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The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination

  • Lu, Xi;Hu, Xinde;Song, Lingzhen;An, Lei;Duan, Minghui;Chen, Shulin;Zhao, Shanting
    • BMB Reports
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    • v.48 no.2
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    • pp.97-102
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    • 2015
  • Neurons in the developing brain form the cortical plate (CP) in an inside-out manner, in which the late-born neurons are located more superficially than the early-born neurons. Fyn, a member of the Src family kinases, plays an important role in neuronal migration by binding to many substrates. However, the role of the Src-homology 2 (SH2) domain in function of Fyn in neuronal migration remains poorly understood. Here, we demonstrate that the SH2 domain is essential for the action of Fyn in neuronal migration and cortical lamination. A point mutation in the Fyn SH2 domain ($Fyn^{R176A}$) impaired neuronal migration and their final location in the cerebral cortex, by inducing neuronal aggregation and branching. Thus, we provide the first evidence of the Fyn SH2 domain contributing to neuronal migration and neuronal morphogenesis.

Spontaneous Spinal Epidural Hematoma with Intraoperative Acute Massive Bleeding - Case Report - (수술중 급성 대량 출혈을 동반한 자발성 척추경막외혈종 - 증 례 보 고 -)

  • Kim, Hyoung Jong;Hwang, Soo Hyun;Park, In Sung;Kim, Eun-Sang;Jung, Jin-Myung;Han, Jong Woo
    • Journal of Korean Neurosurgical Society
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    • v.29 no.9
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    • pp.1184-1187
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    • 2000
  • Spontaneous spinal epidural hematoma is rare disease and usually presents with a progressive neurological syndrome for which surgical decompression is usually indicated. The cause of bleeding in epidural hematoma remains unknown in most of the cases. The most frequently identified risk factor is coagulopathy or treatment with anticoagulants. Recently, authors experienced a case of spontaneous spinal epidural hematoma with intraoperative profuse bleeding at the cervicothoracic location. Laboratory examination showed no evidence of coagulopathy or hepatic disease. On neurologic examination, left hemiparesis(Grade : II) and left side sensory change were noted. On MRI scan, there was a mass of high signal intensity in T2WI and isosignal intensity in T1WI compressing the cord to left side. The patients had good surgical outcome after decompressive laminectomy and hematoma removal.

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The Numerical Analysis for the Surface Crack Behavior in the Planar Solid Oxide Fuel Cell (평판형 고체산화물 연료전지 표면균열거동에 관한 수치해석)

  • Park, Cheol Jun;Kwon, Oh Heon;Kang, Ji Woong
    • Journal of the Korean Society of Safety
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    • v.33 no.5
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    • pp.1-8
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    • 2018
  • A fuel cell is an energy conversion device that converts a chemical energy directly into an electrical energy and has higher energy efficiency than an internal combustion engine, but solid oxide fuel cell (SOFC) consisting of brittle ceramic material remains as a major issue regarding the mechanical properties as the crack formation and propagation. In this study, the stress distribution and crack behavior around the crack tip were evaluated, due to investigated the effects of the surface crack at the operating condition of high temperature. As a result, the difference of the generated stress was insignificant at operating conditions of high temperature according to the surface crack length changes. This is because, the high stiffness interconnect has a closed structure to suppress cell deformation about thermal expansion. The stress intensity factor ratio $K_{II}/K_I$ increased as the crack depth increased, at that time the effect of $K_{II}$ is larger than that of $K_I$. Also the maximum stress intensity factor increased as the crack depth increased, but the location of crack was generated at the electrolyte/anode interface, not at the crack tip.

Anatomical Location of the Tendinous Intersections of the Rectus Abdominis Muscle in Korean Women (한국 여성의 배곧은근에서 나눔힘줄(Tendinous Intersection)의 위치)

  • Suh, Hyun Suk;Eom, Jin Sub;Lee, Taik Jong
    • Archives of Plastic Surgery
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    • v.33 no.4
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    • pp.469-473
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    • 2006
  • Purpose: The transverse rectus abdominis myocutaneous(TRAM) flap has become a reliable method for autogenous breast reconstruction. However, dissection of the tendinous intersections of rectus abdominis is technically difficult. The tendinous intersection has significant vascularity within its fascial layers raising in importance of technique in elevation. If tendinous intersections are damaged during the elevation of the rectus muscle, circulation to TRAM flap can be endangered. The purpose of this study is to evaluate the number of tendinous intersections and to predict anatomical position of the tendinous intersections. Methods: We dissected 182 consecutive TRAM flaps and measured the distance between xiphoid process and each tendinous intersection and evaluated the statistic correlation among the distance, patient's height and position of umbilicus. Results: In this study, in 30.7% of patients, two tendinous intersections were observed in one rectus abdominis muscle, in 67.7% three tendinous intersections, and in 1.6% four tendinous intersections, respectively. But there was no correlation between patient's height and the distance between xiphoid process and each tendinous intersection. Conclusion: It still remains difficult to predict the position of tendinous intersections just by topography before the dissection. Careful and meticulous dissection of the tendinous intersections is still required.

A Study on the Characteristics of House Arrangement of Unified Silla Period - Focused on the Capital Remains of Silla in Gyeongju - (통일신라시대 주택의 배치특성 - 경주 신라왕경 발굴유구를 중심으로 -)

  • Han, Ji-Man;Lee, Jeong-Mee
    • Journal of the Korean housing association
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    • v.27 no.3
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    • pp.23-30
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    • 2016
  • Among the unearthed House ruins in Gyeongju of the capital of Silla period, the ruins to see the overall appearance of building arrangement is the ruins of Silla capital S1E1 area, Inwangdong 412, and the Jaemaejeong. In this study, the characteristics of urban house arrangement of the Unified Silla period was analyzed that, through a review of the arrangement relationship between the gate and the individual buildings found in these ruins. The urban house of the Unified Silla period was surrounded with wall, and the way to distinguish between functional areas within it are shown differently, depending on the size of the house. In other words, the small house was divided each area by installation of inner fence, and the large house was by arranging attached buildings. Thai is, the central area is not divided by inner fence is the Characteristics that is different from the small house. And in all houses, a large courtyard is located in the front of main building. Conatruction of the courtyard determines the location and direction of the main building. And the each area has external space of courtyard in the center.

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

  • Zeng, Rong;Duan, Lei;Kong, Yu-Ke;Wu, Xiao-Lu;Wang, Ya;Xin, Gang;Yang, Ke-Hu
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6103-6108
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    • 2014
  • Many studies have reported ${\beta}$-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of ${\beta}$-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of ${\beta}$-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of ${\beta}$-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of ${\beta}$-catenin could be a predicative factor of poor prognosis for EC patients.

Object Tracking based on Weight Sharing CNN Structure according to Search Area Setting Method Considering Object Movement (객체의 움직임을 고려한 탐색영역 설정에 따른 가중치를 공유하는 CNN구조 기반의 객체 추적)

  • Kim, Jung Uk;Ro, Yong Man
    • Journal of Korea Multimedia Society
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    • v.20 no.7
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    • pp.986-993
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    • 2017
  • Object Tracking is a technique for tracking moving objects over time in a video image. Using object tracking technique, many research are conducted such a detecting dangerous situation and recognizing the movement of nearby objects in a smart car. However, it still remains a challenging task such as occlusion, deformation, background clutter, illumination variation, etc. In this paper, we propose a novel deep visual object tracking method that can be operated in robust to many challenging task. For the robust visual object tracking, we proposed a Convolutional Neural Network(CNN) which shares weight of the convolutional layers. Input of the CNN is a three; first frame object image, object image in a previous frame, and current search frame containing the object movement. Also we propose a method to consider the motion of the object when determining the current search area to search for the location of the object. Extensive experimental results on a authorized resource database showed that the proposed method outperformed than the conventional methods.

Depth Measurement System Using Structured Light, Rotational Plane Mirror and Mono-Camera (선형 레이저와 회전 평면경 및 단일 카메라를 이용한 거리측정 시스템)

  • Yoon Chang-Bae;Kim Hyong-Suk;Lin Chun-Shin;Son Hong-Rak;Lee Hye-Jeong
    • Journal of Institute of Control, Robotics and Systems
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    • v.11 no.5
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    • pp.406-410
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    • 2005
  • A depth measurement system that consists of a single camera, a laser light source and a rotating mirror is investigated. The camera and the light source are fixed, facing the rotating mirror. The laser light is reflected by the mirror and projected to the scene objects whose locations are to be determined. The camera detects the laser light location on object surfaces through the same mirror. The scan over the area to be measured is done by mirror rotation. Advantages are 1) the image of the light stripe remains sharp while that of the background becomes blurred because of the mirror rotation and 2) the only rotating part of this system is the mirror but the mirror angle is not involved in depth computation. This minimizes the imprecision caused by a possible inaccurate angle measurement. The detail arrangement and experimental results are reported.

A Survey of Human Injury and Crowd Packing in Mass Gathering (군중집회 시의 인명피해 및 군중눌림 현상의 고찰)

  • Wang, Soon-Joo;Byun, Hyun-Joo
    • Journal of the Society of Disaster Information
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    • v.7 no.1
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    • pp.12-20
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    • 2011
  • This study was performed for identifying the characteristics of mass gathering and human injury in mass gathering based on the literature survey and analysis of mass gathering and crowd packing. The size and density of crowd influenced the characteristics of mass gathering according to type of mass gathering. The variables and causes of human injuries of mass gathering have positive or negative influences based on the weather, attendance, duration, location, mobility, event type, crowd mood, alcohol, drug, crowd density and age. Based on the physical mechanism of crowd packing, the degree of crowd packing was influenced by crowd pressure, crowd density and lasting time. But the magnitude of pressure for pedestrian injury criteria remains for further research.

Accurate Pig Detection for Video Monitoring Environment (비디오 모니터링 환경에서 정확한 돼지 탐지)

  • Ahn, Hanse;Son, Seungwook;Yu, Seunghyun;Suh, Yooil;Son, Junhyung;Lee, Sejun;Chung, Yongwha;Park, Daihee
    • Journal of Korea Multimedia Society
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    • v.24 no.7
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    • pp.890-902
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    • 2021
  • Although the object detection accuracy with still images has been significantly improved with the advance of deep learning techniques, the object detection problem with video data remains as a challenging problem due to the real-time requirement and accuracy drop with occlusion. In this research, we propose a method in pig detection for video monitoring environment. First, we determine a motion, from a video data obtained from a tilted-down-view camera, based on the average size of each pig at each location with the training data, and extract key frames based on the motion information. For each key frame, we then apply YOLO, which is known to have a superior trade-off between accuracy and execution speed among many deep learning-based object detectors, in order to get pig's bounding boxes. Finally, we merge the bounding boxes between consecutive key frames in order to reduce false positive and negative cases. Based on the experiment results with a video data set obtained from a pig farm, we confirmed that the pigs could be detected with an accuracy of 97% at a processing speed of 37fps.