• 순환기질환의공학회:학술대회논문집
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• 2006.10a
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• pp.10-13
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• 2006

Inflammation plays an important role in the progression of atherosclerosis and plaque destabilization converting a chronic process into an acute disorder with ensuing thromboembolism. Current therapeutic effective in preventing atherosclerosis and stroke such as statins, ASS and RAS inhibitors my exert part of their effects by modulating inflammatory responses in the vessel walls. As alternative approaches, discovery to find having inhibitory action of MMP activity, COX-2, macrophage infiltration, such as APE1/ref-1 and fusion technology for cell permeable protein may provide a new antiatherosclerotic therapy in the future.

• Fisheries and Aquatic Sciences
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• v.22 no.12
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• pp.28.1-28.8
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• 2019

Background: In the present study, we evaluated four commonly used housekeeping genes, viz., actin-β, elongation factor-1α (EF1α), acidic ribosomal protein (ARP), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as internal references for quantitative analysis of immune genes in nervous necrosis virus (NNV)-infected seven-band grouper, Hyporthodus septemfasciatus. Methods: Expression profiles of the four genes were estimated in 12 tissues of healthy and infected seven-band grouper. Expression stability of the genes was calculated using the delta Ct method, BestKeeper, NormFinder, and geNorm algorithms. Consensus ranking was performed using RefFinder, and statistical analysis was done using GraphpadPrism 5.0. Results: Tissue-specific variations were observed in the four tested housekeeping genes of healthy and NNV-infected seven-band grouper. Fold change calculation for interferon-1 and Mx expression using the four housekeeping genes as internal references presented varied profiles for each tissue. EF1α and actin-β was the most stable expressed gene in tissues of healthy and NNV-infected seven-band grouper, respectively. Consensus ranking using RefFinder suggested EF1α as the least variable and highly stable gene in the healthy and infected animals. Conclusions: These results suggest that EF1α can be a fairly better internal reference in comparison to other tested genes in this study during the NNV infection process. This forms the pilot study on the validation of reference genes in Hyporthodus septemfasciatus, in the context of NNV infection.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.45.1-45.1
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• 2021

The polarization degree as a function of phase angle (the Sun-target-observer's angle), so-called the polarimetric phase curves (PPC), have provided priceless information on asteroids' albedos since B. Lyot (1929). Succeeding experimental works in 1970s have confirmed the Umow law: There is a universal and strong correlation between the albedo and the PPC slope (slope of the tangential line at the zero of the PPC at phase angle ~ 20 degrees). Experiments in 1990s (ref [1]), on the other hand, have demonstrated that the negative branch of PPC is dependent on the size parameter (X ~ π * particle-size / wavelength), especially when X <~5. The change in particle size changed the minimum polarization degree, location of the minimum, and the width of the negative branch (called the inversion angle). From polarimetry[2] and spectroscopy[3], large asteroids are expected to be covered with fine (<~ 10 ㎛ size) particles due to the gravity. The size parameters are X ~ 30 at the optical wavelength (λ ~ 0.5 ㎛) and X ~ 10 in near-infrared (J, H, Ks bands; λ ~ 1.2-2.2 ㎛), if the representative particle size of 5 ㎛ is considered. Accordingly, the near-infrared polarimetry has a great potential to validate the idea in ref[1]. We conducted near-infrared photopolarimetry of the large asteroid (4) Vesta using the Nishiharima Infrared Camera (NIC) at Nishi-Harima Astronomical Observatory (NHAO). NIC allows simultaneous polarimetric measurements in J, H, and Ks bands, and thus the change of PPC is obtained for three different size parameters. As a result, we found a signature of the change in the negative branch in the PPC of asteroid (4) Vesta. We will introduce our observation and the results and give an interpretation of the regolith on Vesta.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1993.10a
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• pp.74-78
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• 1993

Compared with rigid-jointed latticed dome, in pinned-joint latticed dome, results of Ref.1 showed reduction of buckling strength by decline of junction's rotational rigidity. Moreover, with decline of junction's rotational rigidity, geometrical initial imperfection incurs more and more reduction of buckling-strength. This study, subsequently the case of rigid-joint domes, is aimed at analyzing buckling-characteristics of pinned-joint single-layer latticed domes with triangular network subjected to initial imperfection.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.05a
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• pp.108-108
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• 2004

• Korean Journal of Optics and Photonics
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• v.21 no.1
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• pp.26-32
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• 2010

Line lamps, which utilize leaky optical fibers based on periodic bending of plastic optical fibers, are proposed. The LED-optical fiber coupler, the key component of the line lamp, is designed and analyzed. The analysis by the Monte Carlo photon simulation method has shown that the optical coupling efficiency is affected rather sensitively by $\theta_w$, the slanting angle of the reflecting cup sidewall and $\rho_{ref}$, the reflectivity of the reflecting cup. The optical coupling efficiency of the coupler reaches the maximum when $\theta_w$ is about $60^{\circ}$, which is significantly larger than $\theta_w=45^{\circ}$, the typical sidewall slanting angle of the reflecting cup adopted in most LED lamps. When the reflectivity of the reflecting cup is above 0.8, the optical coupling efficiency is larger than 80%, which is the typical efficiency to be achieved in LD-optical fiber coupler.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.6
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• pp.557-564
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• 2007

The effect of wave and current interactions on regular wave transformation over a submerged elliptic shoal is investigated based on numerical simulations of the Vincent and Briggs experiment [Vincent, C.L., Briggs, M.J., 1989. Refraction-diffraction of irregular waves over a mound. Journal of Waterway, Port, Coastal and Ocean Engineering, 115(2), pp. 269-284]. The numerical simulations are conducted by constituting two numerical model systems: a combination of SWAN(a wave model) plus SHORECIRC(a current model) and a combination of REF/DIF 1(a wave model) plus SHORECIRC. A time dependent phase-resolving wave-current model, FUNWAVE, is also utilized to simulate the experiment. In the simulations, the breaking-induced currents defocus waves behind the shoal and bring on a wave shadow zone that shows relatively low wave height distributions. The computed results of the two model systems agree better with the measurements than the computed results obtained by neglecting wave-current interaction do. However, it is found that the radiation stresses for standing waves are misevaluated in the wave models. In addition, the results of FUNWAVE show very good agreement with the measurements. The agreement indicates that it is necessary to take into account the effect of breaking-induced current on wave refraction when wave-breaking occurs over a submerged shoal.

• Journal of Energy Engineering
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• v.20 no.4
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• pp.303-308
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• 2011

The present study has been carried out to predict the heat transfer characteristics of reverse heat loss method for a residential refrigerator by using numerical analysis and corresponding experiment. From the measured values of temperature and heat input, one can conclude that, the temperature inside the refrigerator has a nearly linear relationship with heat input. The effect of gasket heat loss was examined with the change of thermal conductivity of gasket region. The appropriate thermal conductivity of gasket region was acquired from the comparison of heat losses with the experimental result and numerical analysis. The result of calculated heat losses had accuracy within 1.8% error with the experimental result. With the selected thermal conductivity of gasket region, the effectiveness of reverse heat loss method was examined with the change of thermal conductivity of vacuum insulation panel.

• Food Science of Animal Resources
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• v.44 no.3
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• pp.586-606
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• 2024

The study was performed to determine the effect of faba bean protein isolate (FBPI) alone or in combination with microbial transglutaminase (MTG) on the rheological properties of pork myofibrillar protein gel (MPG), and physiochemical and textural properties of reduced-salt, low-fat pork model sausages (LFMSs). The cooking yields of MPGs with MTG or FBPI alone decreased and increased, respectively. However, the combination of FBPI and MTG was similar to the control (CTL) without FBPI or MTG. Gel strength values of MPG added with both FBPI and MTG were higher than treatments with FBPI or MTG alone. The hydrophobicity values of CTL were lower than those of MPG with FBPI alone, whereas the addition of MTG decreased the hydrophobicity of MPGs. The incorporation of FBPI alone or in combination with MTG decreased sulfhydryl groups (p<0.05). Shear stress values of MPGs with MTG tended to be higher than those of non-MTG treatments at all shear rates, and the addition of FBPI into MPGs increased shear stress values. Reduced-salt (1.0%) LFMSs with FBPI alone or combined with MTG had both lower cooking loss and expressible moisture values than those of CTL and similar values to the reference sample (REF, 1.5% salt). Textural properties of reduced-salt LFMSs with FBPI or MTG were similar to those of REF. These results demonstrated that the combination of FBPI and MTG could improve the water binding capacity and textural properties of pork MPGs and LFMSs and might be suitable for application in the development of healthier meat products.

• Microbiology and Biotechnology Letters
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• v.17 no.5
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• pp.429-435
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• 1989

A bacterial strain of Brevibaterium sp. CH1 was isolated and used to produce an enzyme (nitrile hydratase) necessary for earring out the bioconversion of acrylonitrile to acrylamide. The culture and reaction conditions, and medium optimization were studied for the strain. The conversion yield was nearly 100％ with a trace amount of acrylic acid produced. The strain showed strong activity of nitrile hydratase toward acrylonitrile and extremely low activity of the amidase toward acrylamide. We sought optimum culture conditions for the formation of nitrile hydratase by Brevibacterium sp. CH1. The effects of temperature and pH on the activity of free and immobilized tells were investigated. The nitrite hydratase of Brevibacterium sp. CH1 acted not only on various aliphatic nitrites such as acrylonitrile, propionitrile and acetonitrile, but also on aromatic nitrile as nicotinonitrile.