• Title/Summary/Keyword: Reaction factor

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방기 전탕액의 비만세포 매개성 아나필락시반응 및 종양괴사인자알파 생성 억제효과 (Inhibitory Effect of Mast Cell-Mediated Anaphylactic Reactions and Tumor Necrosis $Factor-{\alpha}$ Production by Aqueous Extract of Sinomenium acutum stem)

  • 김동혁;송봉근;이언정;김형균
    • 대한한의학회지
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    • 제21권2호
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    • pp.52-59
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    • 2000
  • Objectives: The root and stem of Sinomenium acutum has been used for treatment of arthritis and neuralgia in oriental medicine. To find new substances of the anti-anaphylactic drugs, we studied Sinomenium acutum. Methods: To investigate the effect of this plant, the effect on anaphylactic reaction, plasma histamine level, and tumor necrosis $factor-{\alpha}-(TNF-{\alpha})$ production were measured after the aqueous extract of Sinomenium acutum stem (SSAE) was administrated to mice and rats. Results: The SSAE (0.1 to 1000 mg/kg) dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice. Especially, SSAE reduced compound 48/80-induced anaphylactic reaction with 50% at the dose of 1000 mg/kg. SSAE (100 to 1000 mg/kg) also significantly inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. When mice were pretreated with SSAE at a concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were reduced in a dose-dependent manner. SSAE (1 to 1000 g/ml) dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMCs) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMCs, when SSAE was added, increased compared with that of a normal control. In addition, SSAE (0.1 g/ml) had a significant inhibitory effect on anti-DNP IgE-induced $TNF-{\alpha}$ production. Conclusions: These results indicate that SSAE inhibits mast cell-mediated anaphylactic reactions and $TNF-{\alpha}$ production from mast cells.

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아동의 부정적 정서표현에 대한 어머니 반응 척도 개발과 타당화 (The Development and Validity of a Scale for Measuring Mother's Reaction to Children's Negative Emotions)

  • 오지현
    • 아동학회지
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    • 제34권6호
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    • pp.97-122
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    • 2013
  • The aim of this study was to develop and validate measures of a mother's reaction to children's negative emotions. After construct factors of a mother's reaction to children's negative emotions based on the theoretical basis and existing scales were explored, the first preliminary items were extracted. After the content validity was confirmed by expert opinions, the second preliminary items were composed, and the initial survey was carried out. Using exploratory factor analysis, three principal factors and 21 items were revealed to be most suitable. The factors of the scale consist of emotion-coaching-reactions, oversensitive reactions, and emotion-minimizing-reactions, respectively. In addition, the reliability analysis and validation analysis of the scale was conducted, by means of surveying 413 elementary students. The internal coherence reliability and test-retest reliability were verified as was the general internal coherence and timing stability of the scale. There were three additional verifications to validate the scale. (1)For the evidence based on internal structure, the confirmatory factor analysis and convergent-discriminant evidence; this resulted in confirming the factor structure of the scale as being reliable. (2)In order to understand the relationships to other variables, the correlation analysis came in effect to the overall scale and each of its sub-factors, showing that they are significantly correlated with the scale of the child's perception on rearing attitudes of the mother. (3)As for evidence based on the consequences of the test, the correlation analysis produced a result showed that sub-factors of the scale have as significant correlation with the child's emotional intelligence and resilience.

Small Black Soybean (Glycine max Merr.) Inhibits Mast Cell-mediated Allergic Reaction and Inflammatory Cytokine Secretion

  • Shin, Hye-Young;Lim, Jong-Pil;Kim, Dae-Keun;Chae, Byeong-Suk;Kwon, Young-Ee;Oh, Chan-Ho;Cho, Moon-Gu;Lee, Tae-Kyoo;Park, Jeong-Suk;Lee, Jae-Hyeok;Jeon, Hoon;Shin, Tae-Yong
    • Natural Product Sciences
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    • 제13권3호
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    • pp.263-267
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    • 2007
  • The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of mast cell-mediated immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of small black soybean (Glycine max Merr.) (Leguminosae) on mast cell-mediated allergic reaction and pro-inflammatory cytokine secretion. Small black soybean (SBS) inhibited compound 48/80-induced systemic reaction. SBS attenuated immunoglobulin (Ig) E-mediated local allergic reaction. In addition, SBS decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-8 secretion in human mast cells. These results indicate that SBS may be beneficial in the treatment of mast cell-mediated immediate-type allergic reactions.

Comparison of Motor Skill Acquisition according to Types of Sensory-Stimuli Cue in Serial Reaction Time Task

  • Kwon, Yong Hyun;Lee, Myoung Hee
    • The Journal of Korean Physical Therapy
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    • 제26권3호
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    • pp.191-195
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    • 2014
  • Purpose: The purpose of this study is to investigate whether types of sensory-stimuli cues in terms of visual, auditory, and visuoauditory cues can be affected to motor sequential learning in healthy adults, using serial reaction time task. Methods: Twenty four healthy subjects participated in this study, who were randomly allocated into three groups, in terms of visual-stimuli (VS) group, auditory-stimuli (AS) group, and visuoauditory-stimuli (VAS) group. In SRT task, eight Arabic numbers were adopted as presentational stimulus, which were composed of three different types of presentational modules, in terms of visual, auditory, and visuoauditory stimuli. On an experiment, all subjects performed total 3 sessions relevant to each stimulus module with a pause of 10 minutes for training and pre-/post-tests. At the pre- and post-tests, reaction time and accuracy were calculated. Results: In reaction time, significant differences were founded in terms of between-subjects, within-subjects, and interaction effect for group ${\times}$ repeated factor. In accuracy, no significant differences were observed in between-group and interaction effect for groups ${\times}$ repeated factor. However, a significant main effect of within-subjects was observed. In addition, a significant difference was showed in comparison of differences of changes between the pre- and post-test only in the reaction time among three groups. Conclusion: This study suggest that short-term sequential motor training on one day induced behavioral modification, such as speed and accuracy of motor response. In addition, we found that motor training using visual-stimuli cue showed better effect of motor skill acquisition, compared to auditory and visuoauditory-stimuli cues.

홍삼추출물 및 농축물의 마이야르 갈색화반응 촉진에 미치는 아미노산 및 당의 영향 (Effects of Amino Acids and SLlgars on the Maillard Brou'nine Reactions during Extraction and Concentration of Red Ginseng)

  • 이광승;최강주
    • Journal of Ginseng Research
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    • 제14권2호
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    • pp.117-121
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    • 1990
  • Browning intensity is a major factor to estimate the quality of red ginseng or red ginseng products. The Maillard type of browning reaction proceeds nonenzymatically during extraction and concentration of red ginseng. The present studies were carried out to investigate the effects of amino acids and sugars on the browning reaction during extraction and concentration of red ginseng. Red ginseng was pulverized to 115 mesh and then tenfold (v/w) of water was added to the powder to make the substrate of red ginseng. Solution (0.1 M) of fourteen amino acids and of folly silgars were added to the substrates of red ginseng powder and these were then extracted and concentrated to examine their browning intensities. Amino acids were more effective than sligars in acrelerating the browning reaction. Acceleration of the browning reaction in the concentrate was in the order of arginine> histidine>glycine>alanine>lysine phenyl alanine>aspartic acid>lelicine>threonine>gllitamic acid>tyrosine>valine>istleucine>methionine for amino acids, and was glucose>frlictose >silcrose, maltose for sugars.

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청년층과 노인층의 단순반응속도 비교에 관한 연구 (The Comparison of Simple Reaction Time between Young and Old Generation)

  • 권규식;최철
    • 산업경영시스템학회지
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    • 제27권4호
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    • pp.133-140
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    • 2004
  • This study deals with human reaction speed according to human physical conditions (body size) such as head width, thickness, breast width, arm extent, and age. Especially, the results of this study are compared between young and old generation. According to this study, the thickness and extent factor do not have any correlation with human reaction speed, but width factors(head width, breast width, etc) have some correlation with human reaction speed. The result of this study can be used to find fitter person for a special job such as emergency condition job, sports man (because you can find a person having a good talent for it without test). Also, the purpose of this study is to find CNT (Channel Noise Time). The word of CNT is to explain the relation between Channel Noise and working speed. (Channel Noise is a kind of noise happening between the human information transmission channel.)

한국형 폭력 반응 측정도구의 타당도 및 신뢰도 검증: 응급실 간호사 대상 (Validity and Reliability of ARQ-K (Korean Version of the Assault Response Questionnaire) for Emergency Department Nurses in Korea)

  • 장문정;이은남
    • 대한간호학회지
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    • 제45권4호
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    • pp.544-553
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    • 2015
  • Purpose: To investigate the validity and reliability of the Korean Version of the Assault Response Questionnaire (ARQ-K) measuring the intensity of reaction to victimization of emergency nurses in Korea. Methods: An internal consistency reliability and construct validity using exploratory and confirmatory factor analysis were conducted using SPSS WIN (20.0) and AMOS (20.0). Survey data were collected from 321 nurses who worked in 3 levels - wide regional emergency centers, regional emergency centers, appointed emergency centers - of emergency care facilities in Busan, Korea. Results: The Cronbach's alpha values regarding internal consistency were .77~.93 for the subscales of ARQ-K. Factor loadings of the 26 items on the four subscales ranged from .59 to .84. The four-subscale model was validated by confirmatory factor analysis (${\chi}^2/df=3.85$, p<.001, RMR=.06, GFI=.80, NFI=.81, TLI=.83, CFI=.85, RMSEA=.09). Conclusion: This study shows that the Korean Version of the Assault Response Questionnaire is a valid and reliable instrument to assess nurses' reaction to victimization of emergency nurses in Korea.

LaMnO3 비등온 합성반응의 열적특성 (Thermal Characteristics of LaMnO3 Non-isothermal Synthesis Reaction)

  • 전종설;이정훈;윤창혁;유동준;임대호;강용
    • Korean Chemical Engineering Research
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    • 제54권3호
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    • pp.404-409
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    • 2016
  • 비등온의 열중량분석기(TGA)에 의해 nitrate-citrate 혼합물의 전구체로부터 $LaMnO_3$ 합성반응의 열적특성과 반응특성을 고찰하였다. TGA의 승온속도는 5.0, 10.0, 15.0, 20.0 K/min으로 조정하였다. $LaMnO_3$ 합성반응은 승온속도의 변화에 따라 450~600 K (X=0.4~0.7)에서 빠르게 진행되었다. $LaMnO_3$ 합성반응의 활성화에너지는 Friedman, Ozawa-Flynn-Wall 그리고 Vyazovkin의 방법으로 해석하였는데, 반응전환율의 변화에 따라 23~243 kJ/g-mol 범위 값을 나타내었다. 반응차수는 승온속도와 반응전환율이 증가함에 따라 감소하였다. 반응차수의 평균값은 반응전환율이 0.1~0.3의 범위인 반응초기에는 4.5이었으며, 반응전환율이 0.7~0.9 범위인 반응의 종결 부분에서는 1.87이었다. 반응속도의 빈도인자는 승온속도와 반응전환율의 증가에 따라 점차 증가하였다. 반응속도의 빈도인자(frequency factor)는 반응전환율이 0.1~0.3인 경우에는 205.6 ($min^{-1}$)이었으며 반응전환율이 0.7~0.9인 경우에는 475.2 ($min^{-1}$)이었다.

케블라/에폭시 프리프레그의 경화특성에 관한 연구 (A Study on the Curing Properties of Kevlar/Epoxy Prepreg)

  • 제갈영순;이원철;권오혁;윤남균;임길수;안종기;박경준
    • Composites Research
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    • 제14권2호
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    • pp.1-7
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    • 2001
  • 본 논문은 항공기 노스콘(nose cone) 제작에 사용되는 Kevlar/Epoxy 프리프레그의 조성과 경화거동을 연구한 것이다. 이 소재의 경화거동을 dielectrometer와 시차주사열분석기를 사용하여 연구하였다. 이 프리프레그는 $120^{\circ}C$ 부근에서 가장 낮은 이온점도를 보였으며, 이 이후 경화반응의 진행과 함께 점도가 $200^{\circ}C$ 까지는 상승하는 경향을 보여 주었다. 이것은 이 프리프레그의 경화반응이 $120^{\circ}C$ 부근에서 개시됨을 의미하며, 이 온도 이후부터 가속화된 분자간 가교화 반응을 통해서 분자량이 현저히 커짐을 의미한다. 본 프리프레그의 dynamic scan에 따른 loss factor 및 tan $\delta$값을 측정/연구하였는데, 매트릭스의 유동성과 매우 밀접한 관계에 있는 loss factor 거동은 이온점도 거동과 매우 유사하였다. 본 프리프레그의 열반응 특성을 시차주사열분석기를 사용해서 연구하였다.

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CaO/Ethylene glycol 용액에 의한 Polyester섬유의 분해에 관한 연구 (The Decomposition Kinetics of PET Microfiber Fabrics by Saturated CaO/Ethylene glycol Solution)

  • Yoon, Jong Ho;Huh, Man Woo;Kim, Kyung Jae
    • 한국염색가공학회지
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    • 제9권3호
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    • pp.18-26
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    • 1997
  • Polyester microfiber fabrics were decomposed at 100, 110, and 12$0^{\circ}C$ in saturated CaO/ethylene glycol solutions(CaO/EG), and the characteristics of decomposition kinetics were discussed in comparison to those by hot aqueous hydroxide solution(NaOH). The Arrhenius pre-exponential factor(A) was 9.17x $10^{14}$/M $sec^{-1}$and the activation energy($E_{a}$) was 8.19kcal/mol. While the A value was 1.947x $10^{14}$/M $sec^{-1}$ and the ($E_{a}$ value was about 15~19kcal/mol in NaOH-PET decomposition reaction. The much higher A value of the CaO/EG-PET decomposition reaction means that CaO/EG-PET decomposition reaction will occur in a less selective fashion in comparison to the NaOH-PET decomposition reaction. On the other hand, the lower ($E_{a}$) value of the CaO/EG-PET decomposition reaction than that of the NaOH-PET decomposition reaction means that CaO/EG-PET decomposition reaction is less sensitive on the variation of temperature than NaOH-PET decomposition reaction.

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