• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권4호
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• pp.329-345
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• 2020

Purpose: This was a nationwide population-based study conducted to investigate the epidemiology, treatment, disease outcomes, and associated factors of childhood intussusception in South Korea. Methods: Data from the Korean National Health Insurance Service database on all patients <18 years old diagnosed with intussusception from 2007 to 2017 were analyzed. Results: A total of 34,688 cases were identified among 30,444 patients. The overall incidence was 28.3/100,000 person-years with a male predominance. Most cases (83.1%) occurred in children <3 years old, with an annual incidence of 195.2, 200.1, and 118.6 cases per 100,000 children in their first, second, and third year of life, respectively. The median age at the first occurrence was 18.7 months, and it was higher in boys than in girls. The post-discharge recurrence rate was 10.6% (3,226/30,444) and the in-hospital recurrence rate was 6.1% (1,842/30,444). The total recurrence rate (post-discharge recurrence and/or in-hospital recurrence) was 15.0% (4,580/30,444). Enema reduction was successful in 90.0% of cases. Enema reduction was more successful in girls than in boys. A total of 3,296 (10.8%) patients underwent 3,481 surgeries, including 735 (21.1%) laparoscopic surgeries. Post-discharge recurrence and surgery were significantly affected by age, sex, and hospital type. Mortality was noted in nine cases (0.03%). Conclusion: Our study provides accurate epidemiologic data on the treatment and outcomes of intussusception through complete enumeration during an 11-year-period.

• 한국산학기술학회논문지
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• 제12권11호
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• pp.5094-5101
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• 2011

위암 완치수술을 받은 환자들의 재발수준과 재발에 미치는 영향을 파악하고자 2010년 9월부터 2011년 5월까지 한 대학병원에서 위암으로 진단받고 수술받은 환자 386명을 대상으로 조사하였다. 이들의 의무기록지와 병원암등록 자료에서 인구사회학적 특성, 생화학적 검사치, 임상병리학적 특성 등을 조사하였으며, 통계학적 검증으로 카이스퀘어 검정과 로지스틱 회귀분석을 실시하였다. 전체 조사대상자의 위암 재발률은 2.6%이었고, 성별 재발률은 남자에서 3.45%, 여자는 0.89%로 남자가 여자보다 약 4배정도 높았다. 단변량 로지스틱 회귀분석에서 재발이 발생할 위험은 림프전이가 있을수록 8.793배, 헬리코박터 파이로니균에 감염시 6.495배, 총콜레스테롤이 비정상일 때 14.333배 높았다. 다변량 로지스틱 회귀분석에서 림프전이와 헬리코박터 파이로니 감염이 재발에 중요한 요인으로 작용하였다. 결론적으로 위암의 재발에는 림프전이, 헬리코박터 파이로니 감염과 총콜레스테롤을 관리하고, CEA 및 CRP와 같은 생화학적 물질을 모니터링하여 재발을 조기에 발견하기 위한 노력이 함께 필요할 것으로 보인다.

• Parasites, Hosts and Diseases
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• 제54권6호
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• pp.733-742
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• 2016

Acquaintance is scanty on primaquine (PQ) efficacy and Plasmodium vivax recurrence in Udupi district, Karnataka, India. We assessed the efficacy of 14 days PQ regimen (0.25 mg/kg/day) to prevent P. vivax recurrence. Microscopically, aparasitemic adults (${\geq}18years$) after acute vivax malaria on day 28 were re-enrolled into 15 months' long follow-up study. A peripheral blood smear examination was performed with participants at every 1-2 month interval. A nested PCR test was performed to confirm the mono-infection with P. vivax. Of 114 participants, 28 (24.6%) recurred subsequently. The median (IQR) duration of the first recurrence was 3.1 (2.2-5.8) months which ranged from 1.2 to 15.1 months, including initial 28 days. Participants with history of vivax malaria had significantly higher risk of recurrence, with hazard ratio (HR) (95% CI) of 2.62 (1.24-5.54) (P=0.012). Severity of disease (11.4%, 13/114) was not associated (P=1.00) with recurrence. Of 28 recurrence cases, the nPCR proved that P. vivax mono-infection recurrence rate was at least 72.7% (16/22) at first recurrence. In Udupi district, PQ dose of 0.25 mg/kg/day over 14 days seems inadequate to prevent recurrence in substantial proportion of vivax malaria. Patients with a history of vivax malaria are at high risk of recurrences.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2001년도 춘계학술대회 논문집
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• pp.74-80
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• 2001

The estimation of recurrence interval for fault activity and earthquake is an important input parameter for seismic hazard assessment. In this study, the methods of recurrences interval estimation were reviewed and tentative calculation was performed for age dating data which have uncertainty. Age dating data come from previous studies of Ulsan fault system which is a well developed lineament in the southeastern part of korean Peninsula. Age dating for fault gouges, parent rocks, Quaternary sediments and veins were carried out by several researchers through various methods. Recurrence interval for fault activity was estimated on the basis of the age dating data of minor fault gouge and sediments during past 3Ma. The estimated recurrence interval was about 430-500 ka. Exact estimation of recurrence interval for fault activity need to compile more geological data and fault characteristics such as fault length, amount of displacement, slip rate and accurate fault movement age. In the future, the methods and results of fault recurrence interval estimation should be considered for establishing the criteria for domestic active fault definition.

• 대한족부족관절학회지
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• 제8권1호
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• pp.97-100
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• 2004

1993년 3월부터 2003년 4월까지 성분도 병원 정형외과에서 족부 및 족관절 결절종의 진단으로 수술적 치료를 받은 17예의 경우에서 추적 관찰한 결과 다음의 결론을 얻을 수 있었다. 1. 위치는 족배측(Zone III)이 가장 많았고 수술 적응증은 동통 12예(70.6%)로 가장 많으며 외관상의 문제 4예 (23.5%), 신경학적 증상과 동통이 동반된 경우 1예 (5.9%)였다. 2. 족부 및 족관절의 결절종은 재발률이 비교적 높다. 따라서 술전에 환자에게 이에 대한 충분한 설명이 필요하다. 3. 족부 결절종의 수술은 관절낭의 연결 부위와 종괴의 완전한 적출이 재발을 낮추는데 도움이 될 수 있으나 해부학적인 특성상 어려움이 있어 시술전 정확한 종괴에 대한 평가와 수술시 결절종의 완전한 제거에 노력해야 할 것이다.

• Journal of Chest Surgery
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• 제40권5호
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• pp.356-361
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• 2007

배경: 암에 대한 수술적 치료의 치근의 발전은 임상적으로 가장 혁신적인 발전 중의 하나이다. 저자들은 비소세포성 폐암환자에서 시행한 수술적 치료의 효과를 검토해 보았다. 대상 및 방법: 1995년부터 2005년까지 저자들이 수술적 치험한 증례 중 완전 절제가 시행되었던 폐암환자 432예를 대상으로 하여 임상적 소견들과 수술방법 그리고 재발 양상 등에 대하여 분석하였다. 결과: 폐엽절제술이 가장 많이 시행되었으며(66.7%),소매 폐엽절제술(5.6%)이 가장 적게 시행되었다. 179예(42.6%)에서 관찰기간 중 재발이 확인되었으며, 국소 재발 예는 67예(16.0%)로서 전신적 재발 112예(26.7%)보다 현저히 작았다. 주된 국소 재발 부위는 폐문부(37.3%)와 동측 종격동(25.4%)이었으며, 병원 사망률은 2.8% (12/432예)였고 수술 유병률은 12.5% (52/432예)였다. 결론: 낮은 사망률과 국소 재발률을 얻었으며, 따라서 저자들의 수술적 치료방법은 안전하며 유효한 방법이라고 생각되었다.

• Journal of Korean Neurosurgical Society
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• 제52권1호
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• pp.14-20
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• 2012

Objective : Intracranial meningiomas are primarily benign tumors with a good prognosis. Although WHO grade II meningiomas are rare (2-10%), WHO grade II meningiomas have higher recurrence and mortality rates than benign. We evaluated the patient recurrence rate and investigated the prognostic factors of WHO grade II meningiomas. Methods : Between 1993 and 2005, 55 patients were diagnosed with WHO grade II meningiomas in our hospital. WHO grade II meningiomas (n=55) were compared with other WHO grades meningiomas (I, n=373; and III, n=20). The patients had a median age of 48.4 years (range, 14-17 years), a male-to-female ratio of 26 : 29, and a mean follow-up time of 45 months (range, 3-175 months). Results : In WHO grade II meningiomas, only the extent of resection was a significant prognostic factor. Post-operative radiotherapy had no significant influence on tumor recurrence (p=0.053). The relative risk of recurrence was significantly higher in WHO grade II meningiomas with incomplete resection (10/27, RR=37%) than in WHO grade II meningiomas with complete resection (4/28, RR=14%) regardless of post-operative radiotherapy. In the incomplete resection group, Simpson grade III or IV had a significantly high risk of recurrence regardless of post-operative RT (n=3, RR=100%) However, if the degree of resection was Simpson grade II, the recurrence rate was similar to the complete resection group even though post-operative RT was not performed. Conclusion : Complete resection was the most powerful independent predictive factor of the recurrence rate in WHO grade II meningiomas. Post-operative adjuvant RT was not a significant factor in this study.

• Radiation Oncology Journal
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• 제1권1호
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• pp.85-94
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• 1983

A total of 47 patients with a diagnosis of nasopharyngeal carcinoma was treated in Department of Therapeutic Radiology, Seoul National University Hospital during last 4 years. Of the 47 patients, 23(49%) had undifferentiated carcinoma, 20(43%) had squamous cell carcinoma, while 4(8%) had lymphoepithelioma. Most of the patients(71%) has Stage IV disease, cervical lymph node metastases were found in 36(77%) and distant metastasis was found in 1 at the time of diagnosis. Complete response rate after radiotherapy for 47 patients of nasopharyngeal carcinoma was 85.1%. The overall actuarial 3 year survival rates was 0.718 and the disease free actuarial 3 year survival rates was 0.468. Nodal involvement and symptom duration were statistically significiant influencing factors for actuarial survival rate. Treatment failures were found in 20 patients (42.6%), local recurrence only in 6(30%), local and neck recurrence in 3(15%), local recurrence with metastasis in 4(20%) and distant metastasis only in 7(35%). Local failures were more frequent in the patients with cranial nerve symptoms (P=0.032). Distant metastases were more frequent with T4 lesions (P=0.047), and with nodal involvement (P<0.01). Retreatment after the tumor recurrence was chemotherapy and/or radiotherapy, two pationts refreated for local recurrence were alive without evidence of disease for more than 19 and 44 months after retreatment.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권5호
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• pp.207-216
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• 2013

Objectives: The purpose of this study is to analyze clinical impact factors on the survival rate, and to acquire basic clinical data for the diagnosis of oral cancer, for a determination of the treatment plan with long-term survival in oral cancer patients. Materials and Methods: Through a retrospective review of the medical records, the factors for long-term survival rate were analyzed. Thirty-seven patients, among patient database with oral cancer treated in the Department of Oral and Maxillofacial Surgery at Pusan National University Hospital within a period from March 1998 to March 2008, were selected within the study criteria and were followed-up for more than 5 years. The analyzed factors were gender, age, drinking, smoking, primary tumor site, type of cancer, TNM stage, recurrence of affected region, and metastasis of cervical lymph node. The 5-year survival rate on the impact factors was calculated statistically using the Kaplan-Meier method. Results: By classification of clinical TNM at the 1st visit, there were 11 (29.7%) cases for stage I, 11 (29.7%) cases for stage II, 3 (8.1%) cases for stage III, and 12 (32.5%) cases for stage IV. The 5-year survival rate of total oral cancer patients after the operation were 75.7%, pathological TNM stage related 5-year survival rate were as follows: stage I 90.0%, stage II 81.8%, stage III 100% and stage IV 45.5%; in which the survival rate difference by each stage was significantly observed. The recurrence of cervical lymph node was the significant impact factor for the survival rate, because only 30.0% the survival rate in recurrent cases existed. During the follow-up, there were 15 (40.5%) patients with confirmed recurrence, and the 5-year survival rate of these patients was decreased as 46.7%. Conclusion: The classification of clinical and pathological TNM stage, local recurrence after surgery, and metastasis of cervical lymph node after surgery were analyzed as the 3 most significant factors.

• Journal of Chest Surgery
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• 제56권6호
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• pp.403-411
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• 2023

Background: The concept of oligo-recurrence has not been generally applied in esophageal cancer. This study aimed to determine the prognostic significance of the number of recurrences in esophageal cancer. Methods: Patients with squamous cell carcinoma who underwent curative esophagectomy with R0 or R1 resection and who experienced a confirmed recurrence were included. The study included 321 eligible participants from March 2001 to December 2019. The relationship between the number of recurrences and post-recurrence survival was investigated. Results: The mean age was 63.8±8.1 years, and the majority of the participants (97.5%) were men. The median time to recurrence was 10.7 months, and the median survival time after recurrence was 8.8 months. Multiple recurrences with simultaneous local, regional, and distant locations were common (38%). In terms of the number of recurrences, single recurrences were the most common (38.3%) and had the best post-recurrence survival rate (median, 17.1 months; p<0.001). Patients with 2 or 3 recurrences showed equivalent survival to each other and longer survival than those with 4 or more (median, 9.4 months; p<0.001). In the multivariable analysis, the significant predictors of post-recurrence survival were body mass index, minimally invasive esophagectomy, N stage, R0 resection, post-recurrence treatment, and the number of recurrences (p<0.05). Conclusion: After esophagectomy, the number of recurrences was the most significant risk factor influencing post-recurrence survival in patients with esophageal cancer. In esophageal cancer, oligo-recurrence can be defined as a recurrence with three or fewer metastases. More intensive treatment might be recommended if oligo-recurrence occurs.