• The Korean Journal of Nuclear Medicine
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• v.39 no.3
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• pp.174-181
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• 2005

Purpose: Reduction of respiratory motion artifacts in PET images was studied using respiratory-gated PET (RGPET) with moving phantom. Especially a method of generating simulated helical CT images from 4D-CT datasets was developed and applied to a respiratory specific RGPET images for more accurate attenuation correction. Materials and Methods: Using a motion phantom with periodicity of 6 seconds and linear motion amplitude of 26 mm, PET/CT (Discovery ST: GEMS) scans with and without respiratory gating were obtained for one syringe and two vials with each volume of 3, 10, and 30 ml respectively. RPM (Real-Time Position Management, Varian) was used for tracking motion during PET/CT scanning. Ten datasets of RGPET and 4D-CT corresponding to every 10% phase intervals were acquired. from the positions, sizes, and uptake values of each subject on the resultant phase specific PET and CT datasets, the correlations between motion artifacts in PET and CT images and the size of motion relative to the size of subject were analyzed. Results: The center positions of three vials in RGPET and 4D-CT agree well with the actual position within the estimated error. However, volumes of subjects in non-gated PET images increase proportional to relative motion size and were overestimated as much as 250% when the motion amplitude was increased two times larger than the size of the subject. On the contrary, the corresponding maximal uptake value was reduced to about 50%. Conclusion: RGPET is demonstrated to remove respiratory motion artifacts in PET imaging, and moreover, more precise image fusion and more accurate attenuation correction is possible by combining with 4D-CT.

• Economic and Environmental Geology
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• v.48 no.1
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• pp.25-39
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• 2015

$CO_2$ geological storage plays an important role in reduction of greenhouse gas emissions, but there is a lack of research for CCS demonstration. To achieve the goal of CCS, storing $CO_2$ safely and permanently in underground geological formations, it is essential to understand the characteristics of them, such as total storage capacity, stability, etc. and establish an injection strategy. We perform the impedance inversion for the seismic data acquired from the Ulleung Basin in 2012. To review the possibility of $CO_2$ storage, we also construct porosity models and extract attributes of the prospects from the seismic data. To improve the quality of seismic data, amplitude preserved processing methods, SWD(Shallow Water Demultiple), SRME(Surface Related Multiple Elimination) and Radon Demultiple, are applied. Three well log data are also analysed, and the log correlations of each well are 0.648, 0.574 and 0.342, respectively. All wells are used in building the low-frequency model to generate more robust initial model. Simultaneous pre-stack inversion is performed on all of the 2D profiles and inverted P-impedance, S-impedance and Vp/Vs ratio are generated from the inversion process. With the porosity profiles generated from the seismic inversion process, the porous and non-porous zones can be identified for the purpose of the $CO_2$ sequestration initiative. More detailed characterization of the geological storage and the simulation of $CO_2$ migration might be an essential for the CCS demonstration.

• Toxicological Research
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• v.17
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.2
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• pp.59-65
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• 2022

Rodent model for chronic cerebral hypoperfusion caused by bilateral carotid artery occlusion (BCAO) show clinically relevant evidences for vascular dementia and impairments of synaptic plasticity in the hippocampus. The purpose of this study was to evaluate effect of fermented garlic (F-Garlic) extract with NO metabolites on cognitive behaviors, synaptic plasticity, and molecular events in the hippocampus following BCAO. Adult male Sprague-Dawley rats were randomly divided three experimental groups into: control+water; BCAO+water; BCAO+F-Garlic. Animals were treated with oral administration of F-Garlic in tap water as a drinking water after surgery for 4 weeks. On passive avoidance test and Y-maze test, BCAO+water showed a significant decrease in step-through latency and spontaneous alteration, indicating deficit of hippocampal memory formation but the treatment of F-Garlic significantly increased these cognitive behaviors. In control+water, a robust increase in the amplitude of evoked field excitatory postsynaptic potentials was observed by theta burst stimulation to hippocampal neural circuit indicating formation of long-term potentiation (LTP) in the hippocampal CA1. BCAO+water showed a highly significant deficit in LTP induction 4 weeks after BCAO. On other hand, daily oral administration of F-Garlic extract caused the marked preservation of LTP induction. Moreover, parvalbumin was markedly reduced in the CA1, especially, in the stratum radiatum of BCAO+water. In contrast, BCAO+F-Garlic mitigate a significantly reduction of the parvalbumin. In summary, these results suggest that daily oral administration of F-Garlic extract can ameliorate cognitive memory deficit through the preservation of synaptic plasticity and interneurons integrity in the hippocampus in rodent model of chronic cerebral hypoperfusion.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.23-23
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• 2003

It has been suggested that the impairment of smooth muscle cell (SMC) function by alterations in the $Ca^{2+}$-activated $K^{+}$ ( $K_{Ca}$ ) channels accounts for the reduction in coronary reserve during left ventricular hypertrophy (LVH). However, this hypothesis has not been fully investigated. The main goal of this study was to assess whether the properties of $K_{Ca}$ channels in coronary SMCs were altered during LVH. New Zealand white rabbits (0.8-1.0 kg) and Sprague-Dawley rats (300-400 g) were randomly selected to receive either an injection of isoproterenol (300 $\mu\textrm{g}$/kg body weight) or an equal volume of 0.9％ saline (1 mL/kg body weight). The animals developed LVH 10 days after injection. In patch-clamp experiments, the unitary current amplitude and open probability for the $K_{Ca}$ channels were significantly reduced in LVH patches compared with control patches. The concentration-response curve of the $K_{Ca}$ channel to [C $a^{2+}$]$_{i}$ was shifted to the right. Inhibition of the $K_{Ca}$ channels with TEA was more pronounced in LVH cells than in the control cells. The whole-cell currents of $K_{Ca}$ channels were reduced during LVH. Western blot analysis indicated no differences in $K_{Ca}$ channel expression between the control and LVH coronary SM membranes. In contraction experiments, the effect of a high $K^{+}$concentration on the resting tension of the LVH coronary artery was greater than on that of the control. The effect of TEA on the resting tension of the LVH coronary artery was reduced as compared with the effect on the control. Our findings imply a novel mechanism for reduced coronary reserve during LVH.ing LVH.

• Journal of Korean Society of Steel Construction
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• v.10 no.3 s.36
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• pp.423-435
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• 1998

In this paper fatigue strength reduction of butt weld with penetration defect, which can be seen frequently in the steel bridge, was assessed quantitatively. S-N curves were derived and investigated through the constant amplitude fatigue test of fully or partially penetrated welded specimen made of SWS490 steel. The fracture mechanical method was applied in order to calculate the remaining fatigue life of the partially penetrated butt welds. The fatigue limit of the fully penetrated butt welds was higher than that of category A in AASHTO's fatigue design curves, and the slope of S-N curves with 5.57 was stiffer than that of other result for welded part generally accepted as 3. The fatigue strength of the partially Penetrated butt weld was strongly influenced by the size of lack of penetration, D. It decreased drastically with increasing D from 3.9 to 14.7mm. Fracture behaviour of the partially penetrated butt weld is able to be explained obviously from the beach mark test that a semi-elliptical surface crack with small a/c ratio initiates at a internal weld root and propagates through the weld metal. To estimate the fatigue life of the partially penetrated butt weld with fracture mechanics, stress intensity factors K of 3-dimensional semi-elliptical crack were calculated by appling finite elements method and fracture mechanics parameters such as C and m were derived through the fatigue test of CT-specimen. As a result, the fatigue lives obtained by using the fracture mechanical method agreed well with the experimental results. The results were applied to Sung-Su bridge collapsed due to penetration defects in butt weld of vertical member.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.2 no.4
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• pp.545-551
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• 1998

The Radio communication by existing SSB, VHF, etc. in a coast station and a base station for military affairs is still used to a very important the device of information delivery or transmitting and receiving by the remote controller to using to the exclusive cable for a equipment established at a long distance. When a number of consumer to connected and operated by a number of transceiver is essential for a circuit controller of ICS, in KOREA, is devoted by import to considerable quantity because of to be delayed development of this field. This Paper has been realized to optimal algorithm and designing of a circuit connection controller by multi-processor to pre-stage for the development of ICS. The H/W is composed able to remote control to circuit connector with the several slave processor and a processor for master, and this has taken possible through without any obstacle to communication circuits of a control signal by FSK system. The S/W make possible monitoring for communication condition of other circuits by means of a serial communication system by the multi-processing. This paper has been studied for connecting to a circuits wished to rapidly and precisely by the full application to a interrupt technique. A technique to control by remote to a number of transceiver is a way increasing to application for a frequency resource of the limited MF/SF, VHF and the existing radio communication technique. According to, this paper will achieve to be the reduction of energy & equipment and multiplicity of information delivery in the general communication and disposal to rapid and exact for the important communication as distress, urgency and safety on the sea.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.4
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• pp.203-210
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• 2020

Spatial variation of diffracting wave amplitudes along a semi-infinite breakwater is investigated using the analytical solution of Penney and Price (1952) for wave diffraction. On the front side of the breakwater, the fluctuation of wave amplitudes due to diffracting waves would cause a wave force greater than that of superposed incident and reflected waves. The diffracting wave phase varies in circular shape from the breakwater tip of (x, y) = (0, 0) whereas the incident and reflected wave phases vary in planar shape. So, the total wave amplitude of the incident (or reflected) waves and the diffracting waves would fluctuate at a position away from the energy discontinuity line. The position (x, y) = (0, y) on the front and lee sides of the breakwater is at a distance y(π/2 - β) of the point on the energy discontinuity line along the diffracting wave crest line. The degree of reduction of the diffraction wave energy is proportional to the distance from the point on the energy discontinuity line along the diffracting wave crest line. Therefore, the diffracting wave amplitudes on the front and lee sides of the breakwater would be inversely proportional to the square root of y(π/2 - β).

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.470-476
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• 2018

Facial motor evoked potential (FMEP) by multi-pulse transcranial electrical stimulation (mpTES) can complement free-running electromyography (EMG) and direct facial nerve stimulation to predict the functional integrity of the facial nerve during cerebello-pontine angle (CPA) tumor surgery. The purpose of this paper is to examine the standardized test methods and the usefulness of FMEP as a predictor of facial nerve function and to minimize the incidence of facial paralysis as an aftereffect of surgery. TES was delivered through electrode Mz (cathode) - M3/M4 (anode), and extracranially direct distal facial muscle excitation was excluded by the absence of single pulse response (SPR) and by longer onset latency (more than 10 ms). FMEP from the orbicularis oris (o.oris) and the mentalis muscle simultaneously can improve the accuracy and success rate compared with FMEP from the o.oris alone. Using the methods described, we can effectively predict facial nerve outcomes immediately after surgery with a reduction of more than 50% of FMEP amplitude as a warning criterion. In conclusion, along with free-running EMG and direct facial nerve stimulation, FMEP is a useful method to reduce the incidence of facial paralysis as a sequela during CPA tumor surgery.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.13 no.6
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• pp.115-121
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• 2013

This paper related with the DSE-MMA (Dithered Sign-Error MMA) that is the simplification of computational arithmetic number in blind equalization algorithm in order to compensates the intersymbol interference which occurs the passing the nonlinear communication channel in the presence of the band limit and phase distortion. The SE-MMA algorithm has a merit of H/W implementation for the possible to reduction of computational arithmetic number using the 1 bit quantizer in stead of multiplication in the updating the equalizer tap weight. But it degradates the overall blind equalization algorithm performance by the information loss at the quantization process compare to the MMA. The DSE-MMA which implements the dithered signed-error concepts by using the dither signal before qualtization are added to MMA, then the improved SNR performance which represents the roburstness of equalization algorithm are obtained. It has a concurrently compensation capability of the amplitude and phase distortion due to intersymbol interference like as the SE-MMA and MMA algorithm. The paper uses the equalizer output signal, residual isi, MD, MSE learning curve and SER curve for the performance index of blind equalization algorithm, and the computer simulation were performed in order to compare the SE-MMA and DSE-MMA applying the same performance index. As a result of simulation, the DSE-MMA can improving the roburstness and the value of every performance index after steady state than the SE-MMA, and confirmed that the DSE-MMA has slow convergence speed which meaning the reaching the seady state from initial state of adaptive equalization filter.