• Title/Summary/Keyword: Real-world evidence

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Preparations for the Assessment of COVID-19 Infection and Long-Term Cardiovascular Risk

  • Jaehun Jung
    • Korean Circulation Journal
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    • v.52 no.11
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    • pp.808-813
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    • 2022
  • Studies showing that coronavirus disease 2019 (COVID-19) is associated with an increased risk of cardiovascular disease continue to be published. However, studies on how long the overall cardiovascular risk increases after COVID-19 and the magnitude of its long-term effects have only been confirmed recently. This is partly because the distinction between cardiovascular risk as an acute complication of COVID-19 or post-acute cardiovascular manifestations is ambiguous. Long-COVID has arisen as an important topic in the second half of the pandemic. This term indicates that symptoms persist for more than two 2 months; following three months of SARS-CoV-2 infection and cannot be explained by other medical conditions. Despite the agreement of these international organizations and experts, it is difficult to define whether there is sufficient medical evidence to prove the existence of long-COVID. However, the Korean government and Korea Disease Control and Prevention Agency (KDCA) are preparing a new platform to assess the long-term impact of COVID-19. Using this data, a prospective cohort of 10,000 confirmed COVID-19 cases will be established. This cohort will be linked with claims data from the National Health Insurance Services (NHIS) and it is expected that increased real-world evidence of long-COVID will be accumulated.

Analysis on Mobile Forensic of Smishing Hacking Attack (Smishing 사고에 대한 Mobile Forensic 분석)

  • Park, Dea-Woo
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.18 no.12
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    • pp.2878-2884
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    • 2014
  • The Smishing attacks are caused using smartphone since 2013. Smishing hacking attacks are increasing due to the approximately 104 million private information leakage incidents by the 3 domestic credit card companies occurred in January 2014. The Smishing attack occurred in conjunction with hacking illegal leakage of personal information and direct financial damage. In this paper, i am analyze real-world case studies in the lab and study accident on Smishing Mobile Forensic analysis. I am study of a real case Smishing hacking attacks. And studying evidence for a Mobile Forensic analysis of the technical principles of Smishing attacks. The study for the Mobile Forensic evidence proved the Smishing hacking attacks using Mobile Forensic technic and create Mobile Forensic reports. Through this paper, the research will be safe for the people living in the smartphone can be used safely and conveniently, with the development of Mobile Forensic technology, to study the extraction of Smishing accident evidences from the court.

A Study on Human-AI Collaboration Process to Support Evidence-Based National Innovation Monitoring: Case Study on Ministry of Oceans and Fisheries (Human-AI 협력 프로세스 기반의 증거기반 국가혁신 모니터링 연구: 해양수산부 사례)

  • Jung Sun Lim;Seoung Hun Bae;Kil-Ho Ryu;Sang-Gook Kim
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.46 no.2
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    • pp.22-31
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    • 2023
  • Governments around the world are enacting laws mandating explainable traceability when using AI(Artificial Intelligence) to solve real-world problems. HAI(Human-Centric Artificial Intelligence) is an approach that induces human decision-making through Human-AI collaboration. This research presents a case study that implements the Human-AI collaboration to achieve explainable traceability in governmental data analysis. The Human-AI collaboration explored in this study performs AI inferences for generating labels, followed by AI interpretation to make results more explainable and traceable. The study utilized an example dataset from the Ministry of Oceans and Fisheries to reproduce the Human-AI collaboration process used in actual policy-making, in which the Ministry of Science and ICT utilized R&D PIE(R&D Platform for Investment and Evaluation) to build a government investment portfolio.

Nighttime administration of antihypertensive medication: a review of chronotherapy in hypertension

  • Hyun-Jin Kim;Sang-Ho Jo
    • The Korean journal of internal medicine
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    • v.39 no.2
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    • pp.205-214
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    • 2024
  • Hypertension remains a global health concern because of suboptimal blood pressure control despite advancements in antihypertensive treatments. Chronotherapy, defined as evening or bedtime administration of medication based on biological rhythms, is emerging as a potential strategy to improve blood pressure control and treatment outcomes. Clinical trials have investigated the potential effects of nighttime administration of antihypertensive medication in the improvement of 24 hours blood pressure control and reduction of cardiovascular risk. Implementing chronotherapy in clinical practice could have significant implications in enhancing blood pressure control and improving clinical outcomes in patients with hypertension, particularly those with resistant hypertension. However, recent trials have reported contradictory results, causing confusion in real-world practice. Herein we review, analyze, and critique the current evidence and propose suggestions regarding the clinical application and future directions of chronotherapy.

The Impact of COVID-19 Pandemic on Firm Performance: Empirical Evidence from Vietnam

  • BUI, Trung Huy;NGUYEN, Huong Thu;PHAM, Yen Nhu;NGUYEN, Trang Thu Thi;LE, Linh Thao;LE, Giang Thu Tran
    • The Journal of Asian Finance, Economics and Business
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    • v.9 no.7
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    • pp.101-108
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    • 2022
  • The outbreak of Coronavirus disease 2019 (COVID-19) has caused serious impacts not only on human health but also on the economies around the world. Enterprises play an important role in the development of every country but it is also one of the most affected sectors during the pandemic. Drawing on panel data of 131 enterprises listed on the Vietnamese stock exchange from 2016Q1 to 2021Q3, this study aims to investigate the impact of the COVID-19 pandemic on firm performance. Enterprises are classified into seven industries including Agriculture, Material, Industry, Real estate and Construction, Energy, Consumer, and Service. The paper also analyzes the variation of the effects among companies, focusing on differences in revenue and capital structure. The results show that the COVID-19 pandemic negatively affects business performance. In addition, the empirical findings indicate that revenue and debt decreasing can cause deterioration of firm performance during the pandemic period. The decrease in revenue has a direct impact on firm profitability. The reduction of debt levels affects the corporate leverage leading to adverse effects on firm performance. The negative effect is more pronounced for companies in some specific sectors including industry, real estate, construction, consumption, and services.

Evaluating Conversational AI Systems for Responsible Integration in Education: A Comprehensive Framework

  • Utkarch Mittal;Namjae Cho;Giseob Yu
    • Journal of Information Technology Applications and Management
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    • v.31 no.3
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    • pp.149-163
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    • 2024
  • As conversational AI systems such as ChatGPT have become more advanced, researchers are exploring ways to use them in education. However, we need effective ways to evaluate these systems before allowing them to help teach students. This study proposes a detailed framework for testing conversational AI across three important criteria as follow. First, specialized benchmarks that measure skills include giving clear explanations, adapting to context during long dialogues, and maintaining a consistent teaching personality. Second, adaptive standards check whether the systems meet the ethical requirements of privacy, fairness, and transparency. These standards are regularly updated to match societal expectations. Lastly, evaluations were conducted from three perspectives: technical accuracy on test datasets, performance during simulations with groups of virtual students, and feedback from real students and teachers using the system. This framework provides a robust methodology for identifying strengths and weaknesses of conversational AI before its deployment in schools. It emphasizes assessments tailored to the critical qualities of dialogic intelligence, user-centric metrics capturing real-world impact, and ethical alignment through participatory design. Responsible innovation by AI assistants requires evidence that they can enhance accessible, engaging, and personalized education without disrupting teaching effectiveness or student agency.

A Review of Empirical Research on Citizen Participation in Government Crowdsourcing Platforms: Lessons for Government Leaders and Managers (시민의 정부 크라우드소싱 플랫폼 참여에 관한 실증연구 검토: 정부 지도자와 관리자를 위한 교훈)

  • Lee, Jooho
    • Informatization Policy
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    • v.29 no.1
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    • pp.3-23
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    • 2022
  • As a form of online co-production, government crowdsourcing platforms have received growing attention from scholars and practitioners as a means of enhancing government-citizen co-production. This research aims (1) to introduce government leaders and managers to recent empirical research examining real-world cases of government crowdsourcing from different countries, (2) to systematically organize, analyze, and discuss the findings and implications of recent government crowdsourcing empirical studies, and (3) to provide government practitioners with evidence-based insights that could encourage informed decisions about how they design, implement, and evaluate government crowdsourcing platforms effectively and inclusively. Literature review is limited primarily to empirical works that rigorously examined real-world cases of government crowdsourcing. By focusing on a review of empirical research on crowdsourcing co-design and crowdsourcing design/government delivery platforms, this study discusses the key findings systematically and offers some insights and implications for leaders and managers seeking effective and inclusive design and implementation of government crowdsourcing platforms.

Hwang Woo-Suk, Pasteur and ANT (황우석과 파스퇴르 그리고 ANT)

  • Kang, Yun-Jae
    • Journal of Science and Technology Studies
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    • v.7 no.1
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    • pp.67-90
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    • 2007
  • Could STS throw another-colored light on the Hwang's Affair, the scientific fraud committed by Hwang Woo-Suk and his research team in Korea? And could analytic tools of STS unfold another meanings which have been overlooked in most of the traditionally social-sciences-oriented analyses? In this essay, I try to answer these questions by analyzing the Hwang's Affair in the view of STS, especially by using some concepts of actor-network theory(ANT): movement, translation and displacement. I want to say that the Hwang's Affair seems to be a part of normal scientific activity, not an abnormal phenomenon, and as an evidence, focus on the similarities of their life styles between "pure/real scientist" Louis Pasteur and "impure/political scientist" Hwang Woo-Suk. I try to mobilize some concepts of ANT, especially movement, and find out why scientists came to move toward the opposed direction on the pure/real-impure/political line. I suggest that there exists "laboratory politics" as the key factor in this bifurcation. My tentative conclusion is that Pasteur can take a position to make his great world, so-called the Pasteurian world, owing to the success of "double movement" in which he treated his laboratory as a fulcrum to lift up the world, but Hwang degrades himself to "ugly scientific politician" due to the loss of the momentum of his movement; Hwang treated his laboratory only as the symbolic resources and in turn failed to solidify material entities, his real political resources, even though he knew the importance of laboratory.

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A study on specializing the University Museum in the Perspective of Culture, Arts, and Science (문화.예술.과학의 관점에서 대학박물관의 특성화를 위한 기초연구)

  • Choe, Jong-Ho
    • KOMUNHWA
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    • no.68
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    • pp.25-39
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    • 2006
  • This article attempts to define identity, role and functions of a university museum and to suggest specialization of the university museum in the perspective of culture, arts, and science. A university museum is defined as a center for the service of the university community and its development which acquires, researches, communicates, exhibits and educates, for purposes of eduinfotainment,29 material evidence of people and their environment. The target user of the today's university museum are not only professors, students, university workers, but also university neighbourhood such as the related professionals, patrons, parents, school children and villagers. A multi-dimensional and multi-purpose university museum can be established and managed in a real world and / or a cyber world in the perspective of culture, arts, and science. Based on a ubiquitous system30 in a cyber world vis-a-vie a real world, the university museum can be easily utilized by users anywhere, anytime and any device. In order to specialize the university museum in the perspective of culture, arts and science, it is desirable that the university museum director with the CEO of the university community promote the specialization of the university museum based on philosophy and strategies of university community management after they definitely evaluate the components and resources of the university museum such as human powers, museum collections, organizational, technological, capital, spacial and symbolic resources, The specialization of the university museum should be projected and executed in the direction of maintaining the typical scope of museum activities and managing the effective museum management. Specializing the university museum in the perspective of culture, arts, and science can contribute not only to establish the identity of the university community and to perform role and functions of the university museum but also to encourage academic development, to revaluate the brand of the university community and to promote the marketing for the university.

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Evaluation of the Frequency of the IL-28 Polymorphism (rs8099917) in Patients with Chronic Hepatitis C Using Zip Nucleic Acid Probes, Kerman, Southeast of Iran

  • Iranmanesh, Zahra;Mollaie, Hamid Reza;Arabzadeh, Seyed Alimohammad;Zahedi, Mohammad Javad;Fazlalipour, Mehdi;Ebrahimi, Saeede
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.1919-1924
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    • 2015
  • Polymorphisms in the region of the interleukin IL-28 gene on chromosome 19 have been related with clearance of hepatitis C virus (HCV), a major human pathogen responsible for chronic hepatitis, cirrhosis and hepatocellular carcinoma. About 3% of the world's population is infected with HCV. The long-term response to therapy is influenced by many host and viral factors, and recent evidence has indicated that some host genetic polymorphisms related to IL-28 are the most powerful predictors of virological response in patients with HCV. This study assessed frequency of the IL-28 polymorphism (rs8099917) in 50 patients (39 men and 11 women) with chronic hepatitis C using ZNA probe real time PCR new method. All patients were tested for genotype of HCV and the HCV viral load. In parallel, the levels of SGOT, SGPT and ALK enzymes were assessed. Treatment using Peg-interferon alpha with ribavirin was conducted for patients and subsequently samples were collected to detect any change in viral load or liver enzyme rates. The overall frequency of the TT allele is 74%, TG allele 20% and GG allele 6% and the percent of patients who had T allele was 84%. Clear reduction in viral load and liver enzymes was reported in patients with the T allele. Especially for genotype 1 which is relatively resistant to treatment, these alleles may have a role in this decline. In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.