• Journal of Gastric Cancer
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• 제18권4호
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• pp.400-408
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• 2018

Purpose: This study aimed to evaluate immediate outcomes and clinical courses of patients with early gastric carcinoma with lymphoid stroma (GCLS) who underwent endoscopic resection. Materials and Methods: We retrospectively reviewed the medical records of 40 patients (mean age, 56.9 years; 90.0% male) who underwent endoscopic resection and were pathologically diagnosed with GCLS confined to the mucosa or to the submucosa between March 1998 and December 2017. Results: Forty GCLS lesions in 40 patients were treated using endoscopic resection. Only 4 (10%) patients received diagnosis of GCLS before endoscopic resection. Fourteen (35.0%) lesions were intramucosal cancers and 26 (65.0%) exhibited submucosal invasion. En bloc resection (97.5%) was achieved for all lesions except one, with no significant complications. The complete resection rate was 85.0% (34 of 40 lesions). After endoscopic resection, 17 patients were referred for surgery and underwent gastrectomy with lymph node (LN) dissection because of deep submucosal invasion (n=16) and misclassification as undifferentiated cancer (n=1). No LN metastasis was determined in the specimens obtained during surgery. During a mean follow-up period of 49.7 months for 23 patients without surgical treatment, no regional LN enlargements, distant metastases, or gastric cancer-related deaths were found, although 1 metachronous lesion (undifferentiated adenocarcinoma, follow-up duration: 7 months) was observed. Conclusions: In patients with early GCLS, endoscopic resection is technically feasible and has favorable clinical outcomes. Therefore, endoscopic resection might represent an alternative treatment modality in patients with early GCLS with a low likelihood of LN metastasis.

• Clinical and Experimental Pediatrics
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• 제61권12호
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• pp.397-402
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• 2018

Purpose: Transcatheter device closure of patent ductus arteriosus (PDA) is challenging in early infancy. We evaluated PDA closure in infants less than 6 months old. Methods: We performed a retrospective review of infants less than 6 months of age who underwent attempted transcatheter device closure in our institution since 2004. To compare clinical outcomes between age groups, infants aged 6-12 months in the same study period were reviewed. Results: A total of 22 patients underwent transcatheter PDA closure during the study period. Patient mean age was $3.3{\pm}1.5months$, and weight was $5.7{\pm}1.3kg$. The duct diameter at the narrowest point was $3.0{\pm}0.8mm$ as measured by angiography. The most common duct type was C in the Krichenko classification. Procedural success was achieved in 19 patients (86.3%). Major complications occurred in 5 patients (22.7%), including device embolization (n=1), acquired aortic coarctation (n=2), access-related vascular injury requiring surgery (n=1), and acute deterioration requiring intubation during the procedure (n=1). Two patients had minor complications (9.1%). Twenty-four infants aged 6-12 months received transcatheter device closure. The procedural success rate was 100%, and there were no major complications. The major complication rate was significantly higher in the group less than 6 months of age (P=0.045). There was a trend toward increased major complication and procedural failure rates in the younger age group (P<0.01). Conclusion: A relatively higher incidence of major complications was observed in infants less than 6 months of age. The decision regarding treatment modality should be individualized.

• 병원약사회지
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• 제35권4호
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• pp.430-440
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• 2018

Background : Hyponatremia is the most common electrolyte disturbance in hospitalized patients and has been associated with increased morbidity and mortality. Tolvaptan, a vasopressin receptor antagonist, is increasingly used for the treatment of euvolemic and hypervolemic hyponatremia. The aim of this study was to evaluate the effectiveness and safety of tolvaptan for the management of hyponatremia. Methods : This study was a retrospective evaluation of 106 patients who received at least one dose of tolvaptan for hyponatremia at a single tertiary academic hospital between January 2014 and June 2015. The primary endpoint was the change in serum sodium concentration after tolvaptan administration within 24 hours, with secondary endpoints of overcorrection and adverse effects. Results : The mean initial dose of tolvaptan was $20.2{\pm}7.2mg$ and the median duration of treatment was 15 days (range, 1-261 days). The maximal changes in sodium levels at 24 and 48 hours were $8.2{\pm}4.7mmol/L$ and $10.5{\pm}15.3mmol/L$, respectively. Of 99 patients in whom sodium concentrations were followed up, sodium overcorrection was observed in 26 (26.3%) patients, which was associated with concomitant use of an enzyme inhibitor (odds ratio [OR] = 4.80, 95% Cl: 1.27-18.15). However, sex, body mass index (BMI), serum albumin, a daily dose of tolvaptan, and concomitant use of hypertonic saline did not show any significant difference in overcorrection. The most commonly reported adverse effects were mild and related to aquaresis, such as polyuria, thirst, and constipation. However, severe adverse effects such as hyperkalemia, hypotension, and one death related to osmotic demyelination were also reported. Conclusions : Tolvaptan is effective for treating hyponatremia. Nevertheless, the drug should be used cautiously due to serious adverse effects related to sodium overcorrection.

• Korean Journal of Radiology
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• 제22권7호
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• pp.1124-1131
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• 2021

Objective: To evaluate the feasibility, safety, and effectiveness of CT-guided microcoil localization of solitary pulmonary nodules (SPNs) for guiding video-assisted thoracoscopic surgery (VATS). Materials and Methods: Between June 2016 and October 2019, 454 consecutive patients with 501 SPNs who received CT-guided microcoil localization before VATS in our institution were enrolled. The diameter of the nodules was 0.93 ± 0.49 cm, and the shortest distance from the nodules to the pleura was 1.41 ± 0.95 cm. The distal end of the microcoil was placed less than 1 cm away from the nodule, and the proximal end was placed outside the visceral pleura. VATS was performed under the guidance of implanted microcoils without the aid of intraoperative fluoroscopy. Results: All 501 nodules were marked with microcoils. The time required for microcoil localization was 12.8 ± 5.2 minutes. Microcoil localization-related complications occurred in 179 cases (39.4%). None of the complications required treatment. A total of 463 nodules were successfully resected under the guidance of implanted microcoils. VATS revealed 38 patients with dislocated microcoils, of which 28 underwent wedge resection (21 cases under the guidance of the bleeding points of pleural puncture, 7 cases through palpation), 5 underwent direct lobectomy, and the remaining 5 underwent a conversion to thoracotomy. In 4 cases, a portion of the microcoil remained in the lung parenchyma. Conclusion: CT-guided microcoil localization of SPNs is safe and reliable. Marking the nodule and pleura simultaneously with microcoils can effectively guide the resection of SPNs using VATS without the aid of intraoperative fluoroscopy.

• Journal of Hospice and Palliative Care
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• 제19권2호
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• pp.145-153
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• 2016

목적: 본 연구는 독립형 호스피스기관의 가정호스피스 서비스에 등록한 말기환자의 특성과 가정호스피스 서비스 제공 실태를 파악하여 가정호스피스 서비스 모델 개발을 위한 기초자료를 제공하기 위하여 수행되었다. 방법: 일개 독립형 호스피스기관의 가정호스피스에 등록하여 방문서비스를 받고, 2014년 1월 1일부터 2014년 12월 31일 사이에 서비스가 종료된 말기환자의 의무기록지 75개를 후향적으로 분석하였다. 결과: 등록 환자의 54.7%가 자가 의뢰를 통하여 가정 호스피스를 이용하였다. 종료 후 25.3%가 가정에서 임종하였고, 50.7%는 호스피스병동, 22.6%는 대학병원이나 요양병원으로 입원하였다. 등록 당시 97.3%가 암성질환이었으며, 비암성질환으로 가정호스피스를 이용한 경우는 2.7%였다. 등록 환자의 58.7%가 임종기에 있었으며, 34.7%는 거의 완전한 와상 상태에 있어 전반적으로 낮은 활동수준을 보였다. 등록 당시 환자들이 가진 신체 증상은 통증(89.4%), 수면장애(71.2%), 배변문제(47.8%), 배뇨문제(35.8%) 순으로 나타났다. 전체 환자의 77.4%가 1개월 이내에 서비스가 종결되었다. 환자들에 대한 가정방문 횟수는 평균 3.25회로 전체 환자의 82.7%가 5회 미만의 가정방문을 받고 서비스가 종결되었으며, 전화상담 횟수는 평균 3.4회였다. 의사 방문 횟수는 평균 1.21회였으며, 이는 불안정기에 유의하게 증가하였다. 결론: 독립형 호스피스기관을 이용하는 환자의 특성과 서비스 제공 형태를 반영한 가정호스피스 서비스 모델 개발이 필요하다.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1019-1023
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• 2003

목 적 : 가와사끼병 환아에서 면역글로불린을 조기 투여하였을 때 치료 실패의 빈도와 관상 동맥의 합병증이 증가하는 지를 알아보고자 본 연구를 시행하였다. 방 법 : 2001년 1월부터 2002년 6월 사이에 이화의대 목동병원 소아과에서 가와사끼병으로 치료받은 환아 87명의 입원 및 외래 기록을 후향적으로 조사하였다. 면역글로불린을 발열 4일 이전에 투여받은 환아를 조기투여군(34명), 발열 5일 이후에 투여 받은 환아를 대조군(53명)으로 하였다. 두 군간의 임상양상, 혈액 검사, 발열기간, 치료 및 관상 동맥 합병증을 비교 조사하였다. 결 과 : 1) 두 군간의 인구학적 특징의 차이는 없었다(P>0.05). 2) 총 발열기간은 조기 투여군과 대조군이 각각 $4.8{\pm}2.5$일과 $7.4{\pm}3.0$일로 조기 투여군에서 유의하게 짧았다(P<0.05). 면역글로불린 투여 후 발열 기간과 입원기간은 두 군에서 유의한 차이를 보이지 않았다(P>0.05). 3) 혈색소, 백혈구수, 혈소판수, 혈침속도, CRP, AST, ALT, 알부민은 두 군간에 유의한 차이가 없었다(P>0.05). 4) 면역글로불린 재투여 빈도는 조기 투여군과 대조군에서 각각 11.8%와 5.7%로 유의한 차이를 보이지 않았다(P>0.05). 5) 관상 동맥 합병증은 조기 투여군에서 11.7%와 대조군에서 18.9%로 유의한 차이가 없었다(P>0.05). 6) 가와사끼병의 재발은 각각 3%와 2%로 두 군간에 유의한 차이가 없었다(P>0.05). 결 론 : 가와사끼병에서 면역글로불린 조기투여는 총 발열기간을 감소시키고, 면역글로불린 치료 실패율과 관상 동맥류 발생을 증가시키지 않았다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4791-4794
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• 2013

Purpose: To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi$^{(R)}$) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. Patients and Methods: From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi$^{(R)}$ (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. Results: The overall respnse rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi$^{(R)}$ to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.

• Archives of Plastic Surgery
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• 제47권2호
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• pp.135-139
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• 2020

Background This study aimed to determine the magnitude of volume reduction of the latissimus dorsi (LD) muscle after treatment using only postoperative radiotherapy (PORTx) in patients who underwent immediate breast reconstruction using an extended LD musculocutaneous (eLDMC) flap after partial mastectomy. Methods We retrospectively reviewed 28 patients who underwent partial mastectomy and an eLDMC flap, received only PORTx, and underwent chest computed tomography (CT) 7 to 10 days after surgery and 18±4 months after the end of radiotherapy, from March 2011 to June 2016. The motor nerve to the LD was resected in all patients. One plastic surgeon performed the procedures, and the follow-up period was at least 36 months (mean, 46.6 months). The author obtained LD measurements from axial CT views, and the measurements were verified by an experienced radiologist. The threshold for statistical significance was set at P<0.05. Results A statistically significant decrease in the LD volume was found after the end of PORTx (range, 61.19%-80.82%; mean, 69.04%) in comparison to the measurements obtained 7 to 10 days postoperatively (P<0.05). All cases were observed clinically for over 3 years. Conclusions The size of an eLDMC flap should be determined considering an average LD reduction of 69% after PORTx. Particular care should be taken in determining the size of an eLDMC flap if the LD is thick or if it occupies a large portion of the flap.

• 한국치위생학회지
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• 제10권2호
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• pp.393-411
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• 2010

Objectives : The purpose of this study was to examine factors related to the satisfaction level of patients with dental services. Methods : The subjects in this study were 200 patients at three different dental clinics in South Gyeongsang Province, on whom a survey was conducted from June 1 to July 31, 2009. The collected data were analyzed, and the findings of the study were as follows. Results : In regard to the general characteristics of the patients investigated, the women(61.5%) out-numbered the men. By age, those who were at the age of 30 and down made up the largest age group(47.0%). By academic background, the greatest group received junior-college education(54.0%). By occupation, the company employees constituted the largest group (50.5%). By income, the greatest group earned an income of 2 to 2.99 million won(75.0%). Second, as to connections between the characteristics of dental treatment and the reason of choosing the dental clinics, the largest group(70.4%) chose the dental clinics by word of mouth or the recommendation of others. Concerning the reason of dissatisfaction, the biggest group(72.7%) was unsatisfied with medical costs. As for the degree of explicit complaint, the greatest group(49.7%) sort of complained about what made them dissatisfied. Regarding the type of treatment, the biggest group(49.0%) received prosthodontic treatment. In relation to fear for dental treatment, the largest group(34.0%) feared receiving the treatment, and the biggest group(42.6%) did that due to the sound of machines. Third, satisfaction with services(0.762) had the closest correlation to overall satisfaction level, followed by satisfaction with employees(0.735), satisfaction with dentists(0.644) and satisfaction with convenient facilities (0.579). Fourth, the factors that affected overall satisfaction level were gender, the reason of choosing the dental clinic, satisfaction with dentists, satisfaction with employees, satisfaction with services and satisfaction with convenient facilities. The patients who were better satisfied with services(p<0.001), who were more contented with dentists(p<0.001), who chose the dental clinics by the recommendation of others(p<0.01), who were male(p<0.05), who were more gratified with employees(p<0.05) and who were more contented with convenient facilities expressed better overall satisfaction. Conclusions : The above-mentioned findings suggested that dental institutions should keep track of the expectations of patients to prepare differentiated strategies for marketing and human-resources development in consideration of their own circumstances to boost the satisfaction level of patients. Specifically, it's required to heighten the satisfaction level of patients with dentists.

• Journal of Acupuncture Research
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• 제22권1호
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• pp.177-190
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• 2005

본 연구는 도인기공체조가 여성의 견비통 및 견부 근육에 미치는 효과를 알아보기 위하여 실시하였다. 연구설계는 유사실험설계로 비동등성 대조군 전후설계이며, 연구방법은 실험군, 대조군에게 사전조사로 일반적인 특성, 견비, 견배통 자각 증상, 주관적 동통(VAS), 근육경결정도를 측정하였다. 실험처치로 본 연구자와 한의학 전공교수 1인, 도인기공 전문가 1인이 함께 개발한 도인기공체조를 첫 2주 동안에는 도인기공 전문가와 연구자가 함께 연구대상자들에게 1회 45분, 주 3일을 실시하였다. 3주째부터는 연구자가 혼자 지도하면서 1회 45분 동안 주 3일 총 24회를 실시했다. 매회 출석을 체크하고, 불참 시에는 개발된 도인 기공체조 비디오를 사전 배부하여 집에서 개인 적으로 도인기공체조를 실시하도록 격려하였고, 운동실시여부는 전화로 확인했다. 실험처치 후 사후조사는 사전조사와 동일하게 측정하였다. 자료분석은 SPSS/WIN 10.0을 사용하였으며, 동질성 검증은 $x^2$검정, t검정, Fisher's exact test로 분석하였고, 가설검정은 ANCOVA와 t점정으로 측정도구의 신뢰도는 Cronbach' alpha 계수를 산출하였다. 본 연구의 결과는 다음과 같다. 1. 도인기공체조를 받은 실험군은 대조군에 비해 유의하게 견비, 견배통 자각증상의 점수가 감소되었다(t=10.245, p=.000). 2. 도인기공체조를 받은 실험군은 대조군에 비해 유의하게 주관적인 동통 점수(VAS)가 감소되었다(t=6.816, p=.000). 3. 도인기공체조를 받은 실험군은 대조군에 비해 근육경결정도가 감소되었다(t=7.114, p=.000).