• 한국시뮬레이션학회논문지
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• 제18권4호
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• pp.59-66
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• 2009

VLSI(Very Large Scale Integration)와 WSI(Wafer Scale Integration)와 같은 통합기술로 인해 큰 용량의 메모리 대량생산이 가능 하게 된 지금 Redundancy는 메모리 칩의 제조와 결함이 있는 셀을 지닌 디바이스를 치료하는데 광범위하게 사용되어져왔다. 메모리칩의 밀도가 증가함에 따라 결함의 빈도 또한 증가한다. 많은 결함이 있다면 어쩔 수 없겠지만 적은 결함이 발생한 경우에는 해당 다이를 reject 시키는 것 보다는 수선해서 사용하는 것이 메모리생산 업체 입장에서는 보다 효율적이고 원가 절감 차원에서 필수적이다. 이와 같은 이유로 laser repair라는 공정이 필요하고 laser repair공정의 정확한 타깃을 설정하기 위해 redundancy analysis가 필요하게 되었다. CRA시뮬레이션은 기존의 redundancy analysis 알고리즘의 개념에서 벗어나 결함 유형별로 시뮬레이션한 후 RA를 진행함으로써 RA에 소요되는 시간을 절약함으로써 원가 경쟁력 강화를 할 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제21권8호
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• pp.1088-1096
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• 2008

Data from milk performance testing were used to analyze genetic and environmental trends for purebred Tsigai, Improved Valachian and Lacaune sheep. 103,715 (Tsigai), 212,962 (Improved Valachian) and 2,196 (Lacaune) test-day records gathered by the State Breeding Institute of the Slovak Republic entered the analyses. The respective pedigree data comprised 23,724 (Tsigai), 51,401 (Improved Valachian) and 438 (Lacaune) records. The multiple-trait, mixed model methodology was used to predict the breeding values for daily milk yield, fat and protein content and to estimate the fixed and remaining random effects assumed to affect the above mentioned traits, separately for each breed. The breeding values for daily milk yield were adjusted for 150-day standardized lactation length by multiplying with the constant 150, as the breeding goal of the selection scheme in Slovakian sheep is to increase 150-day milk production and constant heritability throughout the whole lactation is assumed. The genetic trends were expressed as changes in averages of breeding values across birth years of animals. For Tsigai and Lacaune breeds, cumulative genetic changes over the analyzed period were 3.8 and 5.1 kg for 150-day milk, 0 and -0.16% for fat content and 0 and -0.12% for protein content. For Improved Valachian breed, either a low (1.6 kg for 150-day milk yield) or zero (fat and protein content) cumulative genetic change was found. The environmental trends were calculated as averages of solutions for flock-test day effect across years and months in which measurements were taken. A distinctive cyclical pattern which reflected short-time variation in milk production traits was found. Possible explanations for this phenomenon are given and discussed.

• Asian-Australasian Journal of Animal Sciences
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• 제25권9호
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• pp.1216-1222
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• 2012

Somatic cells count (SCC), milk yield (MY) and pedigree information of 2,791 first lactation cows that calved between 1990 and 2010 on 259 Thai farms were used to estimate genetic parameters and trends for SCC and its genetic association with MY. The SCC were log-transformed (lnSCC) to make them normally distributed. An average information-restricted maximum likelihood procedure was used to estimate variance components. A bivariate animal model that considered herd-yr-season, calving age, and regression additive genetic group as fixed effects, and animal and residual as random effects was used for genetic evaluation. Heritability estimates were 0.12 (SE = 0.19) for lnSCC, and 0.31 (SE = 0.06) for MY. The genetic correlation estimate between lnSCC and MY was 0.26 (SE = 0.59). Mean yearly estimated breeding values during the last 20 years increased for SCC (49.02 cells/ml/yr, SE = 26.81 cells/ml/yr; p = 0.08), but not for MY (0.37 kg/yr, SE = 0.87 kg/yr; p = 0.68). Sire average breeding values for SCC and MY were higher than those of cows and dams (p<0.01). Heritability estimates for lnSCC and MY and their low but positive genetic correlation suggested that selection for low SCC may be feasible in this population as it is in other populations of dairy cows. Thus, selection for high MY and low SCC should be encouraged in Thai dairy improvement programs to increase profitability by improving both cow health and milk yield.

• Asian-Australasian Journal of Animal Sciences
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• 제32권4호
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• pp.508-518
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• 2019

Objective: This research aimed to determine biological pathways and protein-protein interaction (PPI) networks for 305-d milk yield (MY), 305-d fat yield (FY), and age at first calving (AFC) in the Thai multibreed dairy population. Methods: Genotypic information contained 75,776 imputed and actual single nucleotide polymorphisms (SNP) from 2,661 animals. Single-step genomic best linear unbiased predictions were utilized to estimate SNP genetic variances for MY, FY, and AFC. Fixed effects included herd-year-season, breed regression and heterosis regression effects. Random effects were animal additive genetic and residual. Individual SNP explaining at least 0.001% of the genetic variance for each trait were used to identify nearby genes in the National Center for Biotechnology Information database. Pathway enrichment analysis was performed. The PPI of genes were identified and visualized of the PPI network. Results: Identified genes were involved in 16 enriched pathways related to MY, FY, and AFC. Most genes had two or more connections with other genes in the PPI network. Genes associated with MY, FY, and AFC based on the biological pathways and PPI were primarily involved in cellular processes. The percent of the genetic variance explained by genes in enriched pathways (303) was 2.63% for MY, 2.59% for FY, and 2.49% for AFC. Genes in the PPI network (265) explained 2.28% of the genetic variance for MY, 2.26% for FY, and 2.12% for AFC. Conclusion: These sets of SNP associated with genes in the set enriched pathways and the PPI network could be used as genomic selection targets in the Thai multibreed dairy population. This study should be continued both in this and other populations subject to a variety of environmental conditions because predicted SNP values will likely differ across populations subject to different environmental conditions and changes over time.

• Asian-Australasian Journal of Animal Sciences
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• 제32권3호
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• pp.334-340
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• 2019

Objective: The objective of this study was to investigate the genetic components of daily milk yield and to re-rank bulls in South Korea by estimated breeding value (EBV) under heat stress using the temperature-humidity index (THI). Methods: This study was conducted using 125,312 monthly test-day records, collected from January 2000 to February 2017 for 19,889 Holstein cows from 647 farms in South Korea. Milk production data were collected from two agencies, the Dairy Cattle Genetic Improvement Center and the Korea Animal Improvement Association, and meteorological data were obtained from 41 regional weather stations using the Automated Surface Observing System (ASOS) installed throughout South Korea. A random regression model using the THI was applied to estimate genetic parameters of heat tolerance based on the test-day records. The model included herd-year-season, calving age, and days-in-milk as fixed effects, as well as heat tolerance as an additive genetic effect, permanent environmental effect, and direct additive and permanent environmental effect. Results: Below the THI threshold (${\leq}72$; no heat stress), the variance in heat tolerance was zero. However, the heat tolerance variance began to increase as THI exceeded the threshold. The covariance between the genetic additive effect and the heat tolerance effect was -0.33. Heritability estimates of milk yield ranged from 0.111 to 0.176 (average: 0.128). Heritability decreased slightly as THI increased, and began to increase at a THI of 79. The predicted bull EBV ranking varied with THI. Conclusion: We conclude that genetic evaluation using the THI function could be useful for selecting bulls for heat tolerance in South Korea.

• Animal Bioscience
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• 제37권4호
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• pp.576-590
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• 2024

Objective: The objective of this study was to identify genes associated with 305-day milk yield (MY) and fat yield (FY) that also influence the adaptability of the Thai multibreed dairy cattle population to tropical conditions. Methods: A total of 75,776 imputed and actual single nucleotide polymorphisms (SNPs) from 2,661 animals were used to identify genomic regions associated with MY and FY using the single-step genomic best linear unbiased predictions. Fixed effects included herd-year-season, breed regression, heterosis regression and calving age regression effects. Random effects were animal additive genetic and residual. Individual SNPs with a p-value smaller than 0.05 were selected for gene mapping, function analysis, and quantitative trait loci (QTL) annotation analysis. Results: A substantial number of QTLs associated with MY (9,334) and FY (8,977) were identified by integrating SNP genotypes and QTL annotations. Notably, we discovered 17 annotated QTLs within the health and exterior QTL classes, corresponding to nine unique genes. Among these genes, Rho GTPase activating protein 15 (ARHGAP15) and catenin alpha 2 (CTNNA2) have previously been linked to physiological traits associated with tropical adaptation in various cattle breeds. Interestingly, these two genes also showed signs of positive selection, indicating their potential role in conferring tolerance to trypanosomiasis, a prevalent tropical disease. Conclusion: Our findings provide valuable insights into the genetic basis of MY and FY in the Thai multibreed dairy cattle population, shedding light on the underlying mechanisms of tropical adaptation. The identified genes represent promising targets for future breeding strategies aimed at improving milk and fat production while ensuring resilience to tropical challenges. This study significantly contributes to our understanding of the genetic factors influencing milk production and adaptability in dairy cattle, facilitating the development of sustainable genetic selection strategies and breeding programs in tropical environments.

• 대한산업공학회지
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• 제43권3호
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• pp.192-202
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• 2017

This study develops a text spam filtering system for Facebook based on two variable categories: keywords learned from Instagram and meta-information of Facebook posts. Since there is no explicit labels for spam/ham posts, we utilize hash tags in Instagram to train classification models. In addition, the filtering accuracy is enhanced by considering meta-information of Facebook posts. To verify the proposed filtering system, we conduct an empirical experiment based on a total of 1,795,067 and 761,861 Facebook and Instagram documents, respectively. Employing random forest as a base classification algorithm, experimental result shows that the proposed filtering system yield 99% and 98% in terms of filtering accuracy and F1-measure, respectively. We expect that the proposed filtering scheme can be applied other web services suffering from massive spam posts but no explicit spam labels are available.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2011년도 춘계학술발표대회
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• pp.28.2-28.2
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• 2011

Resistance random access memory (ReRAM) is a promising candidate for next-generation nonvolatile memory because of its advantageous qualities such as simple structure, superior scalability, fast switching speed, low-power operation, and nondestructive readout. We investigated the resistive switching behavior of tantalum oxide that has been widely used in dynamic random access memories (DRAM) in the present semiconductor industry. As a result, it possesses full compatibility with the entrenched complementary metal-oxide-semiconductor processes. According to previous studies, TiN is a good oxygen reservoir. The TiN top electrode possesses the specific properties to control and modulate oxygen ion reproductively, which results in excellent resistive switching characteristics. This study presents fully room temperature fabricated the TiN/$TaO_x$/Pt devices and their electrical properties for nonvolatile memory application. In addition, we investigated the TiN electrode dependence of the electrical properties in $TaO_x$ memory devices. The devices exhibited a low operation voltage of 0.6 V as well as good endurance up to $10^5$ cycles. Moreover, the benefits of high devise yield multilevel storage possibility make them promising in the next generation nonvolatile memory applications.

• 한국지반공학회지:지반
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• 제4권2호
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• pp.5-14
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• 1988

균질토 사면에서 진행성 파괴에 대한 확를론적 모델이 제시되었다. 파괴면 위의 어떤 절편에 대한 국부적인 Safety Margin은 정규분포차 가정하였다. 파괴면을 따라 존재하는 전단강도의 불확실성은 1차원 Random Field Models로 표현되었다. 이 연구에서는 파괴가 Toe에서 시작되어 사면 정상까지 진행되는 경우만을 고려하였다. 파괴면위의 어느 두 인접 절편의 Safety Margin의 Joint Distribution은 Bivariate Normal로 가정하였다. 활동파괴의 전체적인 파괴확률은 일련의 Conditional events의 급으로 표현되었다. 최종적으로 개발된 절차가 절취사면의 신뢰도를 얻기 위하여 한 예에 적용되었다.

• 대한토목학회논문집
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• 제8권3호
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• pp.85-90
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• 1988

균질토 사면에서 파괴에 대한 확률론적모델이 제시되었다. 사면의 안전은 관례적인 안전을 보다는 파괴확률로써 측정된다. 사면파괴의 Safety Margin은 정규분포라 가정하였다. 어떤 균질한 흙층에 있어서 흙의 특성에 영향을 주는 불확실성의 원인은 본래의 공간적인 가변성, 불충분한 시료에서 오는 판단오차 그리고 실험오차등이 었다. 파괴면을 따라 존재하는 전단강도의 불확실성은 1차원 Random Field Madels로 표현되었다. 파괴aus의 양상은 대수나선 곡선을 따른다고 가정하였다. 파괴면과 그것을 따라 작용하는 힘의 통계적 특성을 유도하여 사면의 파괴확률을 계산하였다. 마지막으로 개발된 절차가 사면의 신뢰성 해석에 대한 하나의 예제 연구에 적용되었다.