• Archives of Pharmacal Research
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• 제24권3호
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• pp.224-228
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• 2001

DA-5018, a recently synthesized capsaicin analog, appears to possess potent analgesic activity when administered topically. The objective of this study is to test the feasibility of the topical administration of this compound. Specifically, our goal was to identify vehicle system that permit a reasonable transdermal permeation of the compound in mice. Among the vehicles examined, isopropyl myristate (IPM) showed the largest in vitro permeability across the intact skin (83.6 ${\pm}$ 5.42${\mu}$l/$\textrm{cm}^2$/h ). However, due to the limited solubility of DA-5018 in IPM (0.53 mg/ml), the maximal flux from the IPM medium remained at only 44.3 ${\pm}2.87{\mu}$g/$\textrm{cm}^2$/hr. In order to increase the flux, addition of better solvents for DA-5018 was attempted, under the assumption that flux is the result of both solubility and permeability. Ethoxydiglycol (EG) and oleic acid (OA) were selected as examples of food solvents. The addition of IC or OA to IPM at a 1:1 volume ratio resulted in a comparable increase in the solubility of the compound (i.e., to 61.1 and 50.2 mg/ml for EG and OA, respectively). However, the addition of EG at a 1:1 volume ratio, for example, increased the flux 6.3 fold (i.e., $279{\mu}$g/$\textrm{cm}^2$/hr), while OA, at a 1:1 volume ratio, decreased the flux 5 fold (i.e., $9.26{\mu}$g/$\textrm{cm}^2$//hr). The mechanism of this discrepancy between EG and OA was investigated by measuring the permeabilty of DA-5018 across the stratum corneum-removed skin of the mouse, under the hypothesis that the viable skin layer may serve as a barrier for the permeation of lipophilic substances such as DA 5018. The permeability of DA-5018, from the medium of EG or OA, across the viable skin differed greatly for EG ($0.41{\mu}$l/$\textrm{cm}^2$/hr) and OA ($0.086{\mu}$l/$\textrm{cm}^2$/hr), suggesting that a higher permeability across the viable skin layer is needed for the second solvents. The maximum flux across the intact skin was achieved for DA-5018 when EG was added to IPM at a 1:1 volume ratio. Thus, the use of a binary system appears to be the best approach for realizing the transdermal delivery of DA-5018 at a reasonable rate.

• 한국지반공학회논문집
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• 제25권1호
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• pp.65-76
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• 2009

본 연구에서는 불포화 지반의 특성을 파악하고, 포화투수계수($k_s$)와 강우강도(i) 및 함수특성곡선(SWCC)이 사면의 안정성에 어떠한 영향을 주는지 연관성을 파악하기 위해 국내 지반에 폭넓게 분포하고 있는 화강풍화토에 대해 연구를 수행하였다. 기존 연구자료 및 실험을 통해 얻은 정규화함수특성곡선을 데이터베이스화하고 통계적 개념을 도입하여 상한 평균 하한의 함수특성곡선을 추정하였다. 입도분포곡선과 상한 평균 하한의 함수특성곡선과의 관계를 바탕으로 함수특성곡선 자료가 없는 지반의 함수특성곡선을 개략적으로 추정하는 방법 또한 제안하였다. 그리고 추정된 상한 평균 하한의 함수특성곡선을 이용하여 강우시 사면 구조물의 시간 의존적 안전율 변화 추이를 통해 실무적으로 사용할 수 있는 포화투수계수와 강우강도의 비를 제안하였다. 연구결과에 의하면 강우 침투에 의한 안전율 변화는 강우강도의 절대 크기에 좌우되지 않고 강우강도와 투수계수의 비에 영향을 받는다. 그리고 사면의 안전율은 강우침투에 의해 감소하기 시작하며 임계값에 도달한 이후 다시 상승하는 것을 알 수 있다. 수치해석결과 가장 낮은 안전율을 보이는 때는 상한의 함수특성곡선을 이용할 경우로, 이때 포화 투수계수값이 강우강도와 같거나 두 배가 될 때이다.

• 지구물리와물리탐사
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• 제17권3호
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• pp.121-128
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• 2014

투과도는 다공질 암석 내에서 유체의 유동 특성을 나타내는 중요한 매개변수로서 일반적으로 코어 시료의 유체 유동실험을 통해 산출된다. 하지만, 유체 유동실험을 위해서는 별도의 실험장치가 필요하며, 투과도가 낮을 경우 많은 시간이 소요될 수 있다. 본 연구에서는 일련의 투과도 측정 실험 없이 시료의 건조과정만으로 투과도를 도출하기 위해 유체투과도, 공극률, 건조율간의 상관관게를 분석하였다. 공극률은 표면건조 포화시료를 건조시키면서 무게 변화를 연속적으로 측정하는 건조 모니터링 방법을 이용하여 산출하였으며, 건조율은 물 포화율에 따른 시료의 무게 변화율로부터 구했다. 70 ~ 670 mD의 투과도를 보이는 6개의 베레아 사암을 이용해 회귀분석한 결과 공극률 및 건조율로부터 다공성 사암의 투과도를 예측할 수 있는 새로운 경험식을 도출하였다.

• The Plant Pathology Journal
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• 제19권4호
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• pp.189-194
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• 2003

The effects of prochloraz on membrane permeability and germination of uredospores of Puccinia recondita were investigated to determine its potential mode of action on wheat leaf rust control activity. Disease control activity of ergosterol biosynthesis inhibitors (EBIs) and their activities on uredospore membrane permeability and germination were examined with wheat leaf rust pathogen, both in vitro and in vivo. While wheat leaf rust was not controlled by prochloraz, electrolytic leakage and spore germination of P. recondita uredospore was the highest with the use of prochloraz among the eight fungicides tested. Prochloraz stimulated uredospore of P. recondita to germinate at a higher ratio. Although certain EBIs, such as hexaconazole, showed excellent control activity, their effects on uredospore membrane permeability and germination was much inferior to prochloraz. Therefore, results of this study suggest that effects of EBIs on membrane permeability and germination of uredospore are not always correlated with their disease control activity.

• International Journal of Concrete Structures and Materials
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• 제19권1E호
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• pp.41-48
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• 2007

Addition of latex to concrete is known to increase its durability and permeability. The purpose of this study is to analyze air void systems in latex-modified concretes using a reasonable and objective method of image analysis with such experimental variables as water-cement (w/c) ratios, latex contents (0%, 15%) and cement types (ordinary portland cement (OPC), high-early strength (HES) cement and very-early strength (VES) cement). The results are analyzed by spacing factor, air volume (content) after hardening, air void distribution and structure. Additionally, air void systems and permeability of latex-modified concrete (LMC) are compared by a correlation analysis. The results are as follows. The LMC of the same w/c ratio showed better air entraining (AE) effect than OPC with AE water reducer. The VES-LMC showed that the quantity of entrained air below $100{\mu}m$ increased more than four times. For the case of HES-LMC, microscopic entrained air between the range of 50 to $500{\mu}m$ increased greater than 7 times even in the absence of anti-foamer. Although spacing factor was measured rather low, the permeability of latex-modified concrete was good. It is construed that air void system does not have a considerable effect on the property of latex-modified concrete, but latex film (membrane) has a definite influence on the durability of LMC.

• 한국농공학회지
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• 제26권3호
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• pp.81-89
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• 1984

To examine the moisture adsorption and permeability characteristics, weathered granite soils of different degrees of weathering, cultivated upland soils and sands of Han-river were sampled. The results are as follows: 1. In case that the mother rock was same, the pF values under same moisture content decreased according as the grain size of soil became finer by the weathering process. 2. In case that the mother rock was different, the pF value varied by the behavior of clay minerals, and the cultivated upland soils showed more sensitive reaction than sands and fresh granite soils. 3. The pF value changed by the difference of primary moisture content and also influenced by soil structure, testing method and etc. 4. The pF value and compaction curve had close relation, however under same moisture content, the pF value decreased by the increment of density. 5. The permeability depend on the available void ratio between the soil particles according to the degree of weathering, and the pF value of available void water between the soil particles which related directly to permeability was about 3.3 except the void water holded in the soil particles. 6. As the above, the pF value and permeability were differentiated by degree of weathering, primary moisture content, density and etc. Therefore it is considered unreasonable to define uniformly by soil texture.

• 물과 미래
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• 제7권2호
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• pp.83-91
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• 1974

Fill Type Dam에 있어서 일반적으로 축조재료는 경제성을 감안하여 Dam Site 부근에서 구해야하므로 Core 용재료로서는 차수성의 문제만 해결된다면 마시토도 사용가능할 것이라는 전제하에 본문에서는 마사토를 단독 또는 혼합재료로서 각종시험을 실시하여 사용가능성 여부를 검토하고 기사용범위를 정함으로써 앞으로의 사용자들에게 편의를 제공코저 한다.

• 공업화학
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• 제16권1호
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• pp.144-149
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• 2005

Poly(ether ether ketone)을 설폰화시킨 후 poly(ether sulfone) (PES)과 다양한 조성으로 혼합하여 블렌드 막을 제조하였고, 직접메탄올 연료전지(DMFC; Direct Methanol Fuel Cell)용 고분자 전해질 막으로의 응용 가능성을 살펴보기 위하여 조성의 변화에 따른 메탄올 투과도, 수소 이온 전도도, 이온 교환 용량, 그리고 함수율의 변화를 살펴보았다. Sulfonated poly(ether ether ketone) (SPEEK)의 경우 수소 이온 전도도는 비교적 우수하였으나 메탄올 투과도 역시 비교적 높았다. 그러나, PES의 양이 증가함에 따라 수소 이온 전도도보다 메탄올 투과도가 급격히 감소하여서 PES의 양이 40%일 때 가장 좋은 선택성을 나타내었다.

• Geosystem Engineering
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• 제21권6호
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• pp.344-351
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• 2018

It is reported that the flooding rate in low permeability sandstones is low and the oil recovery is hard to increase after water breakthrough. Understanding characteristics of waterflood is hence important for the recovery improvement. In this work, flooding tests on low permeability sandstones were conducted. The corresponding flooding characteristics were investigated by means of CT scanning and Nuclear Magnetic Resonance. Effects of irreducible water and different rates were also discussed in detail. Experimental results reveal a piston-like displacement at a low rate in low permeability samples. The saturation profile is steep and almost vertical to the forward direction. The results at a low rate confirm that once water broke through, increasing the flooding rate or flooding time can hardly reduce the remaining oil inside the sample. It is probably due to the high pore-throat ratio proven by rate-controlled mercury. Results also confirm that the presence of initial water enhanced sweep efficiency substantially. On one hand, because water had previously occupied the small pores, the subsequent oil can only invade relatively large pores and became more movable. On the other hand, stable collars can not form due to the steep front, which may suppress the snap-off.

• 한국지반공학회지:지반
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• 제8권3호
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• pp.61-74
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• 1992

Geoteztile drain의 설계를 위한 기초자료를 제시하기 위하여 배수용 geotextile을 대상으로 평면투수성능을 실험적으로 분석하였다. 일반적으로 압축응력의 증가에 대한 geotextile의 두께, 평면투수계수 및 전수성은 10KN/m2 정도 이하에서 현자한 감소를 보였으며 Geotextile의 평면투수계수는 장섬유부직포가 단섬유부직포나 복합포 보다 낮게 나타났다. 또한 Geotextile의 압축률은 PES. 계부직포가 PP계 부직포 보다 큰 경향을 보였으며 geotextile의 압축음력 e(KN In)와 압축률 Cr(oA)의 관계식은 Cr=13.37 In+23.28로 표시되었고 2KN In"를 기준 으로 한 압축률 Cr'와 평면 투수계수 감소율 Pr의 관계식은 Pr=1.250r'로 표시되었다.