• The Korean Journal of Applied Statistics
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• v.29 no.7
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• pp.1459-1473
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• 2016

Both longitudinal data and survival data are collected simultaneously in longitudinal data which are observed throughout the passage of time. In this case, the effect of the independent variable becomes biased (provided that sole use of longitudinal data analysis does not consider the relation between both data used) if the missing that occurred in the longitudinal data is non-ignorable because it is caused by a correlation with the survival data. A joint model of longitudinal data and survival data was studied as a solution for such problem in order to obtain an unbiased result by considering the survival model for the cause of missing. In this paper, a joint model of the longitudinal zero-inflated count data and survival data is studied by replacing the longitudinal part with zero-inflated count data. A hurdle model and proportional hazards model were used for each longitudinal zero inflated count data and survival data; in addition, both sub-models were linked based on the assumption that the random effect of sub-models follow the multivariate normal distribution. We used the EM algorithm for the maximum likelihood estimator of parameters and estimated standard errors of parameters were calculated using the profile likelihood method. In simulation, we observed a better performance of the joint model in bias and coverage probability compared to the separate model.

• Journal of Life Science
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• v.14 no.5
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• pp.874-881
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• 2004

Angiogenesis has been implicated in progression of inflammation, arthritis, psoriasis, atherosclerosis as well as tumor growth and metastasis. Intensive studies have been carried out to develop a strategy for cancer treatment by blocking angiogenesis. During angiogenesis, endothelial proliferation and migration essentially occurs upon activation. In this study, we compared the expression profiles of human umbilical endothelial cells activated by incubating in vitro in the rich medium containing several growth factors, and non-activated ones. cDNA targets derived from total RNAs of HUVEC activated for 13 h in M199 medium containing endothelial cell growth supplement, 20% fetal bovine serum, and heparin, after reaching 70～80% confluency, or non-activated, were hybridized onto oligonucleotide microarrays containing 1,8864 genetic elements. Unsupervised hierarchical clustering analysis resulted in two subgroups on dendrogram exhibiting activated and non-activated HUVECs. We then extracted 122 outlier genes which were shown to be up-regulated or under-expressed by at least 2-folds in activated HUVECs. Among these, 32 annotated genes were up-regulated and 38 were down-regulated in activated HUVECs. Interestingly, genes involved in cell proliferation, motility, and inflammation/ immune response were up-regulated in activated HUVEC, whereas genes for cell adhesion or vessel morphogenesis/function were down-regulated. Unexpectedly, the expression of genes well-characterized as angiogenesis markers was not changed except Eph-B4, which was down-regulated about 4 folds. 52 unknown genes were also up- or down-regulated. Therefore, these results could provide an opportunity to targeting new vascular molecules for the development of anti-angiogenic molecules.

• Journal of the Korean Ceramic Society
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• v.42 no.2 s.273
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• pp.104-109
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• 2005

To study the role of PbO as the buffer layer, Pt/PZT/PbO/Si with the MFIS structure was deposited on the p-type (100) Si substrate by the r.f. magnetron sputtering with $Pb_{1.1}Zr_{0.53}Ti_{0.47}O_3$ and PbO targets. When PbO buffer layer was inserted between the PZT thin film and the Si substrate, the crystallization of the PZT thin films was considerably improved and the processing temperature was lowered. From the result of an X-ray Photoelectron Spectroscopy (XPS) depth profile result, we could confirm that the substrate temperature for the layer of PbO affects the chemical states of the interface between the PbO buffer layer and the Si substrate, which results in the inter-diffusion of Pb. The MFIS with the PbO buffer layer show the improved electric properties including the high memory window and low leakage current density. In particular, the maximum value of the memory window is 2.0V under the applied voltage of 9V for the Pt/PZT(200 nm, $400^{\circ}C)/PbO(80 nm)/Si$ structures with the PbO buffer layer deposited at the substrate temperature of $300^{\circ}C$.

• Korean Journal of Remote Sensing
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• v.37 no.6_3
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• pp.2027-2034
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• 2021

Using multi-temporal KOMPSAT-3/3A high-resolution satellite images, the Normalized Difference Vegetation Index (NDVI) for the area around the Fukushima daiichi nuclear power plant was determined, and the pattern of vegetation changes was analyzed. To calculate the NDVI, surface reflectance from the KOMPSAT-3/3A satellite image was used. Satellite images from four years were used, and the zones where the images overlap was designated as the area of interest (AOI) for the study, and by setting a profile passing through highly vegetated area as a data analysis method, the changes by year were examined. In addition, random points were extracted within the AOI and displayed as a box plot to quantitatively indicate change of NDVI distribution pattern. The main results of this study showed that the NDVI in 2014 was low within AOI in the vicinity of the nuclear power plant, but vegetated area continued to expand until 2021. These results were also confirmed in the change monitoring results shown in a profile or box plot. In disaster areas where access is restricted, such as the Fukushima nuclear power plant area, where it is difficult to collect field data, obtaining land cover classification products with high accuracy using satellite images is challenging, so it is appropriate to analyze them using primary outputs such as vegetation indices obtained from high-resolution satellite imagery. It is necessary to establish an international cooperation system for jointly utilizing satellite images. Meanwhile, to periodically monitor environmental changes in neighboring countries that may affect the Korean peninsula, it is necessary to establish utilization models and systems using high-resolution satellite images.

• Korean Journal of Agricultural and Forest Meteorology
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• v.21 no.2
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• pp.97-109
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• 2019

Degree days have been determined using temperature data measured at nearby weather stations to a site of interest to produce information for supporting decision-making on agricultural production. Alternatively, the data products of Moderate Resolution Imaging Spectroradiometer (MODIS) can be used for estimation of degree days in a given region, e.g., Korean Peninsula. The objective of this study was to develop a simple tool for processing the MODIS product for estimating cooling degree days (CDD), which would help assessment of heat stress conditions for a crop as well as energy requirement for greenhouses. A set of scripts written in R was implemented to obtain temperature profile data for the region of interest. These scripts had functionalities for processing spatial data, which include reprojection, mosaicking, and cropping. A module to extract air temperature at the surface pressure level was also developed using R extension packages such as rgdal and RcppArmadillo. Random forest (RF) models, which estimate mean temperature and CDD with a different set of MODIS data, were trained at 34 sites in South Korea during 2009 - 2018. Then, the values of CDD were calculated over Korean peninsula during the same period using those RF models. It was found that the CDD estimates using the MODIS data explained >74% of the variation in the CDD measurements at the weather stations in North Korea as well as South Korea. These results indicate that temperature data derived from the MODIS atmospheric products would be useful for reliable estimation of CDD. Our results also suggest that the MODIS data can be used for preparation of weather input data for other temperature-based agro-ecological models such as growing degree days or chill units.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1996.06a
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• pp.179-200
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• 1996

The intrinsic instabilities of fluid flow occurred in the melt of the Czochralski crystal growth system Czochralski method, asymmetric flow patterns and temperature profiles in the melt have been studied by many researchers. The idea that the non-symmetric structure of the growing equipment is responsible for the asymmetric profiles is usually accepted at the first time. However further researches revealed that some intrinsic instabilities not related to the non-symmetric equipment structure in the melt could also appear. Ristorcelli had pointed out that there are many possible causes of instabilities in the melt. The instabilities appears because of the coupling effects of fluid flow and temperature profiles in the melt. Among the instabilities, the B nard type instabilities with no or low crucible rotation rates are analyzed by the visualizing experiments using X-ray radiography and the 3-D numerical simulation in this study. The velocity profiles in the Silicon melt at different crucible rotation rates were measured using X-ray radiography method using tungsten tracers in the melt. The results showed that there exits two types of fluid flow mode. One is axisymmetric flow, the other is asymmetric flow. In the axisymmetric flow, the trajectory of the tracers show torus pattern. However, more exact measurement of the axisymmetrc case shows that this flow field has small non-axisymmetric components of the velocity. When fluid flow is asymmetric, the tracers show random motion from the fixed view point. On the other hand, when the observer rotates to the same velocity of the crucible, the trajectory of the tracer show a rotating motion, the center of the motion is not same the center of the melt. The temperature of a point in the melt were measured using thermocouples with different rotating rates. Measured temperatures oscillated. Such kind of oscillations are also measured by the other researchers. The behavior of temperature oscillations were quite different between at low rotations and at high rotations. Above experimental results means that the fluid flow and temperature profiles in the melt is not symmetric, and then the mode of the asymmetric is changed when rotation rates are changed. To compare with these experimental results, the fluid flow and temperature profiles at no rotation and 8 rpm of crucible rotation rates on the same size of crucible is calculated using a 3-dimensional numerical simulation. A finite different method is adopted for this simulation. 50×30×30 grids are used. The numerical simulation also showed that the velocity and flow profiles are changed when rotation rates change. Futhermore, the flow patterns and temperature profiles of both cases are not axisymmetric even though axisymmetric boundary conditions are used. Several cells appear at no rotation. The cells are formed by the unstable vertical temperature profiles (upper region is colder than lower part) beneath the free surface of the melt. When the temperature profile is combined with density difference (Rayleigh-B nard instability) or surface tension difference (Marangoni-B nard instability) on temperature, cell structures are naturally formed. Both sources of instabilities are coupled to the cell structures in the melt of the Czochralski process. With high rotation rates, the shape of the fluid field is changed to another type of asymmetric profile. Because of the velocity profile, isothermal lines on the plane vertical to the centerline change to elliptic. When the velocity profiles are plotted at the rotating view point, two vortices appear at the both sides of centerline. These vortices seem to be the main reason of the tracer behavior shown in the asymmetric velocity experiment. This profile is quite similar to the profiles created by the baroclinic instability on the rotating annulus. The temperature profiles obtained from the numerical calculations and Fourier transforms of it are quite similar to the results of the experiment. bove esults intend that at least two types of intrinsic instabilities can occur in the melt of Czochralski growing systems. Because the instabilities cause temperature fluctuations in the melt and near the crystal-melt interface, some defects may be generated by them. When the crucible size becomes large, the intensity of the instabilities should increase. Therefore, to produce large single crystals with good quality, the behavior of the intrinsic instabilities in the melt as well as the effects of the instabilities on the defects in the ingot should be studied. As one of the cause of the defects in the large diameter Silicon single crystal grown by the

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.3A
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• pp.342-350
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• 2000

In this paper, the bit error performance for the reverse link of a synchronous direct sequence code division multiple access (DS-CDMA) system employing an imperfect power control scheme over a frequency selective Rayleigh fading channel is analyzed. The system capacity degradation due to power control error (PCE), which is approximated by a log-normally distributed random variable, is estimate as a function of a standard deviation of the PCE. In addition, the impact of the multipath intensity profile (MIP) shape and the number of resolvable paths on the performance of the synchronous transmission is investigated. To estimate the system capacity, the coded bit error performance is evaluated and compared with the conventional CDMA. It is found tat synchronous transmission has less sensitivity to imperfect power control and eases the power control requirements. In particular, as the decay constant $\delta$ of MIP increases, the synchronous transmission in the DS-CDMA reverse link results in a significant BER improvement over the asynchronous transmission even in the presence of imperfect power control. We further conclude that the capacity can be improved by employing the synchronous transmission.

• Journal of Astronomy and Space Sciences
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• v.31 no.1
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• pp.1-6
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• 2014

Quite recently, it has been suggested that the interaction of the solar wind with Mercury results in the variation in the solar wind velocity in the Earth's neighborhood during inferior conjunctions with Mercury. This suggestion has important implications both on the plasma physics of the interplanetary space and on the space weather forecast. In this study we have attempted to answer a question of whether the claim is properly tested. We confirm that there are indeed ups and downs in the profile of the solar wind velocity measured at the distance of 1 AU from the Sun. However, the characteristic attribute of the variation in the solar wind velocity during the inferior conjunctions with Mercury is found to be insensitive to the phase of the solar cycles, contrary to an earlier suggestion. We have found that the cases of the superior conjunctions with Mercury and of even randomly chosen data sets rather result in similar features. Cases of Venus are also examined, where it is found that the ups and downs with a period of ~ 10 to 15 days can be also seen. We conclude, therefore, that those variations in the solar wind velocity turn out to be a part of random fluctuations and have nothing to do with the relative position of inner planets. At least, one should conclude that the solar wind velocity is not a proper observable modulated by inner planets at the distance of 1 AU from the Sun in the Earth's neighborhood during inferior conjunctions.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.5
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• pp.488-497
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• 2009

The freak wave, also known as New-Year-Wave in the north Atlantic, is relatively large and spontaneous ocean surface wave that can sink even large ships and destroy maritime structures. To understand oceanic conditions that develop freak waves, we simulated and generated two versions of scale-downed waves (1:64 and 1:42) in a numerical wave tank and compared the results with the experiment in wave flume. Both of the breaking and non-breaking waves were generated in the simulation. The numerical simulation was implemented based on the finite volume method and a genetic optimization algorithm. Random values were assigned as the initial values for the parameter in the control function, which produced signals representing the motion of wave-maker. The same signal obtained from the optimization process was used for both of the simulation and the experiment. By varying the object function and restrictions of the simulation, a best profile of design wave was selected based on the characteristics, height and period of simulated waves. Results showed that the simulation and experiment with the scale of 1:42 agreed better with freak waves in the natural condition. The presented simulation method will contribute to saving the time and cost for conducting subsequent response analyses of motion under freak waves in the course of the model test for ship and maritime structure.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.10 no.4
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• pp.151-158
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• 1990

Various factors may contribute on the mixing processes in the surf zone formed by irregular waves. The turbulence motion driven by wave breaking may be one of the major causes, the effect due to spatial variation on current velocity be a secondary one, and the additional process may result from the irregular superposition of radiation stresses or wave breaking dissipation incurred by random breaking waves in a broadened surf zone. In the present study a numerical model of spectral waves and induced currents was developed using a superposition technique with ${\kappa}-{\varepsilon}$ closure for mixing process and applied to a field situation of longshore current generated by spectral waves on a uniform beach. It was found from the application that the surf-zone mixing processes formed by irregular waves can be well described by using ${\kappa}-{\varepsilon}$ equations if the source of ${\kappa}$ is properly represented. The nonlinear energy transfer was also found to have some influence on the velocity profile of longshore current particularly in very shallow water region near coast.