• Title/Summary/Keyword: Real-world

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Real-World Clinical Efficacy and Tolerability of Direct-Acting Antivirals in Hepatitis C Monoinfection Compared to Hepatitis C/Human Immunodeficiency Virus Coinfection in a Community Care Setting

  • Gayam, Vijay;Hossain, Muhammad Rajib;Khalid, Mazin;Chakaraborty, Sandipan;Mukhtar, Osama;Dahal, Sumit;Mandal, Amrendra Kumar;Gill, Arshpal;Garlapati, Pavani;Ramakrishnaiah, Sreedevi;Mowyad, Khalid;Sherigar, Jagannath;Mansour, Mohammed;Mohanty, Smruti
    • Gut and Liver
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    • v.12 no.6
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    • pp.694-703
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    • 2018
  • Background/Aims: Limited data exist comparing the safety and efficacy of direct-acting antivirals (DAAs) in hepatitis C virus (HCV) monoinfected and HCV/human immunodeficiency virus (HIV) coinfected patients in the real-world clinic practice setting. Methods: All HCV monoinfected and HCV/HIV coinfected patients treated with DAAs between January 2014 and October 2017 in community clinic settings were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy, factors affecting sustained virologic response at 12 weeks (SVR12) after treatment, and adverse reactions were compared between the groups. Results: A total of 327 patients were included in the study, of which 253 were HCV monoinfected, and 74 were HCV/HIV coinfected. There was a statistically significant difference observed in SVR12 when comparing HCV monoinfection and HCV/HIV coinfection (94% and 84%, respectively, p=0.005). However, there were no significant factors identified as a predictor of a reduced response. The most common adverse effect was fatigue (27%). No significant drug interaction was observed between DAA and antiretroviral therapy. None of the patients discontinued the treatment due to adverse events. Conclusions: In a real-world setting, DAA regimens have lower SVR12 in HCV/HIV coinfection than in HCV monoinfection. Further studies involving a higher number of HCV/HIV coinfected patients are needed to identify real predictors of a reduced response.

Embedded 3D-Sensing Devices with Real-Time Depth-Imaging Technologies

  • Bhowmik, Achintya K.
    • Information Display
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    • v.18 no.3
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    • pp.3-12
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    • 2017
  • In the recent years, significant advances have been made in the development of small form-factor, low power, and low cost 3D-sensing devices based on depth-imaging technologies with real-time performance. This has led to the advent of devices and machines that are able to sense and understand the world, navigate in the environment, and interact naturally with their human users. Human-computer interactions based on touch sensing and speech recognition have already become mainstream, and the rapid developments in 3D sensing is paving the path towards the next level of machine intelligence and interactions. This paper discusses the recent developments in real-time 3D sensing technologies and their emerging system application.

A Paraconsistent Robot

  • Almeida Prado, Jose Pacheco
    • 제어로봇시스템학회:학술대회논문집
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    • 2002.10a
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    • pp.92.2-92
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    • 2002
  • Building autonomous robots have been a central objective of research in artificial intelligence. The development of techniques for autonomous navigation in real environment consist one of the main tendencies of the current researches about Robotics. An important problem in autonomous navigation is the necessity of dealing with a great amount of uncertainties inherent to the real environments. The paraconsistent logic has characteristics that make it become an adequate tool to solve this problem. In this work, it is proposed a technique of mapping the real world in the navigation of an autonomous robot using the paraconsistent logic.

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Development of the Remote Minitoring System of Coastal Ocean Environment based on WWW and PCS (WWW와 PCS를 이용한 원격해양관리 시스템의 구축)

  • 이지홍;노영재;하인수;김인식
    • Proceedings of the IEEK Conference
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    • 2000.06e
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    • pp.167-170
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    • 2000
  • In this paper, we develope a intelligent monitoring system of Coastal Ocean Environment based on WWW(World Wide Web) and PCS(Personal Communication System). This system have capability of real time processing of enviromental variable from various sensors. The system is composed of three part. The first part is mathematical modeling of real ocean. The second is construction server for real time web page. And the third is developing the measurement system which has wireless(PCS) interface to server.

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Exploration of Teaching for Mathematical Connections to Real Worlds in the Knowledge-Based Society (창조적 지식기반사회 구축을 위한 초등수학과 실생활과의 연계 지도 방안 연구)

  • 김민경
    • School Mathematics
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    • v.2 no.2
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    • pp.389-401
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    • 2000
  • The purpose of the study is to introduce how elementary mathematics pre-sevice teachers in pre-service teacher program could use and integrate poster, a kind of instructional media, to connect mathematics knowledge to real worlds. Poster examples include such as connection to mathematicians and mathematical connections to real world as well as nature. Further, future study will continue to foster students and teachers to try to construct their alive mathematics knowledge.

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The World View on the Recreation of the Later World in Daesoonjinrihoe (대순진리회의 후천개벽 세계관)

  • Yoon, Yong-bok
    • Journal of the Daesoon Academy of Sciences
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    • v.27
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    • pp.1-34
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    • 2016
  • This paper aims to understand how Daesoonjinrihoe perceives the Later World. Daesoonjinrihoe supports to establish an earthly paradise through the re-creation of the real world unlike other religions which tend to relegate ultimate fulfillment to the afterlife. In other words, Daesoonjinrihoe endeavors to achieve their objectives in the human world rather than outside of it in a potential act of escapism. The new religions in Korea have been characterized by ethnocentrism and doctrines which present Koreans as the new chosen people by emphasizing Korea's crucial role in world leadership. However, the doctrine of Daesoonjinrihoe differ with other new religions of Korea in this regard as its purpose is to redeem the whole world. Daesoonjinrihoe proposes an open embrace of the religious diversity found in Korean society. Daesoonjinrihoe argues that the Later World has not come yet, even though the Former World is over and progress towards the Later World has already been set in motion. The meaning of human nobility is akin to anthropocentricity. According to a variety of myths and legends, animals and supernatural often attempt to become human. Moreover, it would not be an overstatement to assert that the re-creation of the real world and the Daesoon concept of human nobility correspond with these myths and legends. There were not definite interpretations regarding heaven in Confucianism historically, yet Daesoonjinrihoe differentiates clearly that heaven and Sangje are cosmic structures. Buddhism perceives that heaven separately exists as a cosmic structure and that Buddha is a transcendental entity, however; that entity is not accessible for intercession. On the contrary, the ways to save the world have been adduced in Daesoonjinrihoe. In addition, the earthly paradise of the Later World has likewise been introduced. Specifically, it is Sangje that opens the door to that paradise. Unresolved issues in the formation of a world view still persist. There are no shortage of studies on the notion of gods or divine beings, however; most of these studies focus on genealogical classification, forms, functions and other such topics. The concept of god, ghost, or soul does not seem to have been clearly defined in these studies nor has the relationship among these entities and humanity been satisfactorily examined. For example, if human beings become either gods or divine beings, questions regarding divine beings who have acted as protectors or guardians of human beings then arises. The Daesoon cosmology should be specifically compared to cosmology in Daoism. By conducting additional studies such as a comparative research with Daoism, it will be possible to interpret mantras and Daoist art as they appear in Daesoonjinrihoe in a thought-provoking way which can in turn be compared with other religions.

A Study on Real-Time Planning System in Multi Progress Planning Environment (다중 공정 계획 환경하의 실시간 계획 반영 시스템에 관한 연구)

  • Lee, Dae-Hyung;Kim, Young-Sup;Kim, Jung-Hoon
    • Journal of the Society of Naval Architects of Korea
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    • v.45 no.5
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    • pp.547-553
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    • 2008
  • Multi Progress Planning System problem in a multi-stage manufacturing system have a complexity and peculiarity different from other kinds of production system. World leading company has invested much cost and effort into a Real-Time Planning System and intelligent manufacturing field to obtain their own competitiveness. Especially Real-Time Planning System for ship production process as a part of intelligence for a shipyard. Real-Time Planning System, simulation based system, or virtual manufacturing system is an approach to achieve a such goal. It is expected that the Real-Time Planning System will contribute to the improvement of the productivity in working process at a shipyard. Also, This Real-Time Planning System will optimize the entire shipbuilding process in a multi progress planning environment for the delivery.

A Study of High School Students' and Science Teachers' Understanding of Ideal Conditions involved in the Theoretical Explanation and Experiment in Physics: Part II- Focused on the Implications to the Physics Learning - (물리학에서 이론적 설명과 실험에 포함된 이상조건에 대한 고등학생과 과학교사의 이해조사 II-이상화가 물리학습에 주는 시사점을 중심으로-)

  • Park, Jong-Won;Chung, Byung-Hoon;Kwon, Sung-Gi;Song, Jin-Woon
    • Journal of The Korean Association For Science Education
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    • v.18 no.2
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    • pp.245-256
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    • 1998
  • In this study, we discussed about the implications of the idealization, which take an important role in physics, to the physics education. First, understanding of the idealization help the physics learning itself. This is because that various types of idealizations are included in the physics terms and concepts, derivation processes of physics laws and formulas, and explanation of natural phenomena and problem solving activities. Second, understanding of the idealization can help the application of the physics world to the real world. That is, by understanding the extent and the limit of idealization used in physics world, physics students can understand the discrepancies between the real world and the physics world. And also, by modifying or eliminating the idealization, students can extend the extent of understanding about how predictions based on the idealization used in the physics world will change. To do this, we suggested the application of computer simulation program in physics laboratories. Third, idealization take an important role in the inquiry learning for students' originality. The activities of identifying or controlling the variables, as one of the principal factors of scientific inquiry, need the appropriate establishment of the ideal conditions. And to analyze the limiting case or practice the thought experiments for understanding the impossible situation in the real world, ideal conditions also are needed. This study discussed above three aspects with various concrete examples and, with Park et al.'s study (Park et al., 1998), present the theoretical basis for the study of students' and teachers' understanding the idealization.

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FMEA of Electric Power Management System for Digital Twin Technology Development of Electric Propulsion Vessels (전기추진선박 디지털트윈 기술개발을 위한 전력관리시스템 FMEA)

  • Yoon, Kyoungkuk;Kim, Jongsu
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.7
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    • pp.1098-1105
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    • 2021
  • The International Maritime Organization has steadily strengthened environmental regulations on nitrogen oxides and carbon dioxide emitted from marine vessels. Consequently, the demand for electric propulsion vessels based on eco-friendly elements has increased. To this end, research and development has been steadily conducted for various vessels. In electric propulsion systems, a redundancy configuration is typically adopted to increase reliability and facilitate the onboard arrangement. Furthermore, studies have been actively conducted to ensure the safety of electric propulsion systems through the combination with digital twin technology. A digital twin can be used to predict outcomes in advance by implementing real-world equipment or space in a virtual world like twins, integrating real-world information and data with the virtual world, and performing computer simulations of situations that can occur in a real environment. In this study, we perform failure modes and effects analysis (FMEA) to validate the electric power management system (PMS) redundancy scheme for the digital twin technology development of electric propulsion vessels. Then, we propose the role and algorithm of PMS as a compensation function for preventing primary and secondary damages caused by a single equipment failure of the PMS and preventing additional damages by analyzing the impact on the entire system under real vessel operating conditions based on the redundancy FMEA suggested for the ship classification and certification. We verified the improvement in propulsion conservation through tests.