• Journal of Chest Surgery
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• v.42 no.3
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• pp.364-367
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• 2009

Retroperitoneal pulmonary sequestration is an extremely rare congenital malformation. It is more frequently diagnosed in the antenatal period due to routine ultrasonic examinations that are conducted for a fetus or during the first 6 months of life, although retroperitoneal pulmonary sequestration is incidentally discovered in adults on rare occasions. Because the location and radiological findings of retroperitoneal pulmonary sequestration are very similar to those of another retroperitoneal masses, retroperitoneal pulmonary sequestration, although they are very rare, should be included in the differential diagnosis of a retroperitoneal suprarenal mass. Although fine needle aspiration may be considered as an aid for making the preoperative diagnosis, surgery remains the treatment of choice for symptomatic lesions and this surgery is associated with excellent results and a good prognosis.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7381-7383
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• 2013

Background: Male breast cancer accounts for less than 1% of all cancer in men and only around 1% of all diagnosed breast cancer. Despite a significant raise in the last 25 years, it still remains a rare disease. Materials and Methods: We conducted a retrospective study from 2004-2011 with 21 male breast cancer patients. We aimed to analyze the epidemiologic data (age, personal and family history), tumor characteristics (size, histological type, location, TNM stage, receptors), surgery, adjuvant chemotherapy and radiation therapy, hormonal therapy and survival (relapse, follow up, death) who reffered to our center with breast cancer. Results: The median age was $49.2{\pm}14.2$ years (range 30-83 years). A family history of breast cancer was noted in four cases. The main clinical complaint was a retroareolar mass in 85.7%of patients (n=18). Histologically, 85.7% (n=18)were invasive ductal carcinoma and 4.7% (n=1) had ductal carcinoma in situ and 9.4% (n=2) had mixed histology including invasive medullary and ductal carcinoma. Hormonal therapy was delivered to 16 cases (76.1%) due to ER or PR positivity. During median follow up of 30 months (3-84 month), distant metastases were evident in 4 cases (19%). During the follow-up period, only one patient died due to metastatic disease. The mean time to recurrence detection was 30 months. Conclusions: The percentage of cases of male breast cancer is very low compared to breast cancer in females, explaining why very few investigations have been conducted in Iran. Limited coverage in the literature make gender-specific findings difficult so future research of this entity involving multi-institutional cooperation and longer follow up is essential to provide new insights about the biological and clinical factors of this rare cancer.

• The Journal of the Acoustical Society of Korea
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• v.8 no.4
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• pp.29-38
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• 1989

Detection of an underwater target by acoustic wave raises various difficulties due to unpredictable noise interference which originates from clutter, reverberation, and variations of medium characteristics with time and location. The SNR and the range resolution of conventional SONAR systems using a matched filter are generally poor, since the latter is optimum only in the additive white noise case. Furthermore, it cannot compensate for variations of the detection level which are responsible for the resultant detection errors. In this paper, the unpredictable interferences are compensated for by using an adaptive filter. It recursively estimates the channel impulse response based on the received echo signal. In the low noise environments, the estimated impulse response is close to the true one, providing a good range resolution, and a matched filter is used subsequently for the purpose of detection. It is shown through computer simulation that good performance can be achieved via the two steps of filtering. Also, the detection level remains unchanged without any additional provisions. Finally, we present the characteristics of the employed adaptive filter parameters.

• KOMUNHWA
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• no.69
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• pp.5-40
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• 2007

The research against Youngdong area Bronze Age settlement structure the condition where the investigation against the area and the remains which are limited becomes accomplished and Only the dwelling site will be investigated from the early settlement of most and recognition there is not a possibility which it will investigate synthetically. The Early settlement to the time which reaches the size of the settlement is small and From Bangnae-ri phases the house possession area increases inside the hill and it follows on south and if dwelling site numbers under increasing, from the aspect where the size of the settlement is magnified seems and it is a position. The Middle settlement currently was confirmed as the beginning from the room village A ruins, it investigates a settlement structure to, the increase of data is necessary. Is Pottery with clay stripes, phases the Later Settlement which Dwelling site, Storeage, Earthenware Kiln, Ditch enclosure and Tomb, the Public dwelling site back large scale Pottery with clay stripes settlement of formation will be investigated from Bangdong-ri settlements which correspond to Songhyun-ri settlement which is a hill characteristic settlement which is located in rivers circumference and the higShland characteristic settlement to provide the data the cultural aspect and character and a settlement structure of Bronze Age postscript and it will be able to grasp.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.187-190
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• 2006

In the present study, effects of tree-stream turbulence and surface trip wire on the flow past a sphere at $Re\;=\;0.4\;{\times}\;10^5\;{\sim}\;2.8\;{\times}\;10^5$ are investigated through wind tunnel experiments. Various types of grids are installed upstream of the sphere in order to change the tree-stream turbulence intensity. In the case of surface trip wire, 0.5mm and 2mm trip wires are attached from $20^{\circ}\;{\sim}\;90^{\circ}$ at $10^{\circ}$ interval along the streamwise direction. To investigate the flow around a sphere, drag measurement using a load cell, surface-pressure measurement, surface visualization using oil-flow pattern and near-wall velocity measurement using an I-type hot-wire probe are conducted. In the variation of free-stream turbulence, the critical Reynolds number decreases and drag crisis occurs earlier with increasing turbulence intensity. With increasing Reynolds number, the laminar separation point moves downstream, but the reattachment point after laminar separation and the main separation point are fixed, resulting in constant drag coefficient at each free-stream turbulence intensity. At the supercritical regime, as Reynolds number is further increased, the separation bubble is regressed but the reattachment and the main separation points are fixed. In the case of surface trip wire directly disturbing the boundary layer flow, the critical Reynolds number decreases further with trip wire located more downstream. However, the drag coefficient after drag crisis remains constant irrespective of the trip location.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.6
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• pp.1365-1373
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• 1994

A Monte-Carlo simulation model, developed to predict size distribution of air bubbles in turbulent shear flow, is applied to a laboratory-scale problem. Sensitivity to various numerical and physical parameters of the model is analyzed. Practical applicability of the model is explored through comparisons of results with experimental measurements. Bubble size increases with air-water discharge ratio and friction factor. Bubble size decreases with increasing mean flow velocity, but the total bubble surface area in the aeration region remains fairly constant. The effect on bubble size distribution of the longitudinal length increment in the simulation model is negligible. A larger radial length increment yields more small and large bubbles and fewer in between. Bubble size distribution is significantly affected by its initial distribution and the location of air injection. Collision efficiency is introduced to explain the discrepancy between collisions with and without coalescence.

• Journal of Chest Surgery
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• v.43 no.2
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• pp.199-203
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• 2010

Infected aortic aneurysms are rare, but the mortality of patients with infected aortic aneurysms remains high. Open surgical procedures are the standard of care for infected aneurysms of aorta, but the surgical results are often disappointing. The risk factors related to the high mortality include aneurysm rupture and a suprarenal aneurysm location. The classic method for treating infected aneurysms has been aneurysm resection, soft tissue debridement, remote arterial reconstruction out of the field of infection and antibiotics. Infected anuerysms located in the suprarenal aorta are highly lethal because of the need to reimplant the visceral or renal arteries and the graft related complications. We reported here on a case of suprarenal infected aortic aneurysm in a 55-years-old man. We also include a review of the relevant medical literature.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.2971-2977
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• 2014

Background: Long non-coding RNAs (lncRNAs) have been recently observed in various human cancers. However, the role of lncRNAs in pancreatic duct adenocarcinoma (PDAC) remains unclarified. The aim of this study was to detect the expression of lncRNA MALAT1 in PDAC formalin-fixed, paraffin embedded (FFPE) tissues and to investigate the clinical significance of the MALAT1 level. Methods: The expression of MALAT1 was examined in 45 PDAC and 25 adjacent non-cancerous FFPE tissues, as well as in five PDAC cell lines and a normal pancreatic epithelium cell line HPDE6c-7, using qRT-PCR. The relationship between MALAT1 level and clinicopathological parameters of PDAC was analyzed with the Kaplan-Meier method and Cox proportional hazards model. Results: The relative level of MALAT1 was significantly higher in PDAC compared to the adjacent normal pancreatic tissues (p=0.009). When comparing the MALAT1 level in the cultured cell lines, remarkably higher expression of MALAT1 was found in aspc-1 PDAC cells compared with the immortal pancreatic duct epithelial cell line HPDE6c-7 (q=7.573, p<0.05). Furthermore, MALAT1 expression level showed significant correlation with tumor size (r=0.35, p=0.018), tumor stage (r=0.439, p=0.003) and depth of invasion (r=0.334, p=0.025). Kaplan-Meier analysis revealed that patients with higher MALAT1 expression had a poorer disease free survival (p=0.043). Additionally, multivariate analysis indicated that overexpression of MALAT1, as well as the tumor location and nerve invasion, was an independent predictor of disease-specific survival of PDAC. Conclusion: MALAT1 might be considered as a potential prognostic indicator and may be a target for diagnosis and gene therapy for PDAC.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5789-5795
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• 2013

Background: The high mobility group box 1 (HMGB1) protein is a widespread nuclear protein present in most cell types. It typically locates in the nucleus and functions as a nuclear cofactor in transcription regulation. However, HMGB1 can also localize in the cytoplasm and be released into extracellular matrix, where it plays critical roles in carcinogenesis and inflammation. However, it remains elusive whether HMGB1 is relocated to cytoplasm in clear cell renal cell carcinoma (ccRCC). Methods: Nuclear and cytoplasmic proteins were extracted by different protocols from 20 ccRCC samples and corresponding adjacent renal tissues. Western blotting and immunohistochemistry were used to identify the expression of HMGB1 in ccRCC. To elucidate the potential mechanism of HMGB1 cytoplasmic translocation, HMGB1 proteins were enriched by immunoprecipitation and analyzed by mass spectrometry (MS). Results: The HMGB1 protein was overexpressed and partially localized in cytoplasm in ccRCC samples (12/20, 60%, p<0.05). Immunohistochemistry results indicated that ccRCC of high nuclear grade possess more HMGB1 relocation than those with low grade (p<0.05). Methylation of HMGB1 at lysine 112 in ccRCC was detected by MS. Bioinformatics analysis showed that post-translational modification might affect the binding ability to DNA and mediate its translocation. Conclusion: Relocation of HMGB1 to cytoplasm was confirmed in ccRCC. Methylation of HMGB1 at lysine 112 might the redistribution of this cofactor protein.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2171-2174
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• 2012

Background: Pancreatic cancer is a distressing disease with a miserable prospects and early recognition remains a challenge due to ubiquitous symptomatic presentation, deep anatomical location, and aggressive etiology. False positives and problems in distinguishing pancreatitis from adenocarcinoma limit the use of CA 19-9 as both disorders can present with similar symptoms and share radiographic physiognomies. This study aimed to assess the relative increase in accuracy of diagnosing the patients with chronic pancreatitis, benign neoplasm of pancreas and adenocarcinomas with CA 19-9, haptoglobin, and serum amyloid A in comparison to CA 19-9 alone. Materials and Methods: This hospital based case control study was carried out in the Departments of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal, between $1^{st}$ January 2010 and $31^{st}$ December 2011. The variables assessed were age, gender, serum CA19-9, serum haptoglobulin, serum Amyloid A. The data were analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Out of 197 cases of pancreatic disease, maximum number of assumed cases were of adenocarcinoma of pancreas (95). Number of males (59) were more than females (36) in assumed cases of adenocarcinoma of pancreas. The mean values of CA19-9 raised considerably in cases of chronic pancreatitis, benign neoplasm and adenocarcinoma of pancreas when compared to controls. The highest augmention in CA19-9 values were in cases of adenocarcinoma of pancreas. The p-value indicates that in cases of chronic pancreatitis, there was not significant increase in precision of diagnosis. Conclusions: These statistics established that haptoglobin and SAA are useful in discriminating cancer from benign conditions as well as healthy controls.