• 대한전자공학회논문지TC
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• 제42권11호
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• pp.27-34
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• 2005

Mobile Ad Hoc Networks (MANETs)은 기존의 기반구조에 의존하지 않고 자치적으로 구성${\cdot}$운영되는 네트워크이다. 다른 네트워크 토폴로지에서처럼, 보완은 MANET의 사용 확산에 중요한 요소이며, 특히 노드들의 구성이 자주 빠르게 변하고, 기존의 기반구조에 대한 접속이 불가능한 MANET에서 이러한 특성을 지원하는 보안 프로토콜의 개발이 중요하다. 유선의 기반구조를 적용한 네트워크에서 이미 개발되어 사용 중인 신뢰 모델과 인증 프로토콜은 MANET에서 사용될 수 없다. 이 논문에서는 아주 넓은 지역에 걸쳐 분포된 이동 사용자에게 효율적인 인증 문제를 주제로 주목하고, 위와 같은 MANET 환경에 맞는 새로운 인증 방법을 제안한다. 제안된 방법은 노드들에게 CA(Certification Authority)의 기능을 분산시키고 CA이 기능이 구현된 노드들 사이에 인증 정보를 효율적으로 공유하기 위해 randomized group을 사용한다. 또한 randomized group을 적용한 인증 메커니즘의 성능을 평가한다.

• 대한전자공학회논문지TC
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• 제46권8호
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• pp.22-33
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• 2009

모바일 애드혹 네트워크는 유선 환경 기반구조의 도움없이 이동 노드에 의해 자치적으로 자가조직되는 구조이다. 이동 노드가 모바일 애드혹 네트워크를 구성하기 위해서는 라우팅 정보같이 네트워크의 관리에 필요한 정보들이 이동 노드들 간에 자치적으로 전달되는 특성으로 인해 네트워크의 보안이 중요한 주제이다. 특히 네트워크를 구성하는 이동 노드들이 서로를 신뢰 하는데 기반이 되는 인증 메커니즘은 필수적이다. 우리는 [1]에서 분산된 이동 노드들 간의 효율적인 인증을 위하여 랜덤 그룹을 이용한 인증 메커니즘을 제안하였다. 이 논문에서는 [1]에서 제안한 메커니즘의 성능을 분석하고 그 결과를 시뮬레이션 결과와 비교하였다 성능 분석 결과는 모바일 애드혹 네트워크를 구성하는 이동노드나 CA의 수에 상관없이 랜덤 CA 그룹의 크기가 10-12일 때, 최저의 비용으로 인증 메커니즘이 동작함을 보여주며, 추후 분산 인증 체계에서 공개키 방식을 적용하는 경우의 분석 모델로 활용될 수 있다.

• Journal of Nutrition and Health
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• 제44권6호
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• pp.474-480
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• 2011

Calcium (Ca) is an essential element to maintain body homeostasis. However, many factors disturb calcium absorption. Aspartic acid chelated calcium (AAC) was synthesized by new methods using calcium carbonate and aspartic acid. This study was carried out to investigate the bioavailability of AAC in Ca-deficient rats. The experimental groups were as follows: NC; normal diet control group, CD-C; untreated control group of Ca-deficient (CD) rats, CD-$CaCO_3$; $CaCO_3$ treated group of CD rats, CD-AAC; AAC treated group of CD rats, and CD-SWC; and seaweed-derived Ca treated group of CD rats. The Ca content of various types of Ca was held constant at 32 mg/day, and the four CD groups were fed for 7 days after randomized grouping. Ca content in serum, urine, and feces within feeding periods were analyzed to confirm Ca absorption. Serum Ca content was significantly higher in the CD-AAC (11.24 mg/dL) and CD-SWC (10.12 mg/dL) groups than that in the CD-C (8.6 mg/dL) group 2 hours following the first administration. The Ca content in feces was significantly lower in the CD-AAC (35.4 mg/3 days) and CD-SWC (71.1 mg/3 day) groups than that in the CD-$CaCO_3$ (98.7 mg/3 days) group (p > 0.05). AAC had a 2.3-fold higher absorption rate of Ca than that of SWC. No differences in fibula length were observed in the NC and CD groups. The fibula weights of the CD-AAC (0.33 g) and CD-SWC (0.33 g) groups increased compared to those in the CD-C (0.27 g) group; however, no significant difference was observed between the CD groups. We conclude that bioavailability of AAC is higher than that of seaweed-derived Ca or inorganic Ca. Thus, these findings suggest the AAC has potential as a functional food material related to Ca metabolism.

• Journal of Nutrition and Health
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• 제27권2호
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• pp.162-171
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• 1994

The purpose of this study was to describe the effects of caffeine ingestion on the metabolic responses during submaximal exercise. Ten male of rowing player aged 18-22yrs. participated in the study. No subjects had any remarkable medical history and none were taking medications. According to the administration of dehydrated caffeine(CA) (6mg/kg) or placebo(PA), they were classified into two groups such as caffeine group and placebo group. A randomized, double-blind, crossover protocol was employed using either CA or PA. Subjects underwent a submaximal bicycle ergometer. Blood was drawn intravenously prior to 60 min., at rest, at 30, and 45 min. of exercise, and recovery period. Plasma concentrations of glucose, free fatty acid and lactate were obtained using enzymatic method. Followings were obtained by the tests and analyses; 1) Blood glucose(BG) of 45 minute of exercise was significantly decreased in CA group of 76.3$\pm$14.8 mg/100ml compared with PA group of 94.9$\pm$11.2 mg/100mg(p<0.5). 2) Free fatty acid(FFA) of 30minute of exercise was significantly increased in CA group of 720$\pm$80 $\mu$Eq/1 compared with PA group of 360$\pm$120 $\mu$Eq/1(p<0.5). After exercise, FFA was significantly higher in CA group than those in PA group(p<0.1). 3) Blood lactate(BL) was not significantly different between the two. After exercise, BL was significantly different in 30 minute(p<05).

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7517-7522
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• 2015

Onion (Allium cepa) consumption has been remarked in folk medicine which has not been noted to be administered so far as an adjunct to conventional doxorubicin-based chemotherapy in breast cancer patients. To our knowledge, this is the first study aimed to investigate the effects of consuming fresh yellow onions on hepatic enzymes and cancer specific antigens compared with a low-onion containing diet among breast cancer (BC) participants treated with doxorubicin. This parallel design randomized controlled clinical trial was conducted on 56 BC patients whose malignancy was confirmed with histopathological examination. Subjects were assigned in a stratified-random allocation into either group received body mass index dependent 100-160 g/d of onion as high onion group (HO; n=28) or 30-40 g/d small onion in low onion group (LO; n=28) for eight weeks intervention. Participants, care givers and laboratory assessor were blinded to the assignments (IRCT registry no: IRCT2012103111335N1). The compliance of participants in the analysis was appropriate (87.9%). Comparing changes throughout pre- and post-dose treatments indicated significant controls on carcinoembryonic antigen, cancer antigen-125 and alkaline phosphatase levels in the HO group (P<0.05). Our findings for the first time showed that regular onion administration could be effective for hepatic enzyme conveying adjuvant chemotherapy relevant toxicity and reducing the tumor markers in BC during doxorubicin-based chemotherapy.

• 대한한방부인과학회지
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• 제34권2호
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• pp.48-61
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• 2021

Objectives: This study was aimed to review the effect of acupuncture on endometriosis related pain in patients. Methods: Researchers searched data through 6 online databases up to November 2020. The data was limited to randomized controlled trial studies on endometriosis patients diagnosed with laparoscopy. Results: 7 Randomized controlled trials were included in this study. All of studies were published in Chinese, in China. Intervention of treatment group were composed of simple acupuncture and electroacupuncture. Intervention of control group were made up with mifepristone, herbal medicine and acupuncture. Outcome measurements were effective rate, serum Cancer antigen-125 (CA-125), Visual analogue scale (VAS)/pain score, and recurrence rate in 1 year. In all outcome measurements, treatment group were more effective than control group and it was statistically significant. Conclusions: Acupuncture therapy is effective in decreasing endometriosis related pain and preventing recurrence. However, because endometriosis is easy to recur, additional long-term research is needed.

• 동의신경정신과학회지
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• 제32권2호
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• pp.81-93
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• 2021

Objectives: Mild cognitive impairment (MCI) is condition of cognitive decline shown in transition from normal aging to dementia. Hominis placenta pharmacopuncture (HPP) is a treatment that combines effects of medication and acupuncture by injecting Hominis placenta into acupoints. The objective of this study was to evaluate the efficacy and safety of HPP for MCI. Methods: This was a randomized, double-blind, placebo-controlled, two-center clinical trial. Eligible patients were randomly allocated to either the HPP group or the placebo group. HPP or saline as placebo was administered to participants for eight weeks. Changes in symptoms were observed. The primary outcome was difference in mean change of Korean Version of the Montreal Cognitive Assessment (MoCA-K) score between the HPP group and the placebo group. Cognitive function, overall status of mood and sleep, and quality of life (QoL) were also assessed. Safety assessment and economic analysis were then conducted. Results: Thirty participants were enrolled. One participant in the placebo group dropped out. The score of MoCA-K increased after treatment. Its mean change was smaller in the HPP group than in the control group. HPP ameliorated Global Deterioration Scale and Korean Dementia Rating Scale subtests for attention, organization, and memory compared to the placebo. However, none of them was significantly different between the two groups. Mood, sleep, and QoL all improved more in the HPP group than in the placebo group, although differences between the two groups were not statistically significant. There was no adverse event probably related to the drug. HPP treatment needed KRW 345,000 more than the placebo group in improving Geriatric Quality of Life scale-Dementia score by one point for one year. Conclusions: Although HPP treatment did not significantly improve cognition, it changed behavioral and psychological symptoms in MCI.

• Fisheries and Aquatic Sciences
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• 제25권8호
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• pp.450-461
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• 2022

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2'-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (MoCA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

• 대한전자공학회논문지TC
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• 제45권10호
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• pp.40-48
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• 2008

기존의 기반 구조에 의존하지 않고 이동 노드들에 의해 자가 구성되는 모바일 애드혹 네트워크는 네트워크 관리에 필요한 주요 정보들이 자치적으로 구성되는 노드들에 의해 관리되므로 보안이 중요한 이슈가 된다. 특히 이동 노드들의 인증 메커니즘은 네트워크 구성에 참여하는 노드들의 신뢰 구축에 필수적이다. 기존의 네트워크에서 사용되는 인증 모델은 모바일 애드혹 네트워크의 특성상 적용하기 어렵고 가장 널리 사용되는 방법의 하나인 공개키 알고리즘 기반 방법 역시 기반 구조를 갖지 않는 모바일 애드혹 네트워크에 그대로 적용되기 어렵다. 이 논문에서는 모바일 애드혹 네트워크에서 공개키 알고리즘에 기반한 이동 노드의 인증 알고리즘을 제공하기 위해 [1]에서 제안한 임의의 CA 그룹 알고리즘과 홈 CA 방법을 성능 비교한다. 그 결과 CA의 기능이 분산되고 인증 정보에 대한 접근이 효율적인 방법인 임의의 CA 그룹 방법이 모바일 애드혹 네트워크 내에서 인증 메커니즘을 제공하는 데 높은 신뢰도를 가지며 저비용을 소요하는 것을 보여준다. 이러한 결과는 이동 노드의 이동 속도나 네트워크 내의 CA의 수, 이동 노드들의 업/다운 시간 비율에 상관없이 나타나는 것을 알 수 있다.

• 대한한방내과학회지
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• 제26권3호
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• pp.615-625
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• 2005

Objectives : Poststroke depression is a frequent and specific entity that impaires the rehabilliation and functional recovery of patients with hemiplegia. The author evaluated the effect of Banhahubak-tang(Banxiahoupotang) in patients with poststroke depression. Methods : 38 patients suffering from poststroke depression(determined by Diagnostic and Statistical Manual of Mental Disorders, revised. 3rd edition. and Beck Depression Inventory[BDI] cutoff $point{\geqq}10$) in Kyunghee Oriental hospital were randomized into two groups; treatment group(n=19) and control group(n=19). The treatment group was prescribed with Banhahubak-tang(Banxiahoupotang) three times a day fur a week. Control troop was prescribed with other herbal medicines used for stroke Patients three times a day for a week. Patients were evaluated by use of BDI scale, Modified Barthel Index, Depression of Ki score, Yin syndrome score, and Yang syndrome score. Among 38 patients, 24 patients got BDI scores above 21, which is the cut-off score for depression in Korean. The same procedures and assessments described above were applied. Results : Treatment group did not significantly improve compared with control group. Results yielded only slight significance (P=0.086). Especially. patients with poststroke depression as yin syndrome improved more significantly on BDI than those classified as yang syndrome. When BDI cutoff point for depression was defined as being ${\geq}\;21$, treatment group did not significantly improve compared with control group(P=0.114). However, patients with poststroke depression classified as yin syndrome were also significantly improved on BDI than those classified as yang syndrome. Conclusions : This study suggests that Banhahubak-tang(Banxiahoupotang) is significantly effective in patients with poststroke depression classified as yin syndrome.