• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.16
• /
• pp.7211-7217
• /
• 2015

Background: The aims of this study were to evaluate the diagnostic and prognostic roles of serum osteopontin (OPN) and single nucleotide polymorphisms (SNPs) in the OPN promoter in patients with hepatitis B-related hepatocellular carcinoma (HCC). Materials and Methods: Four groups were studied, which included 157 patients with HCC, 73 with liver cirrhosis (LC) and 97 with chronic hepatitis (CH), along with 80 healthy subjects. Serum OPN and alpha-fetoprotein (AFP) levels were measured. The SNPs -66 T/G, -156 G/${\Delta}G$ and -433 C/T within the OPN promoter were determined by direct sequencing. Results: Serum OPN levels were significantly higher in patients with HCC than in the other groups. Area under receiver operating characteristics curves in distinguishing HCC from chronic liver disease (CLD; CH and LC) were 0.782 (95% CI; 0.729-0.834) for OPN and 0.888 (95% CI; 0.850-0.927) for AFP. Using the optimal cut-off value (70 ng/mL), OPN had sensitivity and specificity of 72% and 71%, respectively. Serum OPN was superior to AFP in detecting early-stage HCC (68% vs. 46%). A combination of both markers yielded an improved sensitivity for detecting early HCC to 82%. A high OPN level was significantly correlated with advanced BCLC stage and was an independent prognostic factor for HCC. The SNPs -156 and -443 were associated with susceptibility to HCC, but were not related to overall survival. Conclusions: Serum OPN is a useful diagnostic and prognostic marker for HCC. The combined use of serum OPN and AFP improved the diagnosis of early HCC. Genetic variation in the OPN promoter is associated with the risk, but not the prognosis of HCC.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.27 no.5
• /
• pp.445-453
• /
• 2016

This paper presents the implementation and design of the 1T-1R wireless HD video streaming systems over 28 GHz mmWave frequency using 3GPP LTE-TDD standard on NI USRP RIO SDR platform. The baseband of the system uses USRP RIO that are stored in Xilinx Kintex-7 chip to implement LTE-TDD transceiver modem, the signal that are transceived from USRP RIO up or down converts to 28 GHz by using self-designed 28 GHz RF transceiver modules and it is finally communicated HD video data through self-designed $4{\times}8$ sub array antennas. It is that communication method between USRP RIO and Host PC use PCI express ${\times}4$ to minimize delay of data to transmit and receive. The implemented system show high error vector magnitude performance above 25.85 dBc and to transceive HD video in experiment environment anywhere.

• IMMUNE NETWORK
• /
• v.6 no.1
• /
• pp.43-51
• /
• 2006

Background: The DR-$70^{TM}$ immunoassay is a newly developed cancer diagnostic test which quantifies the serum fibrin degradation products (FDP), produced during fibrinolysis, by antibody reaction. The purpose of this study was to evaluate the potential of DR-$70^{TM}$ Immunoassay in screening malignant tumor. Methods: Sample subjects were 4,169 adults, both male and female, who visited the health promotion center of a general hospital from March 2004 to April 2005 and underwent the DR-$70^{TM}$ immunoassay test and other tests for cancer diagnosis. The patient group was defined as 42 adults out of the sample subjects who were newly diagnosed with cancer during the same time period when the DR-$70^{TM}$ immunoassay test was performed. Final confirmation of a malignant tumor was made by pathological analysis. Results: The mean DR-$70^{TM}$ level was $0.83{\pm}0.65{\mu}g/ml$ (range: 0.00 (0.0001)${\sim}7.42{\mu}g/ml)$ in the control group (n=4,127) as opposed to $2.70{\pm}2.33{\mu}g/ml$ (range: $0.12{\sim}9.30{\mu}g/ml)$ in the cancer group (n=42), and statistical significance was established (p<0.0001, Student t-test). When categorized by the type of malignant tumor, all cancer patients with the exception of the subgroups of colon and rectal cancer showed significantly higher mean DR-$70^{TM}$ levels compared with the control group (p<0.0001, Kruscal-Wallis test). The receiver operating characteristic (ROC) curve analysis revealed ${\geq}1.091{\mu}g/ml$ as the best cut-off value. Using this cut-off value, the DR-$70^{TM}$ immunoassay produced a sensitivity of 71.4%, a specificity of 70.1%, a positive predictability of 69.4%, and a negative predictability of 69.2% (1). Conclusion: A significant increase in the mean DR-$70^{TM}$ value was observed in the cancer group (thyroidal, gastric, breast, hepatic and ovarian) com pared with the control group. In particular, the specificity and sensitivity of the DR-$70^{TM}$ immunoassay was relatively high in the subgroups of breast, gastric, and thyroidal cancer patients. There is need for further studies on a large number of malignant tumor patients to see how the DR-$70^{TM}$ level might be changed according to the differentiation grade and postoperative prognosis of the malignant tumor.

• Journal of Advanced Navigation Technology
• /
• v.22 no.5
• /
• pp.415-419
• /
• 2018

This paper predicts and measures the C/N ratio of a beacon signal transmitted from geostationary orbit satellite KorSat 5A ($113^{\circ}E$) at a ground station located in Kimpo. Based on the ground stations, we compared the rain attenuation of the zone K of ITU-R and the rain attenuation which analyzed the domestic weather information. In ITU-R, the Korean rainfall characteristics are classified into zone K, but forecasting the rainfall intensity and attenuation of three adjacent cities based on the cumulative rainfall data per minute from 2013 to 2017. The calculation of rainfall path and attenuation is based on ITU-R recommendations. The change of the C/N according to the rainfall amount was confirmed through the 2 week satellite beacon signal C/N measurement. The predicted critical C/N was decreased to 12 dB at $A_{0.3}$. During the experiment, it was confirmed that it decreased up to 8 dB according to the concentrated rainfall.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.19 no.2
• /
• pp.106-110
• /
• 1983

As the first step to investigate the effect of ship's motion when detecting target with an echo sounder, variations in the incident sound level at the optional position within the sound beam due to roll motion of the transmitter have been measured and calculated. In this experiment, the transmitter (75 KHz) was mounted to the bottom of a FRP model of the 2,275 G. T. stern trawler and the receiver (75 KHz) was installed at each measuring point within the transmitter's beam. Then, the incident sound level was measured for the roll angles from the free roll test on the model ship. For a range of roll angle of $\pm$20$^{\circ}$from the vertical, the measuring values of the incident sound level at each measuring point were rapidly fluctuated from 12.9% to 78.1 depending on the roll angle, and agreed well with the caculated ones. Consquently, we concluded that the effect of ship's motion when detecting target with an echo sounder should be sufficiently considered.

• Journal of the Korean Solar Energy Society
• /
• v.21 no.3
• /
• pp.1-8
• /
• 2001

The chemical heat storage as the one way of utilization for high temperature solar energy was considered. The stram reforming reaction of methane was chosen for endothermic reaction. The reactor was made of stainless steel and the dimension was 6.25 mm I.D. and 30 cm long coiled tube because of the geometry requirement of solar receiver. The methane conversion was increased linearly with reaction temperature and nickel content of catalyst. The methane conversion was 60% at $600^{\circ}C$ and 90% at $900^{\circ}C$. The feasibility of steam reforming of methane as the conversion of solar energy to chemical heat storage was confirmed.

• Journal of the Korean Solar Energy Society
• /
• v.22 no.3
• /
• pp.31-37
• /
• 2002

This experimental study represents the results of an analysis on the characteristics of flux density distributions in the focal region of solar concentrator. The characteristics of flux density distributions are investigated to optimally design and position a cavity receiver. This deemed very useful to find and correct various errors associated with a dish concentrator. We estimated the flux density distribution on the target placed along with focal lengths from the dish vertex to experimentally determine the focal length. It is observed that the actual focal point exists when the focal length is 2.17 m. We also evaluated the position of flux centroid, and it was found that there were errors within 2 cm from the target center. The total integrated power of 2467 W was measured under focal flux distributions, which corresponds to the intercept rate of 85.8%. As a result of the percent power within radius, approximately 90% of the incident radiation is intercepted by about 0.06 m radius.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2002.03a
• /
• pp.751-758
• /
• 2002

Boreholes that are drilled in soft or unconsolidated materials such as gravels and coals are prone to collapse. To maintain the hole, some kinds of casing pipes are needed. If thereby a plastic pipe e.g. PVC is used for the casing, Televiewer tool is still capable of detecting structural features such as fractures in the borehole wall behind the pipe, whereas other borehole-imaging logging devices such as BIPS (Borehole Image Processing System) and FMS(Formation Micro Scanner) won't provide any information about that. Televiewer's primary component is a piezoelectric transducer centered in the hole. It acts as both a transmitter and receiver, and sends an ultrasonic beam. That is reflected, in the same manner as the seismic wave propagation, from the both sides(inner and outer surfaces) of the casing pipe, transmits through the pipe and then reflected from the borehole wall. With an appropriate choice of time-windowing, it is possible to capture the returning signals from both the borehole wall and the outer side of casing pipe as well. A suite of laboratory tests were performed on various physical models composed of plastic pipes with different diameters. Although the amplitudes of returning signals were reduced to about half the usual value due to the transmission loss, the dynamic range of Televiewer tool was sufficient to observe the structural features behind the casing pipe. Besides, several representative case studies at various research areas in our country are presented. The results demonstrate the usefulness of the transmissivity of Televiewer acoustic km, which will assist in further structural interpretation.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.12
• /
• pp.5095-5099
• /
• 2015

Background: The statistical methods to analyze and predict the related dangerous factors of deep fungal infection in lung cancer patients were several, such as logic regression analysis, meta-analysis, multivariate Cox proportional hazards model analysis, retrospective analysis, and so on, but the results are inconsistent. Materials and Methods: A total of 696 patients with lung cancer were enrolled. The factors were compared employing Student's t-test or the Mann-Whitney test or the Chi-square test and variables that were significantly related to the presence of deep fungal infection selected as candidates for input into the final artificial neural network analysis (ANN) model. The receiver operating characteristic (ROC) and area under curve (AUC) were used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. Results: The prevalence of deep fungal infection from lung cancer in this entire study population was 32.04%(223/696), deep fungal infections occur in sputum specimens 44.05%(200/454). The ratio of candida albicans was 86.99% (194/223) in the total fungi. It was demonstrated that older (${\geq}65$ years), use of antibiotics, low serum albumin concentrations (${\leq}37.18g/L$), radiotherapy, surgery, low hemoglobin hyperlipidemia (${\leq}93.67g/L$), long time of hospitalization (${\geq}14$days) were apt to deep fungal infection and the ANN model consisted of the seven factors. The AUC of ANN model($0.829{\pm}0.019$)was higher than that of LR model ($0.756{\pm}0.021$). Conclusions: The artificial neural network model with variables consisting of age, use of antibiotics, serum albumin concentrations, received radiotherapy, received surgery, hemoglobin, time of hospitalization should be useful for predicting the deep fungal infection in lung cancer.

• Journal of radiological science and technology
• /
• v.46 no.5
• /
• pp.367-377
• /
• 2023

This study investigates the utility of the Triglyceride-glucose(TyG) index and Cardiometabolic Index(CMI) as predictors for diagnosing metabolic syndrome. The study involved 1970 males, 1459 females, totaling 3429 participants who underwent health checkups at P Hospital in Busan between January 2023 and June 2023. Metabolic syndrome diagnosis was based on the presence of 3 or more risk factors out of the 5 criteria outlined by the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI), and participants with 2 or fewer risk factors were categorized as normal. Statistical analyses included independent sample t-tests, chi-square tests, Pearson's correlation analysis, Receiver Operating Characteristic(ROC) curve analysis, and logistic regression analysis, using the Statistical Package for the Social Sciences(SPSS) program. Significance was established at p<0.05. The comparison revealed that the metabolic syndrome group exhibited attributes such as advanced age, male gender, elevated systolic and diastolic blood pressures, high blood sugar, elevated triglycerides, reduced LDL-C, elevated HDL-C, higher Cardiometabolic Index, Triglyceride-glucose index, and components linked to abdominal obesity. Pearson correlation analysis showed strong positive correlations between waist circumference/height ratio, waist circumference, Cardiometabolic Index, and triglycerides. Weak positive correlations were observed between LDL-C, body mass index, and Cardiometabolic index, while a strong negative correlation was found between Cardiometabolic Index and HDL-C. ROC analysis indicated that the Cardiometabolic Index(CMI), Triglyceride-glucose(TyG) index, and waist circumference demonstrated the highest Area Under the Curve(AUC) values, indicating their efficacy in diagnosing metabolic syndrome. Optimal cut-off values were determined as >1.34, >8.86, and >84.5 for the Cardiometabolic Index, Triglyceride-glucose index, and waist circumference, respectively. Logistic regression analysis revealed significant differences for age(p=0.037), waist circumference(p<0.001), systolic blood pressure(p<0.001), triglycerides(p<0.001), LDL-C(p=0.028), fasting blood sugar(p<0.001), Cardiometabolic Index(p<0.001), and Triglyceride-glucose index (p<0.001). The odds ratios for these variables were 1.015, 1.179, 1.090, 3.03, and 69.16, respectively. In conclusion, the Cardiometabolic Index and Triglyceride-glucose index are robust predictive indicators closely associated with metabolic syndrome diagnosis, and waist circumference is identified as an excellent predictor. Integrating these variables into clinical practice holds the potential for enhancing early diagnosis and prevention of metabolic syndrome.