• Nutrition Research and Practice
• /
• 제16권3호
• /
• pp.298-313
• /
• 2022

BACKGROUND/OBJECTIVES: The effectiveness of natural compounds in improving athletic ability has attracted attention in both sports and research. Gynostemma pentaphyllum (Thunb.) leaves are used to make traditional herbal medicines in Asia. The active components of G. pentaphyllum, dammarane saponins, or gypenosides, possess a range of biological activities. On the other hand, the anti-fatigue effects from G. pentaphyllum extract (GPE) and its effective compound, gypenoside L (GL), remain to be determined. MATERIALS/METHODS: This study examined the effects of GPE on fatigue and exercise performance in ICR mice. GPE was administered orally to mice for 6 weeks, with or without treadmill training. The biochemical analysis in serum, glycogen content, mRNA, and protein expressions of the liver and muscle were analyzed. RESULTS: The ExGPE (exercise with 300 mg/kg body weight/day of GPE) mice decreased the fat mass percentage significantly compared to the ExC mice, while the ExGPE showed the greatest lean mass percentage compared to the ExC group. The administration of GPE improved the exercise endurance and capacity in treadmill-trained mice, increased glucose and triglycerides, and decreased the serum creatine kinase and lactate levels after intensive exercise. The muscle glycogen levels were higher in the ExGPE group than the ExC group. GPE increased the level of mitochondrial biogenesis by enhancing the phosphorylation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein and the mRNA expression of nuclear respiratory factor 1, mitochondrial DNA, peroxisome proliferator-activated receptor-δ, superoxide dismutase 2, and by decreasing the lactate dehydrogenase B level in the soleus muscle (SOL). GPE also improved PGC-1α activation in the SOL significantly through AMPK/p38 phosphorylation. CONCLUSIONS: These results showed that GPE supplementation enhances exercise performance and has anti-fatigue activity. In addition, the underlying molecular mechanism was elucidated. Therefore, GPE is a promising candidate for developing functional foods and enhancing the exercise capacity and anti-fatigue activity.

• 대한본초학회지
• /
• 제23권4호
• /
• pp.71-79
• /
• 2008

Objectives: SimJeok-Hwan(CP, Cardiotonic Pills) was made to treat patients with coronary arteriosclerosis, angina pectoris and hyperlipidemia. This study was designed to investigate the effects of CP on Proliferation rates neuroglia cells and protective effect of CP against oxidative stress, and also investigate the effects on regional Cerebral Blood Flow(rCBF) in normal rats. Methods: In this experiment, effects of CP on proliferation rates of neuroglia cells were measured using modified MTT methods. Oxidative stress was induced by treatment with 200 mM of hydrogen peroxide for 2 hr. rCBF and MABP were measured using Laser doppler flowmeter. Results: Treatment with CP elevated proliferation rates in C6 cells. In addition, CP protected cell death of C6 cells induced by oxidative stress. In results, rCBF was elevated by treatment with CP in normal rats. But, Mean Arterial Blood Pressure(MABP) did not affected by CP. In addition, the elevation of rCBF was blacked by pre-treatment with 1 mg/kg of indomethacin effectively. On the other hand, pre-treatment with 0.01 mg/kg of methylene blue did not affect rCBF level in normal rats. Conclusions: In conclusion, these results suggest that CP can act as anti-oxidant to protect neuroglia cells and also suggest that CP can elevate rCBF, which are involved in cyclooxygenase pathway.

• 보건교육건강증진학회지
• /
• 제21권4호
• /
• pp.75-97
• /
• 2004

Objectives: To examine whether the socioeconomic characteristics of communities (contextual effects) are related to the self-rated health of community residents after controlling individual characteristics (compositional effects). Methods: A linked data set including information on individuals from raw data of 1998 Korean National Health and Nutrition Survey(KNHNS) and information on the regions where the individuals lived from the socioeconomic statistical indices of Si-Gun-Gu (city-county-ward) in 1998 was established. The contextual factors of communities were generated from these socioeconomic indices through factor analysis. The contextual effects of community over and above the individual characteristics on the self-rated health were investigated using multilevel analysis. Results: The contextual factors of the community expressed as the factor scores have influence on the self-rated health of their residents above the compositional factors. When the communities were categorized into 5 groups (highest, high, middle, low, lowest) according to each of their factor scores, for factor 1 reflecting urbanization reversely, the residents of the communities that had the high, middle, and low factor scores showed significantly poor subjective health status than the residents of the lowest (most urbanized) group. For factor 2 reflecting community services and health resources, the subjective health status of the residents gradually became poorer when the group went from the highest to the lowest, and the low and lowest groups showed a significant difference. For factor 3 reflecting the manufacturing industry, as compared with the communities that have the highest factor scores, the other 4 groups showed significantly poorer subjective health status. And for factor 4 reflecting the scale of the regional government, as compared with the middle group, the rest of the 4 groups showed significantly better self-rated health. Conclusions: There existed regional contextual effects on their residents' health in Korean adults. To make policies tackling these contextual effects possible, more elaborate researches to find more specific factors and to explain the mechanisms of how health is influenced by the contextual factors are needed.

• 디자인학연구
• /
• 제15권1호
• /
• pp.379-388
• /
• 2002

본 연구는 현재 각 지역에서 지방자치단체를 중심으로 일률적으로 적용되어 온 지역활성화를 위한 방향이 캐릭터, 지역공동 브랜드, 특산품 개발 등 개별적인 응용아이템 개발위주로 진행됨에 따라 디자인의 역기능이 노출되고 있으므로 이를 최소화하는 한편, 무한 경쟁으로써 의 지방 자치단체 개념 변화에 대응하여 기업혁신의 수법으로 이용되어져온 CI계획을 지역 경쟁력 강화 프로그램에 거시적으로 적용함으로서, 지역아이덴티티를 정립하고, 지역자원을 개발하며, 지역경제의 활성화를 위한 새로운 발상전환의 기회를 제공하고자 한다. 따라서, 지역진홍을 도모함에 있어 디자인이 중심적 역할을 도모하기 위해서는 지역성장 방향을 기반으로 하면서 행정조직의 활성화, 행정 이미지 향상, 지역이미지의 개성화라는 보다 복합적인 목표달성 뿐 만 아니라 지역자원으로서의 인재네트워크 개발까지도 시야에 넣는 보다 고도의 다양한 변혁, 표현 프로그램으로서 커뮤니케이션전략의 개발이 필요하다. 특히, 이러한 커뮤니케이션 전략이 효과적으로 수행되기 위해서는 지역의 자기검증 및 인식 작업, 자기 재정의(再定義) 작업, 자기 혁신운동 전개, 지역이미지 통합을 위한 시각화, 디자인 시스템 구축, 프로그램 실행과 확인등 6가지의 단계별디자인개발 프로세스에 의한 전략적이고 통합적인 지역진흥프로그램의 운용이 불가피 할 뿐만 아니라, 디자인 프로그램검증을 통한 지속적인 관리와 피드백에 의한 프로그램의 개선으로 지역 진흥을 목표로 하는 지역의 기본구상이 미래비젼을 담은 지역의 독특한 개성으로 변환시켜 표출케 하는 지역개발기반 시스템으로서의 활용을 필요로 한다.

• 한국지역지리학회지
• /
• 제11권4호
• /
• pp.463-475
• /
• 2005

본 연구에서는 영남지역의 산업구조 현황을 살펴보고 특화산업을 분석하여, 지역산업정책에의 시사점을 도출하였다. 분석결과에서 보듯이, 영남지역 내에서도 시도별로 정태 동태적 관점, 정태적 관점, 동태적 관점에서 선정된 특화산업의 특성이 차별적으로 나타났으며, 이러한 특화산업의 성격에 따른 지역적 특성을 3가지 유형으로 분류할 수 있었다. 또한 이러한 유형별로 특화산업 육성 전략의 효과가 차별적으로 나타날 수 있음을 살펴보았다. 이러한 분석결과를 토대로, 다음과 같은 정책적 시사점을 도출할 수 있다. 첫째, 특화산업의 육성과 관련하여 지역별로 특화산업의 특성에 따라 유형별로 차별적인 특화산업 육성 전략을 구사해야 할 것이고, 둘째, 특화산업의 성격에 따라 특화산업 육성전략과 지역산업 구조개편 및 혁신전략을 맞춤식으로 차별적으로 구사해야 할 것, 마지막으로 지식기반경제로의 전환에 맞추어 특화산업 육성전략과 지역혁신전략을 적절히 병행할 것이다.

• Journal of Korean Biological Nursing Science
• /
• 제19권3호
• /
• pp.191-197
• /
• 2017

Purpose: The aim of this study was to determine the effectiveness of a community-based muscle and joint self-management program with muscle stretching and muscle strengthening exercises for community-dwelling older adults. Methods: The study was a pre-and-post design in a single group, which examined the effects after the intervention of muscle and joint self-management program for 6 weeks, on the 42 subjects of the elderly who registered in a Community Senior Center in J city. Data analyses were conducted with paired t-test by using a SAS (version 9.2 for Windows) program. Results: The effectiveness of muscle and joint self-management program on shoulder flexibility and right knee extension (flexibility) were significantly improved (t= 2.72, p= .010; t= -2.26, p= .029). Joint symptoms (pain, stiffness), physical functioning, depression, fatigue, and left knee extension were not significantly improved after the muscle and joint self-management program. Conclusion: The results showed the possibility of this 6-week exercise program in improving shoulder and knee flexibility for community-dwelling older adults.

• Journal of Acupuncture Research
• /
• 제33권4호
• /
• pp.137-148
• /
• 2016

Objectives : This study was performed to review articles concerning acupuncture or moxibustion treatment for Complex Regional Pain Syndromes. Methods : On-line databases including PubMed, Cochrane Library, Ovid-EMBASE, NDSL and OASIS were searched to find articles concerning acupuncture or moxibustion treatment for Complex Regional Pain Syndromes. Several overlapping articles and those not relevant to the topic were excluded, as well as review articles and commentaries. Results : 16 case reports were selected through the procedure, all of which presented successful treatment cases of Complex Regional Pain Syndromes with acupuncture and moxibustion. Most of them presented one single patient case and were published in Korea. However, almost half of them were printed in English, and had been continuously published since 2005. It was remarkable that pharmacopuncture was predominantly used to treat Complex Regional Pain Syndromes. Also, we noted that Chinese scalp acupuncture needs to be studied further as two successful cases were presented from the U.S army. Conclusion : The results show that several case reports have been published regarding Complex Regional Pain Syndromes treated with acupuncture and moxibustion. However, all of them were case reports which are given low status in Evidence-Based Medicine. We expect that a more diverse range of articles, including case control studies, cohort studies and randomized controlled trials will be performed in the near future, and that a unified outcome measure will be developed for Complex Regional Pain Syndromes.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권10호
• /
• pp.4285-4289
• /
• 2015

Purpose: Blood hemoglobin levels are known to influence response to radiotherapy. This retrospective analysis compared the effect of hemoglobin levels upon response to radiation among patients treated with radiation alone (by accelerated hyperfractionated radiotherapy) versus those treated with concurrent cisplatin chemoradiotherapy. Materials and Methods: Among patients treated for locally advanced carcinoma of the cervix (LACC) during 2009-10, a total of 60 fulfilled the eligibility criteria. In this time frame, external beam radiotherapy was delivered with either concurrent chemoradiotherapy (CRT, n=31) (45Gy over 25 fractions, with weekly cisplatin at 40mg/m2), or with accelerated hyperfractionated radiotherapy (AHRT, n=29) (20Gy over 10 daily fractions over the first two weeks, followed by 30Gy over 20 fractions over the next two weeks, with two fractions of 1.5Gy per day, without the use of chemotherapy). Mean weekly hemoglobin (MWH) levels of all patients were calculated as the arithmetic means of weekly recorded blood hemoglobin levels. As per MWH, patients in both of the AHRT or the CRT groups were classified into two subgroups-those with MWH between 10-10.9g/dL, or with MWH>11g/dL. Complete response (CR) to external beam RT phase (prior to brachytherapy) was declared after clinical examinations and computed tomography. The CR rate was noted for both MWH sub-groups within each of the AHRT and CRT groups. Results: Within the AHRT group, patients with MWH>11g/dL had a much better CR rate in comparison to those with MWH:10-10.9g/dL (80% vs. 21.1%) which was statistically significant (p 0.0045). Within the CRT group, there was no significant difference in the outcomes within the MWH>11g/dL and MWH:10-10.9g/dL sub-groups (CR rates of 80% vs. 61.9%, p=0.4285). Conclusions: The importance of maintaining a minimum hemoglobin level of 11g/dL during RT is much greater for patients treated with RT alone, than for patients treated with concurrent chemoradiotherapy. Enhanced haemoglobin levels during RT may to an extent negate the ill-effects that may otherwise arise due to non-use of concurrent chemotherapy.

• Journal of Ginseng Research
• /
• 제45권2호
• /
• pp.228-235
• /
• 2021

Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro and in vivo. This work used an ionic cross-linking method to entrap GK within O-carboxymethyl chitosan (OCMC) nanoparticles (Nps) to form GK-loaded OCMC Nps (GK-OCMC Nps), which enhance the aqueous solubility and stability of GK. Methods: The GK-OCMC Nps were characterized using several physicochemical techniques, including x-ray diffraction, transmission electron microscopy, zeta potential analysis, and particle size analysis via dynamic light scattering. GK was released from GK-OCMC Nps and was conducted using the dialysis bag diffusion method. The effects of GK and GK-OCMC Nps on PC3 cell viability were measured by using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Fluorescent technology based on Cy5.5-labeled probes was used to explore the cellular uptake of GK-OCMC Nps. Results: The GK-OCMC NPs had a suitable particle size and zeta potential; they were spherical with good dispersion. In vitro drug release from GK-OCMC NPs was pH dependent. Moreover, the in vitro cytotoxicity study and cellular uptake assays indicated that the GK-OCMC Nps significantly enhanced the cytotoxicity and cellular uptake of GK toward the PC3 cells. GK-OCMC Nps also significantly promoted the activities of both caspase-3 and caspase-9. Conclusion: GK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK.

• 한국물환경학회지
• /
• 제29권1호
• /
• pp.88-96
• /
• 2013

Much attention has been needed in water resource management at the watershed due to drought and flooding issues caused by climate change in recent years. Increase in air temperature and changes in precipitation patterns due to climate change are affecting hydrologic cycles, such as evaporation and soil moisture. Thus, these phenomena result in increased runoff at the watershed. The Soil and Water Assessment Tool (SWAT) model has been used to evaluate rainfall-runoff at the watershed reflecting effects on hydrology of various weather data such as rainfall, temperature, humidity, solar radiation, wind speed. For bias-correction of RCP data, at least 30 year data are needed. However, for most gaging stations, only precipitation data have been recorded and very little stations have recorded other weather data. In addition, the RCP scenario does not provide all weather data for the SWAT model. In this study, two scenarios were made to evaluate whether it would be possible to estimate streamflow using measured precipitation and long-term average values of other weather data required for running the SWAT. With measured long-term weather data (scenario 1) and with long-term average values of weather data except precipitation (scenario 2), the estimate streamflow values were almost the same with NSE value of 0.99. Increase/decrease by ${\pm}2%$, ${\pm}4%$ in temperature and humidity data did not affect streamflow. Thus, the RCP precipitation data for Hongcheon watershed were bias-corrected with measured long-term precipitation data to evaluate effects of climate change on streamflow. The results revealed that estimated streamflow for 2055s was the greatest among data for 2025s, 2055s, and 2085s. However, estimated streamflow for 2085s decreased by 9%. In addition, streamflow for Spring would be expected to increase compared with current data and streamflow for Summer will be decreased with RCP data. The results obtained in this study indicate that the streamflow could be estimated with long-term precipitation data only and effects of climate change could be evaluated using precipitation data as shown in this study.