• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.415-420
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• 1999

Objectives: We investigated the effects of changes in obesity and life style factors, such as cigarette smoking, alcohol drinking, and exercise, on the changes in blood pressure and serum cholesterol among Korean men. Methods: This study included 7,205 healthy male employees in the steel manufacturing industry. Each subject underwent health examination in 1994 and was re-examined in 1997. The study subjects were classified into four categories, according to changes in body mass index (BMI) (loss; stable; mild gain: severe gain), cigarette smoking (quitter; nor-smoker; smoker continued; smoker started), alcohol drinking (quitter; non-drinker; drinker continued; drinker started) and exercise (more exercise; continuous regular exercise; continuous irregular or no exercise; less exercise), respectively. We evaluated the relationship between the categories of change in those independent variables and the changes in blood pressure and serum cholesterol, adjusted for BMI in 1994 and age by analysis of variance. Results: The change in systolic blood pressure was positively associated with the changes in BMI (p<0.001) and drinking (p=0,001), but negatively with smoking (p=0,004), compared to the first category of each independent variables. The systolic blood pressure was significantly less increased in the continuous smoking group than quitter or hon-smoker. The changes in diastolic blood pressure and serum cholesterol appeared to have statistically significant linear relationships only with the change in BMI. The change in exercise showed a marginal significance with diastolic blood pressure (p=0.088). Conclusions: These prospective data emphasize the importance of obesity as a determinant of the changes in blood pressure and serum cholesterol. In addition, the changes in smoking and drinking habits can affect systolic blood pressure.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권2호
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• pp.125-127
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• 2010

The coexistence of aspergillosis and squamous cell carcinoma (SCC) in the maxillary sinus was very rare. To our knowledge, this is the second report of coexistent SCC and aspergillosis in the maxillary sinus. A 58-year-old man underwent surgery for unilateral maxillary sinus infection with oroantral fistula. In the surgical specimen, SCC and aspergillosis were co-detected with routine and immunohistochemical stainings. Moreover, human papillomavirus 18 (HPV-18) was detected by polymerase chain reaction in the sinus specimen. The patient was re-operated with subtotal maxillectomy and has been followed up for two years without any evidence of recurrence or metastasis. Although it is not understood how aspergillosis could induce carcinoma formation, the chronic inflammation caused by prolonged fungal infection might be carcinogenic. Moreover, HPV-16 and -18 were another causative pathogens of SCC in the head and neck region. We recommend careful examination, including preoperative cytology, in patients with maxillary sinus fungal infections because of the potential for cancer development.

• Clinics in Shoulder and Elbow
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• 제1권1호
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• pp.19-25
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• 1998

Appropriate clinical examination and imaging may lead to early diagnosis and treatment of the shoulder impingement syndrome, thus preventing progressing to a complete tear of rotator cuff. The impingement syndrome was caused by repeated entrapment and compression of supraspinatus tendon between the proximal end of humerus inferiorly, particullary its greater tuberosity. and one or m <)re component of coracoacromial arch superiorly. The purpose of this study is to critically, evaluate the result of twenty-five consecutive subacromial decompression with impingement syndrome and to assess the diagnostic accuracy of MR imaging by using oblique coronal and oblique sagittal plan. These patients were treated by arthroscopic subacromial decompression after their pains failed to improve with conservative therapy over three month. The average follow up was 25 month(range, 12 to 50). The mean age was 43 year old. The results were rated based on subjective response and the UCLA shoulder rating scale of the result. Ten patients(40%) were rated as excellent, 11patients(44%) were good. while four patients(16%) were fair. Radiologic evaluation suggested that the oblique sagittal plan of MRI can be helpful in evaluation of bony and soft-tissue structure of the coracoacromial arch and determining depth of bony resection. There were no infection or neurovascular injury. In reviewing our result, it appears that the arthroscopic subacromial decompression can be successful sugery for shoulder impingement syndrome and diagnostic accuracy of supplimentary oblique sagittal view of MRI was relatively higher than oblique coronal view alone for apprqpriate surgical plan.

• Journal of Preventive Medicine and Public Health
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• 제49권2호
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• pp.118-128
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• 2016

Objectives: The purposes of this study were to examine the status of children and adolescents with regard to enrollment in private medical insurance (PMI) and to investigate its influence on their utilization of medical services. Methods: The present study assessed 2973 subjects younger than 19 years of age who participated in five consecutive Korea Health Panel surveys from 2009 to 2012. Results: At the initial assessment, less than 20% of the study population had not enrolled in any PMI program, but this proportion decreased over time. Additionally, the number of subjects with more than two policies increased, the proportions of holders of indemnity-type only ('I'-only) and of fixed amount+indemnity-type ('F+I') increased, whereas the proportion of holders with fixed amount-type only ('F'-only) decreased. Compared with subjects without private insurance, PMI policyholders were more likely to use outpatient and emergency services, and the number of policies was proportionately related to inpatient service utilization. Regarding outpatient care, subjects with 'F'-only PMI used these services more often than did uninsured subjects (odds ratio [OR], 1.69), whereas subjects with 'I'-only PMI or 'F+I' PMI utilized a broad range of inpatient, outpatient, and emergency services relative to uninsured subjects (ORs for 'I'-only: 1.39, 1.63, and 1.38, respectively; ORs for 'F+I': 1.67, 2.09, and 1.37, respectively). Conclusions: The findings suggest public policy approaches to standardizing PMI contracts, reform in calculation of premiums in PMI, re-examination regarding indemnity insurance products, and mutual control mechanisms to mediate between national health insurance services and private insurers are required.

• 한국방사선학회논문지
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• 제9권4호
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• pp.249-255
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• 2015

본 연구는 PET/CT의 이미지 추가 정보를 통해 이미지 재형성과 합성기능을 바탕으로 TPS 임상 적용과 기초 자료 활용 및 지속적인 연구 개발을 위하여 True-D 기법과 MIM 소프트웨어를 접목하여 각각의 영상 간 합성 작업을 기반으로 이미지의 폭 넓은 활용으로 임상에서 판독에 소용되는 시간 및 비용을 줄이고 효율적 진단 및 방사선치료 시 종양 표적 결정에 유효한 도구로 사용하고자 함이며 정밀한 치료효과 판정에 활용하여 임상에서 판독에 소요되는 시간과 불필요한 추가 검사를 줄일 수 있을 것으로 기대하며 종양환자 판독 보고서 작성 및 PACS 등 타 소프트웨어와의 호환성 개발로 PET/CT 기기의 성능평가에 활용 될 것으로 기대한다.

• 한국임상수의학회지
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• 제21권2호
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• pp.154-160
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• 2004

This study was carried out to monitor the response of ovaries and cyst according to treatment with dinoprost or fenprostalene in dairy cows with ovarian luteal cyst. Twenty cows were diagnosed as luteal cysts by rectal palpation, ultrasonography and progesterone analysis. The cystic cows were treated with dinoprost or fenprostalene. All the animals were re-examined by ultrasonography and blood was collected for the measurement of plasma progesterone concentration at day 0 (the day of treatment), 3, 13 and 24, respectively. Mean plasma progesterone concentrations on day -11 and day -1 before treatment were 2.1$\pm$0.2 ng/ml and 2.8$\pm$0.3 ng/ml, respectively. On day 3 and day 13 were 0.3$\pm$0.1 ng/ml and 4.3$\pm$0.2 ng/ml, respectively. Mean cystic wall thickness on day -11 and day -1 were 3.2$\pm$0.2 mm and 3.9$\pm$0.2 mm, respectively. And on day 3 was 2.4$\pm$0.3 mm. The responses of luteal cyst after treatment noted during ultrasonography included dramatical degeneration of the luteal tissue of cystic wall on day 3 (all cows), slowly reduction of cyst size (cyst resolution) until last examination (8 cows), complete disappearance on day 13 (7 cows) and no changes of cyst size (5 cows). A group of 10 cows with luteal cysts injected fenprostalene compared with another 10 cows treated dinoprost showed a slightly higher pregnancy rate on first service after initial treatment (50.0 vs 30.0%). But treatment effects of dinoprost or fenprostalene did not significantly different results for each groups. This study suggested that the response of the cyst according to treatment revealed various types. Therefore, veterinarians should have attention on monitoring of the response of cystic ovaries after treatment, specially on no change of cyst size after treatment.

• 한국임상수의학회지
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• 제27권2호
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• pp.159-162
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• 2010

랫드 꼬리는 연속적인 채혈을 위해서 주로 이용되는 채혈부위로 꼬리 절개법, 꼬리 절단법, 꼬리 천자 등의 방법을 통해 채혈이 이루어지고 있다. 하지만, 랫드 꼬리에 대한 혈관 구조는 아직 잘 밝혀져 있지 않다. 그래서 본 연구에서는 독성학이나 약리학에서 가장 많이 이용되는 폐쇄군인 Sprague-Dawley 랫드 꼬리의 혈관구조 규명하기 위해 혈관조형술과 면역조직학적인 방법을 실시하였다. 그 결과 SD 랫드 꼬리는 한 개의 등쪽 정맥과 두개의 외측정맥, 한쌍의 배쪽 정맥과 동맥이 존재했다. 그러므로, 본 연구는 SD 랫드 꼬리를 이용해서 채혈을 하고자 하는 연구자들이 꼬리의 혈관구조를 이해하고, 그 연구 목적에 맞게 채혈부위와 방법을 선택하는데 도움이 될 것으로 생각된다.

• 대한두개안면성형외과학회지
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• 제11권1호
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• pp.41-44
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• 2010

Purpose: The epicanthus is a specific feature in Asian. Many techniques have been described to eliminate the epicanthal fold: resection of glabellar skin, resection of medial canthal skin, V-Y advancement, V-W technique, modified Z-plasty, multiple Z-plasties, and others. The authors observed postoperative epiphora after correction of epicanthal fold by periciliary skin flap without damaging lacrimal duct. Methods: A 19-year-old woman underwent non-incisional blepharoplasty, septorhinoplasty, and periciliary epicanthoplasty. On her history, she didn't have any symptom of epiphora preoperatively. And there was no specific complaint of epiphora during the postoperative two weeks. However epiphora got worse from one month after the surgery. She was out of this country, so the patient re-visited the clinic on the postoperative six months for this on-going symptom. On an ophthalmologic examination, patient's lacrimal duct and sac was intact but both lacrimal puncta of the patient were covered with a thin membrane. This membrane was punctuated by a 25 gauge needle and dilated with a standard dilator. Results: After ophthalmologic treatment, no recurrence was observed during five weeks of follow-up periods. Conclusion: Both lacrimal puncta of the patient were only covered with membranes. And we could not confirm the direct relationship between periciliary epicanthoplasty and postoperative epiphora. The probable factors will be a predisposing narrowed punctum, post operative peri-punctal edema and decrease in muscular function of orbicularis oculi.

• Journal of Korean Neurosurgical Society
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• 제50권6호
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• pp.503-506
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• 2011

Objective : The aim of this study was to assess the safety and efficacy of radiation-sterilized allografts of iliac bone and fascia lata from cadaver specimens to repair skull base defects after transsphenoidal surgery. Methods : Between May 2009 and January 2010, 31 consecutive patients underwent endonasal transsphenoidal surgery and all patients received sellar reconstruction using allografts following tumor removal. The allografts were obtained from the local tissue bank and harvested from cadaver donors. The specimens used in our approach were tensor fascia lata and the flat area of iliac bone. For preparation, allografts were treated with gamma irradiation after routine screening by culture, and then stored at $-70^{\circ}C$. Results : The mean follow-up period after surgery was 12.6 months (range, 7.4-16 months). Overall, postoperative cerebrospinal fluid (CSF) leaks occurred in three patients (9.7%) and postoperative meningitis in one patient (3.2%). There was no definitive evidence of wound infection at the routine postoperative follow-up examination or during re-do surgery in three patients. Postoperative meningitis in one patient was improved with the use of antibiotics and prolonged CSF diversion. Conclusion : We suggest that allograft materials can be a feasible alternative to autologous tissue grafts for sellar reconstruction following transsphenoidal surgery under selected circumstances such as no or little intraoperative CSF leaks.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.76-76
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• 2003

Pluripotent embryonic stem cells can differentiate into beating cardiomyocytes with proper culture conditions and stimulants via embryo-like aggregates. We describe here the use of mouse embryonic stem (mES03) cells as a reproducible differentiation system for cardiomyocyte. mES03 cells growing in colonies were dissociated and allowed to re-aggregated in suspension [embryoid body (EB) formation〕. To induce cardiomyocytic differentiation, cells were exposed to 0.75% dimethyl sulfoxide (DMSO) during EB formation for 4 days and then another 4 days without DMSO (4+/4-). Thus treated EB was plated onto gelatin-coated dishes for differentiation. Spontaneously contracting colonies which appeared in approximately 4~5 days upon differentiation were mechanically dissected, enzymatically dispersed, plated onto coverslips, and then incubated for another 48~72 hrs. By RT-PCR, robust expression of cardiac myosin heavy chain $\alpha$, cardiac muscle heavy polypeptide 7 $\beta$($\beta$-MHC), cardiac transcription factor GATA4, and skeletal muscle-specific $\alpha$$_1$-subunit of the L-type calcium channel ($\alpha$$_1$CaC $h_{sm}$ ) were detected as early as 8 days after EB formation, but message of cardiac muscle-specific $\alpha$$_1$-subunit of the L-type calcium channel ($\alpha$$_1$CaCh) were reveled at a low level. In contrast, expression of myosin light chain (MLC-2V) and atrial natriuretic factor (ANF) were not detected during EB formation for 8 days. However, a strong expression of the atrial-specific ANF gene was expressed from day 8 onward, which were remained constant in EB. (cardiac specialization and terminal differentiation stage). Electrophysiological examination of spontaneously contracting cells showed ventricle-like action potential 17 days after the EB formation. This study indicates that mES03 cell-derived cardiomyocytes via 4+/4- protocol displayed biochemical and electrophysiological properties of subpopulation of cardiomyocytes.