• Title/Summary/Keyword: Reference Analysis

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Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases

  • Kim, Jung Hyun;Park, Hyoung Su;Pae, Munkyong;Park, Kyung Hee;Kwon, Oran
    • Nutrition Research and Practice
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    • 제16권sup1호
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    • pp.57-69
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    • 2022
  • BACKGROUND/OBJECTIVES: Vitamin D is produced in the skin during sun exposure and is also ingested from foods. The role of vitamin D needs to be considered in the prevention and management of various diseases. Moreover, since the majority of Koreans spend their days indoors, becoming susceptible to the risk of vitamin D deficiency. The current study aims to prepare a basis for determining dietary reference intake of vitamin D in Korea, by reviewing the evidence against various diseases and risks. MATERIALS/METHODS: Literature published in Korea and other countries between 2014 and 2018 was prioritized based on their study design and other criteria, and evaluated using the RoB 2.0 assessment form and United States Department of Agriculture Nutrition Evidence Library Conclusion Statement Evaluation Criteria. RESULTS: Of the 1,709 studies, 128 studies were included in the final systematic analysis after screening. To set the dietary reference intakes of vitamin D based on the selected articles, blood 25(OH)D levels and indicators of bone health were used collectively. Blood vitamin D levels and ultraviolet (UV) exposure time derived from the Korean National Health and Nutrition Examination Survey were analyzed to establish the dietary reference intakes of vitamin D for each stage of the life cycle. The adequate intake levels of vitamin D, according to age and gender, were determined to be in the range of 5-15 ㎍/day, and the tolerable upper intake level was established at 25-100 ㎍/day. CONCLUSIONS: The most important variable for vitamin D nutrition is lifestyle. A balanced diet comprising foods with high contents of vitamin D is important, as is vitamin D synthesis after UV exposure. The adequate intake level of vitamin D mentioned in the 2015 Dietary Reference Intakes for Korean (KDRI) remained unchanged in the 2020 KDRI for the management of vitamin D nutrition in Koreans.

Effects of Expert-Determined Reference Standards in Evaluating the Diagnostic Performance of a Deep Learning Model: A Malignant Lung Nodule Detection Task on Chest Radiographs

  • Jung Eun Huh; Jong Hyuk Lee;Eui Jin Hwang;Chang Min Park
    • Korean Journal of Radiology
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    • 제24권2호
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    • pp.155-165
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    • 2023
  • Objective: Little is known about the effects of using different expert-determined reference standards when evaluating the performance of deep learning-based automatic detection (DLAD) models and their added value to radiologists. We assessed the concordance of expert-determined standards with a clinical gold standard (herein, pathological confirmation) and the effects of different expert-determined reference standards on the estimates of radiologists' diagnostic performance to detect malignant pulmonary nodules on chest radiographs with and without the assistance of a DLAD model. Materials and Methods: This study included chest radiographs from 50 patients with pathologically proven lung cancer and 50 controls. Five expert-determined standards were constructed using the interpretations of 10 experts: individual judgment by the most experienced expert, majority vote, consensus judgments of two and three experts, and a latent class analysis (LCA) model. In separate reader tests, additional 10 radiologists independently interpreted the radiographs and then assisted with the DLAD model. Their diagnostic performance was estimated using the clinical gold standard and various expert-determined standards as the reference standard, and the results were compared using the t test with Bonferroni correction. Results: The LCA model (sensitivity, 72.6%; specificity, 100%) was most similar to the clinical gold standard. When expert-determined standards were used, the sensitivities of radiologists and DLAD model alone were overestimated, and their specificities were underestimated (all p-values < 0.05). DLAD assistance diminished the overestimation of sensitivity but exaggerated the underestimation of specificity (all p-values < 0.001). The DLAD model improved sensitivity and specificity to a greater extent when using the clinical gold standard than when using the expert-determined standards (all p-values < 0.001), except for sensitivity with the LCA model (p = 0.094). Conclusion: The LCA model was most similar to the clinical gold standard for malignant pulmonary nodule detection on chest radiographs. Expert-determined standards caused bias in measuring the diagnostic performance of the artificial intelligence model.

측정시스템 분석용 통계소프트웨어의 개발 (A Statistical Software for Measurement Systems Analysis)

  • 이승훈;이종환
    • 품질경영학회지
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    • 제28권1호
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    • pp.175-195
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    • 2000
  • In this study, we developed a statistical software for measurement systems analysis. This software is patterned after the Measurement Systems Analysis Reference Manual developed by the Automotive Industry Action Group (AIAG). This software includes stability analysis, bias and linearity analysis, and gage R&R studies. This software was developed by using Delphi(version 4.0) and can be implemented on MS Windows 95 or higher level.

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An assessment of the taxonomic reliability of DNA barcode sequences in publicly available databases

  • Jin, Soyeong;Kim, Kwang Young;Kim, Min-Seok;Park, Chungoo
    • ALGAE
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    • 제35권3호
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    • pp.293-301
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    • 2020
  • The applications of DNA barcoding have a wide range of uses, such as in taxonomic studies to help elucidate cryptic species and phylogenetic relationships and analyzing environmental samples for biodiversity monitoring and conservation assessments of species. After obtaining the DNA barcode sequences, sequence similarity-based homology analysis is commonly used. This means that the obtained barcode sequences are compared to the DNA barcode reference databases. This bioinformatic analysis necessarily implies that the overall quantity and quality of the reference databases must be stringently monitored to not have an adverse impact on the accuracy of species identification. With the development of next-generation sequencing techniques, a noticeably large number of DNA barcode sequences have been produced and are stored in online databases, but their degree of validity, accuracy, and reliability have not been extensively investigated. In this study, we investigated the extent to which the amount and types of erroneous barcode sequences were deposited in publicly accessible databases. Over 4.1 million sequences were investigated in three largescale DNA barcode databases (NCBI GenBank, Barcode of Life Data System [BOLD], and Protist Ribosomal Reference database [PR2]) for four major DNA barcodes (cytochrome c oxidase subunit 1 [COI], internal transcribed spacer [ITS], ribulose bisphosphate carboxylase large chain [rbcL], and 18S ribosomal RNA [18S rRNA]); approximately 2% of erroneous barcode sequences were found and their taxonomic distributions were uneven. Consequently, our present findings provide compelling evidence of data quality problems along with insufficient and unreliable annotation of taxonomic data in DNA barcode databases. Therefore, we suggest that if ambiguous taxa are presented during barcoding analysis, further validation with other DNA barcode loci or morphological characters should be mandated.

중국 여대생들의 의복관여 수준에 다른 소비자 특성 및 의복구매행동에 관한 연구 (A Study on Consumer Characteristics, and Clothing Buying Behavior by Clothing Involvement of College Female Students in China)

  • 이옥희;김용숙
    • 한국의류학회지
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    • 제26권2호
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    • pp.205-215
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    • 2002
  • The purpose of this study was to identity the relationship of clothing involvement, consumer characteristics, and clothing buying behavior of college female students in China. A questionnaire was developed to measure clothing involvement, materialism, conspicuous consumption, reference group influence, clothing purchasing modes, fashion information sources. The questionnaire was administered to 390 college female students in Dandong of china. The data were analyzed using percentage, frequency, factor analysis, and t-test. The results of the study were as follows: 1. Subjects were divided into low clothing involved and high clothing involved groups according to the level of clothing involvement. 2. Three dimensions of materialism were derived by factor analysis such as Happiness-pursuing, Life-centered, and Sucess-symbolic. And three dimensions of conspicuous consumption and reference group influence were derived by factor analysis such as luxury oriented, Status symbolic, Brand-name oriented, and Comparative, Informational, Normative exactly. Clothing purchasing motives and fashion information sources were factor analysed as Social and Individual mole, and Printed & Electric-wave media, Marketer managed, Personal exactly. 3. There were significant differences between high involved and low involved consumers in consumer characteristics and clothing purchasing behavior. The high involved consumers showed more importance than low involved consumers about materialism especially in Happiness-pursuing about conspicuous consumption in status symbolic and about influence of reference group in comparative. The high involved consumers put more importance than low involved consumer individual motive as clothing purchasing motive, and marketer managed in clothing fashion information. The high invoked consumers showed more importance than low invoked consumers about evaluating attributes of product, and about store patronage criterion.

모의실험을 통한 한국 연근해 고등어(Scomber japonicus)의 가입당 생산 분석 (Simulation-based Yield-per-recruit Analysis of Chub Mackerel Scomber japonicus in Korean Waters)

  • 이경환;고성길;정석근
    • 한국수산과학회지
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    • 제51권3호
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    • pp.313-320
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    • 2018
  • Chub mackerel Scomber japonicus is an economically important pelagic species in the western North Pacific. In the last 50 years, the annual total catch in Korean waters showed large fluctuations, ranging from 100 to $420{\times}10^3tons$. To provide a biological reference point for management of chub mackerel, we applied a simulation-based yield-per-recruit (Y/R) model that considered both temperature-dependent growth and size-dependent mortality. We estimated the fisheries yield with respect to varying biological reference points and environmental conditions, including 1) the instantaneous rate of fishing mortality (F), 2) length of fish at first capture ($L_c$), and 3) water temperature. The result of our analysis showed that the Y/R could be greatest when the $L_c$ ranges from 19-27 cm and F ranges from $1.48-2.00yr^{-1}$. Y/R increases with increased water temperature between 15 and $23^{\circ}C$. We suggest targeting an $L_c$ of 17 cm (age=0.6 years) under the assumed current of $F=0.48yr^{-1}$ for maximizing the chub mackerel harvest. Further analysis considering spawning and recruitment processes are required to provide biological reference points to ensure the sustainability of chub mackerel fisheries in Korean waters.

Network RTK 품질 분석 방법론별 성능 지표와 사용자 항법 정확도의 상관성 (Correlation between the Position Accuracy of the Network RTK Rover and Quality Indicator of Various Performance Analysis Method)

  • 임철순;박병운;허문범
    • 한국항행학회논문지
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    • 제22권5호
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    • pp.375-383
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    • 2018
  • 정지한 객체의 측위에 사용되던 Network RTK (real time kinematics) 기술을 이동형 항체의 항법에 적용하기 위해서는 보정정보와 함께 사용자의 성능을 대표할 수 있는 지표가 함께 제공되어야 한다. 이를 위하여 본 논문에서는 I95 (ionospheric index 95) / G95 (geodetic index 95), SBI (semivariance based index), RIU (residual interpolation uncertainty) 등의 지표 도출 알고리즘을 분석하고 이를 국토지리정보원의 기준국 원시 데이터와 VRS (virtual reference station) 사용자에 적용함으로써 정밀 항법 성능 지표로의 활용 가능성을 타진하였다. 24시간 데이터를 처리한 결과 보정정보의 비선형성을 나타낼 수 있는 RIU 지표와 Network RTK 사용자의 위치 정확도와의 상관성이 0.52로 타 지표에 비해 훨씬 높은 것으로 나타났으므로 향후 이동 항체의 항법 성능 지표로 사용이 가능할 것으로 예상된다.

The impact of reorienting cone-beam computed tomographic images in varied head positions on the coordinates of anatomical landmarks

  • Kim, Jae Hun;Jeong, Ho-Gul;Hwang, Jae Joon;Lee, Jung-Hee;Han, Sang-Sun
    • Imaging Science in Dentistry
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    • 제46권2호
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    • pp.133-139
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    • 2016
  • Purpose: The aim of this study was to compare the coordinates of anatomical landmarks on cone-beam computed tomographic (CBCT) images in varied head positions before and after reorientation using image analysis software. Materials and Methods: CBCT images were taken in a normal position and four varied head positions using a dry skull marked with 3 points where gutta percha was fixed. In each of the five radiographic images, reference points were set, 20 anatomical landmarks were identified, and each set of coordinates was calculated. Coordinates in the images from the normally positioned head were compared with those in the images obtained from varied head positions using statistical methods. Post-reorientation coordinates calculated using a three-dimensional image analysis program were also compared to the reference coordinates. Results: In the original images, statistically significant differences were found between coordinates in the normal-position and varied-position images. However, post-reorientation, no statistically significant differences were found between coordinates in the normal-position and varied-position images. Conclusion: The changes in head position impacted the coordinates of the anatomical landmarks in three-dimensional images. However, reorientation using image analysis software allowed accurate superimposition onto the reference positions.

Analysis of Phylogenetic Relationship of 30 Cultivars of Korean Mulberry (Rosales: Moraceae) in Korea

  • Kwon, O-Chul;Kim, Hyun-Bok;Sung, Gyoo-Byung;Kim, Yong-Soon;Ju, Wan-Taek
    • International Journal of Industrial Entomology and Biomaterials
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    • 제37권2호
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    • pp.82-89
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    • 2018
  • This study was carried out to understand phylogenetic relationships of the 30 mulberry cultivars converved in Korea based on the ITS rDNA region, and they were compared to 40 reference sequences from GenBank. The size and the G+C content of the ITS rDNA gene regions from the 30 Korean mulberry cultivars and 40 reference sequences varied from 612-630 bp and 58.19-61.62%, respectively. Based on the results of the comparative phylogenetic analysis of the ITS rDNA regions of the 30 Korean mulberry cultivars and 40 reference sequences, they were divided into three groups (Group 1, 2, and 3) and two subgroups (Group 1A and 1B within Group 1). The sequence lengths of the Korean mulberry cultivar numbers 1-26 and 27-30 were 615 bp and 616 bp, respectively. At 205 bp location of ITS1 rDNA region, the cultivar numbers 1-26 contain the nucleotide thymine but the cultivar numbers 27-30 contain the nucleotide adenine. In addition, the insertion of the nucleotide adenine at 206 bp location was found only in the four Korean mulberry cultivars (numbers 27-30). Based on these sequence information and phylogenetic result, the 30 Korean mulberry cultivars were identified as M. alba and M. australis. This study will contribute to the construction of genetic database constructions and accurate variety identifications for unidentified mulberry varieties in Korea.

지각방사선(라돈) 참조준위별 저감 대책에 따른 비용 편익 분석 (Cost-benefit Analysis on Occupational Reference Levels for Radon)

  • 최은희;정은교;김수근;정명희
    • 한국산업보건학회지
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    • 제29권1호
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    • pp.57-68
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    • 2019
  • Objective: The purpose of this study is to propose the benefits of reduction measures according to the occupational radon reference level in order to present basic data for radon management guidelines considering domestic circumstances. Methods: This study uses radon data measured in the subway stations from 2015 to 2016. Of the total of 4,643 cases, 4,231 cases were analyzed excluding the 412 cases where the values were below $300Bq/m^3$. Results: Cost-Benefit analysis was done on the results of the field survey on subway work sites. At the exposure level of $400Bq/m^3$, the ratio between the cost and the benefit was highest at 1 : 1.81(the cost was KRW 1,398,568,032, while the benefit KRW 2,5248,772,841). At the exposure level of $600Bq/m^3$, the ratio of cost and benefit was 1: 1.80, at $300Bq/m^3$ it was 1.72, at $800Bq/m^3$ it was 1.71, at $200Bq/m^3$ it was 1.54, and at $100Bq/m^3$ it was 1.40. Conclusions: Radon management in the workplace provides economic benefits and appropriate reduction strategies are needed. In addition, it is necessary to establish and distribute radon exposure assessment procedures and guidelines for the safety and health of employees when exceeding the exposure standard, and guidelines for radon management in the workplace should be established.