• Journal of Ginseng Research
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• v.45 no.2
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• pp.228-235
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• 2021

Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro and in vivo. This work used an ionic cross-linking method to entrap GK within O-carboxymethyl chitosan (OCMC) nanoparticles (Nps) to form GK-loaded OCMC Nps (GK-OCMC Nps), which enhance the aqueous solubility and stability of GK. Methods: The GK-OCMC Nps were characterized using several physicochemical techniques, including x-ray diffraction, transmission electron microscopy, zeta potential analysis, and particle size analysis via dynamic light scattering. GK was released from GK-OCMC Nps and was conducted using the dialysis bag diffusion method. The effects of GK and GK-OCMC Nps on PC3 cell viability were measured by using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Fluorescent technology based on Cy5.5-labeled probes was used to explore the cellular uptake of GK-OCMC Nps. Results: The GK-OCMC NPs had a suitable particle size and zeta potential; they were spherical with good dispersion. In vitro drug release from GK-OCMC NPs was pH dependent. Moreover, the in vitro cytotoxicity study and cellular uptake assays indicated that the GK-OCMC Nps significantly enhanced the cytotoxicity and cellular uptake of GK toward the PC3 cells. GK-OCMC Nps also significantly promoted the activities of both caspase-3 and caspase-9. Conclusion: GK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK.

• Journal of the Economic Geographical Society of Korea
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• v.18 no.1
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• pp.115-135
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• 2015

In the glocalization a common phenomenon of several nations reveals knowledge innovation and growth by the important subject of region and state and is studied at theory and practice. the successful cases of regional development in an advanced country have leading innovation through regional innovation system and cluster. therefore we are necessary to analyse how the knowledge spillovers in innovative cluster as the reduced model of regional innovation system guide firm innovation and region growth. this article reviews theories and empirical studies of the knowledge spillovers in the regional innovation system and innovative cluster of innovative geography and proposes a new research issues for further explorations of the knowledge spillovers. Previous studies assist that knowledge spillovers exist in knowledge-based industries of specific local area and local innovation accomplishes through pure knowledge spillover. but limits of these studies include narrow region and technological area, few analytical variable and exclusion of rent knowledge spillover. therefore new research topics related with that exemplifies geographical dimension(concentration and decentralization), technological dimension(knowledge based industry), category of analytic variables(previous indicators, time, and social capital), conceptualization(appropriation means, markets for technology) etc.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.102-111
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• 2016

This study aims to identify the characteristics of the regional innovation system(RIS) and the determinants of innovation performance of SMEs. Data were collected from a questionnaire survey on 64 SMEs in the Daejeon and Chungcheong regions to uncover the relationship between capabilities, regional innovation capacities and innovation performance. The moderating effects of regional innovation capacities on the relationship between firms' innovation capabilities and performance were also tested. Empirical results revealed that R&D, marketing and entrepreneurial orientation had positive effects. The moderating effect of regional innovation capabilities on the relationship between entrepreneurial orientation (risk taking) and performance was also confirmed.

• Journal of Technology Innovation
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• v.12 no.1
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• pp.135-160
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• 2004

We witness now the changing techno-economic paradigm and the emerging learning economy. Reflecting on these changes, the group of Evolutionary Economists study recently the theory on regional innovation system, but their research results are still now not theoretically ‘systemized’. Moreover, they often indeed speak of the ‘social capital’, but do not investigate that. This paper tries to systemize their empirical findings and theoretical results and integrate the discussions on social capital in fields of sociology into a mathematical model. This study emphasizes the role of social capital in the innovating process.

• Journal of the Korean association of regional geographers
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• v.11 no.5
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• pp.391-404
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• 2005

This paper attempts to show the status and network characteristic of regional innovation support agencies(company support agencies and R&D institutes, RISA) which play an important role in the regional system of innovation in Daegu City, using questionnaire data. Most of these agencies were established in 1990s and tend to locate in Buk-Gu and Dalsu-Gu, being major local universities which retain a large number of R&D and industry support agencies. The business areas of the agencies are largely associated with business training and applied research. Their major role is to provide the information that local firms need to acquire. It shows that they have relationships with 1 to 5 agencies, primarily in the form of informal network, for the purpose of sharing information and knowledge about science/technology and market trend. There are not many spin-offs from RISA. But most of spin-offs from RISA are located in Daegu City and maintain cooperative relationships with their parent organization primarily in the form of formal network. The main purpose of cooperative relationships with RISA is to interchange knowledges about technology.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.35-46
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• 2017

This study analyzed the role of innovation intermediaries on the performance of technology-based firms in Korea. Technology-based firms are important to the economy because they contribute to regional economic development and national competitiveness. In Korea, various types of intermediaries, such as Techno-parks and incubators have been established to foster technology-based firms. Researchers analyzed various factors influencing the performance of technology-based firms. On the other hand, there have been few studies on the relationship between the innovation intermediaries and the performance of technology-based firms in Korea. This study identified the firms' capabilities, institutional and environmental factors in the light of the literature. A total of 2,313 technology-based firms in Techno-parks, business incubator of public institutes and universities were surveyed. Of these, 110 respondents were used for empirical analysis. OLS techniques were applied to analyze the data. The empirical results showed that the marketing competence, R&D capacity, which is a firms' innovation capacity, have a positive effect on the performance. The support of intermediaries positively affects the performance of technology-based firms. The economic aspects of regional innovation infrastructure, and cooperation with the customer has a positive effect on the performance of technology-based firms.

• Journal of the Economic Geographical Society of Korea
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• v.14 no.1
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• pp.1-18
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• 2011

This paper explores changing concept of city in the context of globalization with innovation city and examines the characteristics of innovation city along with regional and national competitiveness. It is agreed that construction of innovation city by relocation of public institutions for balanced development of the country has valid logic. However, there are weak possibilities of innovation within the innovation city. Further more it is not a proper solution for the level up of national and regional competitiveness through this policy. The main logic is that physical relocation of institutions do not guarantee innovation of region through integration into globalization network resulting from the scale difference between nation and globe. Rather this paper suggests that regional innovation policy should performed in accordance with regional conditions and for the better competitiveness of nation and region, decentralization of power is needed. Then a region could have connection with global pipeline based on endogenous development power.

• Journal of the Economic Geographical Society of Korea
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• v.24 no.3
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• pp.259-282
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• 2021

This study analyzes actor networks in regional innovation processes with a focus on actors' activities and finds the determinants of the networks, thereby aiming to provide information useful for regional innovation policy makers. To this end, the study conducted a social network analysis of the national R&D projects data and identified the activities of innovation actors. Finding out the network determinants was QAP analysis. The study suggests three main findings as follows. First, a meaningful difference exists in characteristics of innovation activity by region. Second, the network of innovation actors meaningfully differs from region to region. The centrality of the network was found to be high in universities and businesses in Seoul and Gyeonggi, and in public research institutes in Daejeon. There are regions where all the networks of innovative actors are composed of one component, while some regions are not yet established with the network. Finally, although the networks of innovation actors are influenced by the geographical proximity and the size of the R&D fund, it is notable that the previous continuous relationship forms a strong research network.

• Journal of the Korea Society of Computer and Information
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• v.26 no.2
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• pp.157-167
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• 2021

This research strives to find the effective Local Currency Model that considered regional characteristics of Innovation city. Currently, the issuance of the domestic local currency has been increased due to COVID-19 Pandemic, yet most regions operate it in the same way without consideration of the characteristics and environment for each region, which leads to a lack of motivation for local communities to continue to participate. The regional characteristics of innovative cities were analyzed in order of policy characteristics of innovation cities, population growth issues, settlement and consumption environment. The new local currency model was proposed for innovation cities based on a private blockchain system with the participation of public institutions to solve and supplement regional issues.

• Journal of Science and Technology Studies
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• v.15 no.2
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• pp.135-162
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• 2015

The purpose of this article is to reinterpret the existing innovation policy with 'the societal innovation policy' framework. It is looking into characteristics of societal innovation policy and the prospects for socio-technical systems transition and citizen participation are discussed. After the discussion, new interpretation of innovation policy elements will be dealt with lenses of societal innovation policy. It sheds new light on the key elements of innovation policy, such as Innovation policy governance, industrial innovation policy, regional innovation policy, and infrastructure policy and suggests direction of policy improvements from societal innovation policy perspectives. This will be an opportunity to reinterpret the existing innovation policy measures and to approach to science technology innovation policy for system transition with participatory perspective.