• 융합정보논문지
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• 제10권6호
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• pp.1-7
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• 2020

수중 자원 탐색 및 해양 탐사, 환경 조사 등 수중 통신에 대한 수요가 급격하게 증가하고 있다. 하지만 수중 무선 통신을 사용하기 앞서 많은 문제점을 가지고 있다. 특히 수중 무선 네트워크에서 환경적 요인으로 인해 불가피하게 발생하는 불필요한 지연 시간과 노드 거리에 따른 공간적 불평등 문제가 존재한다. 본 논문은 이러한 문제를 해결하기 위해 ALOHA-Q를 기반으로 한 새로운 NAV 설정 방법을 제안한다. 제안 방법은 NAV 값을 랜덤하게 사용하고 통신 성공, 실패 유무에 따라 보상을 측정한다. 이후 보상 값에 따라 NAV 값을 설정 한다. 수중 무선 네트워크에서 에너지와 컴퓨팅 자원을 최대한 낮게 사용하면서 NAV 값을 강화 학습을 통하여 학습하고 한다. 시뮬레이션 결과 NAV 값이 해당 환경에 적응하고 최선의 값을 선택하여 불필요한 지연 시간문제와 공간적 불평등 문제를 해결할 수 있음을 보여준다. 시뮬레이션 결과 설정한 환경 내에서 기존 NAV 설정 시간 대비 약 17.5%의 시간을 감소하는 것을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6181-6186
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• 2014

This meta-analysis was conducted to examine whether the genotype status of Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with endometrial and ovarian cancer risk. Eligible studies were identified by searching several databases for relevant reports published before January 1, 2014. Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. In total, 15 studies (1,293 cases and 2,647 controls for ovarian cancer and 2,174 cases and 2,699 controls for endometrial cancer) were included in the present meta-analysis. When all studies were pooled into the meta-analysis, there was no evidence for significant association between COMT Val158Met polymorphism and ovarian cancer risk (Val/Met versus Val/Val: OR=0.91, 95% CI=0.76-1.08; Met/Met versus Val/Val: OR=0.90, 95% CI=0.73-1.10; dominant model: OR=0.90, 95% CI=0.77-1.06; recessive model: OR=0.95, 95% CI=0.80-1.13). Similarly, no associations were found in all comparisons for endometrial cancer (Val/Met versus Val/Val: OR 0.97, 95% CI=0.77-1.21; Met/Met versus Val/Val: OR=1.02, 95% CI=0.73-1.42; dominant model: OR=0.98, 95% CI=0.77-1.25; recessive model: OR=1.02, 95% CI=0.87-1.20). In the subgroup analyses by source of control and ethnicity, no significant associations were found in any subgroup of population. This meta-analysis strongly suggests that COMT Val158Met polymorphism is not associated with increased endometrial and ovarian cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3691-3698
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• 2014

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A (RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis was here performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to November 2013 on the association between RASSF1A Ala133Ser polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Bothfixed-effect and random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) by using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 10 studies including 4,572 cancer cases and 4,320 controls were included in the meta-analysis. Overall, significantly increased cancer risk was associated with the variant Ser133 when all studies were pooled (Ser vs Ala: OR=1.51, 95% CI=1.08-2.12, $P_{heterogeneity}{\leq}0.001$; Ser/Ser+Ala/Ser vs Ala/Ala: OR=1.55, 95% CI=1.08-2.22, $P_{heterogeneity}{\leq}0.001$). Moreover, in subgroup analyses by cancer types, a significant association between RASSF1A Ala133Ser polymorphism and lung cancer risk was found (Ser vs Ala: OR=2.27, 95% CI=1.29-4.02, $P_{heterogeneity}$=0.61; Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.42, 95% CI=1.33-4.42, $P_{heterogeneity}=0.75$). In addition, in subgroup analyses by ethnicity, it was found that the RASSF1A Ala133Ser polymorphism was associated with overall cancer risk in Asians (Ser vs Ala: OR=1.37, 95% CI=1.06-1.77, $P_{heterogeneity}=0.06$) and Caucasians (Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.21, 95% CI=1.01-4.82, $P_{heterogeneity}{\leq}0.001$). Conclusions: This meta-analysis suggests, for the first time, that RASSF1A Ala133Ser polymorphism may contribute to cancer susceptibility, especially for lung cancer. Besides, additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3477-3482
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• 2014

Objective: Patients with inflammatory bowel disease (IBD) have an increased risk of extra-intestinal cancer, whereas its impact on cholangiocarcinoma (CC) remains unknown. The aim of this study was to obtain a reliable estimate of the risk of CC in IBD patients through a meta-analysis of clinical observational studies. Methods: Relevant studies were retrieved by searching PUBMED, EMBASE and Web of Science Databases up to Dec 2013. Four population-based case-control and two cohort studies with IBD were identified. Summary relative risk (RR) and its corresponding 95% confidence interval (CI) were calculated using a random-effects model. Potential sources of heterogeneity were detected using subgroup analyses. Results: The pooled risk estimate indicated IBD patients were at increased risk of CC (RR = 2.63, 95%CI = 1.47-4.72). Moreover, the increased risk of CC was also associated with Crohn's disease (RR = 2.69, 95%CI = 1.59-4.55) and ulcerative colitis (RR = 3.40, 95%CI = 2.50-4.62). In addition, site-specific analyses revealed that IBD patients had an increased risk of intrahepatic CC (ICC) (RR = 2.61, 95%CI = 1.72-3.95) and extrahepatic CC (ECC) (RR = 1.47, 95%CI = 1.10-1.97). Conclusions: This study suggests the risk of CC is significantly increased among IBD patients, especially in ICC cases. Further studies are warranted to enable definite conclusions to be drawn.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3267-3271
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• 2014

Background: Several studies have investigated the association between methionine synthase reductase (MTRR) A66G polymorphism and breast cancer risk, but controversial results were yielded. Therefore, we performed a meta-analysis to provide a more robust estimate of the effect of this polymorphism on susceptibility to breast cancer. Materials and Methods:Case-control studies investigating the relationship between MTRR A66G polymorphism and breast cancer risk were included by searching PubMed, EMBASE, China National Knowledge Infrastructure and Wanfang Database. Either fixed-effects or random-effects models were applied to calculate odds ratios(ORs) and 95% confidence intervals (CIs) by RevMan5.2 software. Results: A total of 9 studies bearing 7,097 cases and 7,710 controls were included in the meta-analysis. The results were that the combined ORs and 95%CIs of MTRR 66AG, GG, (AG+GG) genotypes were 0.98(0.91-1.05), 1.06(0.97-1.16) and 1.02(0.94-1.10), respectively with p=0.52, 0.19 and 0.65. We also performed subgroup analysis by specific ethnicity. The results of the combined analysis of MTRR 66AG, GG, (AG+GG) genotypes and breast cancer in Asian descent were Z=0.50, 0.53 and 0.21, with p all>0.05; for breast cancer in Caucasian descent, the results were Z=1.14, 1.65 and 0.43, with p all>0.05. Conclusions: Our findings suggested that MTRR A66G polymorphism was not associated with breast cancer susceptibility.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5075-5079
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• 2012

Purpose: The results of recent published studies focusing on IL-8 polymorphism in colorectal cancer susceptibility have often been inconsistent. We therefore carried out a meta-analysis based on independent studies to assess the association. Methods: Nine case-control studies with 7,003 individuals (3,019 cases and 3,984 controls) were included in this meta-analysis through searching the databases of PubMed, Excerpta Medica Database (EMBASE), and Chinese Biomedical Literature Database (CBM; Chinese) (up to Aug 1st, 2012). The odds ratio (OR) and 95% confidence interval (95%CI) were used to assess the strength of the association. Meta-analysis was conducted in a fixed/random effect model. Results: No obvious associations were found for all genetic models when all studies were pooled into the meta-analysis (for A vs. T: OR = 1.084, 95% CI = 0.971-1.209, P = 0.019; for TA vs. TT: OR = 1.18, 95% CI = 0.943-1.475, P = 0.001; for AA vs. TT: OR = 1.155, 95% CI = 0.916-1.456, P = 0.014; for AA+TA vs. TT: OR = 1.170, 95% CI =0.953-1.437, P = 0.001; for AA vs. TT+TA: OR = 1.044, 95% CI = 0.886-1.230, P = 0.097). In the subgroup analyses by ethnicity (Caucasian) and source of controls (population based), also no significant associations were found for all genetic models. Conclusions: Result suggests that the IL-8-251T>A polymorphism is not associated with colorectal cancer risk. Because of the limitations of this meta-analysis, this finding demands further investigation.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3117-3121
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• 2013

Objective: Previous epidemiologic studies demonstrated that obesity might associated with the risk of bladder cancer. However, many of the actual association findings remained conflicting. To better clarify and provide a comprehensive summary of the correlation between obesity and bladder cancer risk, we conducted a meta-analysis to summarize results of studies on the issue. Stratified analyses were also performed on potential variables and characteristics. Methods: Studies were identified by searching in PubMed and Wanfang databases, covering all the papers published from their inception to March 10, 2013. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated by either random-effect or fixed-effect models. Results: A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; $I^2$=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; $I^2$=35.9%). No significant publication bias was detected (p = 0.244 for Egger's regression asymmetry test). Conclusions: Our results support the conclusion that obesity is associated with the increased risk of bladder cancer. Further research is needed to generate a better understanding of the correlation and to provide more convincing evidence for clinical intervention in the prevention of bladder cancer.

• 한국정보과학회논문지:시스템및이론
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• 제27권6호
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• pp.608-618
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• 2000

본 논문에서는 병렬 및 분산 시스템에서 자원을 배치함에 있어서 최소한의 자원 복사(copy)만을 사용하면서 임의의 노드 및 링크 상에서 고장이 발생하더라도 주어진 성능 요건을 만족하게 하는 자원의 최적 배치 방법을 모색하고자 한다. 이러한 성능 요건의 만족과 시스템의 고가용성을 위하여, 모든 노드들에 대하여 최소한의 자원 복사를 사용하여 그 노드나 혹은 인접한 노드 중 적어도 두 개 이상에 자원 복사가 존재해야 하는데, 이것을 본 논문에서는 고장 허용 자원 배치 문제라고 부른다. 병렬 및 분산 시스템은 그래프로 표현할 수가 있다. 여기에서 고장 허용 자원 배치 문제는 그래프 상에서 가장 작은 고장 허용 dominating set을 찾는 문제로 변환이 된다. Dominating set 문제는 NP-complete로 증명이 되어 있으며, 본 논문에서는 A* 알고리즘을 사용하여 상태 공간 탐색 방법으로 최적 배치를 구한다. 또한, 최적 배치를 찾는 데에 걸리는 시간을 단축시키기 위하여, 고장 허용 dominating set의 특성들을 분석하여 유용한 휴리스틱 정보들을 도출한다. 또한 여러가지 정형 그래프와 임의 그래프 상에서의 실험을 통하여, 이들 휴리스틱 정보들을 사용하여 최적 고장 허용 자원 배치를 찾는 데에 걸리는 시간을 상당히 줄일 수 있음을 보인다.

• 한방안이비인후피부과학회지
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• 제30권2호
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• pp.1-18
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• 2017

Objectives : This review aims to evaluate a risk of bias by risk of bias tool and RoBANS(Risk of Bias Assessment tool for Non-randomized Study) tool for clinical trial papers proving treatment effect of Korean medicines to alopecia and provides the newest reason of effectiveness of herbs to alopecia. Methods : Data were collected through electronic database including NDSL, KISS, KMBASE, Koreantk, OASIS, KoreaMed, KISTI, Pubmed, Cochrane CENTRAL and CINAHL. Two experts in Oriental Medicine assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool and non-randomized controlled trials by RoBANS tool after searching, reviewing and selecting papers. Results : Total number of selected trials is 20 including 4 randomized controlled trial, 13 non-randomized controlled trials and 3 case reports. This study evaluate the risk of bias of 17 papers including 4 randomized controlled trials and 13 non-randomized controlled trials except 3 case reports by risk of bias tool and RoBANS tool. All papers of randomized controlled trials are evaluated unclear for random sequence generation and allocation concealment as there are no word on them. And all papers of non-randomized controlled trials are evaluated unclear for blinding of outcome assessments and relatively low for others. Conclusions : Korean medicine intervention can be an effective for treatment in alopecia. It was evaluated by hair density, thickness and expert panel assessment of photographs and all results are statistically significant. But enhancing levels of evidence, we must try to reduce bias in researches and report a safety, protocol and IRB.

• 융합신호처리학회논문지
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• 제5권1호
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• pp.73-78
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• 2004

시간 순서 보전을 만족하는 프레임내 시간 슬롯의 배치 방법에는 임의, 연속, 주기 배치 방식 등이 있다. T-S-T 스위치 구조의 각 입력, 출력, 정터 시간스위치를 256개의 시간슬롯으로, 공간 스위치를 2*2로 구성하고, 시뮬레이션 검색횟수를 32회로 한정하며, 각 경우에 대한 시뮬레이션 시간은 10만 단위로 설정하였다. 시뮬레이션에 적용된 다중호는 기본호, 2배호, 6배호로 한정하였다. 부가된 기본호:2배호:6배호의 구성을 8:1:1, 6:2:2, 4:3:3 로 달리하면서 스위치에 트래픽을 할당하며 트래픽에 따른 호손율을 구하였다. 요약하면, 동일한 트래픽을 부가하였을 때 다중호의 배치 방식은 임의, 연속, 주기 방식의 순서로 호손율이 낮은 결과가 도출되어 다중호의 호손율이 제일 낮은 방식은 주기적 배치방식임을 알 수 있었다.