• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
• /
• pp.549-549
• /
• 2012

Early detection of cancer biomarkers in the blood is of vital importance for reducing the mortality and morbidity in a number of cancers. From this point of view, immunosensors based on nanowire (NW) and carbon nanotube (CNT) field-effect transistors (FETs) that allow the ultra-sensitive, highly specific, and label-free electrical detection of biomarkers received much attention. Nevertheless 1D nano-FET biosensors showed high performance, several challenges remain to be resolved for the uncomplicated, reproducible, low-cost and high-throughput nanofabrication. Recently, two-dimensional (2D) graphene and reduced GO (RGO) nanosheets or films find widespread applications such as clean energy storage and conversion devices, optical detector, field-effect transistors, electromechanical resonators, and chemical & biological sensors. In particular, the graphene- and RGO-FETs devices are very promising for sensing applications because of advantages including large detection area, low noise level in solution, ease of fabrication, and the high sensitivity to ions and biomolecules comparable to 1D nano-FETs. Even though a limited number of biosensor applications including chemical vapor deposition (CVD) grown graphene film for DNA detection, single-layer graphene for protein detection and single-layer graphene or solution-processed RGO film for cell monitoring have been reported, development of facile fabrication methods and full understanding of sensing mechanism are still lacking. Furthermore, there have been no reports on demonstration of ultrasensitive electrical detection of a cancer biomarker using the graphene- or RGO-FET. Here we describe scalable and facile fabrication of reduced graphene oxide FET (RGO-FET) with the capability of label-free, ultrasensitive electrical detection of a cancer biomarker, prostate specific antigen/${\alpha}$ 1-antichymotrypsin (PSA-ACT) complex, in which the ultrathin RGO channel was formed by a uniform self-assembly of two-dimensional RGO nanosheets, and also we will discuss about the immunosensing mechanism.

• 한국정보통신학회논문지
• /
• 제10권9호
• /
• pp.1582-1589
• /
• 2006

잠금기법은 분산 병렬 시스템의 동기화에 필수적이다. 기존의 큐잉 잠금기법은 최초의 잠금 읽기와 잠금 경합발생 시 공유 데이터에 대한 잠금이 해제되었을 때 발생하는 잠금 읽기 재 시도로 두 개의 트래픽을 발생한다. 본 논문에서는 WPV(Waiting Processor Variable) 잠금기법이라 불리는 새로운 잠금기법을 제안한다 새로이 제안하는 기법은 오직 한 개의 잠금 읽기 명령을 사용한다. WPV 기법은 파이프라인 전송방식을 사용하여 최초의 잠금 읽기 단계에서 공유 데이터가 전송될 때까지 대기 한 후 잠금을 실시한다. 데이터에 대한 잠금을 수행중인 프로세서는 대기 상태의 다음 프로세서에 대한 정보를 저장하고 있으므로, 공유 데이터가 캐쉬 대 캐쉬 데이터 전송 기법에 의하여 대기중인 다음 프로세서로 바로 전송된다. 따라서 대기중인 프로세서 에 대한 변수는 연결 리스트 구조를 갖는다. 제안된 기법은 캐쉬 상태의 잠금기법을 사용하여 잠금 오버 헤드를 줄이고 다중 잠금 경합 발생시 FIFO를 유지하게 한다. 또한 본 논문에서는 기존의 메모리 및 캐쉬 큐잉 잠금기법에 대한 WPV 잠금기법의 해석적 모델링을 제시한다. WPV 잠금기법에 대한 시뮬레이션의 결과는 기존의 큐잉 잠금기법에 비하여 50%의 접근 시간의 감소를 보여주었다.

• ETRI Journal
• /
• 제31권4호
• /
• pp.469-471
• /
• 2009

This letter proposes a weighted scheduling mechanism for Internet protocol television (IPTV) to improve the loss performance of multicast transmission over an Ethernet passive optical network (EPON). We propose a new weight policy from the number of multicast receivers to proportionally allocate the downstream bandwidth of IPTV traffic. The proposed mechanism is used in an optical line terminal to decrease lost packets of favorite IPTV services because the lost multicast packets are proportional to the number of receivers. The total proportion of lost multicast packets is reduced by up to 73% in an EPON.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2003년도 춘계학술대회
• /
• pp.1690-1696
• /
• 2003

A two-dimensional direct numerical simulation is performed to investigate the flame structure of $CH_4/N_2$-Air counterflow nonpremixed flame interacting with a single vortex. The detailed transport properties and a modified 16-step augmented reduced mechanism based on Miller and Bowman's detailed chemistry are adopted in this calculation. The results show that an initially flat stagnation plane, where an axial velocity is zero, is deformed into a complex-shaped plane, and an initial stagnation point is moved far away from vortex head when the counterflow field is perturbed by the vortex. It is noted that the movement of stagnation point can alter the mechanism of reactants (fuel and oxidizer) fluxes into the flame surface, and then can alter the flame structure.

• Nuclear Engineering and Technology
• /
• 제50권1호
• /
• pp.80-87
• /
• 2018

Consideration is given to the possibility to use changes in buoyancy as a negative reactivity feedback mechanism during temperature transients in heavy liquid metal fast reactors. It is shown that by the proper use of heavy pellets in the fuel elements, fuel rods could be endowed with a passive self-ejection mechanism and then with a negative feedback. A first estimate of the feasibility of the mechanism is calculated by using a simplified geometry and model. If in addition, a neutron poison pellet is introduced at the bottom of the fuel, then when the fuel element is displaced upward by buoyancy force, the reactivity will be reduced not only by disassembly of the core but also by introducing the neutron poison from the bottom. The use of induced buoyancy opens up the possibility of introducing greater amounts of actinides into the core, as well as providing a palliative solution to the problem of positive coolant temperature reactivity coefficients that could be featured by the heavy liquid metal fast reactors.

• 한국통신학회논문지
• /
• 제32권10B호
• /
• pp.630-637
• /
• 2007

본 논문에서는 현재의 Mobile IPv6 메커니즘을 개선한 방식으로서 이동단말의 정보 공유를 통한 주소 중복 검사 생략과 2 계층에서의 이벤트를 이용한 예상된 핸드오프 기법 그리고 패킷 지연을 줄이기 위해 터널링 기법을 이용하는 방법과 효과적인 자원예약을 위해 2 계층에서의 이벤트를 이용한 anticipated-reservation 메커니즘을 제안한다. 제안한 핸드오프 메커니즘은 기존의 방식에 비해 핸드오프 시 데이터 수신 지연을 줄이고 터널링 되는 시간을 단축함으로써 라우터 간의 데이터 트래픽 양을 줄인다. 또한 anticipated-reservation 메커니즘은 자원예약을 수행하기 위해 자원을 미리 예약한다. 제안한 이동통신망에서의 핸드오프 메커니즘은 시뮬레이션을 통해 성능을 검증하였고 anticipated-reservation 메커니즘은 새로운 에이전트의 도입과 메시지 흐름을 이용하여 타당성을 입증하였다.

• Archives of Pharmacal Research
• /
• 제28권9호
• /
• pp.1065-1072
• /
• 2005

The nascent thyroglobulin (Tg) multimer molecule, which is generated during the initial fate of Tg in ER, undergoes the rapid reductive depolymerization. In an attempt to determine the depolymerization process, various types of Tg multimers, which were generated from deoxy­cholate-treated/reduced Tg, partially unfolded Tg or partially unfolded/reduced Tg, were subjected to various GSH (reduced glutathione) reducing systems using protein disulfide isomerase (PDI), glutathione reductase (GR), glutaredoxin or thioredoxin reductase. The Tg multimers generated from deoxycholate-treated/reduced Tg were depolymerized readily by the PDI/GSH system, which is consistent with the reductase activity of PDI. The PDI/GSH-induced depolymerization of the Tg multimers, which were generated from either partially unfolded Tg or partially unfolded/reduced Tg, required the simultaneous inclusion of glutathione reductase, which is capable of reducing glutathionylated mixed disulfide (PSSG). This suggests that PSSG was generated during the Tg multimerization stage or its depolymerization stage. In particular, the thioredoxin/thioredoxin reductase system or glutaredoxin system was also effective in depolymerizing the Tg multimers generated from the unfolded Tg. Overall, under the net GSH condition, the depolymerization of Tg multimers might be mediated by PDI, which is assisted by other reductive enzymes, and the mechanism for depolymerizing the Tg multimers differs according to the type of Tg multimer containing different degrees and types of disulfide linkages.

• Toxicological Research
• /
• 제16권2호
• /
• pp.133-139
• /
• 2000

This study was designed to evaluate the mechanism by which reactive nitrogen intermediates (RNI) induced the cytotoxicity of human doparminergic neuroblastoma SH-SY5Y cells. 3-Morpholino-sydnonimine (SIN-l), a donor of peroxynitrite (ONOO) and sodium nitroprusside (SNP), a donor of nitric oxide (NO) induced cell detachment and apoptotic death, as characterized by chromatin condensation, the ladder pattern fragmentation of genomic DNA and morphological nuclear changes. SIN-l also induced the activation of caspase 3-like protease in a time-dependent manner. Exogenous antioxidants, such as reduced glutathione (GSH), N-acetylcysteine (NAC), and selenium protected the cells from apoptotic death and reduced the activation of caspase 3-like protease by SIN-1. Furthermore, SIN-l directly reduced the intracellular levels of glutathione. Taken together, these data suggested that RNI including NO and peroxynitrite decrease the concentration of intracellular antioxidant such as GSH, which lead to the apoptotic death of human neuroblastoma SH-SY5Y cells.

• 산업기술연구
• /
• 제24권B호
• /
• pp.83-87
• /
• 2004

A reduced structure model of a wind turbine generator is designed and manufactured. Mode data are obtained by modal testing and analytical method. Vibration response is measured and investigated under various speed condition by using a waterfall plot. Possibility of severe resonance is observed and the mechanism is explained by using the mode data. Simplified theoretical model gives the 1st resonance frequency of wind turbine structure model. The theoretical model can be applied in the design stage of the wind turbine structure to avoid the severe resonance problem.

• 대한기계학회논문집B
• /
• 제27권10호
• /
• pp.1401-1411
• /
• 2003

A two-dimensional direct numerical simulation was performed to investigate the flame structure of CH$_4$$N_2$-air counterflow nonpremixed flame interacting with a single vortex. The detailed transport properties and a modified 16-step augmented reduced mechanism based on Miller and Bowman's detailed chemistry were adopted in this simulation. The characteristic vortex and chemical time scales were introduced to quantify and investigate the extinction phenomenon during a flame-vortex interaction. The results showed that fuel- and air-side vortex cause an unsteady extinction. In this case, the flame interacting with a vortex was extinguished at much larger scalar dissipation rate than steady flame. It was also found that the air-side vortex extinguished a flame more rapidly than the fuel-side vortex. Furthermore, it was noted that the degree of unsteady effect experienced by a flame can be investigated by comparing the above two characteristic time scales, and this analysis could give an appropriate reason for the results of the previously reported experiment.