implants. In particular, it is focused on macrodesign such as thread shape, pitch, width and depth, and crestal module of implants. This study reviews the literature regarding the effect of implant thread geometry on primary stability and osseointegration under immediate loading. The search strategy included both in vitro and in vivo studies published in the MEDLINE database from January 2000 to June 2014. Various geometrical parameters are analyzed to evaluate their significance for optimal stress distribution, implant surface area, and bone remodeling responses during the process of osseointegration.

• Culinary science and hospitality research
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• v.13 no.2
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• pp.22-34
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• 2007

We researched the previous study about the restaurant's physical environment and had made up questionnaires. The purpose of this study is to analyze the effect of physical facilities of family restaurants on customers' satisfaction. The result was as follows: First, customers visited with friends or family irrespective of days $2{\sim}3$ times a month. Second, the physical environment factors of family restaurants were interior design, interior, making atmosphere and exterior. Third, it was the interior factor(0.268), making atmosphere factor(0.353) and exterior factor(0.244) that affected customers' satisfaction in family restaurants(p<0.001). $R^2$ change was 0.659 and the regression model was suited to our study(F=56.475). To increase customers' satisfaction, the physical environment of family restaurants needs remodeling in proper time.

• BMB Reports
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• v.46 no.3
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• pp.139-150
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• 2013

The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.

• Journal of Embryo Transfer
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• v.9 no.1
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• pp.31-41
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• 1994

핵 이식 기술을 이용한 cloning 송아지 생산이 처음 보고(Prather et al., 1987) 된 후, 소 수정란 Cloning에 대한 많은 연구가 분자 생물학 등 여러 분야에서 꾸준히 계속되고 있다. 이 기술은 빈우의 번식 능력을 향상시켜 유전적 개량량을 증대할 수 있는 번식과 육종을 위한 도구로써 많은 잠재력을 지니고 있다. 최근 핵 이식 기술을 이용하여 유전적으로 우수한 빈우로부터 수천개의 수정란을 생산하여, 이들 수정란에게 생산된 송아지가 번식 축군으로 공시되어 있으므로, 그 결과가 주목되나 아직까지는 비용이 많이 들고 송아지 생산 효율이 저조하므로, 가까운 장래에 일반 양축가에 이용될 가능성이 낮다. 그러나 이 기술의 실용화를 위하여 선결되어야 할 많은 문제점들 중, 지난 몇 년 동안 많은 연구기관에서 수행된 활발한 연구의 결실로써, 난포란 제핵, cell fusion 과 oocyte activation의 방법등 주요 장애 요인들이 점차 극복되면서 실용화를 위한 접근이 예견되어지며, 구미의 일부 개량 기관에서는 이를 상업화 하기 위한 여건을 다지고 있다. 그러므로 이 Review에서는 fllicular dynamics, 난포란의 성숙, cell cycle, 난포란 제핵, cell fusion과 oocyte activation, 이식후 핵의 remodeling과 reprogramming에 대한 현재까지의 보고된 자료를 기초로 그 기본 원리를 재고하는데 초점을 맞추었다.