• Title/Summary/Keyword: Randomization test

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Effect of Microcurrent Taping Therapy on Lower Back Pain (미세전류 테이핑 치료의 만성 요통에 대한 효과)

  • Kwon, Dong-Hyun;Lee, Sang-Min;Kim, Ho-Jun;Lee, Jong-Soo
    • The Journal of Korean Medicine
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    • v.32 no.5
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    • pp.114-125
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    • 2011
  • Objectives: The aim of this study was to evaluate the efficacy of microcurrent taping therapy and kinesio taping therapy. Methods: We included 58 participants who met the inclusion criteria and assigned them into two groups after the randomization. We allocated 29 participants to the microcurrent taping therapy group (MCT) and the other 29 to the general kinesio taping therapy group (GT). 27 participants completed the trial in the MCT group, 27 participants in GT. We attached "I" shaped 20cm tape along the erector muscle of the spine starting from the level of S2, and another 30cm tape on the iliac crest horizontally. These "I" shaped tapes were attached on two parts of the body and were performed the same way for both groups. This procedure was done 8 times and participants visited a total of 9 times including a final visit for evaluation. We measured Visual Analog Scale (VAS), Range of Motion (ROM) and Schober's test on every visit. Participants completed a questionnaire of Oswestry Disability Index (ODI) and Beck's Depression Inventory (BDI) on the first and last visits. Results & Conclusion: There was a significant effect of microcurrent taping therapy on lower back pain, but we could not establish the superior effect of microcurrent taping therapy compared with general kinesio taping therapy.

The Effects of Sobi-eum(Xiaofei-yin) Mesotherapy on Abdominal Fat Distribution (소비음을 이용한 경피침주요법이 복부비만에 미치는 영향에 대한 임상연구)

  • Lee, A-Ra;Cho, Yu-Jung;Jung, Won-Suk;Yang, Yu-Jung;Song, Mi-Yeon
    • Journal of Korean Medicine Rehabilitation
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    • v.19 no.2
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    • pp.261-273
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    • 2009
  • Objectives : This study was performed to figure out the effects of herbal mesotherapy on abdominal fat in obese women. Methods : Forty obese women those who were diagnosed abdominal obesity had been recruited during February, 2008. They were randomly assigned experimental or control group under block-randomization. Experimental group were treated with Sobi-eum(Xiaofei-yin) injection during 6 weeks (2 times a week) and placebo group were treated with normal saline injection under same procedures. Anthropometry, body impedance analysis, fat computed tomography, blood test, and questionnaires had been administered before and after the treatment. Results : Four subjects were dropped out (voluntary give up), so 18 in experimental group and 18 in placebo group were evaluated. There were significant changes after treatments in both groups. Although no significant differences have been found in the result of anthropometry, body impedance analysis and fat computed tomography between two groups, in the experimental group, the changes of total fat area had a highly significant relationship with all part of abdominal fat. While the placebo group had highly significant relationships with subcutaneous fat area, superficial and deep subcutaneous fat area but not with visceral fat area. Conclusions : Compaired with saline group, herbal mesotheraphy Sobi-eum(Xiaofei-yin) is effective in reduction of visceral fat after adjusting TFA.

Pharmacophore Design for Anti-inflammatory Agent Targeting Interleukin-2 Inducible Tyrosine Kinase (Itk)

  • Chandrasekaran, Meganathan;Sakkiah, Sugunadevi;Thangapandian, Sundarapandian;Namadevan, Sundaraganesan;Kim, Hyong-Ha;Kim, Yong-Seong;Lee, Keun-Woo
    • Bulletin of the Korean Chemical Society
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    • v.31 no.11
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    • pp.3333-3340
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    • 2010
  • A three dimensional pharmacophore model was generated for the molecules which are responsible for anti-inflammatory activities targeting Interleukin-2 inducible tyrosine kinase (Itk). 16 structurally diverse molecules were selected as training set to generate the hypotheses using Discovery Studio v2.1. The best hypothesis, Hypo1, comprises two hydrogen bond acceptor (HBA), one hydrophobic aromatic (HA), one ring aromatic (RA) and shows high cost difference (63.71), high correlation coefficient (0.97) as well as low RMS deviation (0.81). Hypo1 has been further validated toward a test set, decoy set and Fischer's randomization method. Furthermore, Hypo1 was used to screen NCI and Maybridge databases. Finally, 2 hit molecules were identified as potential leads against Itk, which may be useful for future drug development.

Development and Effects of a Heart Health Diary for Self-Care Enhancement of Patients with Heart Failure (심부전 환자의 자가간호 증진을 위한 심장일지의 개발 및 효과)

  • Shim, Jae Lan;Hwang, Seon Young
    • Journal of Korean Academy of Nursing
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    • v.46 no.6
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    • pp.881-893
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    • 2016
  • Purpose: The purpose of this study was to develop a heart health diary to promote self-care ability among patients with heart failure (HF), and to identify the diary's effect on self-care adherence, self-efficacy, and physical activity. Methods: A randomized control-group pretest-posttest design was adopted using block randomization. A calender-typed health diary was developed and it included a self-care checklist and education information on HF management. The experimental group were given guided counseling and education for 8 weeks and wrote a daily health diary during that period. Data were collected from the outpatient department of a tertiary medical center from February to April 2016. To verify the hypotheses, data for the experimental group (n=28) and control group (n=33) were analysed using the independent t-test with SPSS/WIN 21.0. Results: At the end of 8 weeks the experimental group had significantly higher scores for self-care adherence (t=-2.48, p =.016) and exercise related self-efficacy (t=-3.44, p =.001) compared to the control group. Conclusion: The findings show that the application of a patient-directed heart health diary is an effective nursing intervention for improving HF patients' self-care adherence and exercise self-efficacy. Strategies to promote dietary self-efficacy are necessary along with further studies including repeated research with an increasing intervention period. Healthcare providers need to encourage the utilization of a health diary for HF patients as a tool for evaluation and for implementation that leads to self-care.

Clinical performance of class I cavities restored with bulk fill composite at a 1-year follow-up using the FDI criteria: a randomized clinical trial

  • Chinni Suneelkumar ;Puttaganti Harshala ;Koppolu Madhusudhana;Anumula Lavanya;Anirudhan Subha ;Sannapureddy Swapna
    • Restorative Dentistry and Endodontics
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    • v.46 no.2
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    • pp.24.1-24.11
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    • 2021
  • Objectives: The present study aimed to evaluate the survival rate and clinical performance of class 1 composite restorations restored with the Filtek Bulk Fill composite material using either the bulk fill technique or the incremental technique at baseline (1 week) and at 3, 6 and 12 months of follow-up. Materials and Methods: Forty-two patients with at least 2 carious teeth were selected. Following randomization, one tooth was restored with the Filtek Bulk Fill composite using the incremental fill technique, and the other tooth was restored with the same material using the bulk fill technique. Patients were recalled for follow-up at baseline (1 week) and 3, 6, and 12 months and evaluated using the FDI criteria. Results: The data were analyzed using the McNemar χ2 test. No statistically significant differences were found between the scores of teeth restored with either technique. At baseline and at 3, 6, and 12 months of follow-up; there were no significant difference in the clinical status of both groups of restorations. Conclusions: Within the limitations of this study, using the bulk fill technique for restorations with the Filtek Bulk Fill material seems to be equally efficient to using the incremental fill technique.

The effect of Chiljehyangbuhwan on the abdomial & palmar temperature in the primary dysmenorrhea patients (칠제향부환(七製香附丸)이 원발성(原發性) 월경통(月經痛) 환자(患者)의 복부(腹部) 및 수장부(手掌部) 온도(手掌部 溫度)에 미치는 영향(影響))

  • Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub;Yoon, Young-Jin
    • Journal of Oriental Medical Thermology
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    • v.5 no.1
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    • pp.46-58
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    • 2006
  • Purpose: We intended to observe the relations between Chiljehyangbuhwan and abdominal & palmar temperature according to primary dysmenorrhea severity. Methods: We selected the 100 primary dysmenorrhea patients by the screening tests (first screening test-inquiry, second screening test-clinical test. additionally WHR (Waist-to-Hip ratio) by Inbody 2.0). By the fixed blocked randomization and double blind method, Chiljehyangbuhwan or placebo was administered for 1 menstration period. Finally, 69 patients remainded. Before and after administration, we measured 4 points abdominal temperature (Chon-jung (CV17), Chung-wan(CV12), Kwan-won(CV4). Chung-guk(CV3)) by DITI(DOREX Inc., USA). And then we checked the difference of temperature $({\Delta}T)$ between CV17 and CV12/CV17 and CV4/CV17 and CV3/CV12 and CV4/CV12 and CV3. Also, we measured 2 points (palmar region, upper front of forearm) for the difference of palmar temperature $({\Delta}T)$. Then, we checked palmar temperature minus upper front of forearm temperature and took an average of right and left ${\Delta}T.$ After that. we compared ${\Delta}T$ with primary dysmenorrhea severity evaluated by VRS (verbal rating scale) and MVRS (multidimensional verbal rating scale). In dysmenorrhea severity. we standardized scale score and 3-group-severity by score (mild, moderate. severe). Besides, we compared palmar ${\Delta}T$ with abdominal ${\Delta}T$. For statistics, we used ANOVA and Spearman's rho correlations. SPSS 13.0 for windows. Results: In case of MVRS, though Chiljehyangbuhwan was correlated to abdominal ${\Delta}T$(CV12 and CV3/CV12 and CV4). it was not correlated to palmar ${\Delta}T$. In case of VRS, though Chiljehyangbuhwan was not correlated to abdominal ${\Delta}T$. it was correlated to palmar ${\Delta}T$. However. palmar ${\Delta}T$ was not correlated to abdominal ${\Delta}T$. Statistically they showed significant result (p<0.05). Conclusion: The primary dysmenorrhea patients showed that severity by MVRS was connected with abdominal ${\Delta}T$ (CV12 and CV3/CV12 and CV4) and severity by VRS was connected with palmar ${\Delta}T$ after Chiljehyangbuhwan administration. So we can consider Chiljehyangbuhwan partially effects the abdominal & palmar temperature according primary dysmenorrhea severity. However, palmar temperature was not correlated to abdominal temperature. Therefore, we need further study.

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Effects of Training on Sit to Stand on Various Seat Heights on the Balance in Stroke Patients (다양한 좌석 높이에서 일어서기 훈련이 뇌졸중 환자의 균형에 미치는 영향)

  • Kim, Hyun-Sung;Seo, Byoung-Do
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.253-260
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    • 2020
  • This study aimed to compare the effects of sit-to-stand training, or training to stand up from sitting positions at various seat heights, on the balance recovery among stroke patients. This study included 20 stroke patients who were randomly divided into two groups. Each group was trained for six weeks, three times a week from March to June 2019. Static balance and dynamic balance were measured, and the variations were analyzed using the paired t-test and the independent t-test. There were significant changes observed in both static and dynamic balance (p<.05) before and after training. However, no significant changes were seen in the static balance in the standing posture with eyes closed (p>.05). This study confirmed that there was a significant effect of training on the balance of stroke patients, especially when progressively lower seat heights were used during the training. This suggests new directions for treatment during rehabilitation for balance recovery of stroke patients. Further studies will need to apply this training to a larger number of subjects, and use various training methods such as randomization of seat height to enable the generalization of the results of this study and application in clinical practice.

A Spatial Statistical Approach to Residential Differentiation (I): Developing a Spatial Separation Measure (거주지 분화에 대한 공간통계학적 접근 (I): 공간 분리성 측도의 개발)

  • Lee, Sang-Il
    • Journal of the Korean Geographical Society
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    • v.42 no.4
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    • pp.616-631
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    • 2007
  • Residential differentiation is an academic theme which has been given enormous attention in urban studies. This is due to the fact that residential segregation can be seen as one of the best indicators for socio-spatial dialectics occurring on urban space. Measuring how one population group is differentiated from the other group in terms of residential space has been a focal point in the residential segregation studies. The index of dissimilarity has been the most extensively used one. Despite its popularity, however, it has been accused of inability to capture the degree of spatial clustering that unevenly distributed population groups usually display. Further, the spatial indices of segregation which have been introduced to edify the problems of the index of dissimilarity also have some drawbacks: significance testing methods have never been provided; recent advances in spatial statistics have not been extensively exploited. Thus, the main purpose of the research is to devise a spatial separation measure which is expected to gauge not only how unevenly two population groups are distributed over urban space, but also how much the uneven distributions are spatially clustered (spatial dependence). The main results are as follows. First, a new measure is developed by integrating spatial association measures and spatial chi-square statistics. A significance testing method based on the generalized randomization test is also provided. Second, a case study of residential differentiation among groups by educational attainment in major Korean metropolitan cities clearly shows the applicability of the analytical framework presented in the paper.

A Study of the Effects of Health Contracting on Compliance with Health Behaviors in Clients with Hypertension (자가간호증진을 위한 건강계약이 고혈압자의 건강행위 이행에 미치는 영향)

  • 이향련
    • Journal of Korean Academy of Nursing
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    • v.17 no.3
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    • pp.204-217
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    • 1987
  • It is generally accepted that the delivery of health care is undergoing many changes specially those related to acute, contagious disease care and to the increase of chronic illnesses which can not be cured but are controlable. The health care practitioner can not be soley responsible for the control of their clients' care. Because the clients will play a vital role in controlling their illnesses, long term participation by both the health care provider and the client is necessary. Since most individuals with hypertension do not experience signs or symptoms, the disease is difficult to detect and even when diagnosed, clients do not comply well with their hypertension regimens. The noncompliant client is at increased risk for compliants involving the heart, brain, kidney and other organs. In an effort to explore methods of increasing patient participation in and adherence to treatment programs for hypertension, the researcher used health contracting to promote self care. The research questions are; 1) Will the health contracting increase compliance in health behavior and reduce the blood pressure\ulcorner 2) If clients comply with their regimens will this reduce their blood pressure\ulcorner The research design utilized in this study was a quasi-experimental design. A purposive sample, was abtained from two churches in the 1. area, consisting of 64 clients with hypertension. The data was collected from the middle of January to the 1st of September 1985. Randomization was only of the two church groups into experimental and control groups. Compliance with health behavior related to the hypertensive regimen, blood pressure and body weight were measured, compared and analyzed. In the experimental group measurements were made 6 times; one month before the education program after education program when health contracting was done and 4 more times once a month for 4 months. In the control group measurements were made 3 times; one month before the education program after the education program, and once 4 months later. There was no health contracting. The data were analyzed by t-test, Pearson correlation and ANOVA according to purpose of the study. The result of this study may be summarized as follows: The result related to the hypothesis on the effect of health contracting are as follows: H$_1$; “The hypothesis that the experimental group, with a health contractual agreement will demonstrate increased compliance levels for health behavior than the control group” was supported(t=-5.29, df=62, p=.000). H$_2$; “The hypothesis that the experimental group, with a health contractual agreement, will demonstrate a greater reduction in blood pressure than the control group” was supported (for systolic blood pressure t=2.72, df=62, p=.009, for diastolic blood pressure t=1.95, df=62, p=.050). H$_3$; The hypothesis that the greater the compliance of the client with health behavior the lower the client's blood pressure will be was partially supported (for systolic pressure r=-.2981, p=.008, for diastolic pressure r=-.1720, p=.087). From the examination of the results of this study it can be concluded that the interaction between the nurse and the client, contracting to define goals and reinforcing compliant behavior, leads to improved compliance with health care behaviors and thus to an increase in the effectiveness of nursing care. Further consideration need to be given to the inclusion of the concept of health contracting in primary nursing and to further research in this area.

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Spatial Distribution Patterns of Oplismenus undulatifolius var. undulatifolius on Mt. Hanwoo in Korea (한우산에 분포하는 주름조개풀의 공간적 양상)

  • Huh, Man Kyu
    • Journal of Life Science
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    • v.28 no.11
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    • pp.1262-1267
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    • 2018
  • The patchiness of local environments within a habitat is assumed to be a primary factor affecting the spatial patterns of plants. In this study, a randomization procedure was developed to test the null hypothesis that only spatial association with patches determines the spatial patterns of plants. Oplismenus undulatifolius (Ard.) P. Beauv. var. undulatifolius is an herbaceous plant and a member of the genus Oplismenus in the family Poaceae. Oplismenus hirtellus subsp. undulatifolius occurs in temperate, subtropical, and tropical areas of the world. The spatial pattern of O. undulatifolius var. undulatifolius was analyzed using dispersion indices in different sizes of plots according to several patchiness indexes, population uniformity, or aggregation. Population densities (D) at Mt. Hanwoo varied from 0.453 to 4.375, with a mean of 2.387. The small and mid-sized plots ($2m{\times}2m$, $2m{\times}4m$, $4m{\times}4m$, $4m{\times}8m$, and $8m{\times}8m$) of O. undulatifolius var. undulatifolius were aggregated in the forest community. However, O. undulatifolius var. undulatifolius was uniformly distributed in three large plots ($8m{\times}16m$, $16m{\times}16m$, and $16m{\times}32m$). The greatest mean crowding ($M^*$) and patchiness index (PAI) showed positive values. Aggregation is mainly caused by environmental factors. Many plants on Mt. Hanwoo are being disturbed by climbers, which is preventing these plants from inhabiting their realized niches on Mt. Hanwoo.