• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4759-4763
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• 2014

Radiation therapy in ovarian cancers has been considered an outdated concept for many years, mainly due to its toxicity and failure to show benefit in terms of survival. Chemotherapy has been extensively used after surgery for these cancers and it has almost replaced radiation therapy as an adjuvant treatment. Nevertheless, failures in ovarian cancers continue to occur even with the use of newer and effective chemotherapy regimens. About 70% patients demonstrate recurrence in the abdomen or pelvis after first line chemotherapy in ovarian cancers. With advances in technology and sophistication of radiation techniques, along with the molecular and biological knowledge of distinct histological subtypes, there is a need to redefine the role of radiation therapy. This review article focuses on the literature on use of radiation in ovarian cancers and its rationale and indications in the present day. For this, a literature pub med/medline search was performed from January 1975 to March 2014 to redefine the role of radiotherapy in ovarian cancers.

• Radiation Oncology Journal
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• 제19권4호
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• pp.312-318
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• 2001

목적 : 고위험 유방암 환자의 수술 후 방사선치료 후 국소 재발율, 생존율 및 예후인자를 후향적 분석하여 방사선치료의 역할을 규명하고자 하였다. 대상 및 방법 : 1984년부터 1995년까지 유방암으로 변형 근치적 유방절제술 후 종양의 크기가 4 cm 이상이거나, 4 cm 미만이나 액와 림프절의 전이가 있는 환자 중 방사선치료를 완료한 48명을 대상으로 하였다. 중앙 연령은 47세 ($31\~79$세)이었으며, 종양의 크기가 2 cm미만 1명, $2\~5\;cm$ 15명, 5 cm이상이 32명이었다. 액와림프절에 전이된 환자는 32명이었다. 흉벽과 국소림프절에 방사선치료받은 환자는 42명, 흉벽만 받은 환자는 6명이었으며 방사선량은 1일 1회(1.8 Gy)로 총 선량은 50.4 Gy이었다. 48명 중 18명$(38\%)$은 5-FU를 기본으로 하는 항암화학요법을 방사선치료 전 혹은 후에 투여하였다. 중앙 추적기간은 61개월이었다. 결과 : 국소 재발율은 $8\%$, 원격전이율은 $14\%$이었다. 전체환자의 5년 생존율은 $63\%$, 무병생존율은 $62\%$이었으며 중앙생존기간은 67개월이었다. 병기에 따른 5년 생존율은 IIB는 $70\%$, IIIA는 $58\%$이었으며, 생존율에 미치는 예후인자는 병기이었다(p=0.0076). 결론 : 고 위험군의 유방암 환자의 수술 후 방사선치료는 국소재발율은 감소시키고 생존율을 향상시킬 수 있으며, 생존율에 영향을 주는 인자는 병기이었다.

• 물과 미래
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• 제14권4호
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• pp.53-72
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• 1981

본 연구는 우리나라의 강수빈도 및 강우강도의 시간적. 공간적 분포분석에 관한 것으로 전국을 5개의 권역으로 나누어 분석을 실시하였다. 강수빈도 해석은 39개 지점을 대상지점으로, 강우강도 해석은 36개 지점을 대상지점으로 하여 강수빈도 분포도의 작성과 강수빈도 분포의 시간적, 공간적인 해석 고찰, 각 지점 및 권역별 확률 강우량과 강우 강도식 및 각 강우기간별 회귀직선식을 유도, 제시하였다. 본 연구의 결과는 다음과 같다. (1) 각 권역내의 최다발생빈도 강수량 계급은 여름철을 제외한 모든 기간이 공히 1) 1~5mm, 2) 0.1~1.0mm, 3) 5~10mm 순이었다. (2) 강수량 계급에 따른 최다발생빈도 권역은 연간 20mm 이하의 강수빈도는 II 권역, 30~40mm의 강수빈도는 IV권역, 70mm 이상의 강수빈도는 I권역이었다. (3) 우리나라 전역에 있어서 강수량의 생기확률은 지수함수의 식으로 대표할 수 있음을 알았다.($W(x)=e^{\alpha+\beta}$) (4) 전국의 5개 권역 중 I권역은 자시간 지속, III권역은 단전간 지속 집중 호우지역으로 판단되었다. (5) 강우형태는 10분~40분, 40분~4시간, 4시간~24시간으로 크게 나눌 수 있었으며, 이들 구간에 대해 지점별 확률 강우 강도식을 유도하였다. (6) 각 권역별로 25시간과 10분~18시간 지속시간과의 강우량 상관식을 유도, 도시하였다. (7) 36개 지점에 대한 확률 강우량을 제시하였다.

• Radiation Oncology Journal
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• 제32권3호
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• pp.132-137
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• 2014

Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

• Journal of Chest Surgery
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• 제26권9호
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• pp.686-695
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• 1993

A total of eighty one patients with resected stage II and IIIA non-small cell lung cancer treated with postoperative adjuvant radiation therapy between Jan. 1971 and Dec. 1990 were retrospectively analysed to evaluate whether postoperative radiation therapy improves survival. Patterns of failure and prognostic factors were also analysed. The 5 year overall and disease free survival rate were 40.5%, 43.4% and median survival 30 months. The 5 year actuarial survival rates by stage II and IIIA were 53.9% and 36.2%. Loco-regional failure rate was 14.7% and distant metastasis rate was 33.3% and both 4%. Statistically significant prognostic factor affecting survival was presence of mediastinal lymph node metastasis[N2]. This retrospective study suggests that postoperative radiation therapy in resected stage II and IIIA non-small cell lung cancer can reduce loco-regional recurrence and may improve survival rate as compared with other studies which were treated by surgery alone.

• 대한두개안면성형외과학회지
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• 제11권1호
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• pp.58-61
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• 2010

Purpose: Sebaceous carcinoma is a rare malignant tumor that occurs mostly in head and neck regions. Early diagnosis and treatment are necessary because it tends to be locally aggressive and goes through distal metastasis with fast progression. This study presents reliable surgical methods for sebaceous carcinoma in head and neck regions. Methods: Three patients were included in this study. First, a 61-year-old woman visited the hospital with a yellow-colored, slowly growing mass on the left ala. A 54-year-old woman had a brown-colored mass on her right preauricle. Last case was a 62-year-old man who had a yellow-colored mass on his scalp. CT scan and punch biopsy were done. All cases were diagnosed as sebaceous carcinoma. The lesions were resected with 10 mm safety margin and various regional flaps were used for reconstruction. Results: Histological examination revealed sebaceous differentiation and local invasions. Postoperatively, all patients did not suffer from complication and no recurrence was found. Conclusion: We recommend early wide excision with an enough safety margin, and a regional flap as a treatment of sebaceous carcinoma.

• Advances in pediatric surgery
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• 제3권1호
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• pp.1-5
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• 1997

Regional lymphadenitis is the most common complication following BCG vaccination in this country. The literature describes controversial results with medical, surgical and combined therpy. The purpose of this study is to clarify the therapeutic effect of isoniazid(INH) after surgical procedures. The early and late postoperative complications of 136 children with lymphadenitis following BCG vaccination at the Taegu Fatima Hospital between March 1985 and February 1996 were reviewed. In 90 children, INH was given for 3-4 days before operation and for 3 months after surgery. In the other 46 cases, INH was not given during the pre- or postoperative period. Surgical procedures were excision or incision and currettage according to the states of lesions. Postoperative complications were fluid accumulation, wound infection, sinus formation and others. Complication rates were 14.4 % in INH-treated group and 13.0% of INH-nontreated group. The difference was not significant. There was no recurrence or other late complication in either groups. The result suggest that surgical excision or incision and currettage are sufficient for the treatment of regional lymphadenitis following BCG vaccination and postoperative INH therapy is not necessary.

• 생물환경조절학회지
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• 제3권2호
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• pp.128-135
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• 1994

지역별로 분포하고 있는 특성화된 온실의 장점을 살리고 구조적인 위험요소를 줄임으로서, 지역특성온실로 정착할 수 있도록 하기 위하여 지역별로 특성화된 온실의 구조실태를 조사하고 구조적 안전성을 검토하였으며 그 결과를 요약하면 다음과 같다. 1. 전남지방에 특성화된 온실의 보급이 많았으며, 광폭형하우스와 대형 단동 파이프하우스가 이 지역의 특성화된 온실로서 뚜렷한 경향을 나타내었다. 2. 경남 김해의 목재하우스, 전남 구례의 트러스형하우스, 강원 평창의 돔형 파이프하우스, 충북 옥천의 포도재배하우스 등이 특징적인 온실로 나타나고 있었다. 3. 광폭형하우스, 트러스형하우스, 돔형 파이프하우스 및 포도재배하우스는 15-30년 빈도의 풍하중과 설하중에 대하여 안전한 것으로 나타났으나, 대형 단동 파이프하우스는 약간의 보강이 필요하며, 목재하우스는 매우 불안정하여 사용을 중지하는 것이 좋을 것으로 판단되었다. 4. 대상온실의 기초는 모두 30년 빈도의 강풍에 대하여 충분한 인발저항력을 가지는 것으로 나타나 안전한 것으로 판단되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4853-4858
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• 2015

Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of $2^{nd}$ line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

• 대한토목학회논문집
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• 제13권3호
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• pp.139-154
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• 1993

본 연구는 자연하천 유역에서의 수위관측점들을 대상으로 지점 홍수빈도해석을 실시하고 하천홍수량의 지역빈도해석에 의한 지역화 회귀모형을 개발한 것이다. 홍수빈도해석은 국내 주요 5대 하천유역인 한강, 금강, 영산강, 섬진강 및 낙동강 유역내에 있는 자연하천관측점들을 대상으로 홍수빈도모형을 이용하여 지점별 홍수량의 크기 및 빈도를 추정하였으며, 이를 바탕으로 홍수빈도예측을 위한 모형의 적용성과 효용성을 비교, 검토하였다. 그 결과 단기간 기록년수의 자료에서는 부분기간치계열 방법의 POT(Peaks Over a Threshold)모형이 연최대치계열 방법의 ANNMAX(ANNual MAXimum) 모형보다 효과적이고 합리적임이 판명되었다. 지역 홍수빈도해석에서 홍수빈도모형에 의한 지점별 홍수추정량과 홍수유출에 영향을 미치는 지형학적 유역 특성인자들간의 상관분석법에 의해 미계측 지점에서의 설계홍수량 추정이 용이한 지역화 회귀모형을 개발하고, 첨두홍수량과 유역 특성인자들간의 상관도를 재현기간별로 작성 제시하였다.