• Journal of Pharmaceutical Investigation
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• v.20 no.4
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• pp.223-228
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• 1990

The contribution of endogenous transport systems to the blood-brain barrier (BBB) transport of basic and acidic drugs was studied by using a carotid injection technique in rats and an isolated bovine cerebrovascular disease state were compared between the normotensive rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) which have been well established as an animal model with pathogenic similarities to humans. Basic drugs such as eperisone, thiamine and scopolamine inhibited, in a concentration dependent manner the in vivo uptake of $[{^3}H]choline$ through BBB, whereas amino acids and acidic drugs such as salicylic acid and valproic acid did not inhibit the uptake. The uptake of $[^3H]choline$ by B-CAP increased with time and showed a remarkable temperature dependency. The uptake of $[^3H]choline$ by B-CAP showed the very similar inhibitory effects as observed in the in vivo brain uptake, and was competitively inhibited by a basic drug, eperisone. The in vivo BBB uptakes of $[^3H]acetic$ acid and $[^{14}C]salicylic$ acid were dependent on pH of the injectate and the concentration of drugs. Several acidic drugs such such as salicylic acid, benzoic acid and valproic acid inhibited the in vivo uptake of $[^3H]acetic$ acid, whereas amino acid, choline and a basic drug such as eperisone did not inhibit the uptake. The uptake of acetic acid by B-CAP was competitively inhibited by salicylic acid. The permeability surface area product (PS) through BBB for $[^3H]choline$ in SHRSP was significantly lower than that in WKY. The concentration of choline in the brain dialysate in SHRSP was about half of that in WKY, while no significant difference was observed in the plasma concentration of choline between SHRSP and WKY. No significant difference was observed in the transport of monocarboxylic acids, glucose and neutral amino acid through BBB between SHRSP and WKY. From these results, it was concluded that BBB transport system of choline contributes to the transport of basic drugs through BBB, that acidic drugs can be transported via a moncarboxylic acid BBB transport system and that the specific dysfuntion of the BBB choline transport in SHRSP was ascribed to the reduction of the maximum velocity of choline concentration in the brain interstitial fluids.

• Environmental and Resource Economics Review
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• v.20 no.4
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• pp.827-858
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• 2011

In Korea, various environmentally harmful subsidies are granted in agriculture, fishery, energy, electricity, transportation, steel and shipbuilding industry. Examples include tax-exempt fuel for agriculture & fishery, VAT- exemption for briquette & anthracite, temporary subsidy for fuel, production stabilizing subsidy for coal mining, subsidy for briquette. Korea's yearly total subsidy in energy area is about 5,291 billion won, among them is 4,870 billion won. To reduce air pollutants and to mitigate climate change, Korea has to review the phase-out of environmentally harmful subsidies and the phase-in of environment-friendly subsidy. The reduction or removal of environmentally harmful subsidies will enhance economic efficiency and bring about environmental benefits. Economic efficiency means less use of inputs, which reduces environmental cost and improves social benefits. This paper applies the Shoven and Whalley's model to the Korean economy and analyzes the general equilibrium incidence effects of reforming environmentally harmful subsidies in the energy and electricity in Korea. We consider several counterfactual scenarios in which current environmentally harmful subsidies are reduced or abolished, compare them with the reference case in the economy, and evaluated the change in efficiency costs and distributional incidence of tax reforms related to subsidies.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.2
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• pp.95-105
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• 2020

In this study, using the CADMAS-SURF model, the characteristics of the wave pressures and the wave forces were analyzed according to the installation position of the parapet on top of the caisson, and the stability evaluation was carried out using estimated wave forces for the design wave condition. Numerical results show that adopting the rear-parapet reduces the front maximum wave pressures and wave forces, and the maximum wave pressure acting on the rear-parapet increases slightly compared to the front parapet, but the wave force acting on the rear-parapet has little effect on the stability of the breakwater due to the phase difference with the wave force acting on the front of the breakwater. In addition, impulsive wave pressures did not occur, as Yamamoto et al. (2013) pointed out the problem of the rear-parapet breakwater. As a result of the stability against sliding and overturning, it was estimated that the target safety factor of 1.2 could be secured by the self-weight of 13% less than the case of the front parapet. At this time, the maximum ground pressure was also reduced by 30%, and the applicability of the rear-parapet structure to the actual site was evaluated as high.

• Journal of Biomedical Engineering Research
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• v.19 no.2
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• pp.119-128
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• 1998

This paper describes a filtering algorithm which employs apriori information of SPECT lesion detectability potential for the filtering of degraded projection images prior to the backprojection reconstruction. In this algorithm, we determined m minimum detectable lesion sized(MDLSs) by assuming m object contrasts uniformly-chosen in the range of 0.0-1.0, based on a signal/noise model which provides the capability potential of SPECT in terms of physical factors. A best estimate of given projection image is attempted as a weighted combination of the subimages from m optimal filters whose design is focused on maximizing the local S/N ratios for the MDLS-lesions. These subimages show relatively larger resolution recovery effect and relatively smaller noise reduction effect with the decreased MDLS, and the weighting on each subimage was controlled by the difference between the subimage and the maximum-resolution-recovered projection image. The proposed filtering algoritym was tested on SPECT image reconstruction problems, and produced good results. Especially, this algorithm showed the adaptive effect that approximately averages the filter outputs in homogeneous areas and sensitively depends on each filter strength on contrast preserving/enhancing in textured lesion areas of the reconstructed image.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.3
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• pp.259-270
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• 2001

The present study was attempted to investigate the characteristics of epibatidine on secretion of catecholamines (CA) from the isolated perfused model of the rat adrenal gland, and to establish the mechanism of action. Epibatidine $(3{\times}10^{-8}\;M)$ injected into an adrenal vein produced a great inhibition in secretory response of CA from the perfused rat adrenal gland. However, upon the repeated injection of epibatidine $(3{\times}10^{-8}\;M)$ at 15 min-intervals, CA secretion was rapidly decreased after second injection of epibatidine. However, there was no statistical difference between CA secretory responses of both 1st and 2nd periods by the successive administration of epibatidine at 120 min-intervals. Tachyphylaxis to releasing effects of CA evoked by epibatidine was observed by the repeated administration. Therefore, in all subsequent experiments, epibatidine was not administered successively more than twice only 120 min-intervals. The epibatidine-induced CA secretion was markedly inhibited by the pretreatment with atropine, chlorisondamine, pirenzepine, nicardipine, TMB-8, and perfusion of $Ca^{2+}-free$ Krebs solution containing EGTA, while was not affected by diphenhydramine. Moreover, the CA secretion evoked by ACh for 1st period $(0{\sim}4\;min)$ was greatly potentiated by the simultaneous perfusion of epibatidine $(1.5{\times}10^{-8}\;M),$ but followed by time-dependently gradual reduction after 2nd period. The CA release evoked by high potassium $(5.6{\times}10^{-8}\;M),$ for 1st period $(0{\sim}4\;min)$ was also enhanced by the simultaneous perfusion of epibatidine, but those after 2nd period were not affected. Taken together, these experimental data suggest that epibatidine causes catecholamine secretion in a calcium dependent fashion from the perfused rat adrenal gland through activation of neuronal cholinergic (nicotinic and muscarinic) receptors located in adrenomedullary chromaffin cells. It also seems that epibatidine-evoked catecholamine release is not relevant to stimulation of histaminergic receptors.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.2
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• pp.307-314
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• 2011

A new predistortion technique for dynamic spectrum allocation systems such as cognitive radio (CR) is proposed. The system model considered in this paper occupies a small band at a time, but the center frequency can be changed in the wide range of frequency. In this scenario. the front-end filter may not eliminate the harmonics of the power amplifier (PA) output. The proposed PD reduces the spectral regrowth of the fundamental signal at the carrier frequency (${\omega}_0$) and removes the harmonics ($2{\omega}_0$, $3{\omega}_0$, ...) at the same time. The proposed PD structure is composed of multiple predistorters (PDs) centered at integer multiples of ${\omega}_0$. The PD at ${\omega}_0$ is for removing spectral regrowth of the fundamental signal, and the others are for harmonic reduction. In the proposed PD structure, parameters of PDs are found jointly. Simulation results show that the spectral regrowth can be reduced by 20dB, and the 2nd and 3rd harmonics can be reduced down to -70dB from the power of the fundamental signal.

• Journal of Navigation and Port Research
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• v.39 no.6
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• pp.465-472
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• 2015

SEEMP (Ship Energy Efficiency Management Plan) guidelines for a ship's GHG reduction include a machinery modification of hull, an installation of energy efficiency enhanced attachment in hardware methods. It is also possible to bring a ship energy efficiency improvement by fuel-efficient operations or in other software methods. Hardware modification or installation on ship can bring financial burdens to a ship company compared to its improvement expectation. On the other hand, Software based energy-saving technology can be applicable on various ship types, and it is also expected high efficiency of ship energy use compared to hardware based technology in perspective of the investment costs and efficiency. In this paper, it is described that the ship handling simulator based evaluation was carried out using representative ship model of bulk, container and VLCC. Simulation environments were separated into 6 conditions according to the sea-state and weather condition, and the operation results were compared with those before and after energy saving system applied The container ship showed the largest FOC save rate after energy saving system applied although the others also showed energy save rate after using the system.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.4
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• pp.144-152
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• 2016

This paper focuses on the experimental study for investigating the performance for lap splice of hooked or headed reinforcement in beam with different depths. In the experiment, seven specimens, with its variables as the lap length of headed or hooked bar, the existence of stirrups, etc., was manufactured. Bending test was conducted. Lap strengths by test were compared with the theoretical model based on KCI2012. The result showed that the cracks at failure mode occurred along the axial direction to a headed bar. The initial stiffness and the stiffness after initial crack were similar for all specimens. For HS series specimens without stirrups, a 25% increase in lap length was increased 11.8~18.1% maximum strengths. For HH series specimens without stirrups, a increase in lap length did not affect the maximum strengths because of the pryout failure of headed bar. For HS series specimens, the theoretical lap strengths based on KCI2012 considering the B grade lap and the reduction factor for stirrup were evaluated. They are smaller than the test strengths and can ensure the safety in terms of strength capacity. For HH series specimens, the stirrups in the lap zone are needed to prevent the pryout behaviour of headed bar.

• Journal of the Korean Wood Science and Technology
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• v.35 no.1
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• pp.17-26
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• 2007

This study was conducted to investigate the effects of End-coating (CO) treatment and Vapor-dam (V) treatment on the air circulating oven drying characteristics of green stock (Paulownia tomentosa) for drum. The reduction of the weight of specimens was greatly displayed in order of control (C-NC) treatment, End-coating (C-CO) treatment, Vapor-dam (V-NC) treatment and Vapor-dam/End-coating (V-CO) treatment after the beginning of drying. The V-CO treated specimen showed smoother temperature gradient compared with the V-NC treated specimen throughout whole drying stage and there was little temperature gradient between the inner and outer part of the cylindrical stock. The C-CO treated specimen showed higher value of vapor pressure in both the inner and outer part of the cylindrical stock until the middle stage of drying, while after the middle stage of drying only the inner part of the cylindrical stock presented higher value compared with the C-NC treated specimen. The distribution of the absolute vapor pressure of the V-CO treated specimen was similar to that of the V-NC treated specimen during the initial stage of drying. However, the former showed a large distribution in order of the hollow, the outer part, the inner part of the cylindrical stock after the initial stage of drying, which was entirely different model of distribution from that of the V-NC treated specimen. Surface checks and ring failures were not observed for all of the specimens, while end checks were severely occurred for the C-NC treated specimen and the V-NC treated specimen.

• Journal of Korean Society of Transportation
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• v.27 no.5
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• pp.97-111
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• 2009

Image-based traffic information collection systems have entered widespread adoption and use in many countries since these systems are not only capable of replacing existing loop-based detectors which have limitations in management and administration, but are also capable of providing and managing a wide variety of traffic related information. In addition, these systems are expanding rapidly in terms of purpose and scope of use. Currently, the utilization of image processing technology in the field of traffic accident management is limited to installing surveillance cameras on locations where traffic accidents are expected to occur and digitalizing of recorded data. Accurately recording the sequence of situations around a traffic accident in a signal intersection and then objectively and clearly analyzing how such accident occurred is more urgent and important than anything else in resolving a traffic accident. Therefore, in this research, we intend to present a technology capable of overcoming problems in which advanced existing technologies exhibited limitations in handling real-time due to large data capacity such as object separation of vehicles and tracking, which pose difficulties due to environmental diversities and changes at a signal intersection with complex traffic situations, as pointed out by many past researches while presenting and implementing an active and environmentally adaptive methodology capable of effectively reducing false detection situations which frequently occur even with the Gaussian complex model analytical method which has been considered the best among well-known environmental obstacle reduction methods. To prove that the technology developed by this research has performance advantage over existing automatic traffic accident recording systems, a test was performed by entering image data from an actually operating crossroad online in real-time. The test results were compared with the performance of other existing technologies.