• Title/Summary/Keyword: Rearrangement

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Four-Component Synthesis of 2-(N,N-Dialkylamino)-2,4,6-Cycloheptatrien-1-One Derivatives from Tropolone, an Isocyanide, a Primary Amine and an Aldehyde via Ugi-Smiles Coupling Reaction

  • Massoudi, Abdolhossain;Amini, Issa;Ramazani, Ali;Nasrabadi, Fatemeh Zeinali;Ahmadi, Yavar
    • Bulletin of the Korean Chemical Society
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    • v.33 no.1
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    • pp.39-42
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    • 2012
  • The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien-1-one derivatives. The Ugi four-component reaction of isocyanides with tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines and aldehydes proceeds smoothly and cleanly under mild conditions to afford 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien-1-one derivatives in fairly good yields.

A Study on the Development of Computer-Aided Fashion Design (컴퓨터를 활용한 패션디자인 전개방법 연구)

  • 이순자;박옥련;김주현
    • The Research Journal of the Costume Culture
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    • v.8 no.5
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    • pp.717-725
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    • 2000
  • The purpose of this study was, as an experimental one, to suggest concrete ways to use computer in fashion design from information collection to design completion, and to present a real example based on the suggested ways. The first step to attain the purpose was gathering various sorts of worldwide fashion design information on the Internet, and then the collected data were inserted in a graphic file. Next, two methods of fashion design that use computer graphics were recommended : one was to produce fashion design just by altering some of the inputted Internet fashion materials, and the other was to do it after selected basic materials were put in database. Those methods could enable one to do fashion design just with rearrangement and smallest change of the prepared basic materials, without drawing directly, and at the same time, they could minimize time and efforts required for computer fashion design.

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Aromatic Formation from Vinyl Radical and Acetylene. A Mechanistic Study

  • Natalia, Debby;Indarto, Antonius
    • Bulletin of the Korean Chemical Society
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    • v.29 no.2
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    • pp.319-322
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    • 2008
  • The viability of acetylene addition in each step of aromatic formation initiated by vinyl radical and acetylene also with its competition with structure rearrangement is investigated by determining optimal geometries and barrier and reaction energies using quantum mechanical methods. In principle, the addition reaction has more difficult in term of free energy and enthalpy compared to geometry arrangement. Under combustion conditions, i.e. T = 1200 K, acetylene addition is unfavorable mechanism as the barrier energy values rise much higher than that of geometry arrangement. However, in longer chain hydrocarbon case, e.g. n-CxHx+1 where x ³ 8, C-C bond rotation is rather difficult and requires high energy to form a ring structure, elongation chain is preferable.

An Efficient Synthesis of 4'-Vinylated Carbocyclic Nucleoside Analogues via Two Directional Ring-closing Metathesis

  • Li, Hua;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • v.29 no.5
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    • pp.993-997
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    • 2008
  • Two directional ring-closing metathesis (RCM) was applied successfully to the synthesis of 4'-vinylated carbocyclic nucleoside analogues from the trivinyl intermediate 12, which was readily made using a sequential Claisen rearrangement and ring-closing metathesis (RCM) starting from Weinreb amide 5. An antiviral evaluation of the synthesized compounds against various viruses such as HIV, HSV-1, HSV-2 and HCMV revealed that the guanine analogue 20 have moderate anti-HIV activity in the MT-4 cell line ($EC_{50}$ = 10.2 $\mu$ M).

A Study for Stiffness Improvement Method with Use of Filled Concrete in Continued Steel Box Girder Bridge (강상자형 연속교에서 콘크리트재를 이용한 부모멘트 구간의 강성향상공법)

  • 구민세;이호경
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 1999.10a
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    • pp.69-78
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    • 1999
  • The stiffness of slab concrete section is not considered as effective in the existing method of construction for continued steel box girder bridge. Using lifting system and filled concrete, it is possible to make stiffness of slab concrete section effective and improve stiffness of negative moment section. It was proved that the stress of upper flange in positive moment is significantly lower than case of existing method through the stress comparison. This stress difference made possible to rearrange flange thickness and as the result of this rearrangement, the amount of steel and height of girder can be reduced up to 13.23% and 11.5%.

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The Life of Wang Bing and the Characteristics of His Medical Concepts (왕빙(王氷)의 생애와 그 의학사상의 특징)

  • Kim, Nam il
    • The Journal of Korean Medical History
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    • v.15 no.1
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    • pp.25-42
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    • 2002
  • Wang Bing reorganized "The Yellow Emperor's Inner Canon Essential Questions" by adding 7 more volumes to the original 9 volumes and made it 24 volumes. And also rearranged the order in "preservation of health", "yinyang and five phases", "visceral manifestation", "treatment", "pulsation", "the channels", "diseases", "acupuncture ", "movement of the qi", "medical virtue", "wanton theory" etc. Though this, Wang Bing hoped the "The Yellow Emperor's Inner Canon Essential Questions" to be reborn into a systematic and methodical medical book. Taoism, which is one of the characteristics of Wang Bing's medical conception, is revealed in both the contents of the book and the rearrangement of the book's order. Another feature is that he explains most of the diseases by the channel theory. His insists the script be interpretated in a new way that fits the situation and not to be bound to the words it self. And this also shows one of his conception of medicine.

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An Improvement on Computation Cost and Compression Ratio of Vector Quantization (벡터양자화에서의 계산량과 압축률의 개선)

  • Jung, Il-Hwan;Hong, Choong-Seon;Lee, Dae-Young
    • The Transactions of the Korea Information Processing Society
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    • v.7 no.11
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    • pp.3462-3469
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    • 2000
  • In this paper,new image vector quantization method for improvemtnt computation cost and compression ratio is proposed. A proposed method could saved the cornputatio cost of codebook eneration and encoding using partial codebook search, partial codevector elements, and interuplion criterion. And to improve cornpression ratio of codegook index lossless coding, codebook rearrangement, and variable length coding scheme are used.

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CRYSTAL STRUCTURE OF AN UNCLEAVED $\alpha_1$-ANTITRYPSIN WITH SEVEN STABILIZING MUTATIONS AT 2.7 $\{AA}$ RESOLUTION

  • Ryu, Seong-Eon;Park, Hee-Jeong;Kwon, Ki-Sun;Lee, Kee-Nyung;Yu, Myung-Hee
    • Proceedings of the Korean Biophysical Society Conference
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    • 1996.07a
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    • pp.4-4
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    • 1996
  • $\alpha$$_1$-arantitrypsin, a member of the serpin (serine protease inhibitor) family, undergoes a large structural rearrangement upon the cleavage and insertion of the reactive site loop. This conformational change is driven by the metastability of the native serpin structures and has an important role in the regulation of the inhibitory-serpin function. (omitted)

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Developing a Layout Based Simulation Model for Production Planning of Small Motor Production System (소형모터 생산시스템의 생산계획수립을 위한 설비배치 기반의 시뮬레이션 모형 구축)

  • 김승환
    • Proceedings of the Korea Society for Simulation Conference
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    • 1998.10a
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    • pp.65-65
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    • 1998
  • Manufacturing systems like a motor production process are analyzed using simulations than numerical analyses and/or heuristic methods due to their stochastic properties. The SME(small and medium enterprise) producing automotive motors that develop CIM systems to improve production performance is focused as an application site. We analyze and understand the system exactly using layout based simulation, and then we will suggest the initial feashible production-plan dependent on the layout to overcome weak-points of the current system(i.e., high WIPs, bottle-neck processes, due-date delays and etc.). And, solutions are suggested to increase performances of SMEs producing automotive motors in this paper. The simulation model built in this study is moedlled and analyzed with fully object-oriented methodology using SiMPLE++TM according to properties of production processes of the automotive motor. And, we will introduce ways to verify the model with developed templates for reusability when new needs will be occurred such as designing a new ship, extension or rearrangement of the system, change of production-plans, receiving urgent orders, and so on.

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Allylic fluorination

  • Park, Oee-Sook;Son, Hoe-Joo;Lee, Woo-Young
    • Archives of Pharmacal Research
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    • v.10 no.4
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    • pp.239-244
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    • 1987
  • An efficient and inexpensive method for the substitution of allylic hydroxyl group with fluoride, without allylic rearrangement, and elimination was developed. This method consists of treating an allylic alcohol with methylithium, followed by p-toluene sulfonyl fluoride, lithium fluoride and 12-Crown-4. This methodology was proved to be efficient by preparting geranyl fluoride, neryl fluoride, cinnamyl fluoride, E, E-farnesyl fluoride, retinyl fluoride and 4-fluoro-2-methyl-6-(ptolyl)-2-heptene.

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