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아세트아미노펜 중독 환자에서 간독성 발생 예측인자들의 유용성 (Usefulness of Predictors for Hepatotoxicity in Acetaminophen Poisoning Patient)

  • 김은영;정성필;고동률;공태영;유제성;좌민홍;김민정
    • 대한임상독성학회지
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    • 제16권2호
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    • pp.149-156
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    • 2018
  • Purpose: The purpose of this study was to determine whether hepatotoxicity could be predicted early using biochemical markers in patients with acetaminophen (AAP) poisoning and to assess the usefulness of predictive factors for acute liver injury or hepatotoxicity. Methods: This study was a retrospective observational study involving a medical records review. The participants were patients who were admitted to the emergency department (ED) with AAP overdose at two hospitals over a 10-year period. Demographic data, age, time from ingestion to visit, initial AAP level, initial hepatic aminotransferases, and initial prothrombin time were recorded. Acute liver injury was defined as a peak serum ALT >50 U/L or double the admission value, and hepatotoxicity was defined as a peak ALT >1,000 U/L. Receiver operating characteristic curve analyses were performed to compare the prognostic performance among variables. Results: A total of 97 patients were admitted to the ED with AAP overdose, of whom 26 had acute liver injury and 6 had hepatotoxicity. Acute liver injury was associated with the time interval after taking the drug, and hepatotoxicity was associated with the initial PT and the ALT level. The scoring system proposed by the authors has a significant ability to predict both acute liver injury and hepatotoxicity. Conclusion: To predict the prognosis of AAP poisoning patients, the time interval after taking AAP was important, and initial prothrombin time and ALT level were useful tests. Also a scoring system combining variables may be useful.

Performance of passive and active MTMDs in seismic response of Ahvaz cable-stayed bridge

  • Zahrai, Seyed Mehdi;Froozanfar, Mohammad
    • Smart Structures and Systems
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    • 제23권5호
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    • pp.449-466
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    • 2019
  • Cable-stayed bridges are attractive due to their beauty, reducing material consumption, less harm to the environment and so on, in comparison with other kinds of bridges. As a massive structure with long period and low damping (0.3 to 2%) under many dynamic loads, these bridges are susceptible to fatigue, serviceability disorder, damage or even collapse. Tuned Mass Damper (TMD) is a suitable controlling system to reduce the vibrations and prevent the threats in such bridges. In this paper, Multi Tuned Mass Damper (MTMD) system is added to the Ahvaz cable stayed Bridge in Iran, to reduce its seismic vibrations. First, the bridge is modeled in SAP2000 followed with result verification. Dead and live loads and the moving loads have been assigned to the bridge. Then the finite element model is developed in OpenSees, with the goal of running a nonlinear time-history analysis. Three far-field and three near-field earthquake records are imposed to the model after scaling to the PGA of 0.25 g, 0.4 g, 0.55 g and 0.7 g. Two MTMD systems, passive and active, with the number of TMDs from 1 to 8, are placed in specific points of the main span of bridge, adding a total mass ratio of 1 to 10% to the bridge. The parameters of the TMDs are optimized using Genetic Algorithm (GA). Also, the optimum force for active control is achieved by Fuzzy Logic Control (FLC). The results showed that the maximum displacement of the center of the bridge main span reduced 33% and 48% respectively by adding passive and active MTMD systems. The RMS of displacement reduced 37% and 47%, the velocity 36% and 42% and also the base shear in pylons, 27% and 47%, respectively by adding passive and active systems, in the best cases.

Relevance of emergency level assessment by the Korean Triage and Acuity Scale for adult patients in a local emergency medical center

  • ;이숙희
    • 대한응급의학회지
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    • 제29권6호
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    • pp.595-602
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    • 2018
  • Objective: The Korean Triage and Acuity Scale (KTAS), which was implemented in 2016, needs to be assessed for its validity and reliability. Here we evaluate the relevance of emergency level assessment by analyzing the validity of KTAS as a Korean standardized triage system. Methods: We retrospectively analyzed the medical records of adults who presented to a local emergency room (ER) during an 18-month period. We compared medical resources used, life-saving interventions performed, length of stay (LOS) in ER, admission rate, and mortality at each KTAS level. Results: Among a total of 40,339 patients, most patients were at KTAS 4 (n=19,532, 48.4%) and the longest median LOS in ER was 450 minutes at KTAS 2. As the KTAS level increased, the percentage of medical resources used and lifesaving interventions performed increased significantly. The odds of total admission and intensive care unit admission were significantly higher at KTAS 1 through 4 compared to those at KTAS 5. The odds related to admission and mortality were also significantly higher at KTAS 3 than at KTAS 4. Conclusion: We concluded that the KTAS, as a Korean standardized triage system of emergency level assessment, is relevant. Further, KTAS 1-3 and KTAS 4-5 are appropriate criteria to distinguish emergency and non-emergency patients.

Slope topography effect on the seismic response of mid-rise buildings considering topography-soil-structure interaction

  • Shabani, Mohammad J.;Shamsi, Mohammad;Ghanbari, Ali
    • Earthquakes and Structures
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    • 제20권2호
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    • pp.187-200
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    • 2021
  • The main factor for the amplification of ground motions near the crest or the toe of a slope is the reflection of the incident waves. The effects of the slope topography on the surrounding lands over the crest or at the toe can amplify the seismic responses of buildings. This study investigates the seismic performance of the slope topography and three mid-rise buildings (five, ten, and fifteen-storey) located near the crest and toe of the slope by 3D numerical analysis. The nonlinear model was used to represent the real behavior of building and ground elements. The average results of seven records were used in the investigations. Based on the analysis, the amplification factor of acceleration near the crest and toe of the slope was the most effective at distances of 2.5 and 1.3 times the slope height, respectively. Accordingly, the seismic performance of buildings was studied at a distance equal to the height of the slope from the crest and toe. The seismic response results of buildings showed that the slope topography to have little impact on up to five-storey buildings located near the crest. Taking into account a topography-soil-structure interaction system increases the storey displacement and base shear in the building. Accordingly, in topography-soil-structure interaction analyses, the maximum lateral displacement was increased by 71% and 29% in ten and fifteen-storey buildings, respectively, compare to the soil-structure interaction system. Further, the base shear force was increased by 109% and 78% in these buildings relative to soil-structure interaction analyses.

중국 마임에 대한 역사적 고찰 (A Historical Study on the Mime in Chinese Theater)

  • 안상복
    • 공연문화연구
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    • 제18호
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    • pp.201-221
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    • 2009
  • 본고는 중국 마임에 대해 역사적 고찰을 진행한 글이다. 중국 전통극에서의 마임이 어디에서 기원했는가 하는 문제는 대답하기 매우 어려운 문제이나, 고대 배우들의 행위를 통해서 대략적이나마 초기의 자취가 발견된다. 필자는 사기(史記) "골계(滑稽)열전"에 수록된 초(楚)나라 장왕(莊王: B.C.613-591) 때의 배우 우맹(優孟) 이야기 속에서 그 근거를 찾아 제시할 수 있었고, 이를 근거로 중국의 마임은 최소 2600년 이상의 역사를 지닌것으로 판단하였다. 중국의 마임은 전통극 중에서도 제의극을 통해 형성되었고, 그 발전은 각색행당제(脚色行當制)와 긴밀히 연계되어 진행되었다. 주(做)나 타(打)를 구성하는 대부분의 정식동작(程式動作)들은 최근 몇 세기에 걸쳐 구체화되었지만 그것들의 좀 더 먼 기원은 고대의 무(舞)라 할 수 있다. 그런데 고대의 무는 다시 문무(文舞)와 무무(武舞)로 나뉘어 전개되었으니, 현재의 주나 타에 더 직접적으로 연결된 것은 문무와 무무라 할 수 있다.

Comparison of pregnancy outcomes using a time-lapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: An age-stratification analysis

  • Chera-aree, Pattraporn;Thanaboonyawat, Isarin;Thokha, Benjawan;Laokirkkiat, Pitak
    • Clinical and Experimental Reproductive Medicine
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    • 제48권2호
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    • pp.174-183
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    • 2021
  • Objective: The aim of this study was to compare the pregnancy outcomes of in vitro fertilization with embryo transfer between embryos cultured in a time-lapse monitoring system (TLS) and those cultured in a conventional incubator (CI). Methods: The medical records of 250 fertilized embryos from 141 patients undergoing infertility treatment with assisted reproductive technology at a tertiary hospital from June 2018 to May 2020 were reviewed. The study population was divided into TLS and CI groups at a 1 to 1 ratio (125 embryos per group). The primary outcome was the live birth rate. Results: The TLS group had a significantly higher clinical pregnancy rate (46.4% vs. 27.2%, p=0.002), implantation rate (27.1% vs. 12.0%, p=0.004), and live birth rate (32.0% vs. 18.4%, p=0.013) than the CI group. Furthermore, subgroup analyses of the clinical pregnancy rate and live birth rate in the different age groups favored the TLS group. However, this difference only reached statistical significance in the live birth rate in women aged over 40 years and the clinical pregnancy rate in women aged 35-40 years (p=0.048 and p=0.031, respectively). The miscarriage rate, cleavage rate, and blastocyst rate were comparable. Conclusion: TLS application improved the live birth rate, implantation rate, and clinical pregnancy rate, particularly in the advanced age group in this study, while the other reproductive outcomes were comparable. Large randomized controlled trials are needed to further explore the ramifications of these findings, especially in different age groups.

대출 기록에 기초한 대학 도서관 도서 개인화 추천시스템 개발 및 평가에 관한 연구 (A Study on the Development and Evaluation of Personalized Book Recommendation Systems in University Libraries Based on Individual Loan Records)

  • 홍연경;전서영;최재영;양희윤;한채은;주영준
    • 정보관리학회지
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    • 제38권2호
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    • pp.113-127
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    • 2021
  • 본 연구는 대학 도서관 사용 증진을 위하여 개인별 맞춤 도서 추천시스템을 구축하는 것을 목적으로 한다. 특히 사용자의 아이템에 대한 선호도가 존재하는 다수의 추천시스템과는 달리, 선호도가 존재하지 않을 때에 도서 추천이 가능하도록 하는 방안인 도서관 이용자의 도서 대출 목록과 성향을 활용하여 평가지표를 생성하는 방법을 제안하고자 한다. 이용자가 아직 읽지 않은 책에 대한 예상 선호도를 산출하는 방식으로 도서를 추천하는 행렬 분해 방법인 Singular Value Decomposition(SVD)과 Stochastic Gradient Descent(SGD) 알고리즘을 활용한 모델을 구축했다. 더불어 유사도가 높은 이용자 그룹 내의 도서 대출 목록을 참조하여 추천하는 사용자 기반 협업 필터링 알고리즘을 활용해 모델을 구현했다. 최종적으로 평가지표를 활용한 세 가지 모델에 대하여 사용자 평가를 진행했다. 각각의 모델이 제시한 개인별 맞춤 도서 다섯 권의 목록을 해당 대출자에게 제공하고, 추천 도서에 대한 만족/불만족 여부를 이진화 점수화하여 모델에 대한 평가를 진행했다.

낸드 플래시 메모리 시스템 기반의 지속성을 고려한 핫 데이터 식별 경량 기법 (A lightweight technique for hot data identification considering the continuity of a Nand flash memory system)

  • 이승우
    • 사물인터넷융복합논문지
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    • 제8권5호
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    • pp.77-83
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    • 2022
  • 낸드 플래시 메모리는 구조적으로 쓰기 전 지우기(Erase-Before-Write) 동작이 요구된다. 이것을 해결하기 위해서는 데이터 업데이트 동작이 빈번히 발생하는 페이지(Hot data page)를 구분하여 별도에 블록에 저장함으로 해결할 수 있으며 이러한 Hot data를 분류하는 기법을 핫 데이터 판단기법이라 한다. MHF(Multi Hash Function Framework)기법은 데이터 갱신요청의 빈도를 시스템 메모리에 기록하고 그 기록된 값이 일정 기준 이상일 때 해당 데이터 갱신요청을 Hot data로 판단한다. 하지만 데이터 갱신요청에 빈도만을 단순히 카운트하는 방법으로는 정확한 Hot data로 판단에 한계가 있다. 또한 데이터 갱신요청의 지속성을 판단 기준으로 하는 기법의 경우 갱신요청 사실을 시간 간격을 기준으로 순차적으로 기록한 뒤 Hot data로 판단하는 방법이다. 이러한 지속성을 기준으로 하는 방법의 경우 그 구현과 운용이 복잡한 단점이 있으며 갱신요청에 빈도를 고려하지 않는 경우 부정확하게 판단되는 문제가 있다. 본 논문은 데이터 갱신요청에 빈도와 지속성을 함께 고려한 경량화된 핫 데이터 판단기법을 제안한다.

Validity of the scoring system for traumatic liver injury: a generalized estimating equation analysis

  • Lee, Kangho;Ryu, Dongyeon;Kim, Hohyun;Jeon, Chang Ho;Kim, Jae Hun;Park, Chan Yong;Yeom, Seok Ran
    • Journal of Trauma and Injury
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    • 제35권1호
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    • pp.25-33
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    • 2022
  • Purpose: The scoring system for traumatic liver injury (SSTLI) was developed in 2015 to predict mortality in patients with polytraumatic liver injury. This study aimed to validate the SSTLI as a prognostic factor in patients with polytrauma and liver injury through a generalized estimating equation analysis. Methods: The medical records of 521 patients with traumatic liver injury from January 2015 to December 2019 were reviewed. The primary outcome variable was in-hospital mortality. All the risk factors were analyzed using multivariate logistic regression analysis. The SSTLI has five clinical measures (age, Injury Severity Score, serum total bilirubin level, prothrombin time, and creatinine level) chosen based on their predictive power. Each measure is scored as 0-1 (age and Injury Severity Score) or 0-3 (serum total bilirubin level, prothrombin time, and creatinine level). The SSTLI score corresponds to the total points for each item (0-11 points). Results: The areas under the curve of the SSTLI to predict mortality on post-traumatic days 0, 1, 3, and 5 were 0.736, 0.783, 0.830, and 0.824, respectively. A very good to excellent positive correlation was observed between the probability of mortality and the SSTLI score (γ=0.997, P<0.001). A value of 5 points was used as the threshold to distinguish low-risk (<5) from high-risk (≥5) patients. Multivariate analysis using the generalized estimating equation in the logistic regression model indicated that the SSTLI score was an independent predictor of mortality (odds ratio, 1.027; 95% confidence interval, 1.018-1.036; P<0.001). Conclusions: The SSTLI was verified to predict mortality in patients with polytrauma and liver injury. A score of ≥5 on the SSTLI indicated a high-risk of post-traumatic mortality.

국가지정 입원치료병상에 입실한 COVID-19 환자를 돌보는 간호사의 업무분석 (An Analysis of Tasks of Nurses Caring for Patients with COVID-19 in a Nationally-Designated Inpatient Treatment Unit)

  • 정민호;김문숙;이주연;이경이;박연환
    • 대한간호학회지
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    • 제52권4호
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    • pp.391-406
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    • 2022
  • Purpose: The purpose of this study was to provide foundational knowledge on nursing tasks performed on patients with COVID-19 in a nationally-designated inpatient treatment unit. Methods: This study employs both quantitative and qualitative approaches. The quantitative method investigated the content and frequency of nursing tasks for 460 patients (age ≥ 18 y, 57.4% men) from January 20, 2020, to September 30, 2021, by analyzing hospital information system records. Qualitative data were collected via focus group interviews. The study involved interviews with three focus groups comprising 18 nurses overall to assess their experiences and perspectives on nursing care during the pandemic from February 3, 2022, to February 15, 2022. The data were examined with thematic analysis. Results: Overall, 49 different areas of nursing tasks (n = 130,687) were identified based on the Korean Patient Classification System for nurses during the study period. Among the performed tasks, monitoring of oxygen saturation and measuring of vital signs were considered high-priority. From the focus group interview, three main themes and eleven sub-themes were generated. The three main themes are "Experiencing eventfulness in isolated settings," "All-around player," and "Reflections for solutions." Conclusion: During the COVID-19 pandemic, it is imperative to ensure adequate staffing levels, compensation, and educational support for nurses. The study further propose improving guidelines for emerging infectious diseases and patient classification systems to improve the overall quality of patient care.