• 산업공학
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• 제22권1호
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• pp.1-9
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• 2009

As the LCD fabrication factories (Fab) are highly capital-intensive and the markets are very competitive, it is an essential requirement of operational management to achieve full-capacity production while meeting customer demands on time. In a typical LCD Fab, medium-term schedules such as release plans and production plans are critical to achieve the goal of full-capacity production and on-time delivery. Presented in this paper is a framework for weekly planning system generating medium-term schedules using a finite-capacity planning method. Also this paper presents a release planning method applying capacityfiltering algorithm, especially backward capacity-filtering procedure, which is one of the finite-capacity planning methods. In addition, performance analyses using actual data of a TFT-LCD Fab show that the proposed method is superior to existing methods or commercial S/W products generating release plans.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집B
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• pp.525-532
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• 2001

Experimental study has been conducted to clarify the pneumatic characteristics of brake system for freight train and enhance the performance of diaphragm valve. Empty-load and diaphragm brake systems are mainly used in the freight trains of KNR (Korean National Railroad). The train set is composed of thirty freight cars and diesel locomotive. From the experimental results, new quick release valve shortens release time after brake application. In case of normal brake application, the release time is short by 34% of that of original diaphragm control valve. It will be expected to assure brake-release application and reduce maintenance efforts.

• Membrane and Water Treatment
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• 제13권1호
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• pp.21-28
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• 2022

The use of plastics in our everyday lives have been drastically increased during the last few decades. However with the usage of commercial plastic products there is a possibility of microplastic consumption, due to the fragmentation of the products. Additionally, the potential for microplastic ingestion may also be increased by using damaged products. Hence, the current study was conducted to understand the potential release of micro/nano plastics and organic matter from damaged teabags. To check the leakage tendency, the amount of damage to the tea bags from 1-10 cm were tested along with temperatures of 25-70℃, and exposure times from 5 min to 1 hr was tested. Release of fibrous micro/nanoplastics, and organic leachate from the damaged teabags were observed to understand the outflow conditions. Results showed that with the increased degree of damage, temperature, and exposure time increased the release of fiberous matter, where the increase of temperature, and exposure time increased organic leachate. Additional analysis confirmed the leachate of nylon polymers into the heated water.

• 한국운동역학회지
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• 제14권1호
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• pp.51-63
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• 2004

The purpose of this study was to investigate a three dimensional kinematic variables about the last stride and the release phase of the throwing technique for female javelin throwers. For the motion analysis, Six female javelin throwers were used as subjects. Three-dimensional coordinates were collected using the Kwon3D Motion Analysis Package Version 2.1 Program. Two S-VHS Video Cameras were used to record the locations and orientations of control object and the performances of the subjects at a frequency of 6.0 HZ. After the kinematic variables such as the time, the distance, the velocity, and the angle were analyzed about the last stride and release phase, the followings were achieved; 1. For the effectively javelin throwing, the subjects appeared to do long the approach time in the phasel of landing phase, and short the delivery time in release phase 2. In the release event, the other subjects except for subject A appeared to throwing in the lower condition than the height of themselves. This result showed to slow the projecion velocity. 3. For increase the projection vcelocity of the upper extremity joint in the release event, it appeared to do extend rather the shoulder angle than increase the extension of elbow joint. 4. The body of COG angle showed to gradually increase nearly at the vertical axis in the release event. But the front lean angle of trunk showed a small angle compare to increase of the body of COG angle. Therefore for the effectively momentum transmission of the whole body in the javelin, the front and back lean angle of trunk appeared to do fastly transfer the angle displacement in the arch posture or the crescent condition during the deliverly motion of the release phase.

• Bulletin of the Korean Chemical Society
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• 제35권2호
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• pp.557-561
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• 2014

The aim of the present study was to improve dosing of lacosamide, a functionalized amino acid used as an antiepileptic agent, from twice daily to once daily for the convenience of patients. A sustained-release lacosamide tablet was developed and dissolution testing was employed to determine in vitro release behavior using water or buffer solutions at pH 1.2, 4.0, or 6.8. Lacosamide was released for 12 h from the sustainedrelease (SR) tablet, as compared to complete release within 1 h from an immediate-release $Vimpat^{(R)}$ tablet. Each formulation (100 mg) was orally administered to six beagle dogs and six mini-pigs under fasted conditions, and pharmacokinetic parameters such as the area under the concentration time curve ($AUC_t$), the maximum plasma concentration ($C_{max}$), and the time at which this occurred ($T_{max}$) were calculated. These results showed similar values for $AUC_t$, $C_{max}$, and $T_{max}$ following oral administration of immediate-release ($Vimpat^{(R)}$) and SR lacosamide tablets.

• KSBB Journal
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• 제10권4호
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• pp.461-467
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• 1995

본 연구에서는 약물 전달체(키토산, 키토산.엽, 술폰화키토산)에 prednisolone을 분산시켜 제조한 고분자 매트릭스를 poly (DL-lactide)로 피막을 형성시킨 후 pH 1.2와 pH 7.4 인산염 완충용액에서 약물 방출실험을 하였다. 약물 방출시간은 pH 1.2에서 보다 pH 7.4에서 더 지연되였으며 약물 전달체의 함유량이 증가함에 따라 약물의 방출시간도 지연되었다. 피막된 고분자 매트릭스의 종류에 따라 지연된 약물의 방출시간은 키토산의 경우가 가장 길었으 며, 술폰화키토산, 키토산.염의 순셔였다. Monolith IC 고분자 매트릭스에 비해 2배 정도의 약물의 방출 지연성을 보인 피막된 monolithic 고분자 매트럭스 가 방출조절형 제제로서 더 바람직한 것으로 관찰되었다. 이러한 제형들은 초기 급격한 약물 방출속도의 변화를 억 제 하는 sustained release pattern 제 제 임을 확인할 수 있었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2001년도 추계학술대회 논문집
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• pp.119-124
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• 2001

As the brake control valve of freight car, there are sliding valve and diaphragm one. In this study, we measured and analyzed pneumatic characteristics of brake system of the freight car by using real train experiment. The difference of the release time appears in the freight car incorporated with sliding and diaphragm valve respectively. We adapted quick release valve to reduce the difference of the release time and also found that this valve is useful for the purpose.

• 전기전자학회논문지
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• 제15권1호
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• pp.43-48
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• 2011

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구되었다. 무한고장수를 가진 비동질적인 포아송 과정에 기초하고 수명분포는 최소 및 최대값을 적합 시키는데 효율성을 가진 극값 분포를 이용한 최적 방출시기에 관한 문제를 제시하여 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화 시키는 최적 소프트웨어 방출 정책에 대하여 논의 되었다. 본 논문의 수치적인 예에서는 고장 간격 시간 자료를 적용하여 기존의 로그 포아송 실행시간 모형과 로그 파우어 모형의 대안으로서 극값 분포모형이 또 하나의 대안이 될 수 있음을 입증하였다.

• Journal of Pharmaceutical Investigation
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• 제15권1호
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• pp.32-39
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• 1985

Bioavailability studies in guinea pigs and dissolution tests of sustained release capsules of ascorbic acid were investigated comparing with those of solution. The results were as follows; 1. In the dissolution test sustained release capsules released 90% of ascorbic acid after 12 hours, and ascorbic acid in the chewable tablet was dissolved. completely within 10 minutes. 2. In the determination of total ascorbic acid concentration in serum, the area under the curve between 0 and 24 hours $(AUC\;0{\sim}24h)$ ana the maximum serum concentration $(C_{max})$ did not show any significant difference between solution and sustained release capsule. The time to the maximum concentration $(C_{max})$ and the time over $50{\mu}g/ml$ concentration showed significant difference. 3. The time reached to maximum excretion rate $(T_{max})$ in sustained release capsule was longer than that of solution.

• Journal of Pharmaceutical Investigation
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• 제20권2호
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• pp.79-88
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• 1990

A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of ${\nu}$ parameter: ${\nu}$ value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.