• 동의생리병리학회지
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• 제18권5호
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• pp.1476-1484
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• 2004

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Guisinhwan(GSH : 歸腎丸) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in GSH-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in GSH-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in GSH-treated was significantly decreased in comparison with control. The level of serum phosphorous, calcium, GOT, GPT, T3 did not significant change among the three groups. The level of serum estrogen in control group showed slightly decreased in comparison with sham, but that in GSH-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in GSH-treated was significantly decreased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease In comparison with sham. Those in GSH-treated showed significant increase in comparison with control. Trabecular number did not significant change among the three groups. Trabecular separation only in GSH-treated showed significant decrease in comparison with control. Osteoclast number in control group showed significant increase in comparison with sham. That in GSH-treated showed significant decrease in comparison with control. Oseoblast surface in control group showed significant increase in comparison with sham, but that in GSH-treated showed no change in comparison with control. According to the above these results, GSH has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• 대한교통학회지
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• 제27권3호
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• pp.119-130
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• 2009

본 연구의 목적은 DVR(Driving Video Recorder)의 이용이 교통사고 저감과 교통사고 처리 비용의 절감에 얼마나 효과가 있는 지 살펴보고, DVR의 설치가 택시 운전자의 운전태도 변화에 미치는 영향을 분석하는 것이다. 본 연구를 위한 데이터는 부산 택시운전자를 통해 획득하였으며, 실증적인 분석을 위해 구조방정식 모형과 two-way ANOVA를 이용하였다. 본 연구의 개략적인 결과는 DVR 이용 후 부산 법인 택시 회사 4개소에서 교통사고가 평균적으로 32.7% 정도 감소하는 것을 보여준다. 뿐만 아니라 DVR의 이용은 택시 사고 처리 비용의 측면에서 택시 업체의 경제적 이익에 상당한 영향을 미칠 것으로 예상된다. 더구나 본 연구는 DVR 이용자 집단과 비 이용자 집단 간의 운전태도의 차이를 확인할 수 있었고, 운전자들의 운전태도에 미치는 긍정적인 영향과 부정적인 영향을 구분할 수 있었다. 본 연구는 '태도', '주관적 규범', '행동통제력 지각' 요인이 '행동 의도' 요인을 거쳐 간접적으로 DVR 장착이라는 계획된 '행동'에 미치는 영향력과 '행동통제력 지각' 요인이 직접적으로 '행동' 요인에 미치는 영향력을 정량적으로 도출하였다. 결론적으로, 본 연구는 교통안전법에 의거 사업용 자동차에 의무적으로 운행기록장치(차량용 블랙박스)를 설치할 때 영상기록장치의 영상기록기능을 추가하는 것을 제안한다.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.167-179
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• 2000

Objective : We studied to clarify the effective time zone of mild hypothermic neural protection during ischemia and/or reperfusion after middle cerebral artery occlusion. Methods : In a reversible cerebral infarct model which maintained reperfusion of blood flow after middle cerebral artery occlusion for two hours, the size of cerebral infarction, cerebral edema and the extent of neurological deficit were observed and analyzed for comparison between the control and the experimental groups under hypothermia($33.5^{\circ}C$). The temporalis muscle temperature was reduced to $33.5^{\circ}C$ by surface cooling for two hours during middle cerebral artery occlusion for study group I. The following groups applied hypothermia for two-hour periods after reperfusion : group II(0-2 hours), group III(2-4 hours), and group IV(4-6 hours). They were rewarmed to $36.5^{\circ}C$ until sacrified at 2, 4, 6, 12, and 24 hours after reperfusion. Control group was maintained at normothermia without hypothermia. Results : In the experimental groups with hypothermia, the average value of the size of cerebral infarction($mean{\pm}SD$) was $1.97{\pm}1.65%$, which was a remarkable reduction over that of the control, $4.93{\pm}3.79%$. In the control, a progressive increase was shown in the size of infarction from point of reperfusion to 6 hours after reperfusion without further changes in size afterward. Intra-ischemic hypothermia(group I) prevented ischemic injury but did not prevent reperfusion injury. Group II examplified the most neural protective effect in comparison to the control group and group IV(p<0.05). The cortex was more vulnerable to reperfusion injury than the subcortex. Mild hypothermia showed more neural protective effects on the cortex than subcortex. Conclusion : The most appropriate time zone for application of mild hypothermia was defined to be within four hours following reperfusion.

• 생물환경조절학회지
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• 제29권1호
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• pp.73-79
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• 2020

본 연구는 일정한 풍환경하에 온실 피복재 관류전열손실을 분석하기 위하여 온실 열손실 분석용 소형 풍동을 제작하고 성능을 분석하였으며 모형온실을 적용하였을 때의 관류전열손실을 분석하였다. 소형 풍동은 시험부 측 공기흐름이 정상상태를 유지하고 편차를 최소화하기 위하여 풍동의 각 요소를 반영하여 구성하였으며 송풍부, 확산부, 정류부, 축소부, 시험부로 구성하였다. 소형 풍동의 형태는 개방형, 토출식으로 결정하였고, 시험부 규격은 제작하고자 하는 모형온실의 규격과 상사비율, 시험부의 단면 폐쇄율을 감안하여 결정하였다. 상사비율을 풍동실험에 적용할 모형은 농업시설 중 가장 큰 비중을 차지하고 있는 단동 비닐온실을 대상으로 하였다. 소형풍동 내 풍속을 조절함에 따라 나타나는 모형온실 피복재의 관류전열계수는 피복재 면을 크게 지붕면과 측벽면, 앞뒷면으로 나누고 각 면별 계측 데이터를 평균 내어 산출하였다. 지붕면은 풍속이 증가함에 따라 전열계수도 증가하나 증가폭이 감소하는 구간은 배치각도에 따라 1-2ms^-1과 2-3ms^-1으로 구분되어지는 것으로 판단되었다. 측벽면의 전열계수가 증가하는 폭이 큰 구간은 0-1ms^-1 구간인 것으로 판단된다.

• 동의생리병리학회지
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• 제16권4호
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• pp.788-800
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• 2002

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Yuklinzu(YLZ: 毓麟珠) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in YLZ-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum calcium in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GOT in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GPT did not significant change among the three groups. The level of serum estrogen in control group showed slightly increased in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum T3 in control group showed no change in comparison with sham, and that in YLZ-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham. That in YLZ-treated showed slightly increased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in YLZ-treated showed significant increase in comparison with control. Trabecular number and did not significant change among the three groups. Trabecular separation only in YLZ-treated showed significant decrease in comparison with control. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in YLZ-treated showed slightly decreased in comparison with control. According to the above these results, YLZ has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• Toxicological Research
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• 제17권
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• ALGAE
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• 제30권3호
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• pp.233-239
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• 2015

Microalgae research is gaining momentum because of their potential biotechnological applications, including the generation of biofuels. Genome sequencing analysis of two model microalgal species, polar free-living Coccomyxa sp. C-169 and symbiotic Chlorella sp. NC64A, revealed insights into the factors responsible for their lifestyle and unravelled biotechnologically valuable proteins. However, genome sequence analysis under-explored cytochrome P450 monooxygenases (P450s), heme-thiolate proteins ubiquitously present in species belonging to different biological kingdoms. In this study we performed genome data-mining, annotation and comparative analysis of P450s in these two model algal species. Sixty-nine P450s were found in two algal species. Coccomyxa sp. showed 40 P450s and Chlorella sp. showed 29 P450s in their genome. Sixty-eight P450s (>100 amino acid in length) were grouped into 32 P450 families and 46 P450 subfamilies. Among the P450 families, 27 P450 families were novel and not found in other biological kingdoms. The new P450 families are CYP745-CYP747, CYP845-CYP863, and CYP904-CYP908. Five P450 families, CYP51, CYP97, CYP710, CYP745, and CYP746, were commonly found between two algal species and 16 and 11 P450 families were unique to Coccomyxa sp. and Chlorella sp. Synteny analysis and gene-structure analysis revealed P450 duplications in both species. Functional analysis based on homolog P450s suggested that CYP51 and CYP710 family members are involved in membrane ergosterol biosynthesis. CYP55 and CYP97 family members are involved in nitric oxide reduction and biosynthesis of carotenoids. This is the first report on comparative analysis of P450s in the microalgal species Coccomyxa sp. C-169 and Chlorella sp. NC64A.

• 한국수자원학회논문집
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• 제33권5호
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• pp.581-592
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• 2000

본 연구에서는 식생된 개수로에서의 난류 구조와 부유사 이동을 수치모의하였다. 난류폐합식으로는 $\textsc{k}-\;\varepsilon$ 난류모형을 사용하였다. 수치모의를 통해 평균유속, 난류강도, 레이놀즈 응력, 난류에너지 생성 및 소멸의 분포를 계산하였으며, 기존의 실험결과와 비교하였다. 식생에 의한 항력으로 인하여 평균유속이 전반적으로 감소되었으며, 이에 따라 난류강도와 레이놀즈 응력의 분포 역시 약화되었다. 침수식생의 경우, 식생높이보다 높은 구간에서는 전단에 의한 난류에너지 생성이 지배적이며, 식생높이 보다 낮은 구간에서는 후류에 의한 난류에너지 생성이 지배적임을 확인하였다. 또한 정수식생의 경우, 전채 수심에 걸쳐 후류에 의한 난류에너지 생성이 지배적으로 발생하였다. 대체적으로 수치모의에 의한 결과가 실험값과 유사한 양상을 보이는 것이 확인되었다. 수치모형으로부터 계산된 난류동점성계수 분포를 이용하여 부유사 보존방정식을 수치해석하였다. 식생된 개수로에서의 부유사 농도는 일반 개수로에 비해 전 수심에 걸쳐 균일하게 분포하였다. 또한 식생밀도가 증가할수록 부유사량은 감소하며, 동일한 식생밀도에 대해서는 입자의 크기가 작을수록 부유사량이 증가함을 확인하였다.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.329-335
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• 2018

여러 응용 분야에서 널리 활용되고 있는 위성영상은 지표면을 모니터링 하는데 매우 유용한 자료원이다. 위성자료는 원격 센서를 통해 획득되기 때문에 자료 획득시의 구름이나 에어로졸과 같은 관측 기상 상태나 센서 오작동상태에 따라 많은 노이즈와 에러가 포함되어 있다. 자료의 정확성은 자료 분석 결과의 정확성과 신뢰도에 영향을 주기 때문에 고품질 자료를 위한 노이즈 제거 및 자료 복원은 중요한 전처리(preprocessing) 과정이다. 본 연구에서는 다중주기 하모닉 모형을 이용하여 위성자료의 시계열적 동적 특성을 모형화하고 자료의 공간적 상관관계를 고려하여 적응적으로 자료복원을 수행하는 재구축 시스템을 제안하고 있다. 다중 주기에 기반을 둔 모형은 단일 주기보다 지표면의 연간 변화뿐 아니라 계절적 변화와 같이 내부적인 변화 패턴을 모형화 하는데 적합하다. 또한 기존에 제안된 복원 방법은 일정 기간의 전체 자료에 대한 복원 방법으로 실시간 복원법이 아니지만 제안된 방법은 실시간 자료 복원이 가능하여 위성자료 실시간 재구축을 위한 전처리 시스템의 알고리즘으로 활용될 수 있다. 제안된 방법은 먼저 시뮬레이션 자료를 통해 성능이 평가되었고 2011부터 2016년까지 6년간의 MODIS NDVI 자료에 적용하여 평가되었다. 실험 결과는 제안된 자료 복원 시스템이 위성영상 자료 분석을 위한 고품질 자료 재구축 방법으로 매우 유용함을 보여주고 있다.

• 한국산학기술학회논문지
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• 제19권10호
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• pp.625-632
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• 2018

본 연구는 최근 자원고갈 문제에 따른 에너지 절감을 바탕으로 총 에너지 수요에서 높은 비중을 차지하고 있는 건축물 에너지의 수요 감축에 목적을 두었고 국내에서 에너지절약형 건축물 설계를 위해 고시한 단열기준을 보다 효과적으로 조정하기 위한 보완점을 제시하고 에너지절약형 고단열, 고기밀 건축물의 쾌적성 유지의 한계점을 추가 보완하고자 야간외기 환기시스템을 도입하며 종합하여 최종 저에너지건축물 설계모델을 제시하였다. 먼저, 단열성능의 효과적 조정 모델은 건축물의 각 경사면별로 다르게 조정하여 각각의 수요 민감도를 충분히 고려할 수 있는 방법을 제시하고, 야간외기 도입 모델의 경우 건축물의 에너지 성능을 최대로 할 수 있는 모델을 선정하였다. 두 가지 모델을 결합한 최종 저에너지건축물 모델은 결과적으로 대상 건축물의 남, 북의 경사면 단열을 강화한 모델과 야간외기를 통한 환기 시스템을 단시간 운전한 모델이었으며 국내 단열기준에 의거한 Base 모델과 비교할 때 약 6~7%의 절감효과를 보였다. 따라서, 본 연구에서 제시하는 효과적 단열조정법과 야간외기 도입은 저에너지건축물 모델 설계에 있어 수요 민감도 분석 선행의 필요성을 환기시키는 점에서 시사점이 높고 대상 건축물의 건물에너지 수요를 저감할 수 있는 설계모델로 활용도가 높을 것이다.