• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.1
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• pp.38-49
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• 2017

In general, railroad operation companies sell tickets to maximize their profits by applying the ticketing release time (when selling any tickets regardless of trip distances). This study is to analyze the effect of the release time on KTX ticket reservation behavior. The reservation behavior in this study means the reservation time calculated by difference between ticketing time and departure time. The data come from KTX ticket sales data of Gyeongbu-line for a week including Saturday and Sunday. The results show that the factors to affect the reservation time are day of the week, trip distance and operation direction, in addition to the release time. Furthermore, most of tickets were reserved three hours before their departure time, and most of the up line weekend users reserved their tickets a day before the departure time. Before the release time, reservation time was affected by up line and long distance travel. On the other hand, after the release time, it was affected by long distance travel and Sunday.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.8
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• pp.4749-4755
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• 2014

In this study, to maximize the heat release from the heat generating environment, such as a high-capacity inverter, the heat release performance of the extruded-type heat sinks with the variation of the base thickness were investigated using the experimental and numerical methods. The base thickness was varied from 5 to 14 mm. The heat release was characterized by the amount of heat released through the heat sink, the surface temperature of heat sink base between the heat sources, and temperature of heat sources. The surface temperatures between heat sources and the amounts of heat release were improved more as the base thickness was decreased. In contrast, the temperatures of the heat sources decreased with increasing base thickness. Based on the case study of these heat sinks, it is believed that a heat sink with a 9.5mm-thick base was optimized for the heat release.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.422-426
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• 2008

Hemodialysis graft coated with paclitaxel prevents stenosis; however, large initial burst release of paclitaxel causes many negative effects such as drug toxicity and inefficient drug loss. Therefore we developed and tested a novel coating method, double dipping, to provide controlled and sustained release of paclitaxel locally. Expanded polytetrafluoroethylene (ePTFE) grafts were dipped twice into a solution of several different paclitaxel concentrations. In vitro release tests of the double dipping method showed that early burst release could be somewhat retarded and followed by sustained release for a long time. We observed the effect of paclitaxel coating by double dipping in porcine model of arterio-venous (AV) grafts between the common carotid artery and the external jugular vein. 12 weeks after constructing AV grafts, cross sections of the graft venous anastomosis were obtained and analyzed. Paclitaxel coated ePTFE grafts by double dipping were observed to prevent neointimal hyperplasia and therefore reduced stenosis of the arteriovenous hemodialysis grafts, especially at the graft venous anastomosis sites. Our results demonstrate that second dipping of ePTFE graft, which was already coated once with paclitaxel, washes off the drug on a surface of the graft and affects the ratio of paclitaxel on the surface to that of the inner space, possibly by diffusion: thus the early burst of drug can be somewhat reduced.

• Journal of Ginseng Research
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• v.20 no.3
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• pp.274-283
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• 1996

In this study, the effects of red ginseng components [ginsenosides (total saponins and $Rg_1$) on the function of ryanodine receptor (RyR) -$Ca^{2+}$ release channel complex protein (named as RyR or $Ca^{2+}$ channel), a membrane protein in sarcoplasmic reticulum (SR) of rabbit skeletal muscle were examined at the SR vesicle's level and the molecular levels with Chaps-solubilized and purified $Ca^{2+}$ channel protein and with reconstituted proteoliposomes by dialysis. The results were as follows. 1. The binding of ryanodine known as inhibitor of muscle contraction to the RyR was decreased at the whole range of concentration ($10^2$~$10^7$%) by these two ginseng components. In heavy SR vesicles, Chaps-solubilized and purified $Ca^{2+}$ channel protein, and reconstituted vesicles, its maximal inhibition by total saponins was shown at the concentration of $10^3$, $10^3$%, and $10^5$% respectively, and by gin- senoside $Rg_1}$) each was $10^3$%, $10^3$%, and $10^4$%. 2. The release of $Ca^{2+}$ ion through $Ca^{2+}$ channel in heavy SR vesicles and reconstituted proteoliposomes was increased as a whole by these two ginseng components, and particularly maximal release by both of them was shown at the range of $10^4$~$10^6$%. These results were seemed to be caused by conformational change of $Ca^{2+}$ release channel protein (RyR) by red ginseng components [ginsenosides (total saponins and $Rg_1}$).

• Polymer(Korea)
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• v.36 no.2
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• pp.202-207
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• 2012

Biodegradable poly(${\varepsilon}$-caprolactone)(PCL) microcapsules containing pseudomonas were prepared by W/O/W emulsion system. The characteristics and release behaviors of the microcapsules were investigated as a function of manufacturing conditions. The morphology and particle distribution of the microcapsules were observed by a scanning electron microscope and a particle size analyzer. The release behaviors of the pseudomonas were determined using a cell culture method. It was found that smooth and spherical microcapsules were formed by W/O/W emulsion system and particle size was in the range of 10 to 60 ${\mu}m$. The release behaviors of the pseudomonas were influenced by the manufacturing conditions. It was indicated that the increase of the surfactant content and stirring rate led to an increased release rate, resulting from the high specific surface area of the smaller particle size, and the increase of the PCL content provided the sustained release behaviors by the delay effect of diffusion in the release medium.

• Archives of Pharmacal Research
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• v.20 no.6
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• pp.533-538
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• 1997

Biflavonoid is one of unique classes of naturally-occurring bioflavonoid. Previously, certain biflavonoids were found to possess the inhibitory effects on phospholipase $A_2$ activity and lymphocytes $ proliferation^1$ suggesting their anti-inflammatory/immunoregulatory potential. In this study, effects of several biflavonoids on arachidonic acid release from rat peritoneal macrophages were investigated, because arachidonic acid released from the activated macrophages is one of the indices of inflammatory conditions. When resident peritoneal macrophages labeled with $[^{3}H]$arachidonic acid were activated by phorbol 12-myristate 13-acetate(PMA) or calcium ionophore, A23187, radioactivity released in the medium was increased approximately 4.1-7.3 fold after 120 min incubation compared to the spontaneous release in the control incubation. In this condition, biflavonoids (10 uM) such as ochnaflavone, ginkgetin and isoginkgetin, showed inhibition of arachidonate release from macrophages activated by PMA (32.5-40.0% inhibition) or A23187 (21.7-41.7% inhibition). Amentoflavone showed protection only against PMA-induced arachidonate release, while apigenin, a monomer of these biflavonoids, did not show the significant inhibition up to 10 uM. Staurosporin (1 uM), a protein kinase C inhibitor, showed an inhibitory effect only against PMA-induced arachidonate release (96.8% inhibition). Inhibition of arachidonate release from the activated macrophages may contribute to an anti-inflammatory potential of biflavonoids in vivo.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.26 no.2
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• pp.73-80
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• 2020

Background: This study examined the effects of myofascial release exercise using an inflatable compression therapy ball on spinal flexibility in adults to present basic data to improve spinal flexibility. Methods: The participants were assigned randomly to two groups: the myofascial release exercise group (MRE, n=60) and the stretching exercise group (SE, n=60). The MRE group performed myofascial release exercise for the erector spine muscles using an inflatable compression therapy ball. The SE group performed stretching exercises of the erector spine muscles. Each exercise was performed in 3 sets of 10 repetition daily for one week. Results: The within-group comparison revealed a statistically significant difference between the pre-intervention and post-intervention measurements in only MRE group (p<.05). On the other hand, the between-group comparison revealed the MRE group to show statistically significant improvement in spinal flexibility (p<.05). In effect size, the MRE group was -1.82 (95% CI= -2.24~-1.39), and the SE group was -.7 (95% CI= -1.15~-.41). Conclusion: Myofascial release exercise for the erector spine muscles using an inflatable compression therapy ball was more effective in improving spinal flexibility than stretching exercises for the erector spinae muscles. However, although myofascial release exercise using inflatable compression therapy ball is more effective than stretching exercise, it is insignificant, and research is also insignificant. It is believed that more diverse studies using props will be needed in the future.

• Korean Journal of Applied Biomechanics
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• v.34 no.2
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• pp.53-62
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• 2024

Objective: The purpose of this study was to analyze the differences in kinematic factors according to stretching treatment, myofascial release treatment, and static stretching treatment conditions during squat. Method: Twelve males with resistance training experience participated in this study. Participants performed squats without treatment (Pre-Test), and performed squats after treatment with the myofascial release technique (MRT) and static stretching (SS) on different days (post-test). Squat movements were captured using eight motion capture cameras (sampling rate: 250 Hz), and the peak joint angles of the ankle, knee, hip, and pelvis were calculated for each direction. One-way repeated ANOVA and Bonferroni post hoc analyses using SPSS 27 (IBM Corp. Armonk NY, USA) were used to compare the peak joint angle of the lower extremity joints and pelvis among the normal condition (squat without treatment), MRT condition (squat after MRT treatment) and SS condition (squat after static stretching). The statistical significance level was set at .05. Results: It was observed that the maximum ankle joint flexion angle during squats was statistically reduced under conditions of myofascial release and static stretching (p<.05), in comparison to the scenario where no stretching was performed. Furthermore, static stretching was found to enhance the maximum hip flexion angle during squat (p<.05), whereas the myofascial release stretching technique resulted in the minimal posterior pelvic tilt angle (p<.05). Conclusion: Employing myofascial release stretching as a preparatory exercise proved to be more efficacious in maintaining body stability throughout the execution of high-intensity squat movements by effectively managing the posterior tilt of the pelvis, as opposed to foregoing stretching or engaging in static stretching.

• Journal of Acupuncture Research
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• v.18 no.6
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• pp.1-13
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• 2001

Objective : To broaden understanding about relationship between Meridian Tendino-musculature and muscles in a lumbar area and to evaluate the effect of Meridian Tendino-musculature acupuncture and release therapy on acute lumbar sprain. Materials and Methods : From Oct. 1st, 2000 to Mar. 31th, 2001, 692 outpatient's chart of Kyung Won University Hospital were reviewed. Out of them, 39 outpatients were selected. they had low back pain, were diagnosed with acute lumbar sprain, showed only straightened curvature on lateral view of lumbar spine X-ray and get the Tendino-musculature acupuncture and release therapy. Results : 1. On patients' first visit, 72% had GrIII and Gr.IV predominantly. 2. Major muscles related with low back pain were divided into two groups. One was Quadratus lumborum group and the other was Rectus abdominis group. In the correlation with Meridian Tendino-musculature, the former was mainly related with Chok-taeyang(B) and slightly related with Chok-soyang(G), Chok-taeum(SP), the latter was mainly related with Chok-taeyum(SP), Chok-yangmyong(S) and slightly related with Chok-taeyang(B), Chok-soyang(G). 3. In the evaluation of treatment effect, Exellent was 27(69%), Good was 10(6%), Fair was 2(5%) and Bad was 0(0%). Fair rate reached 100% eventually. 4. Most of Gr.Ⅲ, Gr.Ⅳ patients who had severe conditions that almost every R.O.M. was limited and Milgram test positive was shown on the physical examination, were fully recovered and lived normal daily life without admission by Meridian Tendino-musculature acupuncture and release therapy within 3 to 5, 4 to 7 days, respectively, since they had started to get their outpatient treatment. 5. Two patients was troubled with pain induced, by twitching response and acupuncure stimuli, which lasted around acupunctured muscle for about a day after treatment, so they coudn't endure the pain and quitted treatment in spite of Fair condition. conclusion : Meridian Tendino-musculature acupuncture and release therapy was found to be helpful to patients who wish to recover from their back pain induced by acute lumbar sprain as soon as possible, but the treatment actually had some problems to be overcome such as pain during or after the treatment. therefor, in order to make this treatment method more available, we should pay more attention to improving treatment appliance and acupuncture technique.

• 한국연소학회:학술대회논문집
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• 2007.05a
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• pp.47-53
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• 2007

The laminar combustion characteristics of interacting coal particles in a convective flow are numerically investigated at particle arrangement and size difference. The numerical simulations, which use the two-step global reaction model to account for the surrounding gas effect, show the detailed interaction among the inter-space particles, undergoing devolatilization and subsequent char burning. Several parametric studies, which include the effect of the gas temperature (1700 K), high pressure(10 atm) and variation in geometrical arrangement of the particle diameter on the volatile release rate and the char combustion rate, have been carried out. The comparison indicates that the shift to the multiple particle arrangement resulted in the substantial change of the combustion characteristics and that the volatile release rate of the interacting coal particles exhibits a strong dependency on the particle spacing and size difference.