• Journal of Radiation Protection and Research
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• 제30권1호
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• pp.31-34
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• 2005

The article is devoted to the study of some hi-and tricyclic derivatives of aziridine as materials lot newindicators of ionizing radiation. To create high sensitive materials some aspects of photo induced ring opening processes in aziridine derivatives in ethanol solutions and in polymeric matrix were studied and two steps character of the processes investigated was established. Two types of radioindicators were suggested and preliminary tested. The new way of synthesis of radiochromic derivatives of aziridine was developed and series of target compounds synthesized.

• Applied Microscopy
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• 제38권3호
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• pp.185-193
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• 2008

전자 빔 조사 민감 물질인 gibbsite(${\gamma}-Al(OH)_3$)의 전자 빔 조사 상전이 연구에서 전자회절 자료의 기록에 대한 imaging plate와 필름의 기록 특성을 실험적으로 비교하였다. Imaging plate는 극단적으로 낮은 전자 강도와 높은 전자 강도를 동시 기록하기에 충분한 선형 dynamic range를 갖기 때문에, 매우 낮은 전자 조사 조건(${\leq}0.1\;e^-/{\mu}m^2$)에서 전자 회절 자료를 기록할 때 필름에 비해 회절 자료의 spatial frequency 범위가 두 배 이상 확장되었다. 심지어 이미 기록 포화된 투과 빔 주위의 신호 정보 레벨을 세분화하는 데에도 훨씬 우수한 분해 성능을 나타내었다. 따라서 본 연구 결과는 imaging plate가 극단적으로 낮은 전자 강도 기록이 필요한 전자 빔 조사 민감 물질이나 cryo-biological 시편들의 구조 연구 관점에서 가장 적절한 기록 매체임을 나타낸다.

• 한국자기공명학회논문지
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• 제6권2호
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• pp.84-88
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• 2002

Dating and dosimetry using electron spin resonance (ESR) in 20th Century developed at both Yamaguchi University and Osaka University have been reviewed with emphasis on new prospects and strategies in 21th century. Natural radiation have been generating radicals that accumulated in archaeological and geological materials. ESR detects these radicals and the ESR signal intensity is proportional to the radiation dose and therefore the age. The assessment of the total dose of natural radiation and the annual dose rate give their ESR ages. The ESR dating of stalactites and stalagmites ant Akiyoshi cave in Yamaguchi prefecture in 1975 was extended to anthropological dating using bones and tooth enamel excavated in Greek Petralona cave. Fossils of shells and corals gave the ages of marine terraces and sea-level changes. Quartz grains gave the ages of geothermal alteration and fault movements. Future ESR dating of ices at outer planets anf their satellite are also investigated as basic studies for ices od $H_2O,\;CO_2,\;SO_2$ as well as terrestrial hydrates in laboratory. Atomic bomb radiation dosimetry at Hiroshima and Nagasaki using ESR lead to the dosimetry of personnel, Chemobyl and JCO criticality accidents. Monitoring of radiation dose with sensitive materials with tissue equivalence are being developed. finally a new scanning ESR imaging apparatus (a near field microwave microscope) developed in our laboratory gave ESR images of Radicals from fossils to Si-CVD and diamond films as summarized in my book in 2002.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3211-3217
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• 2014

Background: The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. Materials and Methods: Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longumine combined with X-rays. Conogenic assays were performed to determine the radio-sensitizing effects. Cell survival curves were fitted by single-hit multi-target model and then the survival fraction (SF), average lethal dose ($D_0$), quasi-threshold dose ($D_q$) and sensitive enhancement ratio (SER) were calculated. Cell apoptosis was analyzed by flow cytometry (FCM). Western blot assays were employed for expression of apoptosis-related proteins (Bc1-2 and Bax) after treatment with Piper longumine and/or X-ray radiation. The intracellular reactive oxygen species (ROS) level was detected by FCM with a DCFH-DA probe. Results: The cloning formation capacity was decreased in the group of piperlongumine plus radiation, which displayed the values of SF2, D0, Dq significantly lower than those of radiation alone group and the sensitive enhancement ratio (SER) of D0 was1.22 and 1.29, respectively. The cell apoptosis rate was increased by the combination treatment of Piper longumine and radiation. Piper longumine increased the radiation-induced intracellular levels of ROS. Compared with the control group and individual group, the combination group demonstrated significantly decreased expression of Bcl-2 with increased Bax. Conclusions: Piper longumine at a non-cytotoxic concentration can enhance the radio-sensitivity of MDA-MB-231cells, which may be related to its regulation of apoptosis-related protein expression and the increase of intracellular ROS level, thus increasing radiation-induced apoptosis.

• Nuclear Engineering and Technology
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• 제52권7호
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• pp.1503-1510
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• 2020

Ultra-low noise charge sensitive amplifiers (CSAs) based on various types of circuit board substrates, such as FR4, Teflon, and ceramics (Al₂O₃) with two different designs, PA1 and PA2, have been developed. They were tested to see the noise effect from the dielectric loss of the substrate capacitance before and after irradiation. If the electronic noise from the CSAs is to be minimized and the energy resolution enhanced, the shaping time has to be optimized for the detector, and a small feedback capacitance of the CSA is favorable for a better SNR. Teflon- and ceramic-based PA1 design CSAs showed better noise performance than the FR4-based one, but the Teflon-based PA1 design showed better sensitivity than ceramic based one at a low detector capacitance (<10 pF). In the PA2 design, the equivalent noise and the sensitivity were 0.52 keV FWHM for a silicon detector and 7.2 mV/fC, respectively, with 2 ㎲ peaking time and 0.1 pF detector capacitance. After 10, 100, 10³, 10⁴, and 10⁵ Gy irradiation the ENC and sensitivity characteristics of the developed CSAs based on three different substrate materials are also discussed.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2002년도 추계학술발표대회 논문집
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• pp.269-272
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• 2002

UV curing technology becomes important in various sectors of applications due to the high efficiency, environmental protection, and saving of energy. The effect of different proportion of vinylester (VE) and unsaturated polyester (UP) for VE/UP blend system was investigated in context of mechanical properties. The compositions of VE/UP blend were varied within 0:100, 20:80, 40:60, 60:40, 80:20, and 100:0 by weight percent. 1 wt% 1-hydroxy-cyclohexyl-phenyl-ketone was used as photoinitiator. The used intensity of UV light was in the range of $40~70 mW/\textrm{cm}^2$. The flexural strength of vinylester was not sensitive to the intensity of UV light. But the unsaturated polyester was very sensitive to the intensity of UV light. The flexural strength of vinylester was always superior to that of unsaturated polyester. The addition of the vinylester increased the flexural strength of blend system.

• Journal of Radiation Protection and Research
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• 제42권1호
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• pp.21-25
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• 2017

Background: We are developing L-band and S-band microwave dielectric absorption systems aiming novel dosimetry using DNAs, such as plasmid DNA and genomic DNA, and microwave technology. Materials and Methods: Each system is composed of a cavity resonator, analog signal generator, circulator, power meter, and oscilloscope. Since the cavity resonator is sensitive to temperature change, we have made great efforts to prevent the fluctuation of temperature. We have developed software for controlling and measurement. Results and Discussion: By using this system, we can measure the resonance frequency, f, and ${\Delta}Q$ (Q is a dimensionless parameter that describes how under-damped an oscillator or resonator is, and characterizes a resonator's bandwidth relative to its center frequency) within about 3 minutes with high accuracy. Conclusion: This system will be expected to be applicable to DNAs evaluations and to novel dosimetric system.

• Nuclear Engineering and Technology
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• 제53권7호
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• pp.2075-2083
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• 2021

The article provides a review of the research results obtained during of more than 20 years concerning using the gaseous radiochemical method (GRCM) for detecting of ionizing radiation. This method based on threshold nuclear reactions with production of radioactive noble gas which does not interact with the materials of gaseous tract. The applications of GRCM in the diagnostics of neutrinos, neutrons, charged particles, thermonuclear plasma thermometry, and the study of the structure and dynamics of astrophysical objects, position-sensitive dosimetry of neutron targets with accelerator driving, spatial distribution of the fast neutron flux density in a nuclear reactor allowing the transformation of longitudinal coordinate of neutron flux distribution into a temporal distribution of the radiochemical gas decay counting rate ("barcode" semblance) and measurement of bombarding particles spectra are described. Experimental testing of the described technologies was made on the neutron target driven with the linear proton accelerator of Institute for Nuclear Research of Russian Academy of Sciences (INR RAS).

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.601-607
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• 2022

In recent years, monitoring of spent nuclear fuel inside dry cask storage has become an important area of national security. Muon tomography is a useful method for monitoring spent nuclear fuel because it uses high energy muons that penetrate deep into the target material and provides a 3-D structure of the inner materials. We designed a muon tomography system consisting of four 2-D position sensitive detector and characterized and optimized the system parameters. Each detector, measuring 200 × 200 cm², consists of a plastic scintillator, wavelength shifting (WLS) fibers and, SiPMs. The reconstructed image is obtained by extracting the intersection of the incoming and outgoing muon tracks using a Point-of-Closest-Approach (PoCA) algorithm. The Geant4 simulation was used to evaluate the performance of the muon tomography system and to optimize the design parameters including the pixel size of the muon detector, the field of view (FOV), and the distance between detectors. Based on the optimized design parameters, the spent fuel assemblies were modeled and the line profile was analyzed to conduct a feasibility study. Line profile analysis confirmed that muon tomography system can monitor nuclear spent fuel in dry storage container.

• Radiation Oncology Journal
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• 제29권4호
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• pp.219-227
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• 2011

Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.