• Journal of Pharmaceutical Investigation
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• 제24권3호
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• pp.139-144
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• 1994

The effect of some formulation variables on the release rate of famotidine, a $H_2$ receptor antagonist, from cellulose matrices containing hydroxypropylcellulose (HPC) in different ratios and types was investigated. The effects of tablet shape and compression pressure on dissolution rate of famotidine were studied. And the effect of the pH of dissolution media was also studied. Increase in the ratio of polymer to drug decreased the release rate of famotidine. Increase of the polymer viscosity also decreased the release rate. The release rate of famotidine was dependent on the pH of dissolution media. The release rate of drug was not much dependent on the compression pressure but dependent on the tablet shape and/or surface area. Consequently, the release rate of famotidine can be modified by changing the HPC contents, types of polymers with different viscosity grades or using appropriate fillers.

• 한국자동차공학회논문집
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• 제11권5호
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• pp.22-28
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• 2003

Flash boiling mechanism in the injector interferes with fine fuel metering in a liquid phase LPG injection engine. This study presents a mathematical model to precisely predict an injection quantity. A calibration procedure of injection quantity, which is very prompt and precise in measuring, is developed using a gas analyzer. According to this procedure, injection quantity can be obtained under various fuel compositions, temperatures and injection pressures. The release pressure of liquid phase LPG is estimated based on these experimental data. Although the release pressure is much lower than the saturation pressure, it is linearly proportional to the saturation pressure.

• 대한기계학회논문집B
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• 제26권9호
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• pp.1284-1291
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• 2002

Combustion instabilities are an important concern associated with lean premixed combustion. Laboratory-scale dump combustor was used to understand the underlying mechanisms causing combustion instabilities. Experiments were conducted at atmospheric pressure and sound level meter was used to track the pressure fluctuations inside the combustor. Instability maps and phase-resolved OH chemiluminescence images were obtained at several conditions to investigate the mechanism of combustion instability and relations between pressure wave and heat release rate. It showed that combustion instability was susceptible to occur at higher value of equivalence ratio (>0.6) as the mean velocity was decreased. Instabilities exhibited a longitudinal mode with a dominant frequency of ∼341.8 Hz, which corresponded to a quarter wave mode of combustor. Heat release and pressure waves were in-phase when instabilities occurred. Rayleigh index distribution gave a hint about the location where the strong coherence of pressure and heat release existed. These results also give an insight to the control scheme of combustion instabilities. Emission test revealed that NOx emissions were affected by not only equivalence ratio but also combustion instability.

• 한국자동차공학회논문집
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• 제3권1호
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• pp.129-135
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• 1995

This study aims to compare the heat release calculated using the ensemble average of pressure data with the heat release calculated using the least squares method for pressure data. This paper propose a heat release computation method that can analyze the most correct, straight and simple method to analyse combustion phenomenon. In conclusion, we found that the least squares method of third-order was the best computational method for heat release calculation.

• Nuclear Engineering and Technology
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• 제32권2호
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• pp.108-127
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• 2000

Hot leg break LBLOCA(Large Break LOCA) had a potential to be a containment maximum pressure accident in YGN3&4, which was induced from excessive conservatism in the CE analysis methodology of mass and energy release. This study conducted mass and energy release experiment for the hot leg break LBLOCA during post blowdown with an integral test facility, SNUF(Seoul National University Facility). This facility simulated YGN 3&4 with volume ratio of 1/1140 based on Ishii's three level scaling. Experiment showed that SI(Safety Injection) water refilled cold leg first and core later. SI water was vaporized in the core, which resulted in the repressurization of reactor. This increase of pressure drove the water in cold leg to flow up half height of U tubes. However, since the water was drained back soon, the release through the SG side broken section by evaporation was negligibly small. This study also provided experimental assessment of RELAP5 results by KAERI for the release through the SG side broken section.

• Journal of Advanced Marine Engineering and Technology
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• 제28권7호
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• pp.1063-1071
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• 2004

Accurate heat release analysis of cylinder pressure data is important for evaluating performance in the development of diesel engine However, traditional single zone first law heat release model(SZM) has significant limitations due to the simplified assumption of uniform charge and neglecting local temperature inside cylinder during combustion process. In this study. heat release rate based on single zone heat release model has been evaluated by comparison with computational analysis results using Fire code which is based on multi-dimensional model(MDM). To overcome limitations due to simplicity of single zone assumption. especially the influence of specific heat ratio on gross heat release has been esteemed and newly suggested were the equation $\gamma$= $\gamma$(${T/T}_{max}$) which describes the variations of gases thermodynamic properties with mean temperature and maximum mean temperature inside cylinder Single zone heat release model applied with this equation is shown to give very good results over whole range of operating conditions when compared with computational analysis results based on multi-dimensional model.

• 대한정형도수물리치료학회지
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• 제27권2호
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• pp.87-92
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• 2021

Purpose: This study aimed to investigate the effects of myofascial release technique on pain threshold and hormonal changes in patients with adhesive capsulitis of the shoulder. Methods: Eight patients with adhesive capsulitis were treated with the myofascial release technique. Myofascial release is a form of manual therapy that involves the application of a low load, long duration stretch to the myofascial complex, intended to restore optimal length, decrease pain, and improve function. Blood tests and pressure pain threshold (PPT) examinations were performed on their first visit. On their second visit, the myofascial release technique was applied to the shoulder for 20 min. Then, blood tests and PPT were re-evaluated to determine the effects of the myofascial release technique on pain threshold and hormonal changes. Results: Pain threshold increased from 2.92 to 24.13 lb after treatment. Epinephrine decreased from .13 to .08 ng/mL whereas norepinephrine increased from .25 to .41ng/㎖ after treatment. Conclusion: Myofascial release technique in patients with adhesive capsulitis increased pain thresholds, norepinephrine and decreased epinephrine levels.

• Journal of Ginseng Research
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• 제21권2호
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• pp.119-124
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• 1997

Chronic hypertension is associated with impaired endothelial function such as reduced synthesis/release of endothelium-derived relaxing factor(EDRF, nitric oxide) and increased synthesis/release of endothelium-derived contracting factor(EDCF) including prostaglandin endoperoxide($PGH_2$) , superoxide anion both in animals and in humans. We have previously shown that ginsenosides lower the blood pressure and enhance the release of nitric oxide(NO) from endothelial cells in the rat aorta of the normotensive rats. The aim of the present study is to examine whether in vivo treatment of spontaneously hypertensive rats(SHRs) with protopanaxatriol ginsenosides(PPT) reduces the blood pressure and improves endothelial function in the isolated thoracic aorta of SHR. In addition, the contractile response to $PGH_2$ and superoxide anion in the aorta treated with PPT was assessed. SHRs at the age of 16 weeks were savaged with PPT(30 mg/kg/ day) for 2 weeks and systolic blood pressure was measured by the tail-cuff method. Whereas blood pressure was significantly increased in SHRs by 5.4 mmHg during this period of treatment, treatment of SHRs with PPT blocked the elevation of blood pressure. Endothelium-dependent relaxation to acetylcholine was significantly increased in the PPT-treated animals. $PGH_2$- and oxygen-derived free radical-induced contractions were significantly suppressed in aortic rings without endothelium from PPT-treated SHR. These findings indicate that PPT reduces the blood pressure of SHR, which may be associated with either increase of NO release or by antagonizing superoxide anion and PGH2 in the aortic smooth muscle.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 춘계학술발표회논문집(2)
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• pp.405-410
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• 1996

New methodology for mass and energy release assessment in LBLOCA post blowdown is needed and, first of all, the phenomenologically improved and quantitative assessments through experiment are essential. For tile experiment of a hot leg break LBLOCA in post blowdown, the test facility was set and its feature is that tile broken hot leg has two broken sections in the tore side and in the SG side respectively and a separation valve between the two in order to measure the release rate dividedly. Specially it was focused on whether the mass release through the SG side broken section happened or not. The mass release through the core side broken section is dependent on tile safety injection flow and that through the SG side broken section varies depending on several factors. The principal factor is the primary system pressure and the subfactors such as SI flow rate, SI temperature and initial primary pressure, may contribute, too.

• Journal of Advanced Marine Engineering and Technology
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• 제26권4호
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• pp.457-463
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• 2002

The closed cycle diesel engine is used in a closed circuit system which has no air breathing. The working fluid as intake mixture are consisted of oxygen, argon and recirculated exhaust gas in order to obtain underwater or underground power sources. In the present study, the high pressure diesel engine which can be operated by the closed cycle system with high intake pressure for increasing the net power rate is designed. It has been carried out to investigate the combustion characteristics of high pressure diesel engine according to the power rate. The maximum cylinder pressure and heat release rate were investigated. Also, major experimental data such as specific fuel consumption rate, oxygen concentrations, fuel conversion efficiency, polytropic exponent, and IMEP were compared with low pressure diesel engine experimental data.