• Journal of Microbiology and Biotechnology
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• 제27권5호
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• pp.896-908
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• 2017

In this study, a total of 58 different kinds of nuruk (a traditional Korean fermentation starter) were prepared, including 46 kinds of restored nuruk from ancient documents. Each nuruk was evaluated by analysis of its saccharification power, and the enzyme activities of glucoamylase, ${\alpha}$-amylase, ${\beta}$-amylase, protease, and ${\beta}$-glucanase. The range of saccharification power (sp) of the restored nuruk ranged between 85 and 565 sp. The diastatic enzymes, ${\alpha}$-amylase, ${\beta}$-amylase, and glucoamylase, were significantly correlated to the saccharification power value; conversely, ${\beta}$-glucanase and protease did not have a correlative relationship with saccarification power. In addition, their brewing properties on chemical and organoleptic aspects of traditional alcoholic beverage production were compared. Each raw and supplementary material contained in nuruk showed its own unique characteristics on Korean alcoholic beverage brewing. For the first time, in this study, the traditional Korean nuruk types mentioned in ancient documents were restored using modernized production methods, and also characterized based on their brewing properties. Our results could be utilized as a basis for further study of traditional alcoholic beverages and their valuable microorganisms.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권6호
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• pp.519-525
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• 2001

The oral cavity has frequent contacts with many carcinogenic compounds and its soft tissue is continuously stimulated by numerous dental factors. We have examined the detailed dental factors and its correlation with oral squamous cell carcinoma, and denture-wearing effects to analyze the effect of the dental factors on the genesis of oral squamous cell carcinoma. We have studied clinical contributing factors and the dental factors in the genesis of oral squamous cell carcinoma when the effects of smoking and drinking are controlled. The study cases are 100 patients(75 males and 25 females) who were diagnosed histo-pathologically as squamous cell carcinoma at the Yonsei Medical Center. The control group was 154 patients who have no systemic malignant tumors. The effects of 6 dental factors were analyzed in this study. They were divided into the smoking group, the non smoking group, the drinking group, and the non-smoking group. The effects of dental factors were analyzed in each group. In this study, we have drawn some conclusions on the relationship between the dental factors and oral squamous cell carcinoma using $x^2$-test. 1. The repaired teeth have statistical significance on the genesis of squamous cell carcinoma. This is probably due to the combining effects of past poor oral hygiene and continuous stimulation due to poor prosthesis. 2. There is statistical significance of the lost teeth in the smoking group, and the repaired teeth and the degree of alveolar bone resorption had statistical significance in the non-smoking group. 3. Smoking and drinking by-itself have no statistical significance in the genesis of oral squamous cell carcinoma. However, in combination, they have statistical significance. In this study, dental factors had a synergistic effect with smoking and drinking. Together with avoidance of smoking and drinking, appropriate restoration and oral hygiene control are most important factors in the preventive aspects of the oral squamous cell carcinoma.

• Journal of Forest and Environmental Science
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• 제34권2호
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• pp.101-107
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• 2018

We identified the main impacts, drivers, and restoration projects for Atlantic Forest in Northwest of the Rio Grande do Sul State, Brazil. The objective was to analyze the quantity, distribution, and causes of the environmental crimes in 2000-2014. To verify differences between degraded and restored areas, we performed a t-test; ANOVA for the municipalities with more quantity of crimes, simple linear regression analysis for the relationship between sizes of degraded areas and quantity of seedlings planted, and Principal Component Analysis (PCA) for environmental damages categories and population of the municipalities. The main environmental damages found were deforestation outside permanent preservation area (20%) and those related to Permanent Preservation Area (37%). Environmental crimes in these areas fall into two categories: native and exotic vegetation removal (17%), and impediment to natural regeneration (20%). The average size of the degraded areas was $5,359{\pm}526m^2$, while for restored areas was $3,337{\pm}255m^2$. The sizes of the degraded fragments were similar among the five municipalities with the higher number of environmental crimes (ANOVA: p>0.05, F=1.24; df=241). The number of seedlings planted was positively related to the sizes of the degraded fragments (p<0.001, $R^2=0.53$). Segregation between the less and the most populous municipalities was found with the PCA analysis along PC1 (51.7%), while PC2 represented 19.2% of the total variation. The most populous municipalities showed the highest number of environmental crimes, and the majority of degraded areas were recovered by planting native seedlings. Atlantic Forest fragments need to be recognized and preserved as an ecosystem with a unique ecological function by the population and public administration.

• International Journal of Oral Biology
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• 제45권2호
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• pp.42-50
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• 2020

Lysophosphatidic acid (LPA) is a lipid messenger mediated by G protein-coupled receptors (LPAR1-6). It is involved in the pathogenesis of certain chronic inflammatory and autoimmune diseases. In addition, it controls the self-renewal and differentiation of stem cells. Recent research has demonstrated the close relationship between periodontitis and various diseases in the human body. However, the precise role of LPA in the development of periodontitis has not been studied. We identified that LPAR1 was highly expressed in human periodontal ligament stem cells (PDLSCs). In periodontitis-mimicking conditions with Porphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS) treatment, PDLSCs exhibited a considerable reduction in the cellular viability and osteogenic differentiation potential, in addition to an increase in the inflammatory responses including tumor necrosis factor-α and interleukin-1β expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Of the various LPAR antagonists, pre-treatment with AM095, an LPAR1 inhibitor, showed a positive effect on the restoration of cellular viability and osteogenic differentiation, accompanied by a decrease in NF-κB signaling, and action against Pg-LPS. These findings suggest that the modulation of LPAR1 activity will assist in checking the progression of periodontitis and in its treatment.

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.185-194
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• 1995

The purpose of this study was to estimate primary diagnosis, prediction of prognosis and recognition fo treatment progress for treatment of TMD patients through measuring the various ranges of mandibular movement in normal and TMDs patients using Mandibular Kinesiograph K-6 Diagnostic system. In normal groups, 20 adults were selected, who have normal or class I molar relationship, and have no symptoms on TMJ and masticatory muscles, and have restorations less than 3 surfaces on each tooth, and have no other prosthetic restoration. In Patients group, we selected 31 outpatients who were confirmed to TMDs with clinical examination and radiographic findings. The obtained results were as follows : 1. In maximal opening, patient group was showed the limitation of vertical movement range (P<0.01) and lager lateral deviation than in normal group (P<0.05). And actual dimensional displacement of opening was calculated larger in normal group (P<0.05). 2. In protrusive movement, patients group was showed the limitation of anteroposterior movement range (P<0.001) and larger deviation than in normal group (P<0.01). And actual 3 dimensional displacement of protrusion was calculated larger in normal group (P<0.001). 3. In lateral maximum excursion, compared with normal group patient group was no significant differences to affected side, but was showed the limitation of lateral movement to unaffected side (P<0.001). 4. There was no significant difference in movement velocity of opening and closing in both groups. 5. Mandibular movement from physiologic rest position to centric occlusion was moved more anteroposteriorly in patient group. 6. Mandibular movement from centric relation to centric occlusion was no significant difference in both groups.

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.195-204
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• 1995

The purpose of this study was to evaluate effect of head posture change on initial occlusal contacts through measuring the distances between initial occlusal contacts and maximum intercuspal position at different head posture. Two special devices were designed and constructed. Mandibular movement replicator was used to assess reliability of the K6 diagnostic system(MKG; Myo-tronic Inc, Seatle, USA) and head posture calibrator was used to maintain the constant head posture during experiment. We measured difference of distance between initial occlusal contact and maximum intercuspal position with MKG in upright, supine, 45 degrees extension, 30 degrees flexion, 30 degrees right and left bending postion of the head. The Frankfurt horizontal plane was used as a reference plane. 21 adults aged from 23 to 25 were selected, who have normal or class I molar relationship, and have no symptoms on TMJ and masticatory muscles, and have restorations less than 3 surfaces on each tooth, and have no other prosthetic restoration. The obtained results were as follows : The mean absolute distances between initial occlusal contact and maximum intercuspal postion were 0.39(0.18mm in the upright position, 0.65(0.37mm in the supine position, 0.59(0.33mm in the 45 degree extension, 0.70(0.53mm in the 30 degrees flexion, 1.12(1.10mm in the 30 degrees right bending and 1.94(0.67mm in the 30 degrees left bending of the head. The positions of the initial occlusal contacts have a tendency to locate anterior, left and inferior to maximal intercuspal position in upright position, posterior and inferior in supine position and 45 degrees extension, anterior and inferior in 30 degrees flexion, right and inferior in 30 degrees right bending, and left and inferior in 30 degrees left bending of the head. There were significant differences among the initial occlusal contacts in each head postures(P<0.0001). Therefore, we need to check initial occlusal contacts in the altered head posture during occlusal analysis and adjustment of occlusal appliance and dental occlusion for diagnosis and treatment of temporomandibular disorder.

• 대한치과보철학회지
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• 제58권2호
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• pp.145-152
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• 2020

심미와 기능이 조화를 이루는 총의치 제작을 위해서는 상하악 관계를 정확히 기록하는 것이 필수적이다. 고딕아치 묘기법은 하악의 운동을 시각적으로 보여주며, 정확하고 반복재현성 있는 중심위를 확립하는데 유용하다. 또한, 고도의 치조제 흡수를 갖는 환자에서는 총의치의 적절한 유지 및 안정을 얻기가 어려운데, 이런 경우 환자의 생리적인 동작으로 변연을 형성하여 의치상연 주위가 가동점막으로 봉쇄되도록 하는 폐구 인상법이 유용할 수 있다. 본 증례에서는 우측 하악과두골절 병력과 고도의 하악 치조제 흡수를 보이는 환자에서 폐구인상법과 고딕아치 묘기법을 이용한 총의치로 수복하였고 만족할 만한 결과를 얻어 보고하는 바이다.

• 건축역사연구
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• 제14권1호
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• pp.41-55
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• 2005

Most of researches in Korea by far on Sekino Tadashi were mainly focused on his historical view only. The main observations of this study, instead, are that; (1) his methodology of studying architectural history was closely related to his previous experiences with the conservation of the architectural heritages in Japan, and (2) his earlier activities in Korea made a significant Influence on the conservation of the architectural heritages in Korea. Sekino started his carrier after the graduation from the university by participating in the restoration sites of the architectural heritages in Japan, and his experiences at that time had founded the basis of his methodology of studying architectural history. Later, his on-site experiences were also adapted into the conservation of the architectural heritages in Korea when Korea was about to be colonized by Japan. In other words, Sekino's study on the Korean traditional architectures started from 1902 had a meaning of not only the starting point of the study on the Korean architectural history but also the starting point of the conservation of the Korean architectural heritages. Especially, Sekino's study during 1909 1912 prioritized the conservation of the architectural heritages as the main purpose of the study, and the influences of the study spanned over the entire colonial period by Japan. The influences were that; (1) Sekino's studies in 1909 1912 had outlined the colonial government's policy of the conservation of the architectural heritages, and (2) many restorations were made based on those studies.

• Journal of Ecology and Environment
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• 제38권2호
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• pp.133-143
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• 2015

Freshwater macrophytes improve the structural heterogeneity of microhabitats in water, often providing an important habitat for zooplankton. Some studies have focused on the overall influence of macrophytes on zooplankton, but the effects of macrophyte in relation to different habitat characteristics of zooplankton (e.g., epiphytic and pelagic) have not been intensively studied. We hypothesized that different habitat structures (i.e., macrophyte habitat) would strongly affect zooplankton distribution. We investigated zooplankton density and diversity, macrophyte characteristics (dry weight and species number), and environmental parameters in 40 shallow wetlands in South Korea. Patterns in the data were analyzed using a self-organizing map (SOM), which extracts information through competitive and adaptive properties. A total of 20 variables (11 environmental parameters and 9 zooplankton groups) were patterned onto the SOM. Based on a U-matrix, 3 clusters were identified from the model. Zooplankton assemblages were positively related to macrophyte characteristics (i.e., dry weight and species number). In particular, epiphytic species (i.e., epiphytic rotifers and cladocerans) exhibited a clear relationship with macrophyte characteristics, while large biomass and greater numbers of macrophyte species supported high zooplankton assemblages. Consequently, habitat heterogeneity in the macrophyte bed was recognized as an important factor to determine zooplankton distribution, particularly in epiphytic species. The results indicate that macrophytes are critical for heterogeneity in lentic freshwater ecosystems, and the inclusion of diverse plant species in wetland construction or restoration schemes is expected to generate ecologically healthy food webs.

• 한국실내디자인학회논문집
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• 제24권2호
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• pp.88-99
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• 2015

As architecture is designed for humans to live in based on practicality, what one experiences within such spaces is important. Such experiences are not felt only by appreciating the structure's appearance, but involve physical presence inside the space and the deepening of the individuals relationship with the space through the body's sensory perception. However, in modern times there is a much greater tendency to rely on superficial experiences by way of images or tastes rather than more meaningful human participation, while the standardization of the object universe is gradually erasing the uniqueness of experience. In light of this, the restoration of emotional and sensory spatial experiences through the design of sensory spaces can be regarded as an important task in modern spatial design. This study contemplated the meaning of emotional spatial experiences through a phenomenological understanding of such experiences, and analyzed the meaning and main factors in the creation of spatial atmosphere as a phenomenon of spatial experience. In addition, we highlighted the fact that spatial atmosphere can be applied as space design methodology by devising methods of expression through an analysis of actual examples. O.F. Bollnow's space theory and the spatial design of Peter Zumthor were the subjects of this analysis. The spatial atmosphere analyzed using Bullnow's theory is a phenomenon in which both the human and space are connected and the ensuing spatial experience embodies the emotions of both. This spatial atmosphere can be understood as a condition in which the human and space are fused together. Furthermore, coincidental/accidental meeting, mediums using potential objects, reorganization of the center due to autonomous boundaries, as well as the three temporalities were identified as the main factors in the creation of spatial atmosphere. Based on this analysis, through the identification of methods of expression for spatial atmosphere in Zumthor's spaces.