• Journal of Trauma and Injury
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• 제37권1호
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• pp.28-36
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• 2024

Purpose: Recent advancements in interventional radiology have made angioembolization an invaluable modality in trauma care. Angioembolization is typically performed by interventional radiologists. In this study, we aimed to investigate the safety and efficacy of emergency angioembolization performed by trauma surgeons. Methods: We identified trauma patients who underwent emergency angiography due to significant trauma-related hemorrhage between January 2020 and June 2023 at Jeju Regional Trauma Center. Until May 2022, two dedicated interventional radiologists performed emergency angiography at our center. However, since June 2022, a trauma surgeon with a background and experience in vascular surgery has performed emergency angiography for trauma-related bleeding. The indications for trauma surgeon-performed angiography included significant hemorrhage from liver injury, pelvic injury, splenic injury, or kidney injury. We assessed the angiography results according to the operator of the initial angiographic procedure. The term "failure of the first angioembolization" was defined as rebleeding from any cause, encompassing patients who underwent either re-embolization due to rebleeding or surgery due to rebleeding. Results: No significant differences were found between the interventional radiologists and the trauma surgeon in terms of re-embolization due to rebleeding, surgery due to rebleeding, or the overall failure rate of the first angioembolization. Mortality and morbidity rates were also similar between the two groups. In a multivariable logistic regression analysis evaluating failure after the first angioembolization, pelvic embolization emerged as the sole significant risk factor (adjusted odds ratio, 3.29; 95% confidence interval, 1.05-10.33; P=0.041). Trauma surgeon-performed angioembolization was not deemed a significant risk factor in the multivariable logistic regression model. Conclusions: Trauma surgeons, when equipped with the necessary endovascular skills and experience, can safely perform angioembolization. To further improve quality control, an enhanced training curriculum for trauma surgeons is warranted.

• 한국미생물·생명공학회지
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• 제42권2호
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• pp.170-176
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• 2014

본 연구에서는 Euptelea pleiosperma 에탄올 추출물(EPEE)의 항산화능과 항염증 생리활성을 in vitro assay system 및 cell culture model system을 이용하여 분석하였다. 먼저 EPEE의 항산화능을 DPPH radical scavenging activity로 분석한 결과 radical 소거능의 정도가 양성 대조군으로 사용한 ascorbic acid 보다 높은 활성을 보여 매우 강한 항산화능을 보유함을 확인하였다. 또한 RAW 264.7 세포주를 이용한 $H_2O_2$ 및 LPS의 유도에 의해 생성된 ROS에 대한 소거능을 분석한 결과에서도 농도의존적인 강한 소거능을 보였다. 뿐만 아니라 대표적인 항산화효소 중 하나로 천연물에 의한 항산화능 활성에 의해 주로 발현이 유도되는 hemeoxygenase 1 (HO-1) 및 그 전사 인자인 nuclear factor-E2-related factor 2 (Nrf2)의 단백질 발현이 EPEE의 처리에 의해 유의적으로 증가됨을 보였으며 이러한 HO-1 및 Nrf2의 발현 변화는 상위신호전달계인 MAPKs 및 PI3K/Akt 에 의해 조절될 가능성을 보였다. 한편 EPEE가 LPS에 의해 유도된 NO 생성에 미치는 영향을 분석한 결과 농도의존적인 NO 생성 저해능을 보였으며 이는 NO 생성 단백질인 iNOS의 발현 저해에서 기인함을 확인하였다. 이와 같은 EPEE의 NO 생성 억제 효과는 염증 상위신호전달계인 NF-${\kappa}B$ 및 AP-1의 조절을 통해 일어날 가능성을 보였다. 이러한 결과를 통해 EPEE의 높은 항산화능과 항염증 활성을 처음으로 확인하였으며 향후 기능성 소재로서 유용하게 활용될 수 있을 것으로 판단된다.

• 한국지역지리학회지
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• 제11권1호
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• pp.71-82
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• 2005

최근 수도권의 집중을 완화하고, 국토의 균형발전을 목적으로 수도권에 입지하고 있는 공공기관의 지방이전을 추진하려는 정책이 발표되었다. 본 연구에서는 공공부문의 지방분산을 성공적으로 추진한 프랑스 사례를 분석하였다. 프랑스에서 공공기관의 이전은 지방도시의 전략적 성장, 낙후지역의 고용기회 확대 등 국토균형발전전략과 밀접한 관련을 맺으며 추진되었다. 결과적으로 지방도시의 인구성장, 지방의 과학기술기반의 강화 등 지역균형발전에 상당히 기여한 것으로 평가된다. 특히 연구교육기관의 이전과 지방과학기술거점(테크노폴)과의 연계 등은 지역의 혁신역량 강화에 기여하였다. 우리나라에서도 공공기관의 지방이전을 지역균형발전의 주요한 수단으로 인식할 필요가 있으며, 지역의 발전과 관련된 다른 정책수단과 연계하는 등 파급효과를 극대화하기 위한 전략적 노력이 요구된다.

• 성인간호학회지
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• 제21권6호
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• pp.593-602
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• 2009

Purpose: This study was to provide baseline data about nurses' Influenza A (H1N1) knowledge, awareness, and practice of infection control and to identify the significant factor affecting the level of practice. Methods: The subjects of this study were 144 nurses who worked at Influenza A (H1N1) regional base Hospital in D city. Data were collected by self-reported questionnaires during September 2009. The collected data were analyzed using SPSS/WIN 12.0 program. Results: The knowledge of Influenza A (H1N1) was statistically different according to age, unit, career and experience of seasonal influenza vaccination during the last year. The awareness of infection control was statistically different according to age, career, experience of seasonal influenza vaccination for last year and intention to get seasonal influenza vaccination for this year. The practice of infection control was statistically different according to unit, experience of seasonal influenza vaccination for last year, intention to get seasonal influenza vaccination for this year and intention to get Influenza A (H1N1) vaccination for this year. There was positive correlation among knowledge, awareness and practice (p < .05). Awareness was the significant factor affecting the level of practice. Conclusion: An educational program focusing on strategy to change nurse's awareness can be effective for infection control of Influenza A (H1N1) in regional base hospitals.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.353-356
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• 2016

Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) for glassy cell carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors. For risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. Area under the receiver operating characteristic curves (ROCs) were computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of glassy cell carcinoma death was computed for the predictors for comparison. Results: There were 79 patients included in this study. The mean follow up time (S.D.) was 37 (32.8) months. Female patients outnumbered males 4:1. The mean (S.D.) age was 54.4 (19.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.69). The risks of cause specific death were, respectively, 9.4% for localized, 16.7% for regional, 35% for the un-staged/others category, and 60% for distant disease. After optimization, separation between the regional and unstaged/others category was removed with a higher ROC area of 0.72. Several socio-economic factors had small but measurable effects on outcome. Radiotherapy had not been used in 90% of patients with regional disease. Conclusions: Optimized SEER stage was predictive and useful in treatment selection. Underuse of radiotherapy may have contributed to poor outcome.

• 생명과학회지
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• 제28권9호
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• pp.1092-1099
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• 2018

본 연구에서는 식물자원으로부터 생리활성을 보유한 새로운 기능성 소재를 찾고자 하였다. 이를 위해 수종의 식물 추출물을 분석하여 강한 항산화능을 보유한 5종(Apios fortunei Maxim., Colubrina arborescens Sarg., Croton caudatus Geiseler, Osmanthus matsumuranus Hayata 그리고 Schima noronhae Reinw.)을 선별하고, 각 추출물의 항산화 활성을 시험관 분석법, 세포실험 모델계, 대상 단백질 발현 분석 등을 통해 평가하였다. 먼저 각 추출물의 항산화 활성을 DPPH 라디칼 소거능을 통해 분석한 결과 모두 양성 대조군으로 사용한 아스코르빈산과 유사한 정도의 높은 활성을 보여 각 소재가 매우 강한 항산화능을 보유함을 확인하였다. 또한 RAW 264.7 세포주에서 $H_2O_2$에 의해 유도된 ROS에 대한 각 추출물의 소거능을 분석한 결과에서도 농도의존적인 강한 소거능을 보였다. 뿐만 아니라 대표적인 항산화효소 중 하나로 항산화능 보유 천연물에 의해 발현이 유도되는 HO-1 및 그 전사인자인 Nrf2의 단백질 발현이 각 추출물의 처리에 의해 증가됨을 보였다. 이러한 결과를 통해 5종 식물 추출물의 강한 항산화 활성을 처음으로 확인하였으며 향후 기능성 소재로서 유용하게 활용될 수 있을 것으로 판단된다.

• 한국실내디자인학회논문집
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• 제21권1호
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• pp.280-288
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• 2012

The purpose of this study is to deduct influence factors by analyzing preferences for public design that can increase user satisfaction through differentiated identity of regions. The study methods are as follows. First, consider a concept and semantic change of public design through the relevant literatures and precedent studies and then understand application status of domestic and overseas public design. Second, extract design elements for regional differentiation through precedent studies and reclassify regional resources that have an effect. Third, understand the necessity level of public design for regional differentiation by targeting experts and research the extracted design element and the degree of reflection about regionality. Lastly, understand a correlation between design elements and influence factors about territorial regionality of public design based on the researched contents, and analyze the degree of reflection between each other. As a result of this study, a plan that used 'material' and 'color' had high preference on the aspect of design elements and this is an important element that can show regional differentiation of regions. public design of showing regional differentiation. Thus, it is considered that various methods of using 'material' and 'color' must be planned. 'Public space' among design territories was most effective, and the following was 'public facility'. In particular, 'public space' has high preference of using 'natural resources' and 'industrial resources', and therefore an effect of a plan that uses these is judged to be positive. This study can use these results as basic data that suggested the standard for utilization of regional factors for regional differentiation of public design.

• 한국지역지리학회지
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• 제12권1호
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• pp.59-71
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• 2006

행정구역으로서 '면(面)'은 자연적인 마을 단위와 가장 가까이에 접하고 있는 인위적인 행정구역이다. 시와 군단위의 행정구역명이 역사성이나 인식 측면에서 훨씬 광범위하지만, 면단위는 그 지역에 사는 사람에 한정되는 인식규모가 매우 적은 지리적 단위(범위)이며, 존속여부나 행정구역명의 변화가 가장 심한 행정구역 단위이다. 면단위에서의 지역 중심지가 확립된 것은 1917년 면사무소의 설치와 직접적으로 관련된다. 본 연구에서는 전라북도 전주시 조촌면(동)지역을 사례로 면단위 지역에서의 지리적 범위 변화와 지명(면명)의 변화 유형 및 의미하는 지역과 관계된 정체성, 면단위 지역규모에서 나타나는 지역 중심지의 형성과 그 요인을 살펴봤다. 조촌면의 지역 변화는 첫째, 전주시와 근접한 관계로 전주시의 팽창에 따른 편입 및 통합이 지리적 범위 변화에 많은 영향을 미쳤다. 둘째, 조촌면은 지명(면명)을 유지하고는 있지만, 그 지명이 의미하는 지리적 범위는 달라졌다. 셋째, 신작로와 철도역의 개설, 일본인의 농장 개설, 면사무소의 설치, 정기시장 개장의 과정을 통해서 면의 중심지가 형성되었다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제18권5호
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• pp.26-38
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• 2013

In this study, priority for groundwater contamination management was assessed based on regional vulnerability in Goyang-si area, Gyonggi-do, Korea using analytic hierarchy process (AHP) and geographic information system (GIS). We proposed a concept for regional vulnerability to groundwater contamination with using socio-environmental vulnerability factors, which can be classified into three properties including regional hydrogeological property, contamination property, and groundwater use property. This concept is applied to Goyang-si area. For AHP analysis, an expertise-targeted survey was conducted. Based on the survey, a total of 10 factors (criteria) and corresponding weights for regional vulnerability assessment were determined. The result shows that regional contamination property is the most weighted factor among the three property groups (hydrogeological property: contamination property: groundwater use property = 0.3: 0.4: 0.3). Then, database layers for those factors were constructed, and regional vulnerability to groundwater contamination was assessed by weighted superposition using GIS. Results show that estimated regional vulnerability score is ranged from 22.7 to 94.5. Central and western areas of Goyang-si which have groundwater tables at shallow depths and are mainly occupied by industrial and residential areas are estimated to be relatively highly vulnerable to groundwater contamination. Based on assessed regional vulnerability, we classified areas into 4 categories. Category 1 areas, which are ranked at the top 25% of vulnerability score, take about 2.8% area in Goyang-si and give a high priority for groundwater contamination management. The results can provide useful information when the groundwater management authority decide which areas should be inspected with a high priority for efficient contamination management.

• 지역연구
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• 제11권2호
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• pp.41-51
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• 1995

It has been estimated the total factor productivity(TFP)of the city of Seoul. Average TFP growth rate during 1974-1992 has been estimated as 0.0602. TFP growth rate has been decreased from 0.0804 of 1970's to 0.0561 of 1980 and 1990's Factsro affecting the TFP are found to be core infrastructure, capital stock and land price growth rate. High land price growth rate depresses the TFP growth rate. During 1989, due to the high land price growth rate and extremely low building costruction permit TFP rate has been estimated as negative.