• Nuclear industry
• /
• v.7 no.8 s.54
• /
• pp.6-12
• /
• 1987

본고는 지난 6월 23일 미국원자력학회(ANS) 한국지부 월례회에서 ${\ulcorner}$Canadian Energy : Resources, Policies and Commercial Opportunities${\lrcorner}$라는 제목으로 행한 특별강연문을 번역한 것이다.

• Journal of the Korean Society of Physical Medicine
• /
• v.13 no.1
• /
• pp.121-128
• /
• 2018

PURPOSE: This study assessed the effect of exercise intervention methods on diaphragm movement, pulmonary function, and pulmonary strength in children with cerebral palsy (CP). METHODS: A total of 28 children with CP were randomly allocated to the general exercise group (n=9, GEG), respiratory exercise group (n=10, REG), and intensive exercise group (n=9, IEG). The exercise intervention was performed for 12 weeks. This study measured diaphragm movement, pulmonary function, and pulmonary strength under two different conditions before and after each exercise. Ultrasonography was used for measuring diaphragm movement, and Pony Fx was used to measure the forced expiratory volume in one second ($FEV_1$), peak expiratory flow (PEF), maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP). A Mann-Whitney test and ANOVA with a significance level of .05 were used for statistical analysis. RESULTS: Significant change was observed between the REG and the IEG as well as between the GEG and the IEG (p<.05). No significant difference was observed between the GEG and the REG. The diaphragm movement, $FEV_1$ PEF, MIP, and MEP were most improved in the IEG (p<.01). CONCLUSION: This study confirmed that intensive exercise is the most effective treatment method for improving diaphragm movement and respiratory function in CP children.

• Parasites, Hosts and Diseases
• /
• v.53 no.4
• /
• pp.431-438
• /
• 2015

In Trichinella spiralis infection, type 2 helper T (Th2) cell-related and regulatory T ($T_{reg}$) cell-related immune responses are the most important immune events. In order to clarify which Toll-like receptors (TLRs) are closely associated with these responses, we analyzed the expression of mouse TLR genes in the small intestine and muscle tissue during T. spiralis infection. In addition, the expression of several chemokine- and cytokine-encoding genes, which are related to Th2 and $T_{reg}$ cell mediated immune responses, were analyzed in mouse embryonic fibroblasts (MEFs) isolated from myeloid differentiation factor 88 (MyD88)/TIR-associated proteins (TIRAP) and Toll receptor-associated activator of interferons (TRIF) adapter protein deficient and wild type (WT) mice. The results showed significantly increased TLR4 and TLR9 gene expression in the small intestine after 2 weeks of T. spiralis infection. In the muscle, TLR1, TLR2, TLR5, and TLR9 gene expression significantly increased after 4 weeks of infection. Only the expression of the TLR4 and TLR9 genes was significantly elevated in WT MEF cells after treatment with excretory-secretory (ES) proteins. Gene expression for Th2 chemokine genes were highly enhanced by ES proteins in WT MEF cells, while this elevation was slightly reduced in MyD88/$TIRAP^{-/-}$ MEF cells, and quite substantially decreased in $TRIF^{-/-}$ MEF cells. In contrast, IL-10 and $TGF-{\beta}$ expression levels were not elevated in MyD88/$TIRAP^{-/-}$ MEF cells. In conclusion, we suggest that TLR4 and TLR9 might be closely linked to Th2 cell and $T_{reg}$ cell mediated immune responses, although additional data are needed to convincingly prove this observation.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2012.05a
• /
• pp.199-199
• /
• 2012

기후변화로 인한 기상재해의 피해가 전 세계적으로 계속 증가하고 있으며, 특히 기후변화로 인한 집중호우는 시민들의 안전, 재산, 인명피해를 일으키고 있다. 이러한 피해를 최소화하기 위해서는 한 신뢰성 높은 미래 기후시나리오가 필수적이며, 미래 기후시나리오를 바탕으로 하여 기후변화로 인한 향후 발생할 수 있는 위험성의 정도를 전망하여 적응대책을 수립할 필요가 있다. 본 연구에서는 기후시나리오를 이용하여 한국의 미래 강수량변화를 전망한다. 본 연구를 수행하기 위하여, A2시나리오의 ECHO-G/S에서 생산된 기후 시나리오를 이용하여 지역 기후모델인 RegCM3에 적용하여 기후 시나리오를 생산하였다. RegCM3에서 생산된 기후시나리오는 Sub-BATS라는 기법을 이용하여 한반도 5km 해상도의 기후시나리오가 생산되었다. 또한 생산된 기후시나리오와 비교분석을 위하여 전구 20km 해상도의 기후시나리오를 이용하여 미래 강수량 변화를 각 계급별로 분석 하였다. 역학적 상세화 방법에 의해 생산된 기후시나리오는 전체적으로 과소 추정되는 경향이 크게 나타나고 있었으며, 일강수량의 경우 관측자료 보다 상당히 작게 나타나는 특징이 있었다. 역학적 상세화에 의한 강수량은 기존의 연구에서도 비슷한 특징이 나타나고 있었다. 결과적으로 역학적 상세와에 의한 기후시나리오를 이용하여 미래 강수량 변화를 분석하는 것은 강수량의 경향성을 분석할 수는 있지만 정량적으로 분석하는 것에는 한계가 있다. 전구 20km 해상도의 기후시나리오는 전체적으로 관측자료와 상당히 유사하게 모의되고 있었으며, 일강수량 또한 상당히 유사하게 나타나고 있었다. 전구 20km 해상도의 기후시나리오를 이용하여 미래 강수량을 분석한 결과, 전반적으로 증가하는 경향이 있었으며, 21세기 후반에는 약 18%의 연강수량 증가가 나타났으며, 그 중에서도 겨울철의 강수량 증가가 38%로 가장 크게 나타났다. 강수일수 변화는 약 5mm이하는 감소하는 경향이 있었으며, 5mm 이상은 증가하는 경향이 나타났다. 그리고 각 계급별 강수량 변화는, 상대적으로 강수량이 적은 10, 30mm/day는 여름철에 비해 겨울철에 강수량 증가가 크게 나타나고 있었으며, 상대적으로 강수량이 큰 50, 80, 100, 130mm/day는 겨울철에 비해 여름철에 강수량 증가가 크게 나타났다. 본 연구에서 나타난 결과는 미래 수자원 영향평가 및 적응대책에 유용하게 쓰일 것이다.

• Journal of Biomedical Engineering Research
• /
• v.44 no.5
• /
• pp.303-314
• /
• 2023

This study aimed to assess the practical feasibility of advanced deformable image registration (DIR) algorithms in radiotherapy by employing two distinct datasets. The first dataset included 14 4D lung CT scans and 31 head and neck CT scans. In the 4D lung CT dataset, we employed the DIR algorithm to register organs at risk and tumors based on respiratory phases. The second dataset comprised pre-, mid-, and post-treatment CT images of the head and neck region, along with organ at risk and tumor delineations. These images underwent registration using the DIR algorithm, and Dice similarity coefficients (DSCs) were compared. In the 4D lung CT dataset, registration accuracy was evaluated for the spinal cord, lung, lung nodules, esophagus, and tumors. The average DSCs for the non-learning-based SyN and NiftyReg algorithms were 0.92±0.07 and 0.88±0.09, respectively. Deep learning methods, namely Voxelmorph, Cyclemorph, and Transmorph, achieved average DSCs of 0.90±0.07, 0.91±0.04, and 0.89±0.05, respectively. For the head and neck CT dataset, the average DSCs for SyN and NiftyReg were 0.82±0.04 and 0.79±0.05, respectively, while Voxelmorph, Cyclemorph, and Transmorph showed average DSCs of 0.80±0.08, 0.78±0.11, and 0.78±0.09, respectively. Additionally, the deep learning DIR algorithms demonstrated faster transformation times compared to other models, including commercial and conventional mathematical algorithms (Voxelmorph: 0.36 sec/images, Cyclemorph: 0.3 sec/images, Transmorph: 5.1 sec/images, SyN: 140 sec/images, NiftyReg: 40.2 sec/images). In conclusion, this study highlights the varying clinical applicability of deep learning-based DIR methods in different anatomical regions. While challenges were encountered in head and neck CT registrations, 4D lung CT registrations exhibited favorable results, indicating the potential for clinical implementation. Further research and development in DIR algorithms tailored to specific anatomical regions are warranted to improve the overall clinical utility of these methods.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2011.05a
• /
• pp.93-93
• /
• 2011

전 세계적으로 기후변화로 인한 기상재해의 피해가 매년 증가하고 있으며, 기후변화로 인한 시민들의 안전, 재산, 인명피해 또한 늘어나고 있다. 이러한 피해를 최소화하기 위해서는 도시지역을 중심으로 한 신뢰성 높은 미래 기후전망 기법이 필수적이며, 미래 기후전망을 바탕으로 하여 기후변화로 인한 향후 발생할 수 있는 위험성의 정도를 전망하여 적응대책을 수립할 필요가 있다. 본 연구에서는 도시지역의 미래 기후전망 기법을 개발하여 서울시의 미래기후를 전망한다. 본 연구를 수행하기 위하여 먼저 IPCC 기후시나리오에 대한 조사를 수행하여 자료를 수집한다. 수집한 자료를 바탕으로 역학적 상세화와 통계적 상세화 기법을 이용하여 고해상도 기후 시나리오를 생산하였다. 역학적 상세화 기법은 A2시나리오의 ECHO-G/S에서 생산된 기후 시나리오를 이용하여 지역 기후모델인 RegCM3에 적용하여 상세화 과정을 수행하였다. RegCM3를 이용하여 60km로 상세화한 후에 one-way double-nested system을 구축하여 20km까지 상세화 하였다. 20km 해상도의 기후 시나리오는 서울시와 같은 좁은 지역의 기후를 분석하기에는 어려움이 있으므로, RegCM3에 사용할 수 있는 Sub-BATS라는 기법을 이용하여 5km의 고해상도 기후 시나리오를 생산하였다. 역학적 상세화 결과는 관측결과에 비해 과소 추정되는 경향이 있어, 편차보정을 통하여 관측값에 가까운 자료를 만들어 주었다. 역학적 상세화 결과를 분석한 결과, 기준기간에 비해 미래기간(S3)에는 전체적으로 약 4.9도의 기온상승과 강수량 증가가 나타났으며, 특히 9월에 가장 큰 상승폭을 나타내고 있었다. 강수량의 경우 증가 경향이 뚜렷이 나타나고 있었으며, 여름철에 큰 증가폭을 나타내고 있었다. 통계적 상세화 기법은 역학적 상세화 기법에서 사용된 ECHO-G/S를 포함한 13개의 GCM결과와 우리나라의 57개 지점에 대한 CSEOF기법을 이용하여 기후 시나리오를 생산하였다. 이 자료는 서울시에 대하여 하나의 지점밖에 존재하지 않아, 서울시내의 지역별 미래 기후전망에는 문제가 있었으므로, Delta method라는 기법을 이용하여 서울 및 인근지역의 AWS 35개 지점에 대하여 미래 기후시나리오를 생산하였다. 통계적 상세화 결과, 13개 GCM의 기온변화는 전체평균 약 3.1도 상승하였고, 겨울과 여름철의 변화폭이 가장 크며, 모델의 불확실성 또한 겨울과 여름에 가장 큰 특징을 가지고 있다. 강수량의 경우 MME에서는 약간의 상승은 나타나고 있었지만 모델간의 불확실성은 여름철에 크게 나타나고 있었다. 역학적 및 통계적 상세화 기후 시나리오(ECHO-G/S, A2)를 비교 분석한 결과, 기온은 역학적 상세화 결과가 약간 크게 나타났으며, 전체적으로 유사한 패턴을 보이고 있었다. 강수량 또한 역학적 상세화 결과가 크게 나타나고 있었다. 역학적 및 통계적 상세화 결과는 S1의 경우 유사한 특징을 보이고 있었지만 S3로 갈수록 차이가 크게 나타나고 있었다.

• Journal of Life Science
• /
• v.23 no.11
• /
• pp.1404-1408
• /
• 2013

(-)-Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, has been shown to have strong antibacterial, antiviral, antioxidant, anti-inflammatory, and chemopreventive effects. However it is unknown whether EGCG can recover alcohol-associated pancreatitis. The aim of this study was to investigate the effects of EGCG on pancreatic enzyme activities and the expressions of pancreatic regenerating related markers, such as adenosine monophosphate-activated protein kinase (AMPK), raf-1 kinase inhibitor protein (RKIP), and Regenerating gene 1 (Reg1), in mice pancreatic primary acinar cells. Our results revealed that activities of ${\alpha}$-amylase and chymotrypsin were significantly increased in the cells treated with ethanol compared to the untreated control cells; however, the increased activities of both enzymes were markedly reduced by pretreatment with EGCG. Phosphorylation of AMPK and total expression of RKIP were decreased in the ethanol-treated primary acinar cells; however, these were both significantly increased in the EGCG-pretreated cells. In addition, when EGCG was treated, expression of Reg1 was markedly increased compared with that of the control or the ethanol-treated primary acinar cells, demonstrating that EGCG can modulate pancreatic regenerating related genes. Therefore, our findings suggest that EGCG may have therapeutic utility in the prevention or treatment of alcohol-associated pancreatitis.

• The Korean Journal of Applied Statistics
• /
• v.32 no.1
• /
• pp.161-171
• /
• 2019

Varied methods have been researched continuously because the past as the daily maximum electricity demand expectation has been a crucial task in the nation's electrical supply and demand. Forecasting the daily peak electricity demand accurately can prepare the daily operating program about the generating unit, and contribute the reduction of the consumption of the unnecessary energy source through efficient operating facilities. This method also has the advantage that can prepare anticipatively in the reserve margin reduced problem due to the power consumption superabundant by heating and air conditioning that can estimate the daily peak load. This paper researched a model that can forecast the next day's daily peak load when considering the influence of temperature and weekday, weekend, and holidays in the Seasonal ARIMA, TBATS, Seasonal Reg-ARIMA, and NNETAR model. The results of the forecasting performance test on the model of this paper for a Seasonal Reg-ARIMA model and NNETAR model that can consider the day of the week, and temperature showed better forecasting performance than a model that cannot consider these factors. The forecasting performance of the NNETAR model that utilized the artificial neural network was most outstanding.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.28 no.4B
• /
• pp.363-374
• /
• 2008

Intensity-Duration-Frequency (IDF) curve that is essential to calculate rainfall quantiles for designing hydraulic structures in Korea is generally formulated by regression analysis. In this study, IDF curve derived by the cumulative distribution function ("IDF by CDF") of the proper probability distribution function (PDF) of each site is suggested, and the corresponding parameters of IDF curve are computed using genetic algorithm (GA). For this purpose, IDF by CDF and the conventional IDF derived by regression analysis ("IDF by REG") were computed for 22 Korea Meteorological Administration (KMA) rainfall recording sites. Comparisons of RMSE (root mean squared error) and RRMSE (Relative RMSE) of rainfall intensities computed from IDF by CDF and IDF by REG show that IDF by CDF is more accurate than IDF by REG. In order to accommodate the effect of the recent intensive rainfall of Korea, the rainfall intensities computed by the two IDF curves are compared with that by at-site frequency analysis using the rainfall data recorded by 2006, and the result from IDF by CDF show the better performance than that from IDF by REG. As a result, it can be said that the suggested IDF by CDF curve would be the more efficient IDF curve than that computed by regression analysis and could be applied for Korean rainfall data.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.28 no.5B
• /
• pp.525-533
• /
• 2008

Global circulation models (GCMs) have been used to study impact of climate change on water resources for hydrologic models as inputs. Recently, regional circulation models (RCMs) have been used widely for climate change study, but the RCMs have been rarely used in the climate change impacts on water resources in Korea. Therefore, this study is intended to use a set of climate scenarios derived by RegCM3 RCM ($27km{\times}27km$), which is operated by Korea Meteorological Administration. To begin with, the RCM precipitation data surrounding major rainfall stations are extracted to assess validation of the scenarios in terms of reproducing low frequency behavior. A comprehensive comparison between observation and precipitation scenario is performed through statistical analysis, wavelet transform analysis and EOF analysis. Overall analysis confirmed that the precipitation data driven by RegCM3 shows capabilities in simulating hydrological low frequency behavior and reproducing spatio-temporal patterns. However, it is found that spatio-temporal patterns are slightly biased and amplitudes (variances) from the RCMs precipitation tend to be lower than the observations. Therefore, a bias correction scheme to correct the systematic bias needs to be considered in case the RCMs are applied to water resources assessment under climate change.