• 한국화재소방학회논문지
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• 제34권1호
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• pp.115-120
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• 2020

본 연구는 소방공무원이 지각하는 조직문화 유형과 조직지원인식이 조직몰입에 어떠한 영향을 미치는지 알아봄으로써 이들의 조직문화 유형에 따른 조직몰입을 높이고 조직차원에서의 지원에 관한 실천 방안을 마련하는데 도움을 주고자 하였다. 이를 위하여 경기 북부지역 소방공무원 205명을 대상으로 유의표집 방식으로 조사하였다. 조사결과, 소방공무원의 조직문화 유형 중 집단문화와 합리문화, 그리고 조직지원인식이 조직몰입에 통계적으로 유의미한 영향을 미치는 것으로 조사되었다. 본 연구결과를 토대로, 소방공무원이 지각하고 있는 집단문화와 합리문화의 활성화와 이에 따른 조직몰입을 높이고 조직차원에서의 다양한 지원방안에 대해 제안하였다.

• Journal of Veterinary Science
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• 제22권6호
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• pp.41.1-41.14
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• 2021

Background: Our previously prepared ceftiofur (CEF) hydrochloride oily suspension shows potential wide applications for controlling swine Streptococcus suis infections, while the irrational dose has not been formulated. Objectives: The rational dose regimens of CEF oily suspension against S. suis were systematically studied using a pharmacokinetic-pharmacodynamic model method. Methods: The healthy and infected pigs were intramuscularly administered CEF hydrochloride oily suspension at a single dose of 5 mg/kg, and then the plasma and pulmonary epithelial lining fluid (PELF) were collected at different times. The minimum inhibitory concentration (MIC), minimal bactericidal concentration, mutant prevention concentration (MPC), post-antibiotic effect (PAE), and time-killing curves were determined. Subsequently, the area under the curve by the MIC (AUC_0-24h/MIC) values of desfuroylceftiofur (DFC) in the PELF was obtained by integrating in vivo pharmacokinetic data of the infected pigs and ex vivo pharmacodynamic data using the sigmoid E_max (Hill) equation. The dose was calculated based on the AUC_0-24h/MIC values for bacteriostatic action, bactericidal action, and bacterial elimination. Results: The peak concentration, the area under the concentration-time curve, and the time to peak for PELF's DFC were 24.76 ± 0.92 ㎍/mL, 811.99 ± 54.70 ㎍·h/mL, and 8.00 h in healthy pigs, and 33.04 ± 0.99 ㎍/mL, 735.85 ± 26.20 ㎍·h/mL, and 8.00 h in infected pigs, respectively. The MIC of PELF's DFC against S. suis strain was 0.25 ㎍/mL. There was strong concentration-dependent activity as determined by MPC, PAE, and the time-killing curves. The AUC_0-24h/MIC values of PELF's DFC for bacteriostatic activity, bactericidal activity, and virtual eradication of bacteria were 6.54 h, 9.69 h, and 11.49 h, respectively. Thus, a dosage regimen of 1.94 mg/kg every 72 h could be sufficient to reach bactericidal activity. Conclusions: A rational dosage regimen was recommended, and it could assist in increasing the treatment effectiveness of CEF hydrochloride oily suspension against S. Suis infections.

• 상하수도학회지
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• 제19권5호
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• pp.639-646
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• 2005

In this research, we tried to develop the application method to water management and treatment using toxicity test method. When we measure the toxicity of environmental samples, we have to decide whether we take some countermeasures to reduce the toxicity or not. The first issue is how to set these action levels in each bioassays. A new idea was attempted to authorize indirect approach of each bioassays through the response characteristics against mixture of chemicals in water quality standard. The significant response in the cell-growth-inhibition bioassay was detected for standards-mixture(STDs). For acute toxicity assay, STDs-based implicit correlation between risks to humans and bioassay data showed a rational approach to set action levels in practical management. A simple model was proposed to describe and predict the changes in the total toxicity based on the concentrations of toxic-controlling chemicals during the ozonation of landfill leachates. On the basis of this simple model, toxicity reduction was predicted for pre-aggregation treatment before ozonation and ozone concentration during the ozonation. The method proposed in this study would be useful in optimizing water treatment processes and their running conditions in terms of the toxicity reduction efficacy.

• Steel and Composite Structures
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• 제28권5호
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• pp.573-588
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• 2018

The objective of this paper is to investigate the mechanical performances of polygonal concrete-filled circular steel tubular (CFT) stub columns under axial loading through combined experimental and numerical study. A total of 32 specimens were designed to investigate the effect of the concrete strength and steel ratio on the compressive behavior of polygonal CFT stub columns. The ultimate bearing capacity, ductility and confinement effect were analyzed based on the experimental results and the failure modes were discussed in detail. Besides, ABAQUS was adopted to establish the three dimensional FE model. The composite action between the core concrete and steel tube was further discussed and clarified. It was found that the behavior of CFT stub column changes with the change of the cross-section, and the change is continuous. Finally, based on both experimental and numerical results, a unified formula was developed to estimate the ultimate bearing capacity of polygonal CFT stub columns according to the superposition principle with rational simplification. The predicted results showed satisfactory agreement with both experimental and FE results.

• 한국임상약학회지
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• 제22권3호
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• pp.260-267
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• 2012

The objective of this study was to investigate drug classification system in Korea and other developed countries. Laws and regulations of Korea regarding the system were retrieved from sources posted in Ministry of Government Legislation. We also reviewed previous research reports performed as part of government's effort to reform the system The system in the foreign countries was retrieved from the official homepage operated by each country's government. There have been two research funded by Korean government, which strongly suggested that the system should be reformed. However, we found that the system was never reformed and still effective. Drug classification system in US and most western countries consists of two categories, i.e., prescription drugs and non-prescription drugs except UK, which classifies into three categories: Prescription Only Medicines, Pharmacy Medicines, and General Sales List Medicines. Interestingly, in Japan, non-prescription drugs are further classified into three groups: Group 1, 2, and 3. Recently, Ministry of Health and Welfare (MOHW) in Korea proposed a plan to reclassify all the approved drugs according to purportedly rational and scientific criteria. However, the plan does not include reform of the existing laws and regulations, which appears that it is just one-time action rather than a sustainable administration backed up by law. Therefore, it is recommended that Korean MOHW take appropriate action on laws and regulations with regard to the system to meet global harmonization standard.

• Structural Engineering and Mechanics
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• 제20권6호
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• pp.695-712
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• 2005

Hybrid coupled shear walls in tall buildings are known as efficient structural systems to provide lateral resistance to wind and seismic loads. Multiple hybrid coupled shear walls throughout a tall building should be joined to provide additional coupling action to resist overturning moments caused by the lateral loading. This can be done using a coupling beam which connects two shear walls. In this study, experimental studies on the hybrid coupled shear wall were carried out. The main test variables were the ratios of coupling beam strength to connection strength. Finally, this paper provides background for rational design guidelines that include a design model to behave efficiently hybrid coupled shear walls.

• 경영과정보연구
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• 제16권
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• pp.77-94
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• 2005

Nowadays, to change our country into advanced economy, the factor of growth obstacles was to be eliminated, or it is so important that the logistics base establishment enlarges to improve potential productivity. The best strategy to enforce the competition power is that we should be ready for some condition which can do cooperations and association very well. Also it is necessary for actors, government, firm and logistics field, to part their role. The national effort that firm supported by government and community participates in is reduced to achieve rational logistics system because logistics is complicate action flowing to final consumer. That is, self effort is needed for logistics competition system, adjustable arrangement of logistics field, the establishment of comprehensive informations system, logistics rationalization.

• Computers and Concrete
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• 제14권6호
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• pp.635-656
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• 2014

A rational estimation of moisture distribution in structural concrete is vital for predicting the possible extent and rate of progression of impending degradation processes. The paper proposes a numerical scheme for analysing the evolution of moisture distribution in concrete subjected to wetting-drying exposure caused by intermittent periods of rainfall. The proposed paradigm is based on the stage wise implementation of non-linear finite element (FE) analysis, with each stage representing a distinct phase of a typical wet-dry cycle. The associated boundary conditions have been constituted to realize the influence of various meteorological elements such as rain, wind, relative humidity and temperature on the exposed concrete surface. The reliability of the developed scheme has been demonstrated through its application for the simulation of experimentally recorded moisture profiles reported in published literature. A sensitivity analysis has also been carried out to study the influence of critical material properties on simulated results. The proposed scheme is vital to the service life modelling of concrete structures in tropical climates which largely remain exposed to the action of alternating rains.

• 대한수학회보
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• 제55권4호
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• pp.1051-1063
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• 2018

The real moment-angle complex (or, more generally, real polyhedral product) and its real toric space have recently attracted much attention in toric topology. The aim of this paper is to give two interesting remarks regarding real polyhedral products and real toric spaces. That is, we first show that Moore's conjecture holds to be true for certain real polyhedral products. In general, real polyhedral products show some drastic difference between the rational and torsion homotopy groups. Our result shows that at least in terms of the homotopy exponent at a prime this is not the case for real polyhedral products associated to a simplicial complex whose minimal missing faces are all k-simplices with $k{\geq}2$. Moreover, we also show a structural theorem for a finite group G acting simplicially on the real toric space. In other words, we show that G always contains an element of order 2, and so the order of G should be even.

• 한국임상약학회지
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• 제19권2호
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• pp.89-95
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• 2009

Gemtuzumab ozogamicin (GO) is an antibody-targeted chemotherapeutic agent consisting of calicheamicin, a potent cytotoxic antibiotic linked to a recombinant humanized anti CD33 monoclonal antibody directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). GO is indicated for the treatment of patients with CD33 positive AML in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy. GO has shown moderate activity as a single agent in patients with CD33-positive refractory or relapsed acute myeloid leukaemia, with more promising results in acute promyelocytic leukaemia. The side effect profile may be an improvement on conventional chemotherapy, except for a higher frequency of veno-occlusive disease or sinusoidal obstructive syndrome, especially after a subsequent haematopoietic stem cell transplantation. Because of the different mechanisms of action and non-overlapping toxicities, the integration of this immunoconjugate with standard chemotherapy is a rational approach.