• Title/Summary/Keyword: Rearrangement

Search Result 816, Processing Time 0.029 seconds

Photochemical Rearrangement of Chloranil

  • Kim, Sung-Sik;Yoo, Dong-Yeol;Cho, In-Ho;Shim, Sang-Chul
    • Bulletin of the Korean Chemical Society
    • /
    • v.8 no.4
    • /
    • pp.296-298
    • /
    • 1987
  • Irradiation of a solution of chloranil and cycloheptatriene, or 1,3-cyclohexadiene, in dichloromethane yielded unexpected photorearrangement products as the major product, while chloranil with cyclohexene gave the photorearrangement product as well as 1 : 1 adduct.

A Study on the Rearrangement of 1,3-Oxathiolane Sulfoxides (1,3-옥사티올란술폭시드의 전위에 관한 연구)

  • Wha Suk Lee;Hoh Gyu Han;In Kyu Kim
    • Journal of the Korean Chemical Society
    • /
    • v.33 no.2
    • /
    • pp.238-246
    • /
    • 1989
  • 1,3-Oxathiolane sulfoxide 4 in which the sulfoxide oxygen and the 2-methyl group are on the same face of the oxathiolane ring undergoes a sigmatropic rearrangement to produce a ring expansion product. The structure of this product would be dihydro-1,4-oxathiin 6 or isomeric exo compound 7. This paper describes physical and chemical methods to determine the correct structure of the two alternatives. Thus, $^1HNMR$, UV spectroscopies, and mass spectrometry showed that the product actually obtained had the structure 6. It was also found that from deuteration reactions of the product the compound 7 was initaly formed and then tautomerized to endo compound 6.

  • PDF

Evidence for VH Gene Replacement in Human Fetal B Cells

  • Lee, Jisoo;Cho, Young Joo;Lipsky, Peter E.
    • IMMUNE NETWORK
    • /
    • v.2 no.2
    • /
    • pp.79-85
    • /
    • 2002
  • Background: In contrast to evidences of Ig H chain receptor editing in transformed cell lines and transgenic mouse models, there has been no direct evidence that this phenomenon occurs in human developing B cells. Methods: $V_HDJ_H$ rearrangements were obtained from genomic DNA of individual $IgM^-$ B cells from liver and $IgM^+B$ cells from bone marrow of 18 wk of gestation human fetus by PCR amplification and direct sequencing. Results: We found three examples of H chain receptor editing from $IgM^+$ and $IgM^-human$ fetal B cells. Two types of $V_H$ replacements were identified. The first involved $V_H$ hybrid formation, in which part of a $V_H$ gene from the initial VDJ rearrangement is replaced by part of an upstream $V_H$ gene at the site of cryptic RSS. The second involved a gene conversion like replacement of CDR2, in which another $V_H$ gene donated a portion of its CDR2 sequence to the initial VDJ rearrangement. Conclusion: These data provide evidence of receptor editing at the H chain loci in developing human B cells, and also the first evidence of a gene conversion event in human Ig genes.