• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7719-7724
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• 2014

Background: Lymph node metastasis is believed to be a dependent negative prognostic factor of esophageal cancer. To explore detection methods with high sensitivity and accuracy for metastases to regional and distant lymph nodes in the clinic is of great significance. This study focused on clinical application of FDG PET/CT and contrast-enhanced multiple-slice helical computed tomography (MSCT) in lymph node staging of esophageal cancer. Materials and Methods: One hundred and fifteen cases were examined with enhanced 64-slice-MSCT scan, and FDG PET/CT imaging was conducted for neck, chest and upper abdomen within one week. The primary lesion, location and numbers of metastatic lymph nodes were observed. Surgery was performed within one week after FDG PET/CT detection. All resected lesions were confirmed histopathologically as the gold standard. Comparative analysis of the sensitivity, specificity, and accuracy based on FDG PET/CT and MSCT was conducted. Results: There were 946 lymph node groups resected during surgery from 115 patients, and 221 were confirmed to have metastasis pathologically. The sensitivity, specificity, accuracy of FDG PET/CT in detecting lymph node metastasis were 74.7%, 97.2% and 92.0%, while with MSCT they were 64.7%, 96.4%, and 89.0%, respectively. A significance difference was observed in sensitivity (p=0.030), but not the others (p>0.05). The accuracy of FDG PET/CT in detecting regional lymph node with or without metastasis were 91.9%, as compared to 89.4% for MSCT, while FDG PET/CT and MSCT values for detecting distant lymph node with or without metastasis were 94.4% and 94.7%. No significant difference was observed for either regional or distant lymph node metastasis. Additionally, for detecting para-esophageal lymph nodes metastasis, the sensitivity of FDG PET/CT was 72%, compared with 54.7% for MSCT (p=0.029). Conclusions: FDG PET/CT is more sensitive than MSCT in detecting lymph node metastasis, especially for para-esophageal lymph nodes in esophageal cancer cases, although no significant difference was observed between FDG PET/CT and MSCT in detecting both regional and distant lymph node metastasis. However, enhanced MSCT was found to be of great value in distinguishing false negative metastatic lymph nodes from FDG PET/CT. The combination of FDG PET/CT with MSCT should improve the accuracy in lymph node metastasis staging of esophageal cancer.

• Transactions on Electrical and Electronic Materials
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• 제18권5호
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• pp.279-286
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• 2017

In this paper, an optimal approach for the wide-area regulation of control devices in a transmission network is proposed. In order to realize an improved voltage profile and reduced power loss, existing devices such as tap-changing transformers, synchronous machines, and capacitor banks should be controlled in a coordinated and on-line manner. It is well-understood that phasor measurement units in transmission substations allow the system operators to access the on-line loading and operation status of the network. Accordingly, this study proposes efficient software applications that can be employed in area operation centers. Thus, the implanted control devices can be regulated in an on-line and wide-area coordinated approach. In this process, efficient objective functions are devised for both voltage profile improvement and power loss reduction. Subsequently, sensitivity analysis is carried out to determine the best weighting factors for these objectives. Extensive numerical studies are conducted on an IEEE 14-bus test system and a real-world system named the Azarbayjan Regional Transmission Network. The obtained results are discussed in detail to highlight the promising improvements.

• International Journal of Aeronautical and Space Sciences
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• 제16권1호
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• pp.89-101
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• 2015

To satisfy civil aviation requirements using the Global Navigation Satellite System (GNSS), it is important to guarantee system integrity. In this work, we propose a fault detection algorithm for GNSS ephemeris anomalies. The basic principle concerns baseline length estimation with GNSS measurements (pseudorange, broadcasted ephemerides). The estimated baseline length is subtracted from the true baseline length, computed using the exact surveyed ground antenna positions. If this subtracted value differs by more than a given threshold, this indicates that an ephemeris anomaly has been detected. This algorithm is suitable for detecting Type A ephemeris failure, and more advantageous for use with multiple stations with various long baseline vectors. The principles of the algorithm, sensitivity analysis, minimum detectable error (MDE), and protection level derivation are described and we verify the sensitivity analysis and algorithm availability based on real GPS data in Korea. Consequently, this algorithm is appropriate for GNSS regional implementation.

• 한국식품과학회지
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• 제43권1호
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• pp.1-5
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• 2011

본 연구에서 개발된 시험법은 고감도를 가지고 선택성이 뛰어난 LC/MS/MS를 이용함으로서 한번의 시료 전처리와 동시 분석을 통하여 아미노글리코사이드계 항생제 5종의 잔류량 분석을 가능케 하였다(15,16). 개발된 시험법은 CODEX의 가이드라인에 따라 검량선의 직선성, 회수율, 정성한계 및 정량한계, 정확성 및 정밀성 등을 고찰하여 시험법의 실효성을 검증하였다. 확립된 시험법을 이용하여 돼지고기, 닭고기, 쇠고기 등 총 250건을 분석한 결과 5건이 검출되었으며 검출율은 2%로서 검출된 양은 모두 각각의 잔류허용기준보다 낮은 수준이었으나 한 시료에서 겐타마이신과 디하이드로스트렙토마이신이 동시 검출되었다. 이 결과는 여러 종류의 항생제들을 동시에 처방하고 있다는 사실을 입증하고 있다. 그러나, 기기분석을 이용하여 아미노글리코사이드계 항생제의 잔류량 실태조사 결과 검출율 및 검출량이 낮은 안전한 수준이었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권4호
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• pp.1972-1986
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• 2017

With the advent of the knowledge economy, science and technology resources have played an important role in economic competition, and their optimal allocation has been regarded as very important across the world. Thus, allocation optimization research for regional science and technology resources is significant for accelerating the reform of regional science and technology systems. Regional science and technology resource allocation optimization is modeled as a double-layer optimization model: the entire system is characterized by top-layer optimization, whereas the subsystems are characterized by bottom-layer optimization. To efficaciously solve this optimization problem, we propose a mixed search method based on the orthogonal genetic algorithm and sensitivity analysis. This novel method adopts the integrated modeling concept with a combination of the knowledge model and heuristic search model, on the basis of the heuristic search model, and simultaneously highlights the effect of the knowledge model. To compare the performance of different methods, five methods and two channels were used to address an application example. Both the optimized results and simulation time of the proposed method outperformed those of the other methods. The application of the proposed method to solve the problem of entire system optimization is feasible, correct, and effective.

• 한국식품과학회지
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• 제38권6호
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• pp.773-778
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• 2006

The objective of this study was to evaluate three verocytotoxin-producing Escherichia coli (VTEC) detection kits to detect the presence of VT genes: Doupath Verocytotoxin (GLISA) developed by MERCK, ProsPect Shiga Toxin E. coil (STEC) Microplate Assay (ELISA) developed by Remel, and a polymerase chain reaction method. Our laboratory verified artificially inoculated samples. All three methods could detect very low numbers of VTEC, but VT-PCR had the best sensitivity for VTEC detection. From April through September 2005, 257 ground-beefs from supermakets and traditional markets were examined for the presence of VTEC by polymerase chain reaction immediately after purchase and total viable counts (TVC) were determined. VTEC was isolated from 30 of 257 ground-beefs. A variety of serogroups was found, including 10 stains belonging to the virulence type EHEC, but major serogroups such as O157, O26 and O111 were nor found.

• 대한토목학회논문집
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• 제42권1호
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• pp.11-21
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• 2022

가뭄은 장기간에 걸쳐 광범위하게 발생하며, 사회·경제적으로도 큰 피해를 발생시킨다. 가뭄 위험도는 기상학적 및 수문학적 요소와 더불어 사회적, 환경적, 물리적 및 경제적 요소로 이루어져 있기 때문에, 가뭄 위험도에 대한 영향을 정량적으로 파악하는 것이 중요하다. 본 연구에서는 충청북도를 대상으로 구조방정식모형을 이용하여 가뭄 노출성, 취약성, 대응능력 및 위험도 사이의 영향 관계를 파악하고, 베이지안 네트워크를 적용하여 가뭄 위험도에 대한 영향을 평가하였다. 또한, 가뭄 위험도 평가 인자별 민감도 분석을 통해 가뭄 위험도의 변화 정도를 분석하였다. 그 결과 과거 가뭄 위험도가 가장 큰 지역은 충주시로, 노출성 및 대응능력을 변화시켰을 때에도 가장 크게 산정되었다. 다만, 취약성을 변화시켰을 때에는 음성군이 위험도가 가장 큰 것으로 나타났다. 위험도에 대한 영향인자들의 민감도 분석을 실시한 결과 증평군이 민감도가 가장 컸으며, 노출성, 취약성 및 대응능력에서 제천시, 음성군, 옥천군이 민감도가 크게 나타났다. 이러한 결과를 통해 가뭄 위험도 및 가뭄 위험도에 대한 영향인자를 확인하였으며, 영향인자별 지역의 특성을 고려한 가뭄 대책 마련이 가능하다.

• 한국산업정보학회논문지
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• 제27권6호
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• pp.77-93
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• 2022

본 연구에서 대설의 직접, 간접적인 피해에 영향받는 요소들에 대해 지역적 특성을 반영해 위험도를 분석하는 알고리즘을 제시한다. 229개의 지역별로 대설피해의 영향을 받는 요소들을 영향변수로 선정하고 피해액과의 관계를 통해 민감도라는 개념을 도출한다. 기상 상태(적설량, 습도, 기온)와 민감도를 독립 변수로 설정하고 독립 변수의 변화에 따라 도출된 위험도를 종속변수로 설정해 머신러닝(XGBoost) 알고리즘을 이용한 대설피해 위험도 예측 모델을 개발했다.

• 한국지구과학회지
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• 제45권4호
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• pp.349-362
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• 2024

We aimed to evaluate the effectiveness of ensemble optimal interpolation (EnOI) in improving the analysis of significant wave height (SWH) within wave models using satellite-derived SWH data. Satellite observations revealed higher SWH in mid-latitude regions (30° to 60° in both hemispheres) due to stronger winds, whereas equatorial and coastal areas exhibited lower wave heights, attributed to calmer winds and land interactions. Root mean square error (RMSE) analysis of the control experiment without data assimilation revealed significant discrepancies in high-latitude areas, underscoring the need for enhanced analysis techniques. Data assimilation experiments demonstrated substantial RMSE reductions, particularly in high-latitude regions, underscoring the effectiveness of the technique in enhancing the quality of analysis fields. Sensitivity experiments with varying ensemble sizes showed modest global improvements in analysis fields with larger ensembles. Sensitivity experiments based on different decorrelation length scales demonstrated significant RMSE improvements at larger scales, particularly in the Southern Ocean and Northwest Pacific. However, some areas exhibited slight RMSE increases, suggesting the need for region-specific tuning of assimilation parameters. Reducing the observation error covariance improved analysis quality in certain regions, including the equator, but generally degraded it in others. Rescaling background error covariance (BEC) resulted in overall improvements in analysis fields, though sensitivity to regional variability persisted. These findings underscore the importance of data assimilation, parameter tuning, and BEC rescaling in enhancing the quality and reliability of wave analysis fields, emphasizing the necessity of region-specific adjustments to optimize assimilation performance. These insights are valuable for understanding ocean dynamics, improving navigation, and supporting coastal management practices.

• 한국항만경제학회지
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• 제22권1호
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• pp.87-103
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• 2006

The aim of this paper is to establish the evaluation system of improving urban logistics using the QFD(Quality function Deployment) model which can facilitate to grasp the improving degree of realizing the system conforming to the relationship of all process and the process improvement. At the first stage, the established system through the QFD method will be used to evaluate and diagnosis the level of urban logistics in Cheonbuk District. The second stage is to investigate the important components that can make prompt improvement of urban logistics. Then, the sensitivity analysis is to be performed and the degree of improving urban logistics will be presented according to the rising degree of the relevant components.