• 환경영향평가
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• 제4권1호
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• pp.47-57
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• 1995

This study analyzes the problems of environmental laws, development planning laws, Metropolitan Area Development Planning(MADP), and the level of environmental pollution at Pusan and Asan-Bay Metropolitan Area where MADP will be realized in the near future. In order to prevent the environmental pollution by realization of MADP, Environmental Impact Assessment Act and environmental impact assessment systems in Korea should be revised so as to reflect the followings. First, the impact of national landuse planning change on the environment should be considered at the beginning of environmental impact assessment procedures. Second, the overlapping and greater impact of many projects, whose part is the subject of environmental impact assessment, upon surrounding metropolitan area should be simultaneously evaluated and the environmental pollution protection and abatement alternatives must be made according to the above impact of the projects. Thirdly, total effluent regulation of water pollution, air pollution and solid wastes should be enforced based on the self-purification of the metropolitan area environment.

• 환경영향평가
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• 제4권3호
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• pp.63-71
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• 1995

This study analyzes the problems of environmental laws, development planning laws, Metropolitan Area Development Planning (MADP), and the level of environmental pollution at Asan-bay metropolitan area, where MADP will be realized in the near future. In order to prevent environmental pollution by the implementation of MADP, the Environmental Impact Assessment (EIA) Act and EIA systems in Korea should be revised so as to reflect the followings. First, the impact of national landuse planning changes on the environment should be considered at the beginning of the EIA procedures. Second, the overlapping and greater impact of many projects upon surrounding metropolitan areas should be simultaneously evaluated, though each project is the subject of EIA, and the environmental pollution protection and abatement alternatives must be made in accordance with the above impact of the projects. Thirdly, total effluent regulation of water pollution, air pollution and solid wastes should be enforced based on the self-purification of the metropolitan area environment.

• 농촌지도와개발
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• 제11권1호
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• pp.139-159
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• 2004

Since 1990s, the countrysides in Seoul Metropolitan Area have been exposed to the unprecedented forces like developing telecommunication technology, the boom of exurban housing, increasing concern about food quality. While these new forces are restructuring the social and spatial pattern of countryside, a legal regulation can be assumed as exerting an overarching moulding power. This paper shows how the legal regulation works in the restructuring rurality.

• 해양환경안전학회지
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• 제3권1호
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• pp.111-123
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• 1997

The application of all regulations during building phase, plus constant vigilance in operation is essential to reducing the risk of fire aboard. A Safety by design approach is increasingly important. Fire safety regulation can solve problems which are hard to be solved by HSC code(International Code of Safety for High Speed Craft). Recently HSC code is applied for ship design development or guidance to the designer and demonstrates many advantages. In this pages, ship fire Safety are realistically modeled as ship design and the shipboard fires & muster stations are analyzed using HSC Code.

• BMB Reports
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• 제34권2호
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• pp.95-101
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• 2001

Tissue transglutaminase (TGII, $G{\alpha}h$) belongs to a family of enzymes which catalyze post-translational modification of proteins by forming isopeptides via $Ca^{2+}$-dependent reaction. Although TGII-mediated formation of isopeptides has been implicated to play a role in a variety of cellular processes, the physiological function of TGII remains unclear. In addition to this Tease activity, TGII is a guanosine triphosphatase (GTPase) which binds and hydrolyzes GTP It is now well recognized that the GTPase action of TGII regulates a receptor-mediated transmembrane signaling, functioning as a signal transducer of the receptor. This TGII function signifies that TGII is a new class of GTP-binding regulatory protein (G-protein) that differs from "Classical" heterotrimeric G-proteins. Regulation of enzyme is an important biological process for maintaining cell integrity. This review summarizes the recent development in regulation of TGII that may help for the better understanding of this unique enzyme. Since activation and inactivation of GTPase of TGII are similar to the heterotrimeric G-proteins, the regulation of heterotrimeric G-protein in the transmembrane signaling is also discussed.

• Molecules and Cells
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• 제37권7호
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• pp.511-517
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• 2014

MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may finetune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

• Nuclear Engineering and Technology
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• 제37권3호
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• pp.221-230
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• 2005

This paper reviews the pivotal phases of the evolution of the current technology-dependent nuclear power safety regulation in the United States. Understanding of this evolution is essential to the development of any future regulatory paradigm, including the technology-neutral regulatory approach that the U.S. Nuclear Regulatory Commission (NRC) has recently embarked on to develop. The paper proposes and examines the implications of a predominately rationalist and best-estimate probabilistic regulatory framework called safety goals-driven performance-based regulation. This framework relies on continuous assessment of performance of a set of time-dependent safety-critical systems, structures and components that assure attainment of a broad set of technology-neutral protective, mitigative, and preventive goals. Finally, the paper discusses the steps needed to develop a corresponding technology-neutral regulatory system from the proposed framework.

• Molecules and Cells
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• 제42권11호
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• pp.747-754
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• 2019

The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has been unclear. Among $CD4^+$ T cells, Th17 and follicular helper T (Tfh) cells are known to play pathogenic roles in the development of hyperlipidemia-associated autoimmune diseases. This review gives an overview of the cellular and molecular mechanisms by which dysregulated lipid metabolism impacts the pathogenesis of autoimmune diseases, with specific emphasis on Th17 and Tfh cells.

• BMB Reports
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• 제54권2호
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• pp.89-97
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• 2021

Post-transcriptional regulation is an indispensable cellular mechanism of gene expression control that dictates various cellular functions and cell fate decisions. Recently, various chemical RNA modifications, termed the "epitranscriptome," have been proposed to play crucial roles in the regulation of post-transcriptional gene expression. To date, more than 170 RNA modifications have been identified in almost all types of RNA. As with DNA modification-mediated control of gene expression, regulation of gene expression via RNA modification is also accomplished by three groups of proteins: writers, readers, and erasers. Several emerging studies have revealed that dysregulation in RNA modification is closely associated with tumorigenesis. Notably, the molecular outcomes of specific RNA modifications often have opposite cellular consequences. In this review, we highlight the current progress in the elucidation of the mechanisms of cancer development due to chemical modifications of various RNA species.

• 한국멀티미디어학회논문지
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• 제25권9호
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• pp.1338-1347
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• 2022

In recent years, the number of Chinese college students in unhealthy or sub-healthy state in terms of mental health accounts for about 30% and has been going up. As we know, college students are in the middle of youth, an important stage of physical and psychological development. In this case, how to regulate mental health will become an important research direction. Based on emotion regulation theory, this thesis discussed the impact that 'healing animation' had on college students' psychological capital, and how emotion regulation had done its work in the process. According to documents research and empirical study, 'healing animation' is positively affecting the psychological capital of college students through the medium -- emotion regulation. Finally, this thesis provided a practical layout to accumulate college students' psychological capital, and theoretical reference for 'healing animation' as well.