• Title/Summary/Keyword: Regioselective synthesis

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Total Synthesis of Sufentanil

  • Shin, Dong-Yun;Ryu, Jae-Sang;Hyun, Soon-Sil;Park, Hyun-Ju;Jeon, Ra-Ok;Suh, Young-Ger
    • Archives of Pharmacal Research
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    • v.22 no.4
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    • pp.398-400
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    • 1999

  • Sufentanil, a potent anilidopiperidine analgesic, was synthesized from a simple thiophenylethylamine via six sequence. The key parts of this synthesis involved an efficient construction of thiophenylethylpiperidone by aminomethano desilylation-cyclization followed by Swern oxidation and a direct regioselective N-nucleophilic spiral epoxide cleavage with aniline promoted by Lewis acids.

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Stereoselective Transformation of Phytosphingosine to Safingol

  • Kim, Na-Ri;Lee, Sun-Hee;Namgoong, Sung-Keon
    • Bulletin of the Korean Chemical Society
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    • v.30 no.3
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    • pp.695-699
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    • 2009

  • A short and efficient synthesis of (2S,3S)-safingol from commercially available D-ribo-(2S,3S,4R)-phytosphingosine is described. The highlights of the synthesis are a stereoselective one-pot transformation of a diol into an epoxide under phase transfer catalytic conditions and a regioselective epoxide-opening reduction with a hydride reagent.

  • https://doi.org/10.5012/bkcs.2009.30.3.695 인용 PDF KSCI

Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives (새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성)

  • 박재호;박경란;호현순;김희두;표명윤
    • YAKHAK HOEJI
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    • v.43 no.5
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    • pp.559-565
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    • 1999

  • The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

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