• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.323-329
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• 1997

Ipriflavone is non-hormonal antiosteoporotic drug which inhibits bone resorption by reducing recruitment and/or differentiation of osteoclasts, and stimulates proliferation and differentiation of osteoblast, and also enhances calcitonin secretion in the presence of estrogen. Although some kinds of immediately-released preparation of ipriflavone are available in commercial market, in present study, we tried to formulate sustained-release tablet using coating method with hydrophobic and hydrophilic coating materials. In vitro dissolution test was applied to evaluate sustained-release patterns of several test preparations (Test tablet A, B and C) designed using different preparation method or different compositions. From the results of dissolution test, test tablet A which showed suitable dissolution profile was selected as the candidate of new product. Pharmacokinetic evaluation of test drug, ipriflavone sustained-release tablets, was conducted in 6 beagle dogs weighing $11.5{\pm}0.5\;Kg$ compared with $Theobon^{\circledR}$ tablet, immediately-released tablet (Kukjae Pharm. Co.) as reference drug. Two products were randomly administered to 6 beagle dogs, and after 1 week, cross-over study was conducted. From the present study, AUC and $T_{max}$ of test product were significantly different from those of reference product (p<0.05), respectively$(AUC\;:\;3646.28{\pm}472.56\;vs\;3646.28{\pm}472.56\;ng{\cdot}hr/ml,\;T_{max}\;:\;4.33{\pm}1.03\;vs\;1.42{\pm}0.38\;hr)$. But $C_{max}$ was not significantly different between two products (p>0.05) $(\;512.52{\pm}48.18\;vs\;443.97{\pm}140.53\;ng/ml)$. From the results of pharmacokinetic evaluations, it was noted that absorption amount of test product was increased, but absorption rate was delayed and $C_{max}$ of two products were not changed. And it was concluded that redesign of the sustained-release preparation which has a lower content of iprifavone rather than test tablet A must be considered.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.373-380
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• 2020

A valve product can be over-designed or too heavy. Finite element analysis was performed using ANSYS for two and three-dimensional ball valve models, and the ball weight was reduced by optimization within the allowable design criteria. The ball is structurally safe according to the computed stress values, which are within the material's admissible stress. The weight was reduced by about 22%, and the structural safety factor was 1.25. The structural safety of the seat insert and ring, which are used to prevent leakage, was confirmed through finite element analysis. It is shown that the two-dimensional analysis can result in similar values to the three-dimensional analysis for the axisymmetric structure. The redesign of the valve is not included in the results since such changes require a whole new design process, including all valve components.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.4
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• pp.1216-1221
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• 2010

An industrial growth needs high quality of productivity and accuracy. So, the needs of power electronics became pressing. Recently both interest and demand about the technique of power electronics systems has been increased. Though power electronics has a lot of strong point, there are several problems which are harmonic effect, EMI(Electromagnetic Interference), malfunction of electric machinery, harmful effect on human, audible noise and so on. Because these problem are a potent influence on motor, so there needs the manufacture and redesign of motor. The real motors of industrial application have designed and manufactured on the basis of confidence. The study on motor using utility power source was verified sufficient to identify confidence of electric machinery on utility power source. However, a study on confidence is in progress about pulse source by switching device. An advanced company are studying to solve this problem. In this research, it is studied that each variables effecting motor reliability have correlation through experiment and more over forecasting the reliability of motor under inverter operation.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2005.11a
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• pp.353-357
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• 2005

LOx post damage occurs from the development process of the full-scale gas generator which is necessary to 30 tonf class engine development was described. The cause and analysis for damage was described. The combustion test result of 4 injector, the full-scale gas generator and redesigned injector was described. Combustion instability, purge, the low momentum of LOx spray, small recess number, the low flow of LOx, and the high spray angle is main reason the possibility of knowing. The redesign for the injector in the direction of increase of recess number, increase of LOx and fuel spray angle, decrease of gap interval between the LOx post outer wall and fuel screen and increase of LOx post wall thick became accomplished.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.36
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• pp.143-170
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• 2007

In order to analyze the distribution channel of marine products in Korea, this study shows SCM approach to redesign of the marine distribution channel with case study related to previous literatures. In view of the supply chain and the future impact of RFID on the marine SCM on the recognition of the importance of the seafood traceability system, this study also provides the possibility to accomplish effective SCM for integration of production, storage, transportation, delivery, and sale when RFID is used in the seafood distribution channel based on the expansion of awareness on the marine product traceability. The traceability system for seafood is considered as the distribution infrastructure established in RFID deployment. By introducing Lotte mart case, this case study also discusses the marine distribution structure in view of the supply chain, to present an effective foundation for supplying seafood throughout production, distribution, and consumption. This is achieved by introducing RFID in an ubiquitous environment, and suggesting far more efficient control planning throughout the seafood distribution channel in view of the expected effects resulting from the introduction. In addition, as the alternative of solving this situation, this study propose the supply chain in seafoods by comprehensive management in whole distribution channels. In the SCM in seafood perspectives, HACCP can take into account the whole seafood chain from the point of supply to the point of consumption when assessing hazards. As the contributions of this study, this study emphasizes the seafood industry first should require the establishment of the relevant infrastructure, for which the efforts of the government and demonstrative project participants are essential.

• Journal of Korea Multimedia Society
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• v.13 no.8
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• pp.1221-1234
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• 2010

MANET(Mobile Ad-hoc Network)s have been researched primary at routing protocols and at the guarantees of QoS(Quality of Service) for mobile environments. Otherwise the Ubiquitous Sensor Networks (USNs) have some limitations in power energies and in processing of sensing data, as well as their network topologies are frequently changed by fading off and node failures. Thus we should redesign network protocols with concerning to energy efficiency for the USNs above all. In this paper, we focus on the protocol interface for managing for USNs based on the surveys. And then we figure the topology of USNs out and design the network protocol interface to make power saved, with data gathering and processing more efficient using our designed packet structures.

• The Journal of the Korea Contents Association
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• v.18 no.5
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• pp.11-22
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• 2018

This study examines the structure and contents of the various programs offered by the Cologne City Library in Cologne, Germany, and discusses its implications for the role of the changing public libraries in the era of the Fourth Industrial Revolution. The Cologne Municipal Library, which has continuously played a leading role in the education of German libraries since its opening, has been transforming itself to become a center for producing information and knowledge and developing culture in accordance with the dynamic era of the Fourth Industrial Revolution. Currently, the Cologne Municipal Library plays a role as a multi-cultural space in the community where local members can experience various cultures, such as movies, music and games, and create a culture, beyond the traditional functions of library collection and preservation. The program of the City Library in Cologne, Germany, will help to redesign the functions and roles of public libraries in Korea in the future, and plan library contents for local members.

• Journal of the Korea Society for Simulation
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• v.15 no.3
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• pp.93-101
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• 2006

Recently, work-related musculoskeletal disorders (WMSDs) become a hot issue in the industrial fields. To prevent the potential risk of workers, various approaches have been adopted. One of the approaches is to improve the design of product, that of jig (or fixture) and that of workstation in the early stage of the development. 3D simulation technology is known as the powerful method for detecting such problems before constructing the workstation, because it is possible to evaluate the posture of worker using 3D models in a cyber space. It enables to find the unexpected problems and save the time and cost for redesign and rework. This paper introduces a 3D simulation case study of workers in an excavator factory. 3D models of products, jigs were developed with CATIA. The assembly processes were animated in IGRIP and DPM. Finally the various postures of worker were simulated using Human. As a result, some postures were analysed as the risky jobs and the result of simulation was used to improve the system.

• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.196-202
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• 2020

This study explores conceptions of learning management and examines the effects on study approach and critical thinking. Undergraduates majoring or minoring in management were gathered through convenient sampling and participated in the online survey. A total of 88 responses were analyzed. The results reveal that there is no significant gender or grade difference on conceptions of learning management. Conceptions of "test" and "seeing in a new way" are associated with deep study approach, whereas conceptions of 'test' is associated with surface study approach. Conceptions of "seeing in a new way" has a significant effect on critical thinking. The findings may inform redesign of instruction or curriculum especially focusing on improving high-quality thinking skills as the learning outcomes.

• Tribology and Lubricants
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• v.36 no.2
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• pp.75-81
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• 2020

In this paper, we present an experimental investigation of the leakage and endurance performances of mechanical face seals in a 75-tonf turbopump for the Korea Space Launch Vehicle II first-stage engine. A mechanical face seal is used between the fuel pump and turbine to prevent mixing of the fuel and turbine gas. However, excessive leakage occurs through the carbon attached to the mechanical face seal bellows. To reduce this leakage, we redesign the mechanical face seal such that the contact area between the fuel and carbon is reduced, height of the carbon nose is reduced, and stiffness of the bellows is increased. Then, we conduct static and dynamic leakage tests and endurance tests to compare the performances of the original and modified mechanical face seals. The investigation of the leakage of the old and new mechanical face seals confirms that the leakage performance is significantly improved, by 80%, in the new design in comparison with the old design. The endurance tests demonstrate that the average wear rate of carbon in the new mechanical face seal is 0.1094 ㎛/s. The service lifetime is predicted to be 4,200 s, which is 28 times greater than the requirement. Finally, we present a new mechanical face seal in a 75-tonf turbopump, and perform a validation test in the real-propellant test facility at the NARO Space Center. Based on the test results, we can confirm that the modified mechanical face seal works well under real operating conditions.