• Journal of Ginseng Research
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• 제33권2호
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• pp.132-138
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• 2009

Previous studies suggest that even low-dose irradiation can lead to progressive cognitive decline and memory deficits, which implicates, in part, hippocampal dysfunction in both humans and experimental animals. In this study, whether red ginseng (RG) could attenuate memory impairment was investigated through a passive-avoidance and object recognition memory test, as well as the suppression of hippocampal neurogenesis, using the TUNEL assay and immunohistochemical detection with markers of neurogenesis (Ki-67 and doublecortin (DCX)) in adult mice treated with a relatively low-dose exposure to gamma radiation (0.5 or 2.0 Gy). RG was administered intraperitonially at a dosage of 50 mg/kg of body weight, at 36 and 12 h pre-irradiation and at 30 minutes post-irradiation, or orally at a dosage of 250 mg! kg of body weight/day for seven days before autopsy. In the passive-avoidance and object recognition memory test, the mice that were trained for one day after acute irradiation (2 Gy) showed significant memory deficits compared with the sham controls. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 12 h after irradiation. In addition, the number of Ki-67- and DCX-positive cells was significantly decreased. RG treatment prior to irradiation attenuated the memory defect and blocked apoptotic death as well as a decrease in the Ki-67- and DCX-positive cells. RG may attenuate memory defect in a relatively low-dose exposure to radiation in adult mice, possibly by inhibiting the detrimental effect of irradiation on hippocampal neurogenesis.

• 한국융합학회논문지
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• 제8권2호
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• pp.63-72
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• 2017

본 연구는 간호대학생의 DNR에 대한 융합적 인식 및 윤리적 태도를 파악하여 DNR 환자간호에 도움이 되는 기초자료로 활용하고자 시도하였다. G광역시 4년제 간호대학생 306명을 대상으로 2016년 6월 1일부터 2016년 7월 10일까지 설문조사하였고, SPSS 23.0 Program을 이용하여 최종 분석하였다. 분석결과 DNR에 대한 인식은 DNR의 필요성, 환자와 가족의 의지에 의한 DNR 결정, 문서화된 지침서의 필요성에 찬성하였다. 윤리적 태도는 환자의 의지에 의한 결정, 치료범위, 설명 여부, 지침에 따른 결정에 찬성하였고, 주치의에 의한 결정, 기본간호 제공 감소에는 반대하였다. 일반적 특성에 따른 윤리적 태도는 학년, 임상실습경험, 윤리가치관에 대한 교육경험, DNR에 대한 교육경험, 삶에 대한 만족도, 죽음에 대한 가치관에 따라 유의한 차이가 있었다. 본 연구결과를 토대로 DNR 결정에 관한 기준 및 지침을 마련하기 위한 지속적인 후속연구가 필요하다고 사료된다.

• Journal of Microbiology and Biotechnology
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• 제19권9호
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• pp.911-917
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• 2009

The apoptotic caspases have been classified in accordance with their substrate specificities, as the optimal tetrapeptide recognition motifs for a variety of caspases have been determined via positional scanning substrate combinatorial library technology. Here, we focused on two proteolytic recognition motifs, DEVD and IETD, owing to their extensive use in cell death assay. Although DEVE and IETD have been generally considered to be selective for caspase-3 and -8, respectively, the proteolytic cleavage of these substrates does not display absolute specificity for a particular caspase. Thus, we attempted to monitor the cleavage preference for caspase-3, particularly using the recombinant protein substrates. For this aim, the chimeric GST:DEVD:EGFP and GST:IETD:EGFP proteins were genetically constructed by linking GST and EGFP with the linkers harboring DEVD and IETD. To our best knowledge, this work constitutes the first application for the monitoring of cleavage preference employing the recombinant protein substrates that simultaneously allow for mass and fluorescence analyses. Consequently, GST:IETD:EGFP was cleaved partially in response to caspase-3, whereas GST:DEVD:EGFP was completely proteolyzed, indicating that GST:DEVD:EGFP is a better substrate than GST:IETD:EGFP for caspase-3. Collectively, using these chimeric protein substrates, we have successfully evaluated the feasibility of the recombinant protein substrate for applicability to the monitoring of cleavage preference for caspase-3.

• 철학연구
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• 제137권
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• pp.193-223
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• 2016

본 논문은 "장자"의 철학적 사상을 인식하고 있는 진인(眞人)에 관한 정체성을 분석하고 해석하여 그 것을 파악 한 후에 이론적으로 구성한다. 그리고 그에 따른 장자철학 사상을 고찰하는 데 초점을 두고 작성하는 것을 목적으로 전개하고 있다. "장자" "대종사(大宗師)"에 등장하는 진인의 정체성에 대한 문제의식은 그가 형이상학적 인물이고 그를 나타내는 말들은 현대인이 살펴서 느끼기에 매우 난해한 글로 쓰여 있다. 따라서 진인이 지니고 있는 사색적(思索的) 능력들은 세속적 생활을 하고 있는 인간이 체득하기에는 너무 초월적 개념으로 이루어져 있으며 어쩌면 설화(說話)에 가까운 느낌이 들게 한다. 이러한 진인의 초월적 기능들을 알 수 있는 방법은 장자의 무위(無爲)를 이해하는 데에 있다. 그리고 무위는 만물에 작용하여 생명체를 생성시키는 도리(道理)의 개념을 정리하는 관점에서 만든 언어적 표현으로 볼 수 있다. 여기에는 만물의 생명체들이 자연의 공능에 대하여 불가항력적(不可抗力的) 물리성(物理性)이 내재되어 있는 관점을 간과할 수 없다. 그래서 본고는 자연의 초월적 공능을 진인에서 파악하고 그 원리적 작용을 연구하는데 중점을 두고 있다. 그러면 과연 진인의 안팎은 어떠한 모습을 갖고 있나 궁굼증이 있을 수 있다. 이에 그의 초인적 모습을 "대종사"에서 발췌하여 정리하고, 아울러 그가 천지만물에 대하여 처세하는 방법을 자연적 관점에서 살피고 정리했다. 그런데 여기에서 장자의 글 이외에 유가와 법가의 글이 나타나고 있다. 이것 역시 분석하고 파악하는 절차를 통하여 문제의식을 연구하여 본다. 그러나 조사적(調査的) 개념을 지양(止揚)하고 학문적(學文的) 차원으로 접근하여 동양이 갖고 있는 고유한 정신과 사상을 고찰하는데 중점을 두었다.

• 사상체질의학회지
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• 제12권2호
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• pp.1-7
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• 2000

Greeting the 100 year celebration of the death of Master Dong-mu, through investigating his thoght on Scholarship and Philosophy, and his new view of human being based on Sasang, I tried to reevaluate him as a Confucianist of practical mind. The conclusions were as followings ; 1. Dong-mu's recognition system of things is that based on the mind of summarizing things in view of Affair-Mind-Body-Object originated from Confucianism, and It developed 'the Marvel of Easiness & simpleness based on Yin-yang' into 'the Marvel of Easiness & simpleness based on Sasang' 2 Through understanding old Confucianism newly, Dong-mu summarized human being as having a natural character in view of Nature and Order and an autonomical character in view of Knowledge and Deed, and emphasized an autonomical character in view of Knowledge and Deed 3. In view of Knowledge and Deed, Dong-mu presented How to Say and Behave, and took it as a model of behavior in the new Confucianism. Also he presented the view of Knowledge and Deed based on Constitutions, and took it as a new mind of treatment. 4. Dong-mu can be estimated highly, in that he completed a new confucian view-point of Human being in the period of philosophic chaos, and executed the mind of General health maintenance and the mind of control others through a confucian self-control.

• 의료법학
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• 제9권1호
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• pp.165-196
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• 2008

Recently the Supreme Court held that "in cases in which a patient suffering from a mental disorder attempts to commit suicide, fails, and then succeeds in a subsequent attempt, the following circumstances must be present in order to acknowledge reasonable causation between the negligence of the hospital with regards to taking care of the patient and the death of the patient; there must have existed negligence on the part of the hospital with regards to their failure to stop the 1stsuicide attempt, injurious aftereffects must have been caused to the patient by the1stsuicide attempt, and said aftereffects must have been the main cause for the 2nd successful suicide attemtp." This, in effect, lessens the requirements of past holdings of the Supreme Court which held that "to acknowledge reasonable causation between the negligence of the hospital and the patient that commits suicide, the patient must have experienced such severe physical and mental suffering from the previous attempt so that they could not help but choose to commit suicide". The fact that the Supreme Court did not clearly state such changes in their view on this matter should be corrected. Also, the fact that the court only held the hospital liable for damages of less than 50 million won, only calculating damages up to the point when the deceased passed, is inadequate compared to other cases and should be corrected.

• 중환자간호학회지
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• 제17권1호
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• pp.1-16
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• 2024

Purpose : This study aimed to explore and describe intensive care unit (ICU) nurses' experience of clinical adaptation. Methods : The participants were 14 ICU nurses with more than two years of working experience in the ICU. Data were collected through in-depth individual interviews conducted between July and October 2021. Theoretical sampling was used to the point of theoretical saturation. Data were analyzed using the Strauss and Corbin method. Results : A total of 79 concepts, 37 subcategories, and 16 categories were identified through open coding. Axial coding based on the paradigm model revealed that the central phenomenon was "The harsh adversity faced in the nursing field where life and death are determined" and the core category was "Enduring the adversity of caring for critically ill patients and achieving self-realization." ICU nurses' clinical adaptation process was explained in five phases: "confrontation period," "turbulent period," "seeking period," "struggling period," and "stabilized period." The five phases that affect interventional conditions were "Support from reliable people," "Recognition of administrative and financial support." Conclusion : This study provided novel insights for a comprehensive understanding of ICU nurses' clinical adaptation processes. Furthermore, the findings are expected to be used as basic data to develop multifaceted strategies to help ICU nurses' adaptation to critical care.

• 대한한방내과학회지
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• 제25권3호
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• pp.662-668
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• 2004

Cerebrovascular accident(CVA) is a leading cause of death, and severe sequelae, like motor disturbance, mental disorder, dysphagia, recognition disorder, speech disorder(aphasia) often occur. Most of medical cure about CVA sequelae lay emphasis on motor disturbance, so speech disorder(aphasia) has been neglected. But speech disorder therapy is essential for social rehabiltation. Recently, inside and outside South Korea, various clinical approaches and potential medical cures for speech disorder (aphasia) have been researched. In Korean Medicine, papers pertaining to speech disorders have been but a few. In this study two cases of aphasic stroke patients who were treated for speech and language disorders through Korean medical therapy are reported.

• 한국인터넷방송통신학회논문지
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• 제19권2호
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• pp.237-242
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• 2019

최근, 자율주행 이동체에 대한 대중의 관심도가 높아짐에 따라 자율주행 이동체의 상용화 확대를 위한 유관 기관들의 연구 활동이 꾸준하게 진행되고 있다. 이로 인해, 부분적이지만 실제 사용이 가능한 단계로 발전이 이루어졌다. 하지만, 2018년 3월 우버와 테슬라 자동차로 인해 최초로 두 차례의 사망사고가 발생하였고, 새로운 시스템 보완에 대한 필요성이 대두되고 있다. 이에 본 논문은 자율주행자동차의 사망 사고를 중점적으로 사고 원인을 분석하여 원인이 되었던 사물 인지오류를 확인하고, 이를 보완할 수 있는 시스템의 구현을 위한 새로운 자율주행 이동체의 정보처리 모델을 제안한다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2006년도 추계학술대회 논문집
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• pp.1567-1574
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• 2006

To prevent safety accidents such as injury or death from falling by blocking platforms from trains, the Seoul Metropolitan Subway Corp. have gradually installed screen doors in platforms of 115 subway stations in Seoul on lines 1, 2, 3, and 4. Installation in nine areas among those has been completed and screen doors are being operated as a model operation. Traffic signs should be clear for users. The essential functions of signs should be fully investigated from the aspect of user as well as the visual beauty and recognition. Signs should be able to provide users with information regarding location, position, directions, etc. Particularly, safety and convenient signs should be visually and sensually correlated. However, the entire screen doors in platforms installed in line 2 subway in Seoul are used for commercial advertisement, consequently, the functions and roles as public signs are not fulfilled aggravating inconvenience for users. In this study, cases have been studied to investigate requirements for user-oriented sign system in platform and public sign space to fulfill the functions of sign system in platform. Using an anthropometry approach, the study aimed to obtain the space to install the sign system and to systemize necessary and sufficient conditions for user-oriented system for platform in which screen doors have been installed using. The study suggests fundamental information to obtain the space of public sign system on the entire screen door.