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Prognostic Value of Dynamic Contrast-Enhanced MRI-Derived Pharmacokinetic Variables in Glioblastoma Patients: Analysis of Contrast-Enhancing Lesions and Non-Enhancing T2 High-Signal Intensity Lesions

  • Yeonah Kang;Eun Kyoung Hong;Jung Hyo Rhim;Roh-Eul Yoo;Koung Mi Kang;Tae Jin Yun;Ji-Hoon Kim;Chul-Ho Sohn;Sun-Won Park;Seung Hong Choi
    • Korean Journal of Radiology
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    • v.21 no.6
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    • pp.707-716
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    • 2020
  • Objective: To evaluate pharmacokinetic variables from contrast-enhancing lesions (CELs) and non-enhancing T2 high signal intensity lesions (NE-T2HSILs) on dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging for predicting progression-free survival (PFS) in glioblastoma (GBM) patients. Materials and Methods: Sixty-four GBM patients who had undergone preoperative DCE MR imaging and received standard treatment were retrospectively included. We analyzed the pharmacokinetic variables of the volume transfer constant (Ktrans) and volume fraction of extravascular extracellular space within the CEL and NE-T2HSIL of the entire tumor. Univariate and multivariate Cox regression analyses were performed using preoperative clinical characteristics, pharmacokinetic variables of DCE MR imaging, and postoperative molecular biomarkers to predict PFS. Results: The increased mean Ktrans of the CEL, increased 95th percentile Ktrans of the CELs, and absence of methylated O6-methylguanine-DNA methyltransferase promoter were relevant adverse variables for PFS in the univariate analysis (p = 0.041, p = 0.032, and p = 0.083, respectively). The Kaplan-Meier survival curves demonstrated that PFS was significantly shorter in patients with a mean Ktrans of the CEL > 0.068 and 95th percentile Ktrans of the CEL > 0.223 (log-rank p = 0.038 and p = 0.041, respectively). However, only mean Ktrans of the CEL was significantly associated with PFS (p = 0.024; hazard ratio, 553.08; 95% confidence interval, 2.27-134756.74) in the multivariate Cox proportional hazard analysis. None of the pharmacokinetic variables from NE-T2HSILs were significantly related to PFS. Conclusion: Among the pharmacokinetic variables extracted from CELs and NE-T2HSILs on preoperative DCE MR imaging, the mean Ktrans of CELs exhibits potential as a useful imaging predictor of PFS in GBM patients.

Prostatic Artery Embolization for Lower Urinary Tract Symptoms via Transradial Versus Transfemoral Artery Access: Single-Center Technical Outcomes

  • Ryun Gil;Dong Jae Shim;Doyoung Kim;Dong Hwan Lee;Jung Jun Kim;Jung Whee Lee
    • Korean Journal of Radiology
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    • v.23 no.5
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    • pp.548-554
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    • 2022
  • Objective: To evaluate the safety and feasibility of prostatic artery embolization (PAE) via transradial access (TRA) compared with transfemoral access (TFA). Materials and Methods: This retrospective study included 53 consecutive men with lower urinary tract symptoms (LUTS) who underwent PAE between September 2018 and September 2021. Thirty-one patients (mean age ± standard deviation: 70.6 ± 8.4 years) were treated with TFA, including 14 patients treated before adopting TRA. Since December 2019, TRA has also been attempted with the procedure's selection criteria of patent carpal circulation and a height ≤ 172 cm, with 22 patients treated via TRA (69.1 ± 9.6 years). Parameters of technical success (defined as successful bilateral embolization), clinical success (defined as LUTS improvement), procedural time, radiation dose, and adverse events were compared between the two groups using the Fisher's exact test, independent sample t test, Wilcoxon signed-rank test, or Mann-Whitney test. Results: All patients received at least one-side PAE. Technical success of PAE was achieved in most patients (TRA, 21/22; TFA, 30/31; p > 0.999). No technical problem-related conversion from TRA to TFA occurred. The clinical success rate was 85% (11/13) in patients with TRA, and 89% (16/18) in patients with TFA for follow-up > 2 weeks post-PAE (median, 3 months) (p > 0.999). The median procedure time was similar in both groups (TRA, 81 minutes vs. TFA, 94 minutes; p = 0.570). No significant dose differences were found between the TRA and TFA groups in the dose-area product (median Gycm2, 95 [range, 44-255] for TRA and 84 [34-255] for TFA; p = 0.678) or cumulative air kerma (median mGy, 609 [236-1584] for TRA and 634 [217-1594] for TFA; p = 0.551). No major adverse events occurred in either of the groups. Conclusion: PAE via TRA is a safe and feasible method comparable to conventional TFA. It can be safely implemented by selecting patients with patent carpal circulation and adequate height.

Efficacy and Safety of the Safe Triangular Working Zone Approach in Percutaneous Vertebroplasty for Spinal Metastasis

  • Bi Cong Yan;Yan Feng Fan;Qing Hua Tian;Tao Wang;Zhi Long Huang;Hong Mei Song;Ying Li;Lei Jiao;Chun Gen Wu
    • Korean Journal of Radiology
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    • v.23 no.9
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    • pp.901-910
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    • 2022
  • Objective: This study aimed to assess the technical feasibility, efficacy, and safety of the safe triangular working zone (STWZ) approach applied in percutaneous vertebroplasty (PV) for spinal metastases involving the posterior part of the vertebral body. Materials and Methods: We prospectively enrolled 87 patients who underwent PV for spinal metastasis involving the posterior part of the vertebral body, with or without the STWZ approach, from January 2019 to April 2022. Forty-nine patients (27 females and 22 males; mean age ± standard deviation [SD], 57.2 ± 11.6 years; age range, 31-76 years) were included in group A (with STWZ approach), accounting for 54 vertebrae. Thirty-eight patients (18 females and 20 males; 59.1 ± 10.9 years; 29-81 years) were included in group B (without STWZ approach), accounting for 57 vertebrae. Patient demographics, procedure-related variables, and pain relief as assessed using the visual analog scale (VAS) were collected at different time points. Tumor recurrence in the vertebrae after PV was analyzed using Kaplan-Meier curves. Results: The STWZ approach was successful from T1 to L5 without severe complications. Cement filling was satisfactory in 47/54 (87.0%) and 25/57 (43.9%) vertebrae in groups A and B, respectively (p < 0.001). Cement leakage was not significantly different between groups A and B (p = 1.000). Mean VAS score ± SD before and 1 week and 1, 3, 6, 9, and 12 months after PV were 7.6 ± 1.8, 4.2 ± 2.0, 2.7 ± 1.9, 1.9 ± 1.5, 1.7 ± 1.4, 1.7 ± 1.1, and 1.6 ± 1.3, respectively, in group A and 7.2 ± 1.7, 4.0 ± 1.3, 3.4 ± 1.6, 2.4 ± 1.2, 1.8 ± 1.0, 1.4 ± 0.5, and 1.7 ± 0.9, respectively, in group B. Kaplan-Meier analysis showed a lower tumor recurrence rate in group A than in group B (p = 0.001). Conclusion: The STWZ approach may represent a new, safe, alternative/auxiliary approach to target the posterior part of the vertebral body in the PV for spinal metastases.

A Study on Revitalizing the ISNI-KOREA Consortium and Mid- to Long-term Development Plan (ISNI-KOREA 컨소시엄 활성화 및 중장기 발전 방안 연구)

  • Juseop Kim;Bong-Suk Kang;Suntae Kim
    • Journal of Korean Library and Information Science Society
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    • v.55 no.1
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    • pp.239-261
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    • 2024
  • ISNI is a relay identifier that can integrate universal archival data and has the advantage of being flexibly applied to various fields compared to ORCID, which is limited to academic researchers, but in Korea, it is overwhelmingly issued to researchers and educators, and its purpose is gradually fading. In particular, overseas, ISNI issuance is active with the active participation of the publishing industry, but in Korea, there is no issuance through the publishing industry. This study was designed to expand the issuance of ISNIs to various fields including the Korean publishing industry. In order to achieve the research objectives, in-depth interviews were conducted with representatives of the existing ISNI-KOREA consortium organizations and potential consortium expansion organizations such as the publishing industry. As a result of the interviews, four policy implications were drawn as a way to revitalize ISNI: reorganizing its own system, strengthening governance, promotion and education, and system linkage. To address these policy implications, we proposed a mid- to long-term development plan centered on four policy goals and 12 key tasks. This study is expected to help the National Library of Korea, which operates the ISNI-KOREA consortium, develop policies related to ISNI activation.

The Effects of college students' sense of community on their psychological well-being: The mediating effect of emotional intelligence (대학생의 공동체 의식이 심리적 안녕감에 미치는 영향: 정서지능의 매개효과)

  • Jeong Yeong Mi;Kim Tae Ryang
    • The Journal of the Convergence on Culture Technology
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    • v.10 no.3
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    • pp.313-319
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    • 2024
  • The purpose of this study was to examine the mediating effect of emotional intelligence on college students' sense of community and psychological well-being. Accordingly, a survey was conducted targeting 267 college students attending universities in the Busan and Gyeongnam regions. For data analysis, the SPSS 21 program was used to check the general characteristics of the survey subjects, the mean, standard deviation, skewness, and kurtosis of the main variables. Correlation analysis was performed to check multicollinearity among the main variables, and mediation effects were examined. For this purpose, regression analysis was conducted according to the three-step verification method proposed by Barron and Kenny.The results of this study were as follows. First, college students' sense of community was found to have a significant impact on their psychological well-being. Second, the sense of community perceived by college students was found to have a significant impact on emotional intelligence. Third, emotional intelligence was found to have a significant impact on psychological well-being. Lastly, emotional intelligence was confirmed to have a partial mediating effect in the relationship between college students' sense of community and psychological well-being. Lastly, emotional intelligence was confirmed to have a partial mediating effect in the relationship between college students' sense of community and psychological well-being. Accordingly, we strive to find and implement various ways to increase the sense of community that is closely related to the emotional intelligence skills and social participation of college students in the special situation of college, so that college students can form and sustain a happier and more satisfying life. We will have to help you do it.

The Characteristics of 'Scientific Participation and Action' Lessons designed by Preservice Teachers: Focusing on the Analysis of Lesson Plans about N oise Issue (초등 예비교사들이 설계한 '과학적 참여와 실천' 수업의 특징 - 소음 문제에 대한 교수학습 과정안 분석을 중심으로 -)

  • Chang, Jina;Na, Jiyeon
    • Journal of Korean Elementary Science Education
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    • v.43 no.1
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    • pp.136-147
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    • 2024
  • It has recently be emphasized in science education that lessons that can develop "scientific participation and action" should be implemented to scientifically recognize various problems and respond to them as well as risks that occur in real life. This study aims to analyze the characteristics of scientific participation and action lessons as perceived by the preservice primary school teachers. To do that, the researchers collected and analyzed the lesson plans designed by the preservice teachers based on the achievement standard related to noise for grades 3-4 in 2022 revised science curriculum. Focusing on the stages of "problem recognition," "data collection and analysis," and "implementation and sharing," the results identity the four main characteristics as problem-solving activity, inquiry activity, investigative activity, and activity that encourages practical actions. The two or three features were found to be combinated in a lesson depending on its context. In some cases, only one feature was seen in a lesson. Based on the results, educational implications were discussed in terms of the teaching and learning methods and teacher education for implementing scientific participation and action.

A Study on Seawater Quality Criteria and Assessment of Thermal Discharge from Nuclear Power Plant (원자력발전 온배수 영향에 대한 해수질 환경조사 지침 연구)

  • Park, Yong-Chul;Kim, Sung-Jun;Kim, Eun-Soo;Lee, Hee-Jun;Lee, Hyo-Jin;Kim, Dong-Hwa
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.12 no.1
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    • pp.50-56
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    • 2007
  • Impact of thermal discharge of nuclear power plant on marine environment is naturally reflected in biogeochemical changes of seawater. Until now, many investigation activities and reports of impact analysis of marine environment were occasionally inadequate to provide sufficient justification in resolving controversial conflict of interests related with thermal discharge of nuclear power plant. From the scrutinized examination of recent 17 reports published in Korea between 2002 and 2004, the most apparent issue was inadequacy of sampling design and absence of significance of many measured parameters. In many cases, lack of statistical interpretation of raw data incurred subjective or ambiguous assessment results, which failed in deducing mutual concurrence between the parties of interest. In overall all, the main reasons for impairing integrity of previous reports seem to be inconsistency of environmental investigation procedures between research institutions, inadequate sampling design at the discretion of institutions and lack of objectivity of impact assessment based on statistical interpretation. Therefore, the primary goal of this study is to (1) discuss the blown issues on previous routine practice of seawater quality assessment procedures, and to (2) provide improved investigation procedures and rational standard criteria strictly based on statistical analysis for the better seawater quality assessment, which could be supported by scientific community, public agency, investigation institution and the other parties of interest.

The Effect of Community- and Individual-Level Factors on Suicidal Ideation and Attempts: A Multilevel Analysis (2021년 지역사회건강조사를 활용한 지역사회 및 개인 수준의 요인이 자살 생각과 자살 시도에 미치는 영향: 다수준 분석)

  • So Young Ha;Jinhwan Kim;Haegyun Park;Youngsoo Kim
    • Korean Journal of Psychosomatic Medicine
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    • v.32 no.1
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    • pp.24-33
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    • 2024
  • Objectives : The purpose of this study was to investigate individual- and community-level factors on suicidal ideation and suicide attempt among Korean adults. Methods : This study was conducted on 225,965 adults collected through data from the 2021 Community Health Survey and the Korean Statistical Information Service (KOSIS). The general characteristics, suicidal behavior (e.g., suicidal ideation, and suicide attempts), and community-level characteristics of the study subjects were analyzed using frequency (%) and mean (standard deviation). The effects on individual- and community-level factors on suicidal ideation and suicide attempts was analyzed using multilevel logistic regression models. Results : The community-level factor associated with suicidal ideation was unmet health care (Odds Ratio [OR]=1.053, 95% CI=1.035-1.071), and the community-level factor associated with suicide attempt was the aging rate (OR=1.015, 95% CI=1.001-1.030). Regarding health-related variables, the individual-level factors associated with suicidal ideation were stress status (OR=9.388, 95% CI=8.629-10.213), depressive experience in the past year (OR=6.737, 95% CI=6.454-7.032), and the predominantly individual-level factors associated with suicide attempt were also stress status (OR=5.213, 95% CI=3.699-7.347), and depressive experience in the last one year (OR=13.433, 95% CI: 11.247-16.044). Conclusions : We confirmed individual-level and community-level factors influencing suicidal ideation and suicide attempt. Through these findings, we need to establish suicide prevention policies, considering managing individual-level factors such as stress and depression as well as community-level factors such as unmet health care.

A Study on the Actual Conditions of and Satisfaction with the Existed Female Dress Forms Usage (국내 여성용 인대 사용 실태 및 만족도에 관한 연구)

  • Park Gin-Ah;Lee Hye-Young;Choi Jin-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.30 no.3 s.151
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    • pp.378-385
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    • 2006
  • To release fashion trends in an efficient way, many of the apparel business and fashion educational institutes in land adopt fashion shows employing fashion models. Modeling rather than flat pattern making realizes the majority of the complicated design works for the fashion shows. However, for the different measurements between the dress form and the real human model, problems often occur during the modeling and fitting processes. Researches on the standard dress form development representing professional fashion models' features are therefore in urgent need to enable the related apparel business and fashion institutes to make appropriate use of the dress form in their jobs. The study has been conducted as a preliminary study using a questionnaire method ultimately to develop the female dress form. A questionnaire in the research aimed at an investigation into the actual conditions of and satisfaction with the usage and the body measurements of existed dress forms. Approximately 30 fashion-related educational institutes and 10 apparel companies responded to the survey. Data derived from the survey was analyzed using SPSS version 10.1, the statistics tool. The results throughout the research were discussed in terms of largely three categories that are; (1) the general conditions of the usage of the dress form to prepare fashion shows: e.g. the frequency of holding the fashion show in an annual term, the proportion of professional and amateur models employed for the fashion show, the methods to construct garments, types and number of dress forms utilized and etc.; (2) factors considered to purchase the dress form e.g. its functionality, shapes, sizes, duration, price, A/S condition and etc.; and(3) satisfaction with the similarity between the dress form and the human body in the relation to the body measurements. Measurements in length wise, front and back waist lengths, neck to bust point on the dress forms were apparently differed from the ones of the actual body. In particular, differed torso length measurements cause the problem to have to alter the whole silhouette, consequently, the resultant patterns as well. In girth measurements, in order of bust and waist girths, the satisfaction was low.

The Problems, Confidence and Satisfaction of Teachers on Implementation of "Technology and Home Economics" Subject in the 7th Curriculum (제7차 "기술.가정" 교과 운영에 대한 교사의 애로점, 교수 활동 자신감 및 만족도 -대구광역시 중.고교 "기술.가정" 담당 교사를 중심으로-)

  • Jang Hyun-Sook;Choi Ji-Hye
    • Journal of Korean Home Economics Education Association
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    • v.18 no.1 s.39
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    • pp.17-29
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    • 2006
  • The purpose of this research was to examine the problems, confidence and satisfaction of teachers on the subject ${\ulcorner}technology and home economics{\lrcorner}$ in the 7th national curriculm. For this research, questionnaires were sent by post to teachers who teach technology and home economics in middle schools and high schools. The collected questionnaires were technically analyzed by SPSS/WIN 10.0 program, which measured frequency, percentage, average, standard deviation. According to the types of data, they were also analyzed by t-test and cross tabulation analyses. The results of this research were summarized as follows. 1) There were two teaching types of technology and home economics: the partial charge and the whole charge teaching according to teachers' majors, and both types occurred in similar percentage. The partial charge teaching means that teachers majoring in technology teach only the technology part and teachers majoring in home economics teach only the home economics part when they teach the same subject, technology and home economics. These days the partial charge teaching more often occurs in national or public schools than in private schools, and in coeducational schools than in girls' or boys' schools. 2) The major problems of teaching technology and home economics were caused in order by teachers' lack of skills and knowledge which we not their own major, the lack of students' interests and teaching materials, and burden of tests. 3) Teachers' confidence in teaching the contents of the subject, technology and home economics, made a significant difference according to their majors. Teachers whose major was technology felt more confident when they taught the chapters of the textbooks related to their major, technology, while teachers whose major was home economics felt more confident when they taught the chapters of the textbooks related to their major, home economics. According to implementation types, the partial charge teaching gave higher confidence to the teachers than the whole charge one in teaching almost all the chapters of the textbook. 4) According to implementation types, teachers' satisfaction was showed to be higher in the partial charge teaching than in the whole charge one.

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