• 제목/요약/키워드: Relative stability

검색결과 913건 처리시간 0.028초

효모균에서의 Plasmid 번식체계와 혼성유전자 발현 (Plasmid Propagation and Heterologous Gene Expression in Recombinant Yeast)

  • 홍억기
    • KSBB Journal
    • /
    • 제8권2호
    • /
    • pp.133-142
    • /
    • 1993
  • 효모균에서의 유전자 재조합에 의한 단백절 생산에 미치는 유전학적, 환경적인 요인의 영향을 연구하였. Plasmid 안정도와 개수는 $REP^+$ 체계 에서 대단히 높은 반면, rep 체계에서는 매우 낮았다. $2{\mu}m$ circle plasmid genome을 포함하는 plasmid의 경우에 있어서. $[cir^o]$ 형 세포에서의 plasmid 안정도와 개수가 $[cir^+]$형 세포에서보다 높기때문에 $[cir^+o]$형 세포가 더 선호되는 세포였다. 유전자 발현은 plasmid 개수와 안정도에 좌우 되었다. 촉진제의 양이 유전자 발현에 매우 중요 한 역할을 했다. 유전자 발현의 촉진에 필요한 g떠actose의 농도는 0.8% 이 변 충분했다. 높은 안정 도와 개수를 갖는 plasmid의 경우 촉진속도는 매우 빨랐다. Galactose가 배양의 시작부분부터 첨가 될 때가 mid-exponential ph잃e에 첨가될 때보다 유전자 발현의 극대점에 이르는 시간이 걸었다. 상대적 촉진제의 양이 증가함에 따라 glucc잉e억제 현상은 감소되었다.

  • PDF

소화성궤양시 병용약물이 수용액 중의 오메프라졸 안정성에 미치는 영향 (Effect of Other Medications on the Stability of Omeprazole in Aqueous Solution for the Peptic Ulcer Disease)

  • 이영재;황완균;조성완
    • 한국산학기술학회논문지
    • /
    • 제10권11호
    • /
    • pp.3494-3499
    • /
    • 2009
  • 소화성 궤양의 치료에 일반적으로 병용되어 사용되는 소염진통제인 록소프로펜 또는 알칼리화제인 탄산수소나트륨을 함유한 수용액 중에서 소화성 궤양의 치료에 사용되는 오메프라졸의 안정성에 대한 영향이 실온상태에서 실험하였다. 록소프로펜과 탄산수소나트륨 각각 60 mg을 오메프라졸(600 ${\mu}g$/ml) 용액에 혼합한 후 그 용액을 실온 상태로 80시간 보존하면서 그 분해정도를 원래의 오메프라졸의 농도와 비교하여 각각의 소실 농도를 산출하였다. 오메프라졸의 농도와 크로마토그램의 면적비는 5 - 160 ${\mu}g$/ml 농도에서 상호 직선성을 나타내었고 상대 표준 편차는 3.05 %이하로서 분석이 제대로 이루어졌음을 확인할 수 있었으며 함유 약물과 시간에 따른 오메프라졸의 분해 양상은 가상의 일차 직선 속도식을 나타내는 것을 알 수 있었다. 결론적으로 오메프라졸은 탄산수소나트륨 또는 록소프로 펜과의 병용 투여에 의해 그 안정성이 영향을 받을 수 있다는 것을 확인할 수 있었다.

흑연과 지르콘의 상대적인 함량에 따른 마찰특성에 관한 연구 (Influence of the Relative Amount of Graphite and Zirconium Silicate on Friction Characteristics)

  • 김성진;장호
    • 한국윤활학회:학술대회논문집
    • /
    • 한국윤활학회 2000년도 제31회 춘계학술대회
    • /
    • pp.166-172
    • /
    • 2000
  • Friction characteristics of phenolic resin-based friction composites containing threedifferent relative amounts of graphite and zirconium silicate were investigated by using a pad-on-disk type friction tester. Constant temperature test and constant interval test at three different initial temperatures(100. 200, 300$^{\circ}C$) were performed to examine the effects of friction heat on friction characteristics at elevated temperature. The friction composite(FMO.7) with higher content of ZrSiO$_4$showed unstable friction force at higher temperature and resulted in larger fluctuations of vibration during friction test. The abrasive action of ZrSiO$_4$in friction composite impeded stable transfer film and induced higher friction heat at friction interface. Friction oscillations according to the temperature were associated with the formation of transfer film(i'd body layer) on the friction composite and the counter part.

  • PDF

민감도 분석을 이용한 수중운동체의 계수식별 (Parameter identification for an underwater vehicle using a sensitivity analysis)

  • 박성택;박찬국;임경식;최중락
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
    • /
    • pp.1667-1670
    • /
    • 1997
  • We consider the probelem of identifying and underwater vehicle. It is assumed that a priori information about the parameteric model structure and values of the hydrodynamic coefficients is available from some other schemes. The concept of relative esnsitivity is introduced to plan and efficinet identification procedure. An analysis of the sensitivity of the overall system to a particular hydrodynamic coefficinet provides a tool to evaluate the relative importance of the same coefficient in a particular maneuver. Then it can be made possible to reduce the filter size by selecting some dominatn hydrodynamic coefficients as parameters to be estimated for a given maneuver, and this fact may be used for establishing a gradual identification scheme. The main merit of a gradual identification is substantially reduced computer burden with increased nimerical stability. An illustrative simualtion result is given.

  • PDF

높은 마디면적비 철근의 부착강도에 따른 정착설계 연구 (Study on the Development Design Criteria of High Relative Rib Area bars)

  • 박성규;홍건호;최완철;홍기섭
    • 한국콘크리트학회:학술대회논문집
    • /
    • 한국콘크리트학회 2006년도 춘계학술발표회 논문집(I)
    • /
    • pp.270-273
    • /
    • 2006
  • Bond between reinforcing bar and the surrounding concrete is made up of three components. There are chemical adesion, friction, and mechanical interaction between the rib of the bar and the surrounding concrete. bond of deformed bars depends primarily on the beraing of rib deformation anainst the surrounding concrete. The final objective of the study is to enhance structural stability, and workability thorough increasing the bond strength between deformed bar and surrounding concrete. The results of this study will be used to shorten bond and development length by $20{\sim}30$ percent and it will facilitate to use of high strength and high-relative rib area bars.

  • PDF

기능성블록을 이용한 잠제의 수리학적 특성 (The Hydraulic Characteristics of a Submerged Breakwater Covered with Multi-Function Blocks)

  • 손병규
    • 한국해양공학회지
    • /
    • 제21권6호
    • /
    • pp.47-52
    • /
    • 2007
  • This paper presents the design of a submerged breakwater, which functions as an eco-structure in a marine environment. Newly patented blocks were used in the submerged breakwater to both make it stable and provide an inhabitable space for fish. To investigate the wave transmission of the proposed submerged breakwater, parametric studies were conducted through two-dimensional hydraulic tests, which were carried out at the National Fisheries Research and Development Institute (NFRDI) in South Korea. Those parameters are relative crest width (B/L), wave steepness (H/L), relative crest depth (hB/H), and submerged breakwater configuration. The hydraulic experimental results can be used to predict the performance of the proposed submerged breakwater covered with the multi-function blocks.

수분활성도가 홍삼저장성에 미치는 영향 (The Effect of Water Activity on the Storage Stability of Red Ginseng)

  • 도재호;노해원
    • Journal of Ginseng Research
    • /
    • 제5권2호
    • /
    • pp.108-113
    • /
    • 1981
  • Major quality indices for deterioration of red ginseng including oxidation of lipids and change of brown color intensity were periodically investicated during storage of Red Ginseng under various water activity conditions at 3$0^{\circ}C$. The results obtained were summarized as follows. 1. The monolayer moisture contents were 3.25% and 6.3% for red ginseng and red ginseng powder, respectively, and the corresponding water activities were 0.14 and 0.16, respectively. 2. Oxidation of lipids as measured by TBA value increased with an increase in relative humidity and storage period 3. Under storage conditions above 42% R H., brown color intensity also increased in similar fashion to that of oxidation of lipids as relative humidity and storage Period increased 4. It was concluded from above results that water activity of Red Ginseng should be kept less than 0.57 so that red ginseng could Preserve stable qualify.

  • PDF

A Humidity Sensor Using an Electrochemically Prepared Poly(1,5-Diaminonaphthalene)Film

  • 박덕수;심윤보
    • 센서학회지
    • /
    • 제12권6호
    • /
    • pp.241-248
    • /
    • 2003
  • An electrochemical humidity sensor was fabricated with poly(1,5-diaminonaphthalene) film coated on a gap of two splitted gold electrodes, which were made by vacuum deposition. Response currents according to humidity were measured by the potential sweep method and chronoamperometry. The stability of the polymer film was improved by double step chronoamperometry using the applied voltage of ${\pm}0.5$ Vdc. The response time determined by the pulse technique was about ${\sim}50$ msec and the relative standard deviation of current response was within ${\pm}5.0%$. The response current of the film was intrinsically humidity dependent. The film exhibited a non-linear but reproducible response in ordinary range of relative humidity. The linear equations were $I(nA)=0.28{\times}%RH-1.01$ between 10 to 70 %RH and $I(nA)=6.05{\times}%RH-403.21$ between 70 to 90 %RH.

FOXBY EQUIVALENCE RELATIVE TO C-WEAK INJECTIVE AND C-WEAK FLAT MODULES

  • Gao, Zenghui;Zhao, Tiwei
    • 대한수학회지
    • /
    • 제54권5호
    • /
    • pp.1457-1482
    • /
    • 2017
  • Let S and R be rings and $_SC_R$ a (faithfully) semidualizing bimodule. We introduce and study C-weak flat and C-weak injective modules as a generalization of C-flat and C-injective modules ([21]) respectively, and use them to provide additional information concerning the important Foxby equivalence between the subclasses of the Auslander class ${\mathcal{A}}_C$ (R) and that of the Bass class ${\mathcal{B}}_C$ (S). Then we study the stability of Auslander and Bass classes, which enables us to give some alternative characterizations of the modules in ${\mathcal{A}}_C$ (R) and ${\mathcal{B}}_C$ (S). Finally we consider an open question which is closely relative to the main results ([11]), and discuss the relationship between the Bass class ${\mathcal{B}}_C$(S) and the class of Gorenstein injective modules.

Comparative Study of Two Congestion Management Methods for the Restructured Power Systems

  • Manikandan, B.V.;Raja, S. Charles;Venkatesh, P.;Mandala, Manasarani
    • Journal of Electrical Engineering and Technology
    • /
    • 제6권3호
    • /
    • pp.302-310
    • /
    • 2011
  • Congestion management is one of the most challenging tasks of a system operator to ensure the operation of transmission system within operating limits. In this paper, cluster/zone method and relative electrical distance (RED) method for congestion management are compared based on the considered parameters. In the cluster/zone method, rescheduling of generation is based on user impact on congestion through the use of transmission congestion distribution factors. In the RED method, the desired proportions of generations for the desired overload relieving are obtained. Even after generation rescheduling, if congestion exists, load curtailment option is also introduced. Rescheduling cost, system cost, losses, and voltage stability parameter are also calculated and compared for the above two methods of congestion management. The results are illustrated on sample 6-bus, IEEE 30-bus, and Indian utility 69-bus systems.