• 한국CDE학회논문집
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• 제13권3호
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• pp.235-242
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• 2008

This paper proposes a method for improving the process plan quality by use of dimensional tolerances. Dimensioning and tolerancing plays a key role in manufacturing process plan because the final part must ensure conformance with the dimensions and tolerances in its drawing. As a first step for the improvement of process plan quality, two resultant tolerances in design and process plan should be compared each other, and so a tolerance chart is used for acquisition and comparison of the two tolerances. In addition to two kinds of design and manufacturing tolerances, operational sequences or paths for the resultant dimension and tolerance are additionally recognized for measuring the quality of process plan quantitatively. Rooted tree is applied to find the related paths for the manufacturing resultant tolerances. A quality coefficient is defined by the components of two tolerances and their relations, the paths related to manufacturing resultant tolerances and the difficulty of an operation. In order to improve the quality of manufacturing process plan, the paths that two kinds of tolerances are the same or different in the rooted tree are recognized respectively and a method for tolerance rearrangement is developed. A procedure for improving the quality is suggested by combining the coefficient and the tolerance rearrangement method. A case study is applied to illustrate the efficiency of improvement method.

• 한국정보과학회논문지:시스템및이론
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• 제28권10호
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• pp.530-540
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• 2001

이동용 응용프로그램이 요구하는 계산량이 늘어남에 따라 많은 이동용 컴퓨터시스템이 성능을 높이기위해 VLIW 프로세서를 사용하여 설계되고 있다. VLIW 구조에서는 하나의 명령어(instruction)가 여러개의 연산(operation)을 가지고 있는데, 이들이 명령어안에서 어떻게 배치되는냐에 따라 명령어 추출(fetch)시의전력 소모가 큰 차이를 보인다. 본 논문에서는 저전력 VLIW 명령어 추출을 위해 컴파일어의 후단계로 사용되는 최적의 연산 재배치 기법을 제시한다. 제안된 방법은 연속적인 명령어 추출시의 스위칭 활동(switching activity)이 최소화가 되도록 연산의 순서를 수정한다. 벤치마크 프로그램에 대해 실험해 본 결과, 제안된 기법을 사용하여 명령어를 재배치하는 경우 명령어 추출시 스위칭 활동이 평균적으로 약 34%줄어듬을 확인하였다.

• International Journal of Oral Biology
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• 제39권3호
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• pp.131-136
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• 2014

Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms involved in the internalization of P. gingivalis in human umbilical vein endothelial cells (HUVEC). P. gingivalis internalization was reduced by clathrin and lipid raft inhibitors, as well as a siRNA knockdown of caveolin-1, a principal molecule of lipid raft-related caveolae. The internalization was also reduced by perturbation of actin rearrangement, while microtubule polymerization was not required. Furthermore, we found that Src kinases are critical for the internalization of P. gingivalis into HUVEC, while neither Rho family GTPases nor phosphatidylinositol 3-kinase are required. Taken together, this study indicated that P. gingivalis internalization into endothelial cells involves clathrin and lipid rafts and requires actin rearrangement associated with Src kinase activation.

• Journal of Microbiology and Biotechnology
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• 제16권8호
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• pp.1174-1179
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• 2006

The wild-type Corynebacterium glutamicum ATIC 13032 and Corynebacterium glutamicum ATTC 13032 lysC S301Y, exhibiting a deregulated aspartokinase, were compared concerning growth, lysine production, and intracellular carbon fluxes. Both strains differ by only one single nucleotide over the whole genome. In comparison to the wild-type, the mutant showed significant production of lysine with a molar yield of 0.087 mol (mol glucose$^{-1}$) whereas the biomass yield was reduced. The deregulation of aspartokinase further led to a global rearrangement of carbon flux throughout the whole central metabolism. This involved an increased flux through the pentose phosphate pathway (PPP) and an increased flux through anaplerosis. Because of this, the mutant revealed an enhanced supply of NADPH and oxaloacetate required for lysine biosynthesis. Additionally, the lumped flux through phosphoenolpyruvate carboxykinase and malic enzyme, withdrawing oxaloacetate back to the glycolysis and therefore detrimental for lysine production, was increased. The reason for this might be a contribution of malic enzyme to NADPH supply in the mutant in the mutant. The observed complex changes are remarkable, because they are due to the minimum genetic modification possible, the exchange of only one single nucleotide.

• 한국세라믹학회지
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• 제29권1호
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• pp.65-73
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• 1992

The effect of grain size on the time-dependent piezoelectrice degradation of a poled PZT of MPB composition Pb0.988Sr0.012 (Zr0.52Ti0.48)O3 with 2.4 mol% of Nb2O5 was studied, and the degradation mechanism was discussed. Changes in the internal bias field and the internal stress both responsible for the time-dependent degradation of poled PZT were examined by the polarization reveral technique, XRD and Vickers indentation, respectively. The piezoelectric degradation increased with increasing time and grain size, and the internal bias field due to space charge diffusion decreased with increasing grain size of poled PZT. The internal bias field, however, was almost insensitive to the degradation time regardless of the grain size. On the other hand, both the x-ray diffraction peak intensity ratio of (002) to (200) and the fracture behavior including the crack propagation support that the ferroelectric domain rearrangement of larger grain size showed rapid relaxation of the internal stress compared with smaller one, which is thought the origin of the larger piezoelectric degradation in the former. In conclusion, the contribution of space charge diffusion on the piezoelectric degradation of PZT is strongly dependent on both the grain size and the composition. Thus, the relaxation of internal stress due to the ferroelectric domain rearrangement as well as the amount and time-dependence of the internal bias field due to space charge diffusion should be considered simultaneously in the degradation mechanism of PZT.

• Journal of Korean Dental Science
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• 제8권2호
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• pp.74-81
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• 2015

Purpose: In osteoclast differentiation, actin-rich membrane protrusions play a crucial role in cell adhesion. Odontogenic ameloblast-associated protein (Odam) contributes to cell adhesion by inducing actin rearrangement. Odam-mediated RhoA activity may play a significant role in multinucleation of osteoclasts. However, the precise function of Odam in osteoclast cell adhesion and differentiation remains largely unknown. Here, we identify a critical role for Odam in inducing osteoclast adhesion and differentiation. Materials and Methods: The expression of Odam in osteoclasts was evaluated by immunohistochemistry. Primary mouse bone marrow and RAW264.7 cells were used to test the cell adhesion and actin ring formation induced by Odam. Result: Odam was expressed in osteoclasts around alveolar bone. Odam transfection induced actin filament rearrangement and cell adhesion compared with the control or collagen groups. Overexpression of Odam promoted actin stress fiber remodeling and cell adhesion, resulting in increased osteoclast fusion. Conclusion: These results suggest that Odam expression in primary mouse osteoclasts and RAW264.7 cells promotes their adhesion, resulting in the induction of osteoclast differentiation.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.1554-1561
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• 2005

Geotextiles form one of the two largest groups of geosynthetics and it is consisted two major types of synthetic material (Woven, Non-woven). The functions of geotextiles are separation, reinforcement, filtration, drainage and as a moisture barrier. Within these functions, however, there are a large number of applications or use areas. Although the many research scholar and engineer developed and established the design criteria and construction methodology of geosynthetics filter layer, because the lack of suitable design terminology and uncertainty of long term durability, sustainable research still needed for optimum design methodology to the complicate field conditions. Especially, more intensive research needed about under the cyclic flow condition and fine silty sand base material. In this paper, the filter model test performed under cyclic flow with various boundary conditions (period and frequency of cyclic flow, types of geosynthetic filter material, surcharge etc.).

• 한국주거학회:학술대회논문집
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• 한국주거학회 2008년 추계학술발표대회 논문집
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• pp.163-166
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• 2008

With both Gatdui and Daean areas, under construction for upgrading the old housing in Gyeongju downtown area, this study was carried out to find out implications of upgrading methods in a historical and cultural city, by using a physical survey in the areas and life survey among their residents, as well as by analysing the level of their satisfaction with and requirement for housing and their preferring housing type. The upgrading patterns of residents were analysed by examining cases constructed newly in the manner of upgrading. The findings showed that it is required for both existing authorities and private parties to assume roles and responsibilities for upgrading the old housing while recently there have been continuous conflicts between development and preservation of the historic and cultural resources within the city and even the city identity also has been neglected by residents. In addition, it is necessary to take development conditions and resident's economic situation into consideration and introduce a wide range of methods for rearrangement, by turning the importance of housing upgrading to social rearrangement for the purpose of positive alternation.

• 대한화학회지
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• 제56권4호
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• pp.468-472
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• 2012

마이크로웨이브를 이용한 가열 방법과 MeO-PEG-OMe를 용매로 사용하여, benzo-[1,4]-oxazinone의 효율적인 one-pot 합성방법을 개발하였으며, 개발한 합성방법을 이용하여, 8 가지의 benzo-[1,4]-oxazinone 화합물과 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one을 좋은 수율로 합성하였다.

• BMB Reports
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• 제46권6호
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• pp.310-315
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• 2013

The gene order on the X chromosome of eutherians is generally highly conserved, although an increase in the rate of rearrangement has been reported in the rodent lineage. Conservation of the X chromosome is thought to be caused by selection related to maintenance of dosage compensation. However, we herein reveal that the cattle (Btau4.0) lineage has experienced a strong increase in the rate of X-chromosome rearrangement, much stronger than that previously reported for rodents. We also show that this increase is not matched by a similar increase on the autosomes and cannot be explained by assembly errors. Furthermore, we compared the difference in two cattle genome assemblies: Btau4.0 and Btau6.0 (Bos taurus UMD3.1). The results showed a discrepancy between Btau4.0 and Btau6.0 cattle assembly version data, and we believe that Btau6.0 cattle assembly version data are not more reliable than Btau4.0.