• Radiation Oncology Journal
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• v.15 no.4
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• pp.315-319
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• 1997

Purpose : To evaluate the role of curative radiotherapy and salvage surgery in Patients with T1 T2 glottic canter. Materials and Method : Between June 1989 and December 1994, 23 patients with early glottic cancer, 18 with T1N0M0 and 5 with T2N0M0, were treated with radiotherapy at Gyeongsang National University Hospital All Patients were male. Median follow-up period was 46 months, and $100\%$ were observed for at least 3 years. Results : Actuarial survival rates at 5 years were $84.3\%$ for 23 patients. The 5-year actuarial survival rates were $94.4\%$ for T1 and $53.3\%$ for 72(P=0.05) The 5-rear local control rates was $70.0\%$ for T1 and $60.0\%$ for T2 (P=0.44). Of 8 Patients with treatment failure, 6 patients $(75.0\%)$ were salvaged with surgery. After surgical salvage, the 5-year local control rates were $87.2\%$ for T1 and $80.0\%$ for T2(p=0.55). Conclusion : In early stage (Stage I and II) glottic cancer, curative radiotherapy can be a treatment of choice and surgery reserved for salvage of radiotherapy failure.

• Radiation Oncology Journal
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• v.18 no.4
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• pp.226-232
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• 2000

Purpose :This study was performed to find out the prognostic factors affecting local control in early glottic cancer treated with radiation therapy alone. Materials and Methods :We analysed 37 patients of histologically confirmed early glottic cancer treated at Chonnam National University Hospital between July Im and December 1995, retrospectively. Age of patients ranged from 30 to 73 years (median; 59 years). Thirty-five (95$\%$) patients were male. Histological type was all squamous cell carcinoma. According to the staging system of 1997 American Joint Committee on Cancer, 37 patients were restaged as follows: Tla; U (73$\%$), Tlb; 3 (8$\%$), 72: 7 (19$\%$). Radiation therapy was done using 6 MV X-ray of linear accelerator The range of total radiation dose delivered to the glottic lesion was between 5,040 cGy and 7,020 cGy (median; 6,600 cGy). Median follow-up period was U months. local control rates were calculated by Kaplan-Meier method. Generalized Wilcoxon test was used to evaluate the difference of control rates between comparable groups. Multivariate analysis using Cox proportional hazard model was done to find out prognostic factors affecting local control. Results:5 year survival rate of 37 patients was 89$\%$. Local control rate of 37 patients was 74$\%$ in 5 years. We included age, 7-stage, anterior commissure involvement, fraction size, total radiation dose, treatment time of radiotherapy as potential prognostic factors in univariate and multivariate analysis. As a result, treatment time had statistical significance in local control rate in both univariate (p=0.026) and multivariate (p=0.017) analysis. Complication was not recorded except one patient with hypothyroidism. Conclusion :This study revealed that overall treatment time of radiation was a significant factor affecting local control rate.